RNS Number:1488R
Amersham PLC
21 October 2003


                                  SCHEDULE 10

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES

1)        Name of company
          
          Amersham plc


2)        Name of shareholder having a major interest

          Franklin Resources Inc and its direct and indirect subsidiaries


3)        Please state whether notification indicates that it is in respect
of holding of the shareholder named in 2 above or in respect of a non-beneficial
interest or in the case of an individual holder if it is a holding of that
person's spouse or children under the age of 18

          Non Beneficial interest


4)        Name of the registered holder(s) and, if more than one holder, the
number of shares held by each of them

          Franklin Resources Inc and its direct and indirect subsidiaries

5)        Number of shares/amount of stock acquired

          Not advised


6)        Percentage of issued class

          N/A


7)        Number of shares/amount of stock disposed

          N/A


8)        Percentage of issued class

          N/A


9)        Class of security

          Ordinary shares of 5 pence each


10)       Date of transaction

          Not advised


11)       Date company informed

          20 October 2003


12)       Total holding following this notification

          35,083,560 Ordinary Shares of 5p each





13)       Total percentage holding of issued class following this notification

          4.985%


14)       Any additional information

          N/A


15)       Name of contact and telephone number for queries

          Susan Henderson, Deputy Company Secretary Tel 01494 542063


16)       Name and signature of authorised company official responsible for
making this notification

          Susan M Henderson,



Date of notification 21 October 2003






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