At HUPO 2010, Bruker Showcases High-Performance Mass Spectrometry Platforms and Advances in Applied Proteomics Solutions
September 19 2010 - 6:00AM
Business Wire
At the Human Proteome Organisation's (HUPO) 9th Annual World
Congress (www.hupo2010.com), Bruker displays leading technologies
and solutions for proteomics in the next decade. Bruker’s
“Continuing Revolution” campaign demonstrates the company’s
commitment to enabling the proteomics community to pursue an ever
increasing range of scientific investigations, as well as clinical
proteomics research and emerging applied proteomics methods:
- The autoflex™ speed is a
flexible and high performance MALDI-TOF(/TOF) system specifically
designed for enhanced workflows in proteomics research. The
fields of MALDI tissue biomarker and drug imaging, where
Bruker is leading and continually innovating, is greatly advanced
by the novel FAST-SRM mode for single reaction monitoring
capabilities. Enhanced speed and reliable operation are delivered
by the 1 kHz smartbeam™-II laser and the MALDI
Perpetual™ self-cleaning ion source, previously introduced in
Bruker’s market leading ultrafleXtreme™
MALDI-TOF/TOF.Further enhancements on the autoflex speed as
a proteomics platform for MALDI based workflows are its wide mass
range resolving power of up to 26,000 delivered by the PAN™
technology, the innovative FlashDetector™ system and the
novel 4 Gs/s digitizer. Edmass™ top-down intact protein
sequencing for long sequence readouts, including Bruker’s
patented T³-Sequencing™ technology, is now fully supported
on the autoflex speed.
-
High performance molecular imaging of small molecules
including drugs, metabolites and lipids in tissue is now available
on the new unrivalled MALDI-solariX™ FTMS platform, which
combines extreme performance with resolving power >
1,000,000 at 7 tesla with a robust and highly sensitive MALDI
source. Its unique instrument design with a dual ion funnel
and quad-based ion selection for signal enhancement by
CASITM (continuous accumulation of selected ions)
provides unparalleled sensitivity for the analysis of therapeutic
doses of drugs and their metabolites directly in tissue. Its dual
ESI/MALDI source allows easy switching between both ionization
modes by simple push-button software. Fast data acquisition of up
to 1 pixel/sec with the smartbeamTM II laser
at a 1 kHz laser rate and laser spot sizes down to 20 um for high
spatial resolution are essential features of this ultimate MALDI
small molecule tissue imaging system.
- As MALDI Imaging matures
as a key proteomic application, it becomes essential to cover the
complete workflow for effective and scientifically relevant
clinical research. The MALDI Molecular ImagerTM
concept, on ultrafleXtreme and autoflex speed
MALDI-TOF platforms, as well as on the solariX
MALDI-FTMS, enables non-targeted molecular histology with high
spatial resolution in an integrated solution (research use only)
for biological tissue and clinical pathology investigations. The
entire, highly effective workflow is provided by seamless
integration of the mass spectrometers with sample preparation by
the proprietary Bruker ImagePrep™ station and with the data
processing software FlexImaging™. This workflow is completed
by ClinProTools™, the first commercially available software
solution for small molecule statistical class imaging. By
continuous innovation, Bruker remains committed to the development
of MALDI Imaging as a key proteomics technology.
- Bruker provides high performance
top-down protein sequencing and characterization workflows
across a range of systems. A breakthrough has been recently
achieved in collaboration with scientists by applying ETD on
the maXis™ UHR-TOF system. High mass accuracy, resolving
power and dynamic range, essential for the dissection of complex
patterns of product ions in protein fragmentation, have been
harnessed for the first time to perform ETD dissociation of
intact biomolecules up to 150 kDa with ease. This represents a new
record for mass spectrometric sequencing of intact proteins and
demonstrates the dramatic advantages of maXis ETD technology
in top-down protein structure analysis. This achievement underlines
Bruker’s leading position in all fields of top-down
proteomics.
- The amaZon ETD, Bruker’s
4th generation ion trap platform, offers class leading ETD and PTR
(Proton Transfer Reaction) for unmatched sensitivity in an
extremely robust setup. Ion trap mass resolving power up to 20,000
in full scan mode across the 50-3000 m/z range with scan speeds up
to 52,000 u/sec, fast enough to be useable for LC coupling, make
real-life, routine LC-ETD experiments for PTMs a reality.
- MALDI-ISD (In-Source
Decay), leveraging innovations incorporated into the industry
leading ultrafleXtreme and autoflex speed
MALDI-TOF(-TOF) platforms completes Bruker’s comprehensive
set of workflows as the leading supplier for top-down protein
sequencing and characterization.
- Bruker’s
ProteinScapeTM 2.1 software is the most
established proteomics bioinformatics platform addressing
scientists' needs in biomarker profiling, quantification and
validation. As a comprehensive solution for qualitative and
quantitative LC-MS/MS protein analysis, ProteinScape
supports all current label chemistries including multiplexed
labels, as well as label-free quantification. Interactive
validation of protein quantification based on raw LC/MS data is
simple and straight forward. It streamlines the discovery process
through decoy auto-validation algorithms, combined database
searches with various algorithms and the
ProteinExtractorTM module that produces non-redundant
protein result lists across entire proteomics projects. Its
archiving capabilities allow the retrieval of data generated years
ago, e.g. for their joint re-analysis with novel analytic
capabilities and mining tools. The ProteinScape processing
pipeline adopts the "HUPO Brain Proteomics Project processing
guidelines" (forum.hbpp.org) and will facilitate the direct
submission process of project data adhering to HUPO/PSI publishing
guidelines.
Clive Seymour, Executive Vice President of Bruker Daltonics,
commented: “As the field of proteomics evolves, Bruker continues to
innovate and deliver workflows suited to the needs of those engaged
in an expanding discipline. Offering solutions based on a broad
range of technologies and workflows without compromising
performance and ease of use, underlines the philosophy and defines
our leadership in proteomics. Whatever the application, whether it
is ‘traditional’ expression proteomics or novel fields such as
top-down proteomics, tissue imaging or quantitation with or without
labels, we strive to provide the highest performance
solutions.”
In addition to supporting HUPO 2010 as a Gold Sponsor, Bruker
will be present in the scientific program with more than 40
contributions. Bruker Daltonics staff will be available for
in-depth meetings during exhibit hours at Bruker's booth (No. 1).
The Bruker Luncheon Seminars will be held on Tuesday, September
21st, 12:30-1:30 PM, in the Baysite Gallery Auditorium A during
which a panel of prestigious international researchers including
Christoph Borchers from ProteomeCenter, Victoria, Canada, and
Keith Ashman, CNIO Madrid, Spain, will present talks, detailing
a series of innovative proteomic applications. For more information
on Bruker’s HUPO events, please visit www.bdal.com/hupo
ABOUT BRUKER DALTONICS: For more information about Bruker
Daltonics and Bruker Corporation (NASDAQ: BRKR), please visit
www.bdal.com and www.bruker.com.
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