TIDMNSCI
RNS Number : 4155J
NetScientific PLC
21 December 2020
NetScientific plc
("NetScientific" or the "Company")
PDS Biotech Announces Mount Sinai Publication of Studies Showing
Superior Induction of Antibodies by Versamune â -based COVID-19
Vaccine
Versamune â T-cell activating platform demonstrates breadth
of
anti-SARS-CoV-2 immune responses in a COVID-19 vaccine
London, UK - 21 December 2020 - NetScientific plc (AIM: NSCI),
the life sciences, technology, investment and commercialisation
company, announces that its portfolio company PDS Biotechnology
Corporation ("PDS") (Nasdaq: PDSB) today announced the publication
of research by a leading vaccine research team at the Icahn School
of Medicine at Mount Sinai, showing a powerful antibody induction
by Versamune(R) against SARS-CoV-2 at low antigen doses, suggesting
potential for an effective antigen dose sparing COVID-19 vaccine.
These data are based on preclinical studies combining PDS Biotech's
Versamune(R) technology with an inactivated Newcastle disease virus
(NDV)/SARS-CoV-2 vaccine (NDV vaccine) developed at Mount Sinai.
The peer-reviewed scientific publication "A Newcastle Disease Virus
(NDV) Expressing a Membrane-Anchored Spike as a Cost-Effective
Inactivated SARS-CoV-2 Vaccine" by Sun et al. was published
December 17th, 2020 in Vaccines (2020, volume 8, issue 4, page 771)
and provides strong rationale for clinical development of a
Versamune(R)-based COVID-19 vaccine to maximize the full breadth of
immune responses induced against SARS-CoV-2.
Dr. Frank Bedu-Addo, PDS Biotech's Chief Executive Officer,
commented "The results of this independent preclinical study
highlight the versatility and breadth of immune responses induced
by Versamune(R). The power of Versamune(R) to confer rapid and
long-term protection against infectious agents lies in its ability
to quickly induce effective neutralizing antibody responses in
addition to strong CD8+ and CD4+ T-cell responses."
"The first wave of COVID-19 vaccines focused on antibody
generation. However, there is a growing body of literature that
establishes the importance of T-cells in providing more durable
protection against COVID-19," commented Dr. Lauren V. Wood, Chief
Medical Officer of PDS Biotech, "The preclinical data that has been
generated with our COVID-19 vaccine candidate, PDS0203, establishes
the rapid induction of both protective neutralizing antibodies and
attacking T-cells against the virus. Our encouragement of
independent, expert validation of Versamune(R)'s ability to induce
powerful and effective immune responses underscores our commitment
to developing superior cancer therapies and vaccines."
NetScientific holds approximately 5.75% of PDS' undiluted share
capital.
The full details of the announcement are set out below and can
be found here:
# # #
PDS Biotech Announces Mount Sinai Publication of Studies Showing
Superior Induction of Antibodies by Versamune â -based COVID-19
Vaccine
Versamune â T-cell activating platform demonstrates breadth of
anti-SARS-CoV-2 immune responses in a COVID-19 vaccine
Florham Park, NJ, December 21, 2020 - PDS Biotechnology
Corporation (Nasdaq: PDSB), a clinical-stage immunotherapy company
developing novel cancer therapies and infectious disease vaccines
based on the Company's proprietary Versamune(R) T-cell activating
technology, today announced the publication of data generated by a
leading vaccine research team at the Icahn School of Medicine at
Mount Sinai. The research demonstrated powerful antibody induction
by Versamune(R) against SARS-CoV-2 at low antigen doses suggesting
potential for an effective antigen dose sparing COVID-19 vaccine.
These data are based on preclinical studies combining PDS Biotech's
Versamune(R) technology with an inactivated Newcastle disease virus
(NDV)/SARS-CoV-2 vaccine (NDV vaccine) developed at Mount Sinai.
The peer-reviewed scientific publication "A Newcastle Disease Virus
(NDV) Expressing a Membrane-Anchored Spike as a Cost-Effective
Inactivated SARS-CoV-2 Vaccine" by Sun et al. was published
December 17 th , 2020 in Vaccines ( 2020, volume 8, issue 4, page
771) and provides strong rationale for clinical development of a
Versamune(R)-based COVID-19 vaccine to maximize the full breadth of
immune responses induced against SARS-CoV-2.
The preclinical study compared various treatment regimens in
their ability to induce antibodies against SARS-CoV-2:
-- the NDV vaccine alone at doses of 5<MU>g, 10<MU>g
and 20<MU>g,
-- the NDV vaccine in combination with Versamune(R) at
0.2<MU>g, 1<MU>g and 5<MU>g,
-- and the NDV vaccine in combination with Addavax, an adjuvant
well-known for its ability to induce powerful antibody responses,
at 0.2<MU>g, 1<MU>g and 5<MU>g.
As seen in Figure 3B of the publication, shown below, the NDV
vaccine with R-DOTAP, the active ingredient in Versamune , yielded
the strongest antibody responses. Figure 3C, also shown below,
highlighted Versamune 's ability to induce the highest levels of
neutralizing antibodies even at the lowest studied antigen dose of
0.2<MU>g. Challenge studies also demonstrated that the
Versamune -containing vaccine conferred protection against
SARS-CoV-2 infection.
http://www.rns-pdf.londonstockexchange.com/rns/4155J_1-2020-12-21.pdf
PDS Biotech is jointly developing PDS0203 with the Brazilian
company Farmacore. PDS0203 is a second-generation Versamune -based
COVID-19 vaccine: a simple subunit vaccine that utilizes a
recombinant protein derived from the Spike protein of SARS-CoV-2,
as opposed to an inactivated virus-based vaccine. Preclinical
studies of PDS0203 have confirmed the induction of strong
neutralizing antibodies, virus-specific polyfunctional CD8+
(killer) and CD4+ (helper) T-cells, and long-term memory T-cell
responses.
Dr. Frank Bedu-Addo, PDS Biotech's Chief Executive Officer,
commented "The results of this independent preclinical study
highlight the versatility and breadth of immune responses induced
by Versamune(R). The power of Versamune(R) to confer rapid and
long-term protection against infectious agents lies in its ability
to quickly induce effective neutralizing antibody responses in
addition to strong CD8+ and CD4+ T-cell responses."
"The first wave of COVID-19 vaccines focused on antibody
generation. However, there is a growing body of literature that
establishes the importance of T-cells in providing more durable
protection against COVID-19," commented Dr. Lauren V. Wood, Chief
Medical Officer of PDS Biotech, "The preclinical data that has been
generated with our COVID-19 vaccine candidate, PDS0203, establishes
the rapid induction of both protective neutralizing antibodies and
attacking T-cells against the virus. Our encouragement of
independent, expert validation of Versamune(R)'s ability to induce
powerful and effective immune responses underscores our commitment
to developing superior cancer therapies and vaccines."
The studies detailed in Vaccine were conducted under a drug
testing agreement between PDS Biotech and Icahn School of Medicine
at Mount Sinai.
About PDS Biotechnology
PDS Biotech is a clinical-stage immunotherapy company with a
growing pipeline of cancer immunotherapies and infectious disease
vaccines based on the Company's proprietary Versamune(R) T-cell
activating technology platform. The company's lead investigational
cancer immunotherapy product PDS0101 is currently in Phase 2
clinical studies in multiple indications. Versamune(R) effectively
delivers disease-specific antigens for in vivo uptake and
processing, while also activating the critical type 1 interferon
immunological pathway, resulting in production of potent
disease-specific killer T-cells as well as neutralizing antibodies.
PDS Biotech has developed multiple therapies, based on combinations
of Versamune(R) and disease-specific antigens, designed to train
the immune system to better recognize diseased cells and
effectively attack and destroy them. To learn more, please visit
www.pdsbiotech.com or follow us on Twitter at @PDSBiotech.
AboutPDS0203
PDS0203 is an investigational vaccine designed for the
prevention of COVID-19 being jointly developed by PDS Biotech and
Farmacore. PDS0203 combines the utility of PDS Biotech's
Versamune(R) platform with a recombinant native Severe Acute
Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) protein
recognizable by our immune system (antigen). The Versamune(R)
platform, due to its unique ability to induce both antibody and
T-cell responses is being utilized to develop a next generation
vaccine that may more effectively prevent COVID-19.
# # #
The information contained within this announcement is deemed by
the Company to constitute inside information as stipulated under
the Market Abuse Regulations (EU) No. 596/2014. Following the
publication of this announcement, this inside information is now
considered to be in the public domain.
For more information, please contact:
NetScientific
Ilian Iliev, CEO Tel: +44 (0)20 3514 1800
WH Ireland (NOMAD, Financial Adviser and Broker)
Chris Fielding / Darshan Patel Tel: +44 (0)20 7220 1666
About NetScientific
NetScientific is a life sciences, technology, investment and
commercialisation Group, leveraging trans-Atlantic relationships
and global opportunities to deliver shareholder value.
For more information, please visit the website at www.NetScientific.net
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