By Sara Sjolin, MarketWatch

LONDON (MarketWatch) -- Europe's benchmark stock index snapped a six-day winning streak on Tuesday, tracking U.S. stocks lower after a central-bank member said a reduction in asset purchases could come as soon as next month.

The Stoxx Europe 600 index lost 0.4% to close at 303.50, dropping from its highest closing level since late May reached on Monday.

The index traded close to the flat line earlier in the day, but started moving lower around the U.S. market open.

"Obviously this week, several Fed members talk and that puts tapering back in the firing line and the markets tend to move on comments from Fed members," said Richard Perry, chief market strategist at Central Markets in London.

That was also the case for markets in afternoon action on Tuesday. Dennis Lockhart, the president of the Atlanta Fed Bank, said in an interview with MNI that the Federal Reserve could start tapering its bond purchases at any of the three remaining policy meetings this year: September, October or December. Investors have in recent months worried the central bank will soon scale back its easing program, after Chairman Ben Bernanke said further improvement in economic data could trigger tapering.

Mining firms, which are sensitive to changes in metals prices, added the most pressure on Stoxx 600 as the Lockhart comments slammed gold and other commodity prices.

"Gold is massively influenced by asset purchases and a reduction would certainly have an impact on gold prices," Perry said. "We see some big losses across the board for the general mining sector, with Fresnillo and Randgold down a lot and it's pretty much metals related."

Shares of Fresnillo PLC sank 11%, Randgold Resources Ltd. (GOLD) dropped 5.6% and Anglo American PLC lost 4%.

Upbeat Europe data

Earlier in the day, the pan-European index traded in positive territory after a string of upbeat macroeconomic data. German manufacturing orders beat forecasts by a large margin in June, up 3.8%, as orders from the euro zone leapt 10% from May. See: Goldilocks with a European accent: What strong data means for QE

In the U.K., industrial production rose 1.1% in June and improved 0.6% in the second quarter, with the quarterly figure the strongest since December 2010.

Meanwhile in Italy, gross-domestic-product data showed the county's recession eased in the second quarter, with the economy shrinking 0.2% compared with a 0.6% contraction in the first quarter.

The country-specific indexes, however, closed on a downbeat note, weighed by the U.S. tapering comments.

The FTSE MIB index dropped 0.4% to 16,683.17, while the U.K.'s FTSE 100 index lost 0.2% to 6,604.21.

Germany's DAX 30 index sank 1.2% to 8,299.73, while France's CAC 40 index fell 0.4% to 4,032.57.

Movers

Among notable movers in the indexes, shares of Salzgitter AG slumped 12% in Frankfurt after the steelmaker late Monday cut its profit guidance for the second time this year. J.P. Morgan Cazenove cut the firm to neutral from overweight.

Munich Reinsurance Co. slid 5.4% after the firm said its second-quarter results were marked by claims burdens of EUR230 million from the floods in Germany and neighboring countries.

Lanxess AG shaved off 4.3% after the chemicals firm warned its earnings outlook for 2014 was no longer realistic after a tough second quarter.

On a more upbeat note in Germany, TV operator Sky Deutschland AG climbed 6.6% after it narrowed its net loss in the second quarter and confirmed its full-year outlook.

Shares of GlaxoSmithKline PLC (GSK) dropped 0.7% in London after Citigroup cut the drug maker to neutral from buy, saying the stock seems fairly valued in the near term after a period of outperforming the sector.

HSBC Holdings PLC (HBC) lost 0.8% after Deutsche Bank cut the bank to hold from buy on the back of a disappointing earnings result out on Monday.

Banks were also lower in France. Société Générale SA lost 2.5% and BNP Paribas SA dropped 0.6%. Shares of Crédit Agricole erased 0.9% even after the bank said second-quarter profit surged to 696 million euros ($922.7 million), up from EUR56 million a year earlier.

Outside the major indexes, UniCredit SpA climbed 2.2% after the Italian bank said second-quarter net profit more than doubled from the same period last year.

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