BTH Breathtec BioMedical Inc.

Nash Pharmaceuticals Inc., a wholly owned subsidiary of Breathtec Biomedical Inc. (CSE: BTH) (CNSX: BTH) (FRANKFURT: BTI) (OTCQB: BTHCF) (the “Company” or “Nash Pharma”) is pleased to announce that it has been accepted to present its pre-clinical data on its inflammatory bowel disease (“IBD”) research program for both Colitis and Crohn’s disease at the upcoming Digestive Disease Week Annual Conference, held in San Diego, CA on May 18th -21st.

Results of Nash’s recently announced Crohn's study demonstrated significant improvements in multiple measurements for both NP-120 and NP-178 including:

• Improved body weight, stool consistency, occult positivity, colon length and weight and its ratios
• 5-ASA, the positive control reduced the histopathology severity score by 44.0% (p<0.01)
• NP-120 (30 mg/kg) reduced the histopathology severity score by 45.1% (p<0.01)
• NP-178 (160 mg/kg) reduced the histopathology severity score by 66.8% (p<0.001)

Results of Nash’s recently announced ulcerative colitis study demonstrated significant improvements in multiple measurements for both NP-120 and NP-178 including:

• Both compounds improved body weight, stool consistency, occult positivity, colon length and weight and its ratios
• 5-ASA (100 mg/kg), the positive control and standard of care, reduced the histopathology severity score by 83.5% (p<0.0001)
• NP-120 (30 mg/kg) reduced the histopathology severity score by 81.6% (p<0.0001)
• NP-178 (160 mg/kg) reduced the histopathology severity score by 83.1% (p<0.0001)

The Digestive Disease Week Conference is one of the top 50 medical meetings in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery. The conference is expected to attract worldwide gastroenterologists, clinical investigators, scientists and medical professionals related to the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery.

“We are very pleased to be presenting the data from our IBD research program at the upcoming Digestive Disease Week Conference”, said Christopher J. Moreau, CEO of Nash Pharmaceuticals. “It will be the first time that the Company will have an opportunity to present its findings to the global IBD research community.”

About IBD

In a 2018 report by Visiongain, the Global Inflammatory Bowel Diseases (IBD) Drug Market Forecast 2018-2028 shows that the global inflammatory bowel diseases (IBD) drug market is estimated at $6.7B in 2017 and $7.6B in 2023. Biologic therapies held 57% share of the IBD market in 2017. The antibiotics segment of the IBD market is estimated to grow at a CAGR of 6.3% from 2018-2023. 

About Nash Pharmaceuticals Inc. 

Nash Pharmaceuticals Inc. is a wholly owned subsidiary of Breathtec Biomedical Inc.  Nash is a clinical stage pharmaceutical development company focused on drug repurposing in the areas of non–alcoholic steatohepatitis (NASH), chronic kidney disease (CKD) and inflammatory bowel disease (IBD). Drug repurposing is the process of discovering new therapeutic uses for existing drugs. 

For more information, visit www.nashpharmaceuticals.com

CONTACT INFORMATION

Christopher J. Moreau CEONash Pharmaceuticals Inc.604.398.4175 ext 701info@breathtechbiomedical.com investors@breathtecbiomedical.com www.breathtecbiomedical.com

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