TIDMAZM 
 
RNS Number : 5111S 
Alizyme PLC 
19 May 2009 
 

+------------------------------------+------------------------------------+ 
| For Immediate Release              |                        19 May 2009 | 
+------------------------------------+------------------------------------+ 
 
 
ALIZYME PLC 
 
 
+--------------+---------------------------------------------------------+ 
| TR - 1:      | NOTIFICATION OF MAJOR INTERESTS IN SHARES               | 
+--------------+---------------------------------------------------------+ 
 
 
1.   Identity of the issuer or the underlying issuer of existing shares to which 
voting rights are attached: 
 
 
Alizyme plc 
 
 
2.    Reason for the notification: 
 
 
+-----------------------------------------------------+--------------+ 
| An acquisition or disposal of voting rights         |              | 
+-----------------------------------------------------+--------------+ 
 
 
3.    Full name of person(s) subject to the notification obligation: 
 
 
UBS Investment Bank 
 
 
4.    Full name of shareholder(s) (if different from 3.): 
 
 
UBS AG London Branch 
 
 
5.    Date of the transaction and date on which the threshold is crossed or 
reached: 
 
 
15 May 2009 
 
 
6.    Date on which issuer notified: 
 
 
19 May 2009 
 
 
7.Threshold(s) that is/are crossed or reached: 
 
 
9.0% 
 
 
8.Notified details: 
 
 
+------------------------------------------------------------------------------+ 
| A: Voting rights attached to shares                                          | 
+------------------------------------------------------------------------------+ 
 
 
+---------------+-------------+-------------+-------------+------------+----------+----------+----------+ 
| Class/type    | Situation previous        | Resulting situation after the triggering transaction      | 
| of shares     | to the Triggering         |                                                           | 
| if possible   | transaction               |                                                           | 
| using the     |                           |                                                           | 
| ISIN CODE     |                           |                                                           | 
+               +---------------------------+-----------------------------------------------------------+ 
|               | Number of   | Number      | Number      | Number of voting      | % of voting rights  | 
|               | Shares      | of          | of          | rights                |                     | 
|               |             | Voting      | shares      |                       |                     | 
|               |             | Rights      |             |                       |                     | 
+               +             +             +-------------+-----------------------+---------------------+ 
|               |             |             |             | Direct     | Indirect | Direct   | Indirect | 
+---------------+-------------+-------------+-------------+------------+----------+----------+----------+ 
|  Ordinary     | 18,096,956  | 18,096,956  |  20,504,465 | 20,504,465 |     -    |  9.27%   |     -    | 
|  Shares       |             |             |             |            |          |          |          | 
|  GB0000374289 |             |             |             |            |          |          |          | 
+---------------+-------------+-------------+-------------+------------+----------+----------+----------+ 
 
+------------------------------------------------------------------------------+ 
| B: Financial Instruments                                                     | 
+------------------------------------------------------------------------------+ 
 
 
+----------------+------------+-------------------+--------------------+------------+ 
| Resulting situation after the triggering transaction                              | 
+-----------------------------------------------------------------------------------+ 
| Type of        | Expiration | Exercise/         | Number of voting   | % of       | 
| financial      | date       | Conversion        | rights that may be | voting     | 
| instrument     |            | Period/Date       | acquired if the    | rights     | 
|                |            |                   | instrument is      |            | 
|                |            |                   | exercised/         |            | 
|                |            |                   | converted.         |            | 
+----------------+------------+-------------------+--------------------+------------+ 
| n/a            | n/a        | n/a               | n/a                | n/a        | 
+----------------+------------+-------------------+--------------------+------------+ 
 
 
+------------------------------------------------------------------------------+ 
| Total (A+B)                                                                  | 
+------------------------------------------------------------------------------+ 
 
 
+--------------------------------------+----------------------------------------+ 
| Number of voting rights              | % of voting rights                     | 
+--------------------------------------+----------------------------------------+ 
| 20,504,465                           | 9.27%                                  | 
+--------------------------------------+----------------------------------------+ 
 
9.   Chain of controlled undertakings through which the voting rights and/or the 
financial instruments are effectively held, if applicable: 
 
n/a 
 
 
Proxy Voting: 
 
 
10.    Name of the proxy holder: 
 
 
n/a 
 
 
11.     Number of voting rights proxy holder will cease to hold: 
 
 
n/a 
 
 
12.     Date on which proxy holder will cease to hold voting rights: 
 
 
n/a 
 
 
13.    Additional information: 
 
 
n/a 
 
 
14.    Contact name: 
 
 
Nick Blech, Company Secretary 
 
 
15.    Contact telephone number: 
 
 
+44 (0) 1223 896000 
 
 
Further information on Alizyme can be found on the Company's 
website: www.alizyme.com 
 
This information is provided by RNS 
            The company news service from the London Stock Exchange 
   END 
 
 HOLXKLFFKEBLBBK 
 

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