Targeted Genetics Highlights Inflammatory Arthritis Program and Robust AAV Product Development Platform at the American Society
May 25 2006 - 6:30AM
Business Wire
Presentations Include Preliminary Data from an Ongoing Phase I/II
Trial of tgAAC94 in Patients with Inflammatory Arthritis and 13
Additional Abstracts Targeted Genetics Corporation (Nasdaq:TGEND)
and its academic and corporate collaborators will report data in 14
presentations at the 9th Annual Meeting of the American Society of
Gene Therapy (ASGT). The meeting will take place June 1 - June 5 in
Baltimore, Maryland. Two presentations will discuss preliminary
safety and efficacy data from an ongoing Phase I/II clinical trial
of tgAAC94 in patients with inflammatory arthritis, and two
additional presentations will describe other advances in the
company's inflammatory disease program. Research conducted by Dr.
John Engelhardt, Ph.D., Director of the Center for Gene Therapy,
and Professor, Department of Anatomy and Cell Biology, at the
University of Iowa, and funded by Targeted Genetics, will be
featured as one of the "Top Five Abstracts" at the Presidential
Symposium on June 3rd (Abstract # 807). Additional presentations
will focus on advances in AAV manufacturing, basic and applied AAV
biology and Targeted Genetics' collaborations in the areas of
Huntington's disease and congestive heart failure. "As a company
committed to developing cutting-edge therapies for diseases with
significant unmet medical need, we recognize the importance of
advancing both the science and the commercial potential of
AAV-based therapies," said H. Stewart Parker, president and chief
executive officer of Targeted Genetics. "These presentations at
ASGT reflect our success in both of these endeavors. We are making
significant progress in our product development programs in the
areas of inflammatory disease, Huntington's disease and congestive
heart failure, while also enhancing our manufacturing capabilities.
Our commercial activities are built on a solid foundation of AAV
biology, and we are pleased to share the advances that we and our
collaborators have made in this area with the gene therapy
community." Presentations relevant to Targeted Genetics' product
development programs are: Preliminary Phase I/II data from an
ongoing trial of tgAAC94 in patients with inflammatory arthritis:
Workshop 225: Musculo-Skeletal: Gene Expression and Immunology of
Musculoskeletal Gene Therapy "Clinical Development of an AAV Vector
Expressing the TNF Receptor: Fc Fusion Gene in Inflammatory
Arthritis." Oral presentation -- Thursday, June 1. Abstract #1092
"Clinical Studies of Intra-Articular Administration of a
Recombinant Adeno-Associated Vector Contain a TNF-alpha Antagonist
Gene in Inflammatory Arthritis." Oral Presentation -- Sunday, June
4. Inflammatory arthritis preclinical data: Abstract #578
"Suppression of Inflammation Following Intramuscular Administration
of Pseudotyped AAV-TNFR:Fc Vectors in a Rat Model of Arthritis."
Poster Presentation -- Friday, June 2. Abstract #983 "Repeat
Intra-Articular Administration of AAV2 Vectors to Rat Joints."
Poster Presentation -- Saturday, June 3. AAV Manufacturing:
Abstract #312 "Clearance of Helper Adenovirus by an AAV1 Clinical
Vector Manufacturing Process." Poster Presentation -- Thursday,
June 1. Abstract #499 "Improving the Stability of Ad-AAV Hybrid
Vectors." Poster Presentation -- Friday, June 2. Huntington's
Disease: Abstract #414 "Non-Allele Specific RNA Interference in the
CAG140 Knock-In Mouse Model of Huntington's Disease." Oral
Presentation -- Friday, June 2. Congestive Heart Failure: Abstract
#557 "A Study of AAV2/1/SERCA2a Delivered Via the V-Focus Cardiac
Delivery System in an Ovine Pacing Model of Heart Failure." Poster
Presentation -- Friday, June 2. AAV Biology: Abstract #1 "Species
Choice for Animal Modeling Cystic Fibrosis and Gene Therapy in the
Airway." Oral presentation -- Thursday, June 1. Abstract #10
"Adeno-Associated Virus Type-1 Vectors Transduce Human Polarized
Airway Epithelia without Polarity Preference." Oral Presentation --
Thursday, June 1. Abstract #106 "rAAV2 Traffics through Both the
Late and Recycling Endosomes in a Dose-Dependent Fashion." Poster
Presentation -- Thursday, June 1. Abstract #118 "In Vivo Tracking
of Long Term Gene Expression of AAV1 Using Fluorescence Imaging
System." Poster Presentation -- Thursday, June 1. Abstract #492
"Biodistribution and Integration Assessment of AAV1
gag-PR-RT((delta)RnaseH) after Intramuscular Administration in
Rabbits." Poster Presentation -- Friday, June 2. Abstract #807
"NADPH-Dependent Endosomal ROS is Critical for rAAV Capsid
Processing During Infection." Oral Presentation -- Saturday, June
3. For more information about the 9th Annual Meeting of the
American Society of Gene Therapy, please refer to www.asgt.org.
About Targeted Genetics Targeted Genetics Corporation is a
biotechnology company committed to the development and
commercialization of innovative, targeted molecular therapies for
the prevention and treatment of inflammatory arthritis, HIV/AIDS
and other acquired and inherited diseases with significant unmet
medical need. Targeted Genetics uses its considerable knowledge and
capabilities in the development and manufacturing of gene delivery
technologies to advance a diverse product development pipeline. Its
product development efforts target inflammatory arthritis,
HIV/AIDS, congestive heart failure, Huntington's disease, and
hyperlipidemia. To learn more about Targeted Genetics, visit its
website at www.targetedgenetics.com. Safe Harbor Statement under
the Private Securities Litigation Reform Act of 1995: This release
contains forward-looking statements regarding our potential
development platforms including AAV vectors, the data to be
collected in our clinical trials, the establishment or
determination of efficacy endpoints from the data collected in our
clinical trials, the timely and complete accrual of patients in the
our clinical trials, our ability to commercialize any of our
products in clinical trials, our ability to produce our product
candidates at large scale commercial production and other
statements about our plans, objectives, intentions and
expectations. These statements, involve current expectations,
forecasts of future events and other statements that are not
historical facts. Inaccurate assumptions and known and unknown
risks and uncertainties can affect the accuracy of forward-looking
statements. Factors that could affect our actual results include,
but are not limited to, results of animal research are not
necessarily indicative of results in humans, the timing, nature and
results of our research, potential development of alternative
technologies or more effective products by competitors, our ability
to recruit and enroll suitable trial participants, our ability to
obtain and maintain regulatory or institutional approvals, our
ability to obtain, maintain and protect our intellectual property
and our ability to raise capital when needed, as well as other risk
factors described in Item 1A. Risk Factors in our report on Form
10-K for the year ended December 31, 2005, and updated in Item 1A.
Risk Factors in our Form 10-Q for the quarter ended March 31, 2006.
You should not rely unduly on these forward-looking statements,
which apply only as of the date of this release. We undertake no
duty to publicly announce or report revisions to these statements
as new information becomes available that may change our
expectations.
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