Bruker Announces the Release of New nano-Advance UHPLC for Proteomics
May 21 2012 - 6:00AM
Business Wire
At ASMS 2012, Bruker announced the introduction of its new
nano-Advance UHPLC system for capillary and nano-flow LC-MS
applications. Combining the novel nano-Advance UHPLC with
Bruker’s leading mass spectrometry platforms, including the
amaZon Ion Trap series and maxis UHR-TOF series,
further enhances Bruker’s integrated solutions for proteomics.
The new nano-Advance UHPLC delivers reproducible
retention times with accurate gradients down to 50nL/min. With
run-to-run sample carryover typically less than 0.005%, the
nano-Advance UHPLC delivers industry-leading separation
performance critical to the success of many proteomics workflows.
The nano-Advance UHPLC was specifically designed to
eliminate dead volume and gradient delay wherever possible. When
combined with Bruker’s unique CaptiveSpray Ion source, the
combination can deliver up to twice the MS utilization rate of
typical nano-LC systems coupled to nanospray MS sources. The
increased mass spectrometry utilization rate enables more proteins
and peptides to be identified and quantified in a single LC-MS run.
This is especially significant for detection of low abundance
proteins in complex samples, which are easily missed due to the
inability of the mass spectrometer to keep up with significant
numbers of co-eluting peptides.
The nano-Advance UHPLC delivers precise nanoliter-scale
flow rates without the need for any split-flow due to the
incorporation of two high performance direct drive syringe pumps.
There is also a third pump for trap loading and 2D-LC applications.
In conjunction with the CaptiveSpray Ion source, the
nano-Advance loading capacity is significantly higher than
for conventional nano-LC systems, resulting in higher dynamic range
and increased protein coverage and identification.
Dr. Kerry Nugent, Bruker‘s Senior Vice President - Liquid
Chromatography, commented: “With the introduction of the
nano-Advance UHPLC, Bruker has taken another step to expand
our position as a leading provider of mass spectrometry-based
proteomics solutions. The ability of the nano-Advance UHPLC,
in conjunction with the CaptiveSpray Ion source, to deliver
increased MS productivity, enables the identification of more
proteins with greater confidence in the same period of time.”
About Bruker Corporation
Bruker Corporation (NASDAQ: BRKR) is a leading provider of
high-performance scientific instruments and solutions for molecular
and materials research, as well as for industrial and applied
analysis. For more information, please visit www.bruker.com.
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