Prospect Medical Holdings, Inc. (NYSE Amex: PZZ) (“Prospect” or the “Company”), which owns and operates five hospitals and manages the medical care of HMO enrollees in southern California, today announced that it will file a Form 12b-25 with the Securities and Exchange Commission related to the filing of its Form 10-Q for the fiscal third quarter ended June 30, 2009.

Prospect increased its ownership interest in Brotman Medical Center, Inc. (“Brotman”) from approximately 33% to approximately 72% during this third quarter, requiring first time audits of Brotman and, beginning with the Company’s June 30, 2009 Form 10-Q, inclusion of Brotman’s financial results with Prospect’s consolidated financial results. The Company is in the final stages of completing and consolidating all of the required Brotman information, but such process will not be finalized by today’s filing deadline. Prospect expects to file its Form 10-Q within the five day extension period afforded by Form 12b-25.

ABOUT PROSPECT MEDICAL HOLDINGS

Prospect operates five hospitals in the greater Los Angeles area and manages the medical care of approximately 180,000 individuals enrolled in HMO plans in Southern California, through a network of approximately 14,000 specialist and primary care physicians.

This press release contains forward-looking statements. Additional written or oral forward-looking statements may be made by Prospect from time to time, in filings with the Securities and Exchange Commission, or otherwise. Statements contained herein that are not historical facts are forward-looking statements. Investors are cautioned that forward-looking statements, including the statements regarding anticipated or expected results, involve risks and uncertainties which may affect the Company’s business and prospects, including those outlined in Prospect’s Form 10-K filed on December 29, 2008 and other filings. Any forward-looking statements contained in this press release represent our estimates only as of the date hereof, or as of such earlier dates as are indicated, and should not be relied upon as representing our estimates as of any subsequent date. While we may elect to update forward-looking statements at some point in the future, we specifically disclaim any obligation to do so, even if our estimates change.

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