TIDMSUMM 
 
 
   TR-1: Standard form for notification of major holdings 
 
 
 
 
NOTIFICATION OF MAJOR HOLDINGS 
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1a. Identity of the issuer or the underlying issuer 
 of existing shares to which voting rights are attached(ii)                                                                          Summit Therapeutics PLC 
 :                                                                                                                                         Sedol BN40HZ0 
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1b. Please indicate if the issuer is a non-UK issuer 
 (please mark with an "X" if appropriate) 
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Non-UK issuer 
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2. Reason for the notification (please mark the appropriate 
 box or boxes with an "X") 
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An acquisition or disposal of voting rights                                                                                                                                       X 
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An acquisition or disposal of financial instruments 
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An event changing the breakdown of voting rights 
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Other (please specify)(iii) : 
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3. Details of person subject to the notification obligation(iv) 
Name                                                                                                     Robert W. Duggan 
City and country of registered office (if applicable) 
4. Full name of shareholder(s) (if different from 
 3.)(v) 
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Name                                                                                                     Robert W. Duggan 
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City and country of registered office (if applicable) 
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5. Date on which the threshold was crossed or reached(vi) 
 :                                                                                                       24/12/2019 
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6. Date on which issuer notified (DD/MM/YYYY):                                                           30/12/2019 
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7. Total positions of person(s) subject to the notification 
 obligation 
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                                                                                                                                                                             Total number 
                                                                                                                                                                             of voting 
                                                     % of voting rights attached to shares (total of 8.  % of voting rights through financial instruments  Total of both in  rights of 
                                                                             A)                                      (total of 8.B 1 + 8.B 2)               % (8.A + 8.B)    issuer(vii) 
---------------------------------------------------  --------------------------------------------------  ------------------------------------------------  ----------------  ------------ 
Resulting situation on the date on which threshold 
 was crossed or reached                                                                          49.47%                                            23.31%            72.78%   335,873,208 
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Position of previous notification (if 
 applicable)                                                                                        n/a                                            48.78%            48.78% 
---------------------------------------------------  --------------------------------------------------  ------------------------------------------------  ----------------  ------------ 
 
 
 
 
 
 
 
 8. Notified details of the resulting situation on 
 the date on which the threshold was crossed or reached(viii) 
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A: Voting rights attached to shares 
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Class/type of 
 shares 
 ISIN code (if possible)                                   Number of voting rights(ix)                                 % of voting rights 
-------------------------- 
                                              Direct                                      Indirect                                            Direct                                            Indirect 
                             (Art 9 of Directive 2004/109/EC) (DTR5.1)   (Art 10 of Directive 2004/109/EC) (DTR5.2.1)        (Art 9 of Directive 2004/109/EC) (DTR5.1)         (Art 10 of Directive 2004/109/EC) (DTR5.2.1) 
-------------------------   ------------------------------------------  ---------------------------------------------  -----------------------------------------------------  --------------------------------------------- 
GB00BN40HZ01                                               166,157,050                                                                                                49.47% 
--------------------------  ------------------------------------------  ---------------------------------------------  -----------------------------------------------------  --------------------------------------------- 
SUBTOTAL 8. A                                                      166,157,050                                                                                        49.47% 
--------------------------  -----------------------------------------------------------------------------------------  ---------------------------------------------------------------------------------------------------- 
 
B 1: Financial Instruments according to Art. 13(1)(a) 
 of Directive 2004/109/EC (DTR5.3.1.1 (a)) 
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                                                                                                                         Number of voting rights that may be acquired if the 
Type of financial                                           Expiration                                      Exercise/                                          instrument is 
instrument                                                     date(x)                          Conversion Period(xi)                                   exercised/converted.                             % of voting rights 
--------------------------  ------------------------------------------  ---------------------------------------------  -----------------------------------------------------  --------------------------------------------- 
American Depositary Shares 
 (ADS)                                                             n/a                                            n/a                                             78,288,205                                         23.31% 
--------------------------  ------------------------------------------  ---------------------------------------------  -----------------------------------------------------  --------------------------------------------- 
                                                                                                      SUBTOTAL 8. B 1                                             78,288,205                                         23.31% 
                                                                        ---------------------------------------------  -----------------------------------------------------  --------------------------------------------- 
 
B 2: Financial Instruments with similar economic effect 
 according to Art. 13(1)(b) of Directive 2004/109/EC 
 (DTR5.3.1.1 (b)) 
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Type of financial          Expiration                                   Exercise/ Conversion                           Physical or cash    Number of voting rights            % of voting rights 
 instrument                 date(x)                                     Period (xi)                                    settlement(xii) 
-------------------------  -------------------------------------------  ---------------------------------------------  ------------------  ---------------------------------  --------------------------------------------- 
 
                                                                                                                       SUBTOTAL 8.B.2 
                                                                                                                       ------------------  ---------------------------------  --------------------------------------------- 
 
 
 
 
 
 
 
9. Information in relation to the person subject to 
 the notification obligation (please mark the 
 applicable box with an "X") 
Person subject to the notification obligation is not                                                                                               X 
 controlled by any natural person or legal entity and 
 does not control any other undertaking(s) holding 
 directly or indirectly an interest in the (underlying) 
 issuer(xiii) 
Full chain of controlled undertakings through which 
 the voting rights and/or the 
 financial instruments are effectively held starting 
 with the ultimate controlling natural person or legal 
 entity(xiv) (please add additional rows as necessary) 
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Name(xv)  % of voting rights if it equals or is higher than   % of voting rights through financial instruments if    Total of both if it equals or is higher than the notifiable 
                       the notifiable threshold               it equals or is higher than the notifiable threshold                            threshold 
--------  -------------------------------------------------  -----------------------------------------------------  ------------------------------------------------------------- 
 
 
 
 
 
 
10. In case of proxy voting, please identify: 
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Name of the proxy holder 
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The number and % of voting rights held 
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The date until which the voting rights will be held 
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11. Additional information(xvi) 
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Place of completion  Florida, United States of America 
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Date of completion   30/12/2019 
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(END) Dow Jones Newswires

December 31, 2019 04:00 ET (09:00 GMT)

Copyright (c) 2019 Dow Jones & Company, Inc.
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