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| Holder | Type | Held (Actual) | % of Outstanding | Market Value | Date Reported |
|---|---|---|---|---|---|
| Suvretta Capital Management, LLC | Institution | 2,020,103 | 7.84% | US$ 65.73M | 2026-06-15 |
| Averill Master Fund, Ltd. | Institution | 1,722,652 | 6.68% | US$ 56.06M | 2026-06-15 |
| Mr. Anand Parikh | Insider | 817,699 | 3.17% | US$ 26.61M | 2026-06-22 |
| Vivo Capital, LLC | Institution | 722,020 | 2.80% | US$ 23.49M | 2026-03-31 |
| Cormorant Asset Management, LP | Institution | 306,222 | 1.19% | US$ 9.96M | 2026-03-31 |
| H&S Ventures LLC | Institution | 222,081 | 0.86% | US$ 7.23M | 2026-03-31 |
| Franklin Resources, Inc. | Institution | 133,506 | 0.52% | US$ 4.34M | 2026-03-31 |
| StemPoint Capital LP | Institution | 132,873 | 0.52% | US$ 4.32M | 2026-03-31 |
| Dr. James Peyer | Insider | 130,142 | 0.50% | US$ 4.23M | 2026-06-01 |
| Cambrian BioPharma, Inc. | Institution | 130,142 | 0.50% | US$ 4.23M | 2026-06-01 |
| Caligan Partners, LP | Institution | 126,002 | 0.49% | US$ 4.10M | 2026-03-31 |
| Trails Edge Biotechnology Master Fund, Lp | Institution | 125,000 | 0.48% | US$ 4.07M | 2026-02-18 |
| Trails Edge Capital Partners, LP | Institution | 125,000 | 0.48% | US$ 4.07M | 2026-03-31 |
| Marshall Wace LLP | Institution | 65,730 | 0.25% | US$ 2.14M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 61,568 | 0.24% | US$ 2.00M | 2026-03-31 |
| Hudson River Trading LLC | Institution | 58,001 | 0.23% | US$ 1.89M | 2026-03-31 |
| Dr. Brian Stephenson | Insider | 46,688 | 0.18% | US$ 1.52M | 2026-07-01 |
| Dr. Stephen Hahn | Insider | 44,763 | 0.17% | US$ 1.46M | 2026-06-15 |
| Millennium Management LLC | Institution | 41,561 | 0.16% | US$ 1.35M | 2026-06-01 |
| Ics Opportunities II Llc | Institution | 41,561 | 0.16% | US$ 1.35M | 2026-06-01 |
| Bank of America Corporation | Institution | 33,025 | 0.13% | US$ 1.07M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 32,041 | 0.12% | US$ 1.04M | 2026-03-31 |
| Logos Global Management, L.P. | Institution | 30,000 | 0.12% | US$ 976.20k | 2026-03-31 |
| Boothbay Fund Management, LLC | Institution | 26,124 | 0.10% | US$ 850.07k | 2026-03-31 |
| Brevan Howard Capital Management LP | Institution | 20,333 | 0.08% | US$ 661.64k | 2026-03-31 |
| Fred Alger Management, LLC | Institution | 18,337 | 0.07% | US$ 596.69k | 2026-03-31 |
| Mr. Thomas Ricks | Insider | 17,192 | 0.07% | US$ 559.43k | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 16,205 | 0.06% | US$ 527.31k | 2026-03-31 |
| Catalio Capital Management, LP | Institution | 14,718 | 0.06% | US$ 478.92k | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 9,501 | 0.04% | US$ 309.16k | 2026-03-31 |
| Jane Street Group, LLC | Institution | 8,872 | 0.03% | US$ 288.69k | 2026-03-31 |
| Morgan Stanley | Institution | 8,785 | 0.03% | US$ 285.86k | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 7,750 | 0.03% | US$ 252.19k | 2026-03-31 |
| Ikarian Capital, LLC | Institution | 6,351 | 0.02% | US$ 206.66k | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 6,307 | 0.02% | US$ 205.23k | 2026-03-31 |
| UBS Asset Management AG | Institution | 4,529 | 0.02% | US$ 147.37k | 2026-03-31 |
| Tower Research Capital Europe Limited | Institution | 1,496 | 0.01% | US$ 48.68k | 2026-03-31 |
| Mr. Robert Holmen | Insider | 1,279 | 0.00% | US$ 41.62k | 2026-03-31 |
| Mr. John Celebi | Insider | 1,000 | 0.00% | US$ 32.54k | 2026-03-31 |
| Mr. Christopher Gerry | Insider | 953 | 0.00% | US$ 31.01k | 2026-03-31 |
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