RNS Number:1505I
Alizyme PLC
28 February 2003


Immediate Release                                               28 February 2003


                                  ALIZYME PLC


                   NOTIFICATION OF MAJOR INTERESTS IN SHARES


Cambridge, UK, 28 February, 2003: Alizyme plc (London Stock Exchange: AZM)
announces that it received, yesterday, the following "Notification of Interest"
from ISIS Asset Management plc following their total purchase of 4,975,459
ordinary shares of 2p each in the relevant share capital of the company 
("Shares") as part of the Placing and Open Offer.

"In accordance with the provisions of Sections 198-202 of the Companies Act
1985, we give notice that, as a result of a placing of 1,955,647 ordinary shares
of 2p each in the relevant share capital of your company ("Shares") on 25
February 2003 the following fund management companies in the Friends Provident
group are interested in the Shares referred to below through client holdings:

ISIS Asset Management plc is interested in the following shares:

No of Shares                                   %

14,400,555                                   10.51


Such interest includes the material interests of the clients of ISIS Asset
Management plc referred to below:


Name of Client           No. of Shares       %        Name of Registered Holder

The AIM Trust                5,294,896     3.868      Chase Nominees Ltd
The AIM VCT Trust            1,847,344     1.349      Chase Nominees Ltd
3PC Investment Trust         2,142,143     1.565      Chase Nominees Ltd



Such interest includes the material interest of the client of Friends Provident
Unit Managers referred to below-


Name of Client              No. of Shares       %      Name of Registered Holder

FISIS ICVC Smaller Markets 
Fund                              302,615     0.221    Citifriends
UK Equity Fund                    207,112     0.151    Citifriends
UK Mid/Small Cap Fund           4,146,874     3.029    Citifriends


Such interest includes the material interest of the client of Friends Ivory &
Sime Managed Pension Funds referred to below-


Name of Client              No. of Shares       %      Name of Registered Holder

FISMPF UK Smaller 
Companies                         459,571     0.336    Citifriends


In addition, ISIS Asset Management plc, as the holding company of the company(s)
referred to in the paragraph(s) above is also interested in those Shares.
Furthermore, Friends Provident Life Office, as the holding company of ISIS Asset
Management plc is also interested in the Shares referred to above.

This notification supersedes all previous notifications given by members of the
Friends Provident group in relation to Shares. (It also supersedes all pervious
notifications given by members of the Friends Provident group on behalf of the
client(s) named above in relation to Shares)."


For further information, please contact:


Mr Tim McCarthy, Finance Director
ALIZYME plc                                          Tel No: + 44 (0)1223 896000

Lisa Baderoon
BUCHANAN COMMUNICATIONS                            Tel No: + 44 (0) 20 7466 5000


Further information on Alizyme can be found on the Company's website:
www.alizyme.com


                      This information is provided by RNS
            The company news service from the London Stock Exchange
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