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| Holder | Type | Held (Actual) | % of Outstanding | Market Value | Date Reported |
|---|---|---|---|---|---|
| BVF Partners L.P. | Institution | 1,251,788 | 7.55% | US$ 31.81M | 2026-03-31 |
| Affinity Asset Advisors, LLC | Institution | 1,069,519 | 6.45% | US$ 27.18M | 2026-03-31 |
| Samsara BioCapital LLC | Institution | 1,062,872 | 6.41% | US$ 27.01M | 2026-03-31 |
| Point72 Associates, LLC | Institution | 946,829 | 5.71% | US$ 24.06M | 2026-04-24 |
| Point72 Asset Management, L.P. | Institution | 946,829 | 5.71% | US$ 24.06M | 2026-04-24 |
| Perceptive Advisors LLC | Institution | 898,025 | 5.42% | US$ 22.82M | 2026-04-14 |
| Perceptive Life Sciences Master Fund, Ltd. | Institution | 898,025 | 5.42% | US$ 22.82M | 2026-04-14 |
| Kynam Capital Management, LP | Institution | 872,558 | 5.27% | US$ 22.17M | 2026-03-31 |
| OrbiMed Advisors LLC | Institution | 801,144 | 4.83% | US$ 20.36M | 2026-03-31 |
| Affinity Healthcare Fund, LP | Institution | 748,382 | 4.52% | US$ 19.02M | 2026-01-22 |
| Vanguard Capital Management, LLC | Institution | 720,442 | 4.35% | US$ 18.31M | 2026-03-31 |
| RA Capital Management, L.P. | Institution | 715,307 | 4.32% | US$ 18.18M | 2026-03-31 |
| Eventide Asset Management, LLC | Institution | 715,307 | 4.32% | US$ 18.18M | 2026-03-31 |
| Biotechnology Value Fund L.P. | Institution | 668,693 | 4.04% | US$ 16.99M | 2026-02-18 |
| Samsara Opportunity Fund, L.P. | Institution | 643,777 | 3.89% | US$ 16.36M | 2026-02-11 |
| ADAR1 Capital Management, LLC | Institution | 524,441 | 3.16% | US$ 13.33M | 2026-03-31 |
| Velan Capital Partners LP | Institution | 512,160 | 3.09% | US$ 13.01M | 2026-03-31 |
| Biotechnology Value Fund II, L.P. | Institution | 488,916 | 2.95% | US$ 12.42M | 2026-02-18 |
| Balyasny Asset Management L.P. | Institution | 465,792 | 2.81% | US$ 11.84M | 2026-03-31 |
| Woodline Partners LP | Institution | 457,441 | 2.76% | US$ 11.62M | 2026-03-31 |
| Samsara Biocapital, L.P. | Institution | 419,095 | 2.53% | US$ 10.65M | 2026-02-11 |
| UBS Asset Management AG | Institution | 392,871 | 2.37% | US$ 9.98M | 2026-03-31 |
| Acadian Asset Management LLC | Institution | 335,813 | 2.03% | US$ 8.53M | 2026-03-31 |
| MRL Ventures Fund LLC | Institution | 272,351 | 1.64% | US$ 6.92M | 2026-03-31 |
| Acuta Capital Partners, LLC | Institution | 269,425 | 1.63% | US$ 6.85M | 2026-03-31 |
| BlackRock, Inc. | Institution | 232,684 | 1.40% | US$ 5.91M | 2026-03-31 |
| Kvp Capital Advisors, LP | Institution | 226,575 | 1.37% | US$ 5.76M | 2026-03-31 |
| Marshall Wace LLP | Institution | 222,634 | 1.34% | US$ 5.66M | 2026-03-31 |
| Millennium Management LLC | Institution | 210,378 | 1.27% | US$ 5.35M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 200,000 | 1.21% | US$ 5.08M | 2026-03-31 |
| Opaleye Management Inc. | Institution | 190,671 | 1.15% | US$ 4.84M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 171,386 | 1.03% | US$ 4.35M | 2026-03-31 |
| Integrated Core Strategies (US) LLC | Institution | 129,608 | 0.78% | US$ 3.29M | 2024-09-30 |
| Citadel Advisors LLC | Institution | 117,537 | 0.71% | US$ 2.99M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 97,824 | 0.59% | US$ 2.49M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 94,838 | 0.57% | US$ 2.41M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 84,902 | 0.51% | US$ 2.16M | 2026-03-31 |
| Biotechnology Value Trading Fund OS LP | Institution | 75,359 | 0.45% | US$ 1.91M | 2026-02-18 |
| Eversept Partners, L.P. | Institution | 73,161 | 0.44% | US$ 1.86M | 2026-03-31 |
| Burkehill Global Management, LP | Institution | 71,530 | 0.43% | US$ 1.82M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 65,176 | 0.39% | US$ 1.66M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 52,118 | 0.31% | US$ 1.32M | 2026-03-31 |
| Mr. William Newell | Insider | 40,906 | 0.25% | US$ 1.04M | 2025-03-31 |
| Fisher Asset Management, LLC | Institution | 35,295 | 0.21% | US$ 896.85k | 2026-03-31 |
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