RNS Number:9887H
Acambis PLC
26 February 2003

                                  SCHEDULE 10

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES



1. Name of company


Acambis plc



2. Name of shareholder having a major interest


FMR Corp. (and its direct and indirect subsidiaries incorporating Fidelity Management Trust Company (FMTC)), Fidelity
International Limited (FIL) (and its direct and indirect subsidiaries incorporating Fidelity Investment Services
Limited (FISL)) and Mr Edward C Johnson 3d



3. Please state whether notification indicates that it is in respect of holding
of the shareholder named in 2 above or in respect of a non-beneficial interest
or in the case of an individual holder if it is a holding of that person's
spouse or children under the age of 18


As above



4. Name of the registered holder(s) and, if more than one holder, the number of
shares held by each of them


MSCO 150,000 shares*

Chase Manhattan Bank London 3,772,632 shares**

HSBC 1,399,102 shares

Bank of New York London 57,000 shares

Chase Manhattan Bank London 232,700 shares

Chase Nominees Ltd 181,450 shares

Bankers Trust 54,220 shares

Citibank 163,090 shares



* For this holding, FMTC acts as the management company

** For this holding, FISL acts as the management company

For all the other holdings listed, FIL acts as the management company.



5. Number of shares / amount of stock acquired


989,332



6. Percentage of issued class


1.00%



7. Number of shares / amount of stock disposed


N/a



8. Percentage of issued class


N/a



9. Class of security


Ordinary shares of 10p each



10. Date of transaction


N/a



11. Date company informed


24 February 2003



12. Total holding following this notification


6,010,194 ordinary shares



13. Total percentage holding of issued class following this notification


6.07%



14. Any additional information


N/a



15. Name of contact and telephone number for queries


Elizabeth Brown, Company Secretary

+44 (0) 1223 275 300



16. Name and signature of authorised company official responsible for making
this notification


Elizabeth Brown



Date of notification


26 February 2003



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