FORM 4
[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                       
1. Name and Address of Reporting Person * McDermott Adrian 2. Issuer Name and Ticker or Trading Symbol Zendesk, Inc. [ ZEN ] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable)_____ Director                    _____ 10% Owner
__X__ Officer (give title below)    _____ Other (specify below)
Chief Technology Officer
(Last)          (First)          (Middle)
989 MARKET STREET		 3. Date of Earliest Transaction (MM/DD/YYYY)
5/15/2022
(Street)
SAN FRANCISCO, CA 94103
(City)        (State)        (Zip)
 4. If Amendment, Date Original Filed (MM/DD/YYYY)
 
 6. Individual or Joint/Group Filing (Check Applicable Line) _X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock  5/15/2022    M    504  A  (1) 93506 (2) D   
Common Stock  5/15/2022    F    250 (3) D $102.15  93256  D   
Common Stock  5/15/2022    M    408  A  (1) 93664  D   
Common Stock  5/15/2022    F    203 (3) D $102.15  93461  D   
Common Stock  5/15/2022    M    296  A  (1) 93757  D   
Common Stock  5/15/2022    F    147 (3) D $102.15  93610  D   
Common Stock  5/15/2022    M    408  A  (1) 94018  D   
Common Stock  5/15/2022    F    203 (3) D $102.15  93815  D   
Common Stock  5/17/2022    S(4)    242  D $100.56  93573  D   

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Trans. Date 3A. Deemed Execution Date, if any 4. Trans. Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 6. Date Exercisable and Expiration Date 7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Restricted Stock Unit   (1) 5/15/2022    M        504    (5) 2/7/2026  Common Stock  504.0  $0  4034  D   
Restricted Stock Unit   (1) 5/15/2022    M        408    (6) 2/10/2027  Common Stock  408.0  $0  8564  D   
Restricted Stock Unit   (1) 5/15/2022    M        296    (7) 2/8/2028  Common Stock  296.0  $0  9740  D   
Restricted Stock Unit   (1) 5/15/2022    M        408    (8) 2/28/2029  Common Stock  408.0  $0  18385  D   

Explanation of Responses:
(1)  Restricted stock units convert into common stock on a one-for-one basis.
(2)  Includes 242 shares acquired by the Reporting Person on May 13, 2022, pursuant to the Issuer's Employee Stock Purchase Plan in a transaction exempt under Rule 16b-3(c).
(3)  Represents the number of shares withheld by the Issuer in satisfaction of tax withholding obligations in connection with the vesting of the restricted stock units listed in Table II. Such withholding is mandated by an election of the Issuer made in advance and does not represent a discretionary trade by the Reporting Person.
(4)  This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by Adrian McDermott on August 7, 2020.
(5)  1/48th of the shares issuable pursuant to the restricted stock units shall vest each month after the vesting commencement date of January 15, 2019, subject to the Reporting Person's continuous service to the Issuer on each such date. Unvested shares are subject to acceleration upon the occurrence of certain events.
(6)  1/48th of the shares issuable pursuant to the restricted stock units shall vest each month after the vesting commencement date of February 15, 2020, subject to the Reporting Person's continuous service to the Issuer on each such date. Unvested shares are subject to acceleration upon the occurrence of certain events.
(7)  1/48th of the shares issuable pursuant to the restricted stock units shall vest each month after the vesting commencement date of February 15, 2021, subject to the Reporting Person's continuous service to the Issuer on each such date. Unvested shares are subject to acceleration upon the occurrence of certain events.
(8)  1/48th of the shares issuable pursuant to the restricted stock units shall vest each month after the vesting commencement date of February 15, 2022, subject to the Reporting Person's continuous service to the Issuer on each such date. Unvested shares are subject to acceleration upon the occurrence of certain events.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
McDermott Adrian
989 MARKET STREET
SAN FRANCISCO, CA 94103

Chief Technology Officer

Signatures
/s/ Albert Yeh via Power-of-Attorney for Adrian McDermott 5/17/2022
**Signature of Reporting Person Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
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