Evgen Pharma PLC Recruitment of first patient in STAR trial (0759G)
November 23 2020 - 1:00AM
UK Regulatory
TIDMEVG
RNS Number : 0759G
Evgen Pharma PLC
23 November 2020
Evgen Pharma plc
("Evgen" or the "Company")
Recruitment of first patient in STAR trial
Evaluation of SFX-01 in acute respiratory distress syndrome
commences
Evgen Pharma plc (AIM: EVG), a clinical stage drug development
company, announces that, the first patient has now been enrolled
and dosed in the STAR trial (SFX-01 treatment for Acute Respiratory
Infections).
This Phase II/III trial is a randomised, placebo-controlled
trial and is sponsored by the University of Dundee. It will
investigate whether the Company's lead asset, SFX-01, can reduce
the severity, or prevent the onset of, acute respiratory distress
syndrome ("ARDS") in patients with community-acquired pneumonia who
have been or are being tested for suspected COVID-19. Patients may
therefore present with COVID-19 or other respiratory diseases.
SFX-01 upregulates the Nrf2 pathway which is part of the natural
human defence against inflammatory and oxidative stress, such as
the inflammation that occurs during a severe viral infection.
Preclinical studies have shown that up-regulating the Nrf2 pathway
reduces the severity of ARDS, the progressive lung damage observed
in COVID-19 and pneumonia patients, which can result in the need
for invasive ventilation in an intensive care unit.
Dr Huw Jones, CEO of Evgen, commented: "The initiation of
enrolment is an important milestone for us and marks the first use
of SFX-01 in respiratory disease, targeting the Nrf2 pathway. We
remain hopeful that the outcome of this trial will reduce both the
severity and duration of the disease for COVID-19 patients and
those with pneumonia from other infective agents."
The information communicated in this announcement is inside
information for the purposes of Article 7 of EU Regulation
596/2014.
Enquiries:
Evgen Pharma plc www.evgen.com via Walbrook
Barry Clare, Chairman
Dr Huw Jones, CEO
Richard Moulson, CFO
finnCap www.finncap.com +44 (0)20 7220 0500
Geoff Nash / Teddy Whiley (Corporate
Finance)
Alice Lane (ECM)
Walbrook PR +44 (0)20 7933 878 or evgen@walbrookpr.com
+44 (0)7980 541 893 / +44 (0)7876
Paul McManus / Anna Dunphy 741 001
About Evgen Pharma plc
Evgen Pharma is a clinical stage drug development company
developing sulforaphane based medicines for the treatment of
multiple diseases. The Company's core technology is Sulforadex(R),
a method for synthesising and stabilising the naturally occurring
compound sulforaphane and novel proprietary analogues based on
sulforaphane. The lead product, SFX-01, is a patented composition
of synthetic sulforaphane and alpha-cyclodextrin.
Clinical data from the Company's open-label Phase II STEM trial
has shown that SFX-01 can halt the growth of progressing tumours in
patients with oestrogen-positive (ER+) metastatic breast cancer,
and in some cases significantly shrink the tumour, whilst causing
very few side effects.
The Company commenced operations in January 2008 and has its
headquarters at The Colony, Wilmslow, Cheshire, and its registered
office is at the Liverpool Science Park, Liverpool. It joined the
AIM market of the London Stock Exchange in October 2015 and trades
under the ticker symbol EVG.
For further information, please visit: www.evgen.com
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