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Your Vote Counts! CORTEXYME INC 2022 Annual Meeting Vote by June 07, 2022 11 :59 PM ET You invested in CORTEXYME INC and it•s time to vote! You have the right to vote on proposals being presented at the Annual Meeting. This is an important notice regarding the availability of proxy material for the shareholder meeting to be held on June 08, 2022. Get informed before you vote View the Notice & Proxy Statement, Annual Report online OR you can receive a free paper or email copy of the material(s) by requesting prior to May 25, 2022. If you would like to request a copy of the material(s) for this and/or future shareholder meetings, you may (1) visit www.ProxyVote.com, (2) call 1-800-579-1639 or (3) send an email to sendmaterial@proxyvote.com. If sending an email, please include your control number (indicated below) in the subject line. Unless requested, you will not otherwise receive a paper or email copy. Smartphone users Vote in Person at the Meeting* Point your camera here and June 08, 2022 11:00 AM PDT vote without entering a ~Inumber Virtual Meeting live webcast at https://web.lumiagm.com/294872708 Online check-in will commence at 10:30 A.M. PDT *If you choose to vote these shares in person at the meeting, you must request a “legal proxy.” To do so, please follow the instructions at www.ProxyVote.com or request a paper copy of the materials, which will contain the appropriate instructions. Please check the meeting materials for any special requirements for meeting attendance.


Vote at www.ProxyVote.com THIS IS NOT A VOTABLE BALLOT This is an overview of the proposals being presented at the upcoming shareholder meeting. Please follow the instructions on the reverse side to vote these important matters. Board Voting Items Recommends 1. Election of Directors Nominees: 0 For 01 Christopher Lowe 02 Christopher J. Senner 2 To ratify the selection of BOO USA, LLP as the independent registered public accounting firm of the Company for its OF fiscal year ending December 31, 2022. or 3 To approve, on an advisory basis, the compensation of the Company’s named executive officers. 0 For NOTE: Such other business as may properly come before the meeting or any adjournment thereof.

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