World’s Highest Field 21 Tesla Magnet for FT-ICR Mass Spectrometry Installed at National High Magnetic Field Laboratory (NH...
June 16 2014 - 5:00AM
Business Wire
Bruker Corporation (NASDAQ:BRKR) and the National High Magnetic
Field Laboratory (NHMFL) at Florida State University (FSU) today
announced the successful installation of the world’s first 21 Tesla
(T) magnet for Fourier Transform Ion Cyclotron Resonance (FT-ICR).
The installation represents the world’s highest field, persistent,
superconducting magnet suitable for FT-ICR mass spectrometry, which
is also often referred to as FTMS. The 21T magnet was designed and
built by Bruker in collaboration with NHMFL scientists, and will be
used in the NHMFL FT-ICR program in a project funded by the
National Science Foundation, which makes cutting edge FT-ICR
technologies available to the larger community of scientists.
Pictured with the Bruker 21 Tesla FT-ICR
magnet at the NHMFL lab are (from left to right): Professor Alan
Marshall, the Robert O. Lawton Professor of Chemistry and
Biochemistry at Florida State University and Director of the High
Field FT-ICR program at the NHMFL; John Quinn, 21 T FT-ICR
engineering lead at NHMFL; Dr. Chris Hendrickson, 21 T FT-ICR
project advisor at the NHMFL. (Photo: Business Wire)
FT-ICR is by far the highest resolution mass spectrometry
technique available, and is useful in the analysis of extremely
complex mixtures, including applications in petroleomics, dissolved
organic matter (DOM), metabolomics, top-down proteomics, and MALDI
imaging. The performance of FT-ICR systems improves with increasing
magnetic field, and the 21T magnet is expected to enable further
dramatic improvements in mass resolution, mass accuracy and dynamic
range compared to the previous highest field of 15T. The ICR
Program at the NHMFL is a world leader in instrument and technique
development, as well as the pursuit for novel applications of
FT-ICR mass spectrometry.
Professor Alan Marshall, the Robert O. Lawton Professor of
Chemistry and Biochemistry at Florida State University and Director
of the High Field FT-ICR program at the NHMFL, commented: “We are
delighted to report that the 21T Bruker magnet is at full field.
The other subsystems of the 21T FT-ICR mass spectrometer have been
designed and are currently being assembled, for availability
targeted for early fall of 2014.”
Professor Marshall added: “Three primary science drivers for
this instrument are: (a) faster throughput without loss of mass
resolution for top-down proteomics; (b) extension of the size and
complexity of protein complexes whose contact surfaces are mapped
by solution-phase hydrogen/deuterium exchange, and (c) improved
mass resolution and dynamic range for characterizing
compositionally complex organic mixtures (petroleum, dissolved
organic matter, metabolome). The higher magnetic field should
result in dramatic improvement (by factors of 40-100%) in FT-ICR MS
figures of merit, including mass resolution and resolving power,
mass accuracy, dynamic range, and data acquisition speed.”
The 21 T magnet design offers a 110 mm room temperature
horizontal bore, with fringe field profiles and room temperature
bore access optimized for FT-ICR MS. It includes many design
features pioneered by Bruker, including operation at ~2 Kelvin by
use of Bruker’s unique UltraStabilized™ sub-cooling technology, the
UltraShield™ technology to reduce stray fields, as well as novel
active magnet refrigeration technology that virtually eliminates
cryogen refills and user maintenance of the magnet. In addition to
FTMS, the 21T magnet is also suitable for ultra-high field
preclinical MRI for highest sensitivity and resolution in mouse
neuroimaging.
Dr. Gerhard Roth, the Bruker Ultra-High Field Magnet Manager,
said: “The 21T FT-ICR magnet is based on the wealth of experience
gathered in ultra-high field magnet technology for NMR and for MRI
magnets. Bruker is extremely pleased to supply this cutting-edge
21T magnet to enable new scientific research directions in
ultra-high field FT-ICR mass spectrometry.”
For more information about the High-Field FT-ICR program at the
NHMFL, please
visitwww.magnet.fsu.edu/usershub/scientificdivisions/icr
ABOUT BRUKER CORPORATION (NASDAQ:BRKR)
Bruker is a leading provider of high-performance scientific
instruments and solutions for molecular and materials research, as
well as for industrial, diagnostics and applied analysis. For more
information: www.bruker.com.
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Media Contact:Bruker CorporationTony Lewtas, +1
978-663-3660 ext.1212tony.lewtas@bruker.comorInvestor
Contact:Bruker CorporationJoshua Young, +1 978-663-3660
ext.1479Vice President of Investor
Relationsjoshua.young@bruker.com
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