OraSure Technologies, Inc. (NASDAQ:OSUR) has scheduled its regular earnings conference call covering 2008 fourth quarter and full-year financial results and certain 2009 financial guidance for 5:00 pm ET (2:00 pm PT) on Wednesday, February 11, 2009. An update on certain business developments will also be provided.

February 11, 2009 Schedule

� 4:00 p.m. ET

2008 fourth quarter and full-year financial results will be distributed by Business Wire

� 4:50 p.m. ET

To participate in the conference call, dial 888-742-2024 (Domestic) or 706-643-0033 (International) and reference Conference ID #83800004.

� 5:00 p.m. ET Conference call and simultaneous Webcast begins

The conference call will also be webcast live and may be accessed on the Investor Relations page of OraSure�s website, www.orasure.com. Please click on the webcast link and follow the prompts for registration and access 10 minutes prior to the call.

If you are unable to participate, a replay of the call will be archived on OraSure�s website shortly after the call has ended and will be available for seven days. A replay of the call can also be accessed until midnight, February 16, 2009, by dialing 800-642-1687 (Domestic) or 706-645-9291 (International) and entering the Conference ID # 83800004.

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