RNS Number:5974S
Skyepharma PLC
27 November 2003


Immediate Release                                              27 November 2003


                         SkyePharma PLC ("the Company")

                    Notification of Major Interest in Shares


In accordance with the Companies Act 1985 (as amended) the Company was informed
by Fidelity Investments on 26 November 2003 that FMR Corp and its direct and
indirect subsidiaries and Fidelity International Limited and its direct and
indirect subsidiaries, both being non-beneficial holders ("Fidelity"), had
increased their total holding to 64,685,828 ordinary shares of 10p each,
representing 10.48% of the issued share capital of the Company. In addition
Fidelity have informed the Company that they also hold 5,000,000 SkyePharma PLC
6% Convertible Bonds due 2005.


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