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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM 10-Q
(Mark One)
☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the quarterly period ended September 30, 2023
OR
☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the transition period from __________ to ____________
Commission File Number: 001-38958
Karuna Therapeutics, Inc.
(Exact Name of Registrant as Specified in its Charter)
|
|
Delaware |
27-0605902 |
(State or other jurisdiction of incorporation or organization) |
(I.R.S. Employer Identification No.) |
99 High Street, 26th Floor Boston, Massachusetts |
02110 |
(Address of principal executive offices) |
(Zip Code) |
(857) 449-2244
(Registrant’s telephone number, including area code)
Securities registered pursuant to Section 12(b) of the Act:
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Title of each class |
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Trading Symbol(s) |
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Name of each exchange on which registered |
Common Stock, $0.0001 par value per share |
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KRTX |
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Nasdaq Global Market |
Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ☒ No ☐
Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes ☒ No ☐
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.
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Large accelerated filer |
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☒ |
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Accelerated filer |
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☐ |
Non-accelerated filer |
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☐ |
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Smaller reporting company |
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☐ |
Emerging growth company |
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☐ |
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|
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐
Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No ☒
As of October 31, 2023, the registrant had 37,727,117 shares of common stock, $0.0001 par value per share, outstanding.
Table of Contents
i
PART I—FINANCIAL INFORMATION
Item 1. Consolidated Financial Statements.
KARUNA THERAPEUTICS, INC.
CONSOLIDATED BALANCE SHEETS
(In thousands, except share and per share data)
(Unaudited)
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September 30, 2023 |
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December 31, 2022 |
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Assets |
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Current assets: |
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Cash and cash equivalents |
|
$ |
184,471 |
|
|
$ |
248,329 |
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Restricted cash |
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|
104 |
|
|
|
— |
|
Investment securities, available-for-sale |
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|
1,155,006 |
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|
|
875,715 |
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Short-term investments, other |
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2,033 |
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|
|
— |
|
Accounts receivable |
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— |
|
|
|
57 |
|
Prepaid expenses |
|
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12,876 |
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|
|
29,106 |
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Deferred offering costs |
|
|
829 |
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|
|
568 |
|
Other current assets |
|
|
10,078 |
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|
|
994 |
|
Total current assets |
|
|
1,365,397 |
|
|
|
1,154,769 |
|
Restricted cash, net of current portion |
|
|
— |
|
|
|
261 |
|
Right-of-use lease assets - operating, net |
|
|
14,603 |
|
|
|
4,674 |
|
Property and equipment, net |
|
|
4,715 |
|
|
|
3,201 |
|
Other non-current assets |
|
|
382 |
|
|
|
429 |
|
Total assets |
|
$ |
1,385,097 |
|
|
$ |
1,163,334 |
|
Liabilities and Stockholders’ Equity |
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Current liabilities: |
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Accounts payable |
|
$ |
2,939 |
|
|
$ |
2,379 |
|
Accrued expenses |
|
|
44,129 |
|
|
|
29,285 |
|
Current portion of operating lease liability |
|
|
1,796 |
|
|
|
2,282 |
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Other current liabilities |
|
|
104 |
|
|
|
— |
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Total current liabilities |
|
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48,968 |
|
|
|
33,946 |
|
Operating lease liability, net of current portion |
|
|
13,813 |
|
|
|
3,046 |
|
Other non-current liabilities |
|
|
— |
|
|
|
104 |
|
Total liabilities |
|
|
62,781 |
|
|
|
37,096 |
|
Commitments and Contingencies (Note 10) |
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|
|
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|
Stockholders’ equity: |
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|
|
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|
Preferred stock, $0.0001 par value; 10,000,000 shares authorized and 0 shares outstanding as of September 30, 2023 and December 31, 2022 |
|
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— |
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— |
|
Common stock, $0.0001 par value; 150,000,000 shares authorized at September 30, 2023 and December 31, 2022; 37,719,367 and 34,473,905 shares issued and outstanding at September 30, 2023 and December 31, 2022, respectively |
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4 |
|
|
|
3 |
|
Additional paid-in capital |
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2,209,304 |
|
|
|
1,693,732 |
|
Accumulated deficit |
|
|
(884,063 |
) |
|
|
(564,207 |
) |
Accumulated other comprehensive loss |
|
|
(2,929 |
) |
|
|
(3,290 |
) |
Total stockholders’ equity |
|
|
1,322,316 |
|
|
|
1,126,238 |
|
Total liabilities and stockholders’ equity |
|
$ |
1,385,097 |
|
|
$ |
1,163,334 |
|
The accompanying notes are an integral part of these consolidated financial statements
1
Karuna Therapeutics, Inc.
CONSOLIDATED Statements of Operations
(In thousands, except share and per share data)
(Unaudited)
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Three Months Ended September 30, |
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Nine Months Ended September 30, |
|
|
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2023 |
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2022 |
|
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2023 |
|
|
2022 |
|
License and other revenue |
|
$ |
— |
|
|
$ |
81 |
|
|
$ |
654 |
|
|
$ |
5,359 |
|
Operating expenses: |
|
|
|
|
|
|
|
|
|
|
|
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Research and development |
|
|
103,952 |
|
|
|
61,950 |
|
|
|
281,909 |
|
|
|
158,243 |
|
General and administrative |
|
|
32,266 |
|
|
|
19,125 |
|
|
|
83,936 |
|
|
|
51,756 |
|
Total operating expenses |
|
|
136,218 |
|
|
|
81,075 |
|
|
|
365,845 |
|
|
|
209,999 |
|
Loss from operations |
|
|
(136,218 |
) |
|
|
(80,994 |
) |
|
|
(365,191 |
) |
|
|
(204,640 |
) |
Other income, net: |
|
|
|
|
|
|
|
|
|
|
|
|
Interest income |
|
|
16,952 |
|
|
|
3,884 |
|
|
|
44,894 |
|
|
|
4,611 |
|
Sublease income |
|
|
147 |
|
|
|
147 |
|
|
|
441 |
|
|
|
433 |
|
Total other income, net |
|
|
17,099 |
|
|
|
4,031 |
|
|
|
45,335 |
|
|
|
5,044 |
|
Net loss before income taxes |
|
|
(119,119 |
) |
|
|
(76,963 |
) |
|
|
(319,856 |
) |
|
|
(199,596 |
) |
Income tax provision |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(528 |
) |
Net loss attributable to common stockholders |
|
$ |
(119,119 |
) |
|
$ |
(76,963 |
) |
|
$ |
(319,856 |
) |
|
$ |
(200,124 |
) |
Net loss per share, basic and diluted (Note 6) |
|
$ |
(3.16 |
) |
|
$ |
(2.38 |
) |
|
$ |
(8.72 |
) |
|
$ |
(6.52 |
) |
Weighted average common shares outstanding used in computing net loss per share, basic and diluted |
|
|
37,689,144 |
|
|
|
32,349,111 |
|
|
|
36,682,056 |
|
|
|
30,693,117 |
|
The accompanying notes are an integral part of these consolidated financial statements
2
Karuna Therapeutics, Inc.
CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS
(In thousands)
(Unaudited)
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended September 30, |
|
|
Nine Months Ended September 30, |
|
|
|
2023 |
|
|
2022 |
|
|
2023 |
|
|
2022 |
|
Net loss |
|
$ |
(119,119 |
) |
|
$ |
(76,963 |
) |
|
$ |
(319,856 |
) |
|
$ |
(200,124 |
) |
Other comprehensive loss: |
|
|
|
|
|
|
|
|
|
|
|
|
Unrealized gains (losses) on available-for-sale investments |
|
|
713 |
|
|
|
(703 |
) |
|
|
361 |
|
|
|
(3,201 |
) |
Comprehensive loss |
|
$ |
(118,406 |
) |
|
$ |
(77,666 |
) |
|
$ |
(319,495 |
) |
|
$ |
(203,325 |
) |
The accompanying notes are an integral part of these consolidated financial statements
3
Karuna Therapeutics, Inc.
CONSOLIDATED Statements of Stockholders’ Equity
(In thousands, except share data)
(Unaudited)
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Common Stock |
|
|
Additional Paid-in |
|
|
Accumulated |
|
|
Accumulated Other Comprehensive |
|
|
Total Stockholders’ |
|
|
|
Shares |
|
|
Value |
|
|
Capital |
|
|
Deficit |
|
|
Loss |
|
|
Equity |
|
Balance, December 31, 2022 |
|
|
34,473,905 |
|
|
$ |
3 |
|
|
$ |
1,693,732 |
|
|
$ |
(564,207 |
) |
|
$ |
(3,290 |
) |
|
$ |
1,126,238 |
|
Issuance of common stock upon public offering, net of $23,000 in under-writing discounts and commissions and $281 in offering costs |
|
|
2,851,299 |
|
|
|
1 |
|
|
|
436,719 |
|
|
|
— |
|
|
|
— |
|
|
|
436,720 |
|
Stock-based compensation expense |
|
|
— |
|
|
|
— |
|
|
|
33,510 |
|
|
|
— |
|
|
|
— |
|
|
|
33,510 |
|
Exercise of common options |
|
|
319,090 |
|
|
|
— |
|
|
|
24,184 |
|
|
|
— |
|
|
|
— |
|
|
|
24,184 |
|
Other comprehensive loss |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(352 |
) |
|
|
(352 |
) |
Net loss |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(200,737 |
) |
|
|
— |
|
|
|
(200,737 |
) |
Balance, June 30, 2023 |
|
|
37,644,294 |
|
|
$ |
4 |
|
|
$ |
2,188,145 |
|
|
$ |
(764,944 |
) |
|
$ |
(3,642 |
) |
|
$ |
1,419,563 |
|
Stock-based compensation expense |
|
|
— |
|
|
|
— |
|
|
|
18,296 |
|
|
|
— |
|
|
|
— |
|
|
|
18,296 |
|
Exercise of common options |
|
|
75,073 |
|
|
|
— |
|
|
|
2,863 |
|
|
|
— |
|
|
|
— |
|
|
|
2,863 |
|
Other comprehensive gain |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
713 |
|
|
|
713 |
|
Net loss |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(119,119 |
) |
|
|
— |
|
|
|
(119,119 |
) |
Balance, September 30, 2023 |
|
|
37,719,367 |
|
|
$ |
4 |
|
|
$ |
2,209,304 |
|
|
$ |
(884,063 |
) |
|
$ |
(2,929 |
) |
|
$ |
1,322,316 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Common Stock |
|
|
Additional Paid-in |
|
|
Accumulated |
|
|
Accumulated Other Comprehensive |
|
|
Total Stockholders’ |
|
|
|
Shares |
|
|
Value |
|
|
Capital |
|
|
Deficit |
|
|
Loss |
|
|
Equity |
|
Balance, December 31, 2021 |
|
|
29,770,558 |
|
|
$ |
3 |
|
|
$ |
790,391 |
|
|
$ |
(287,871 |
) |
|
$ |
(497 |
) |
|
$ |
502,026 |
|
Stock-based compensation expense |
|
|
— |
|
|
|
— |
|
|
|
22,768 |
|
|
|
— |
|
|
|
— |
|
|
|
22,768 |
|
Exercise of common options |
|
|
162,545 |
|
|
|
— |
|
|
|
6,274 |
|
|
|
— |
|
|
|
— |
|
|
|
6,274 |
|
Other comprehensive loss |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(2,498 |
) |
|
|
(2,498 |
) |
Net loss |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(123,161 |
) |
|
|
— |
|
|
|
(123,161 |
) |
Balance, June 30, 2022 |
|
|
29,933,103 |
|
|
$ |
3 |
|
|
$ |
819,433 |
|
|
$ |
(411,032 |
) |
|
$ |
(2,995 |
) |
|
$ |
405,409 |
|
Issuance of common stock upon public offering, net of $43,125 in under-writing discounts and commissions and $328 in offering costs |
|
|
4,011,628 |
|
|
|
|
|
|
819,047 |
|
|
|
|
|
|
|
|
|
819,047 |
|
Stock-based compensation expense |
|
|
— |
|
|
|
— |
|
|
|
12,021 |
|
|
|
— |
|
|
|
— |
|
|
|
12,021 |
|
Exercise of common options |
|
|
401,260 |
|
|
|
— |
|
|
|
25,144 |
|
|
|
— |
|
|
|
— |
|
|
|
25,144 |
|
Other comprehensive loss |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(703 |
) |
|
|
(703 |
) |
Net loss |
|
|
— |
|
|
|
— |
|
|
|
— |
|
|
|
(76,963 |
) |
|
|
— |
|
|
|
(76,963 |
) |
Balance, September 30, 2022 |
|
|
34,345,991 |
|
|
$ |
3 |
|
|
$ |
1,675,645 |
|
|
$ |
(487,995 |
) |
|
$ |
(3,698 |
) |
|
$ |
1,183,955 |
|
The accompanying notes are an integral part of these consolidated financial statements
4
Karuna Therapeutics, Inc.
CONSOLIDATED Statements of Cash Flows
(In thousands)
(Unaudited)
|
|
|
|
|
|
|
|
|
|
|
Nine Months Ended September 30, |
|
|
|
2023 |
|
|
2022 |
|
Cash flows from operating activities |
|
|
|
|
|
|
Net loss |
|
$ |
(319,856 |
) |
|
$ |
(200,124 |
) |
Adjustments to reconcile net loss to net cash used in operating activities: |
|
|
|
|
|
|
Stock-based compensation expense |
|
|
51,806 |
|
|
|
34,789 |
|
Amortization of premiums and accretion of discounts on investment securities |
|
|
(27,567 |
) |
|
|
(327 |
) |
Depreciation and amortization expense |
|
|
1,254 |
|
|
|
807 |
|
Changes in operating assets and liabilities: |
|
|
|
|
|
|
Accrued interest on investment securities |
|
|
(2,753 |
) |
|
|
(399 |
) |
Accounts receivable |
|
|
57 |
|
|
|
1,669 |
|
Prepaid expenses |
|
|
16,230 |
|
|
|
(4,454 |
) |
Other current assets |
|
|
(9,084 |
) |
|
|
(1,443 |
) |
Right-of-use assets |
|
|
1,891 |
|
|
|
1,322 |
|
Other non-current assets |
|
|
47 |
|
|
|
108 |
|
Accounts payable |
|
|
413 |
|
|
|
13,777 |
|
Accrued expenses |
|
|
14,341 |
|
|
|
6,643 |
|
Other current liabilities |
|
|
104 |
|
|
|
— |
|
Operating lease liability |
|
|
(1,539 |
) |
|
|
(1,617 |
) |
Other non-current liabilities |
|
|
(104 |
) |
|
|
— |
|
Net cash used in operating activities |
|
|
(274,760 |
) |
|
|
(149,249 |
) |
|
|
|
|
|
|
|
Cash flows from investing activities |
|
|
|
|
|
|
Purchases of investment securities |
|
|
(1,292,308 |
) |
|
|
(459,353 |
) |
Purchase of short-term investments (certificates of deposit) |
|
|
(2,033 |
) |
|
|
— |
|
Maturities of investment securities |
|
|
1,043,698 |
|
|
|
180,199 |
|
Acquisition of property and equipment |
|
|
(2,118 |
) |
|
|
(625 |
) |
Net cash used in investing activities |
|
|
(252,761 |
) |
|
|
(279,779 |
) |
|
|
|
|
|
|
|
Cash flows from financing activities |
|
|
|
|
|
|
Proceeds from public offering, net of underwriting discounts and commissions |
|
|
436,720 |
|
|
|
819,375 |
|
Payment of offering costs |
|
|
(261 |
) |
|
|
(401 |
) |
Proceeds from exercise of stock options |
|
|
27,047 |
|
|
|
31,418 |
|
Net cash provided by financing activities |
|
|
463,506 |
|
|
|
850,392 |
|
Net (decrease) increase in cash, cash equivalents and restricted cash |
|
|
(64,015 |
) |
|
|
421,364 |
|
Cash, cash equivalents and restricted cash at beginning of period |
|
|
248,590 |
|
|
|
207,214 |
|
Cash, cash equivalents and restricted cash at end of period |
|
$ |
184,575 |
|
|
$ |
628,578 |
|
|
|
|
|
|
|
|
Supplemental disclosures of cash flows information |
|
|
|
|
|
|
Lease liabilities arising from obtaining right-of-use assets |
|
$ |
11,820 |
|
|
$ |
— |
|
Purchases of property and equipment included in accounts payable and accrued expenses |
|
$ |
650 |
|
|
$ |
9 |
|
The accompanying notes are an integral part of these consolidated financial statements
5
NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
(Unaudited)
Note 1. Nature of the Business and Basis of Presentation
Description of the Business
Karuna Therapeutics, Inc. (the “Company”) was incorporated under the laws of the State of Delaware in July 2009 as Karuna Pharmaceuticals, Inc. and is headquartered in Boston, Massachusetts. In March 2019, the Company changed its name to Karuna Therapeutics, Inc. The Company is a clinical-stage biopharmaceutical company driven to discover, develop, and deliver transformative medicines for people living with psychiatric and neurological conditions.
Since the Company’s inception, it has focused substantially all of its efforts and financial resources on organizing and staffing the Company, acquiring and developing its technology, raising capital, building its intellectual property portfolio, undertaking preclinical studies and clinical trials, preparing for the potential commercialization of KarXT, and providing general and administrative support for these activities. The Company has not generated any product revenue related to its primary business purpose to date and is subject to a number of risks similar to those of other early stage companies, including dependence on key individuals, regulatory approval of products, uncertainty of market acceptance of products, competition from substitute products and larger companies, compliance with government regulations, protection of proprietary technology, dependence on third parties, product liability, the impact of the effects of the COVID-19 coronavirus pandemic, and the need to obtain adequate additional financing to fund the development of its product candidates.
In March 2023, the Company completed a follow-on public offering under an effective registration statement on Form S-3 (File No. 333-239657) and a related prospectus supplement in which it issued and sold 2,851,299 shares of common stock, which included the full exercise of the underwriters’ option to purchase an additional 371,908 shares of common stock, at a public offering price of $161.33 per share. The aggregate net proceeds to the Company from the offering, inclusive of proceeds from the option exercise, were $436.7 million after deducting underwriting discounts and commissions of $23.0 million and offering expenses of $0.3 million. On June 21, 2023, the Company filed an automatically effective registration statement on Form S-3 (File No. 333- 272813) with the Securities and Exchange Commission (the “SEC"), which registers the offering, issuance and sale of an unspecified amount of common stock, preferred stock, debt securities, warrants and/or units of any combination thereof.
The Company’s consolidated financial statements have been prepared on the basis of continuity of operations, realization of assets and the satisfaction of liabilities in the ordinary course of business. The Company experienced negative operating cash flows of $274.8 million for the nine months ended September 30, 2023 and had an accumulated deficit of $884.1 million as of September 30, 2023. The Company expects to continue to generate operating losses for the foreseeable future.
The Company expects that its cash, cash equivalents and available-for-sale investments of $1,339.5 million as of September 30, 2023 will be sufficient to fund its operating expenses and capital expenditure requirements through at least 12 months from the date of issuance of these consolidated financial statements.
Basis of Presentation
The accompanying consolidated financial statements have been prepared in conformity with accounting principles generally accepted in the United States of America (“U.S. GAAP”). Any reference in these notes to applicable guidance is meant to refer to the authoritative U.S. GAAP as found in the Accounting Standards Codification (“ASC”) and Accounting Standards Updates (“ASUs”) of the Financial Accounting Standards Board (“FASB”).
The consolidated financial statements include the accounts of Karuna Therapeutics, Inc. and its wholly owned subsidiary, Karuna Securities Corporation, a Massachusetts corporation. All inter-company transactions and balances have been eliminated in consolidation.
6
The accompanying consolidated balance sheet as of September 30, 2023 and the consolidated statements of operations, comprehensive loss, and stockholders’ equity for the three and nine months ended September 30, 2023 and 2022, and the statements of cash flow for the nine months ended September 30, 2023 and 2022, are unaudited. The unaudited interim consolidated financial statements have been prepared on the same basis as the audited annual consolidated financial statements and, in the opinion of management, reflect all adjustments, which include only normal recurring adjustments, necessary for the fair statement of the Company’s financial position as of September 30, 2023 and the results of its operations for the three and nine months ended September 30, 2023 and 2022 and cash flows for the nine months ended September 30, 2023 and 2022. Certain information and footnote disclosures typically included in annual financial statements prepared in accordance with U.S. GAAP have been condensed or omitted. Accordingly, these unaudited consolidated interim financial statements should be read in conjunction with the Company’s consolidated financial statements as of and for the year ended December 31, 2022. The results for the three and nine months ended September 30, 2023 are not necessarily indicative of results to be expected for the year ending December 31, 2023, any other interim periods, or any future year or period.
Note 2. Summary of Significant Accounting Policies
The significant accounting policies and estimates used in preparation of the consolidated financial statements are described in the Company’s audited consolidated financial statements as of and for the year ended December 31, 2022, and the notes thereto, which are included in the Company’s Annual Report on Form 10-K. During the three and nine months ended September 30, 2023, there were no material changes to the Company’s significant accounting policies, except for the addition of the following policy:
Policy Regarding Acquired In-Process Research and Development (IPR&D) and Development Milestones
Acquired IPR&D and development milestones include the initial costs of externally developed IPR&D projects, acquired directly in a transaction other than a business combination, that do not have an alternative future use. Prior to regulatory approval of the compound, initial costs are expensed when incurred, and milestone payment obligations related to these transactions are expensed when the event triggering an obligation to pay the milestone occurs. Milestone payments made upon or after regulatory approval are capitalized and amortized over the remaining useful life of the related asset.
Recently Issued Accounting Pronouncements
New pronouncements issued but not effective until after September 30, 2023 are not expected to have a material impact on the Company’s consolidated financial statements.
Note 3. Prepaid Expenses, Other Current Assets, and Accrued Expenses
Prepaid expenses consisted of the following (in thousands):
|
|
|
|
|
|
|
|
|
|
|
September 30, 2023 |
|
|
December 31, 2022 |
|
Research and development expenses |
|
$ |
8,881 |
|
|
$ |
25,285 |
|
Insurance |
|
|
2,581 |
|
|
|
2,472 |
|
Other |
|
|
1,414 |
|
|
|
1,349 |
|
Total prepaid expenses |
|
$ |
12,876 |
|
|
$ |
29,106 |
|
The Company also had other current assets totaling $10.1 million as of September 30, 2023 and $1.0 million as of December 31, 2022, respectively. As of September 30, 2023, other current assets included a refundable regulatory fee of $3.2 million paid in connection with the Company's New Drug Application ("NDA") submission and a receivable of $4.9 million in connection with the acquisition of rights to a general unsecured claim against Goldfinch Bio, Inc. ("Goldfinch Bio"). As of December 31, 2022, other current assets included interest receivable on our investment securities of $0.7 million.
7
Accrued expenses consisted of the following (in thousands):
|
|
|
|
|
|
|
|
|
|
|
September 30, 2023 |
|
|
December 31, 2022 |
|
Research and development expenses |
|
$ |
22,821 |
|
|
$ |
11,962 |
|
Payroll and related expenses |
|
|
14,717 |
|
|
|
11,950 |
|
Professional fees |
|
|
4,593 |
|
|
|
2,943 |
|
Other |
|
|
1,998 |
|
|
|
2,430 |
|
Total accrued expenses |
|
$ |
44,129 |
|
|
$ |
29,285 |
|
Note 4. Stockholders’ Equity
Preferred Stock
On July 2, 2019, in connection with the closing of the Company’s initial public offering of its common stock ("IPO"), the Company filed its amended and restated Certificate of Incorporation, which authorizes the Company to issue up to 10,000,000 shares of preferred stock, $0.0001 par value per share. Through September 30, 2023, no preferred stock has been issued.
Common Stock
As of September 30, 2023, the Company’s amended and restated Certificate of Incorporation authorized the Company to issue 150,000,000 shares of common stock, $0.0001 par value per share.
Holders of the common stock are entitled to one vote for each share of common stock held at all meetings of stockholders and written actions in lieu of meetings. The holders of common stock are entitled to receive dividends out of funds legally available, as declared by the board of directors. These dividends are subject to the preferential dividend rights of the holders of the Company’s preferred stock. Through September 30, 2023, no cash dividends have been declared or paid.
As of September 30, 2023, there were 37,719,367 shares of common stock outstanding.
Note 5. Zai License Agreement
Terms of Agreement
On November 8, 2021, the Company and Zai Lab (Shanghai) Co., Ltd. ("Zai") entered into a license agreement (the "Zai License Agreement"), pursuant to which Karuna granted to Zai the right to exclusively develop, manufacture and commercialize KarXT in Greater China, including mainland China, Hong Kong, Macau, and Taiwan (the “Licensed Territory”). Zai will fund substantially all development, regulatory, and commercialization activities in the Licensed Territory.
Under the terms of the Zai License Agreement, the Company received a non-refundable $35.0 million upfront payment and payment of certain taxes on its behalf. The Zai License Agreement also provides that the Company is eligible to receive total development and regulatory milestone payments of up to $80.0 million, total sales milestone payments of up to $72.0 million and low double-digit to high-teens tiered royalties based on annual net sales of KarXT in the Licensed Territory, subject to reduction under specified circumstances. Receipt of sales milestone payments and royalties are not contingent on any further participation by the Company in the development of KarXT in the Licensed Territory.
The Zai License Agreement will expire upon the latest of the following dates with respect to the last licensed product in any region in the Licensed Territory: (i) the date of expiration of the last valid claim covering such licensed product in such region, (ii) the date that is a specific period after the date of the first commercial sale of such licensed product in such region and (iii) the expiration date of any regulatory exclusivity for such licensed product in such region. Zai may terminate the Zai License Agreement for convenience, subject to the terms thereto, by providing written notice to the Company, which termination will be effective following a prescribed notice period. In addition, the Company may terminate the Zai License Agreement under specified circumstances if Zai or certain other parties challenge the Company’s patent rights or if Zai or its affiliates fail to complete certain development activities with respect to the licensed product for a specified period of time, subject to specified exceptions. Either party may terminate the Zai License Agreement for the other party’s uncured material breach, with a customary notice and cure period, or insolvency.
8
After termination or expiration, the Company is entitled to retain a worldwide, exclusive, and perpetual license from Zai to exploit the licensed product, which license would be non-exclusive after expiration (but not termination), subject to a reasonable royalty to be agreed by the parties if terminated for the Company’s uncured material breach.
Revenue Recognition
The Company concluded that the distinct units of account within the agreement are reflective of a vendor-customer relationship and therefore within the scope of ASC 606, Revenue From Contracts with Customers.
Under the provisions of ASC 606, the Company identified one performance obligation. The Company provided an exclusive license to intellectual property, bundled with the associated know-how and certain professional services that are not substantive.
Under the terms of the Zai License Agreement, Zai has the sole right to manufacture, or have manufactured, KarXT for use in development and commercialization in the Licensed Territory. At the election of Zai, the Company may supply KarXT to Zai at the fully burdened manufacturing cost plus a specified margin, as defined within the Zai License Agreement. This provision was determined to be an option to acquire additional goods or services at a price that approximates the stand-alone selling price for that good or service, and therefore does not represent a material right, or separate performance obligation, within the context of the Zai License Agreement. For the nine months ended September 30, 2023, the Company recognized $0.7 million in revenue associated with sales of clinical drug supply to Zai. No revenue associated with sales of clinical drug supply was recognized during the three months ended September 30, 2023. For the three and nine months ended September 30, 2022, less than $0.1 million revenue was recognized for sales of clinical drug supply to Zai.
The Company determined the transaction price of the Zai License Agreement was equal to $37.0 million, which includes the upfront fee of $35.0 million and payments to taxing authorities on the Company’s behalf. In estimating the stand-alone selling price, the Company determined that there were no significant financing components, noncash consideration or amounts that may be refunded to the customer, and as such the total unconstrained consideration of $37.0 million was included in the total transaction price.
License of Intellectual Property. The license to the Company's intellectual property represents a distinct performance obligation. The license and associated know-how was transferred to Zai in the fourth quarter of 2021 to satisfy this performance obligation. The Company allocated the full transaction price to the license of the Company's intellectual property and accordingly recognized revenue of $37.0 million as license revenue in its Consolidated Statement of Operations for the year ended December 31, 2021.
Milestone Payments. The potential development and regulatory milestone payments, as well as sales milestone payments, are paid upon achievement of certain milestones as defined in the Zai License Agreement. For the three and nine months ended September 30, 2023, there was no revenue related to milestone payments recognized pursuant to the Zai License Agreement. For the nine months ended September 30, 2022, the Company recognized $5.3 million in license revenue for certain development milestones and related payments to taxing authorities on the Company's behalf, and recorded $0.5 million in foreign tax expense to income tax provision. For the three months ended September 30, 2022, there was no revenue related to milestone payments recognized pursuant to the Zai License Agreement.
For all remaining development and regulatory milestones, which, as of September 30, 2023, can total up to $70.0 million, it was determined that their achievement is highly dependent on factors outside of the Company's control. These payments have been fully constrained until the Company concludes that achievement of the milestone is probable, and that recognition of revenue related to the milestone will not result in a significant reversal in amounts recognized in future periods, and as such have been excluded from the transaction price. At the end of each subsequent reporting period, the Company will re-evaluate the probability of achievement of each milestone and any related constraint and, if necessary, adjust its estimate of the overall transaction price.
As of September 30, 2023, the Company has not recognized any revenue associated with sales milestones.
Royalties. Any consideration related to royalties will be recognized if and when the related sales occur, as they were determined to relate predominantly to the license granted to Zai and, therefore, have also been excluded from the transaction price. As of September 30, 2023, the Company has not recognized any revenue associated with royalties.
There was no deferred revenue as of September 30, 2023 or December 31, 2022 related to the Zai License Agreement.
9
Note 6. Net Loss per Share
The following table sets forth the computation of basic and diluted net loss per share of common stock for the three and nine months ended September 30, 2023 and 2022 (in thousands, except share and per share data):
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended September 30, |
|
|
Nine Months Ended September 30, |
|
|
|
2023 |
|
|
2022 |
|
|
2023 |
|
|
2022 |
|
Net Loss |
|
$ |
(119,119 |
) |
|
$ |
(76,963 |
) |
|
$ |
(319,856 |
) |
|
$ |
(200,124 |
) |
Weighted-average shares used in computing net loss per share |
|
|
37,689,144 |
|
|
|
32,349,111 |
|
|
|
36,682,056 |
|
|
|
30,693,117 |
|
Net loss per share, basic and diluted |
|
$ |
(3.16 |
) |
|
$ |
(2.38 |
) |
|
$ |
(8.72 |
) |
|
$ |
(6.52 |
) |
The Company’s potentially dilutive securities, which consist of stock options and restricted stock units ("RSUs"), have been excluded from the computation of diluted net loss per share because including them would have had an anti-dilutive impact. Therefore, the weighted average number of common shares outstanding used to calculate both basic and diluted net loss per share attributable to common stockholders is the same.
The following common stock equivalents, presented based on amounts outstanding at each period end, have been excluded from the calculation of diluted net loss per share:
|
|
|
|
|
|
|
|
|
|
|
September 30, |
|
|
|
2023 |
|
|
2022 |
|
Stock options to purchase common stock |
|
|
5,541,686 |
|
|
|
5,561,493 |
|
Restricted stock units |
|
|
314,854 |
|
|
|
— |
|
|
|
|
5,856,540 |
|
|
|
5,561,493 |
|
Note 7. License Agreements
Acquisition of KAR-2618 and other TRPC4/5 candidates
In January 2023, the Company entered into an exclusive license agreement (the "GFB Agreement"), with GFB (ABC), LLC ("GFB"), assignee of the assignment estate of Goldfinch Bio, pursuant to which GFB granted to the Company the exclusive right and license to develop, manufacture, and commercialize GFB’s TRPC4/5 candidates (the "GFB Compounds"), including the lead clinical-stage candidate known as KAR-2618 (formerly GFB-887). The Company agreed to use commercially reasonable efforts to develop, obtain regulatory approval for, and commercialize at least one licensed product that contains or comprises a GFB Compound in at least two indications in the United States.
Under the terms of the GFB Agreement, the Company paid to GFB a $15.0 million upfront payment, and agreed to pay a total of up to $520.0 million for each GFB Compound upon the achievement of certain development, regulatory and commercial milestones with respect to such GFB Compound, of which $110.0 million, $150.0 million, and $260.0 million are related to development, regulatory, and commercial sales milestones, respectively. The Company also agreed to pay GFB a flat low-single digit royalty on aggregate net sales of each licensed product on a country-by-country basis until the expiration of the applicable royalty term, which ends on the later of (i) the expiration date of the last valid claim covering the licensed product in such country, (ii) the expiration date of regulatory exclusivity with respect to such licensed product in such country, and (iii) the date that is a specific period after the first commercial sale of such licensed product in such country. The royalty rate is subject to reduction on a licensed product-by-licensed product and country-by-country basis under certain circumstances. In the event that the Company sublicenses to a third party any of the rights to the licensed intellectual property granted under the GFB Agreement, the Company will be obligated to pay GFB royalties within the range of 25% to 35% on any consideration the Company receives from the sublicensee, excluding royalties and certain other payments.
Unless earlier terminated, the GFB Agreement will expire on the expiration of the last to expire royalty term. Unless the GFB Agreement is earlier terminated, on expiration of each applicable royalty term, the Company will have a fully paid-up, irrevocable and perpetual license to develop, manufacture and commercialize each applicable licensed product in the applicable country. Either party may terminate the GFB Agreement for the other party’s material breach, following a customary notice and cure period, or insolvency. The Company may terminate the GFB Agreement for any reason upon 90 days written notice to GFB.
The upfront payment of $15.0 million was accounted for as an asset acquisition and recorded within research and development expense in the consolidated statement of operations for the nine months ended September 30, 2023, as
10
KAR-2618 is prior to regulatory approval and has no alternative future use. The Company did not incur or recognize any milestone payments under the GFB Agreement during the three and nine months ended September 30, 2023.
Intellectual Property License with Eli Lilly and Company
In May 2012, the Company entered into an exclusive license agreement (the “Lilly License Agreement”), with Eli Lilly and Company (“Eli Lilly”), pursuant to which Eli Lilly assigned to the Company all of its rights to certain patents (now expired), regulatory documentation, data records and materials related to xanomeline. The Company is also entitled to sublicense or otherwise transfer the rights granted in connection with the Lilly License Agreement.
Under the Lilly License Agreement, the Company is obligated to use commercially reasonable efforts to develop, manufacture, commercialize and seek and maintain regulatory approval for xanomeline, in any formulation, for use in humans.
The Company paid Eli Lilly an upfront payment of $0.1 million and has agreed to make milestone payments to Eli Lilly of up to an aggregate of $16.0 million upon the achievement of specified regulatory milestones and up to an aggregate of $54.0 million in commercial milestones. In addition, the Company is obligated to pay Eli Lilly tiered royalties, at rates in the low to mid single-digit percentages, on the worldwide net sales of any commercialized product on a country-by-country basis until the expiration of the applicable royalty term, which is the longer of six years from the date of first commercial sale of each licensed product within a country or data package exclusivity in such country. During the royalty term, Eli Lilly is prohibited from granting any third party rights to the patents, regulatory documentation, data records and materials that have been licensed to the Company under the Lilly License Agreement.
The Lilly License Agreement will expire on the later of (i) the expiration of the last-to-expire royalty term on a licensed product-by-licensed product basis or (ii) the date on which the Company has made all milestone payments pursuant to the terms of the Lilly License Agreement, unless terminated earlier by the parties. In no event will the term of the Lilly License Agreement exceed 15 years past the anniversary of the first commercial sale of a xanomeline product. The Company may terminate the Lilly License Agreement for any reason with proper prior notice to Eli Lilly. Either party may terminate the Lilly License Agreement upon an uncured material breach by the other party.
The initial upfront payment of $0.1 million was expensed when incurred in May 2012. As of September 30, 2023, no regulatory or commercial milestones have been reached and, accordingly, no milestone payments have been made.
Intellectual Property License with PureTech Health
In March 2011, the Company entered into an exclusive license agreement (the “Patent License Agreement”) with PureTech Health, pursuant to which PureTech Health granted the Company an exclusive license to patent rights relating to combinations of a muscarinic activator with a muscarinic inhibitor for the treatment of central nervous system disorders.
In connection with the Patent License Agreement, the Company has agreed to make milestone payments to PureTech Health of up to an aggregate of $10.0 million upon the achievement of specified development and regulatory milestones. In addition, the Company is obligated to pay PureTech Health low single-digit royalties on the worldwide net sales of any commercialized product covered by the licenses granted under the Patent License Agreement.
In the event that the Company sublicenses any of the patent rights granted under the Patent License Agreement, the Company will be obligated to pay PureTech Health royalties within the range of 15% to 25% on any income the Company receives from the sublicensee, excluding royalties.
The Company may terminate the Patent License Agreement for any reason with proper prior notice to PureTech Health. Either party may terminate the Patent License Agreement upon an uncured material breach by the other party.
The Company incurred no expenses related to the Patent License Agreement during the three and nine months ended September 30, 2023 and 2022. As of September 30, 2023, the remaining development and regulatory milestone payments under the Patent License Agreement total up to $8.0 million. The Company had no outstanding liabilities to PureTech Health related to the Patent License Agreement as of September 30, 2023 and December 31, 2022.
Note 8. Stock-based Compensation
In September 2009, the Company’s board of directors approved the 2009 Stock Incentive Plan (the “2009 Plan”) which provided for the grant of incentive stock options to employees and non-statutory stock options to directors, consultants, and non-employees of the Company. The 2009 Plan terminated in July 2019 effective upon the completion of the Company’s IPO. No additional options will be granted under the 2009 Plan. As of September 30, 2023, there were 1,981,828 options outstanding under the 2009 Plan.
11
In May 2019, the Company’s board of directors approved the 2019 Stock Option and Incentive Plan (the “2019 Plan”) which became effective on June 26, 2019, the date immediately prior to the date on which the registration statement related to the IPO was declared effective by the SEC. The 2019 Plan will expire in May 2029. Under the 2019 Plan, the Company may grant incentive stock options, non-statutory stock options, restricted stock awards, RSUs, and other stock-based awards. There were 1,709,832 shares of the Company’s common stock initially reserved for issuance under the 2019 Plan. The number of shares of common stock underlying awards that expire, or are terminated, surrendered, canceled or forfeited without having been fully exercised under the 2009 Plan will be added to the shares of common stock available for issuance under the 2019 Plan. In addition, the number of shares of common stock that may be issued under the 2019 Plan automatically increases on January 1 of each calendar year, commencing on January 1, 2020, by 4% of the number of shares of common stock outstanding on the immediately preceding December 31 or such lesser amount determined by the Company’s board of directors or the compensation committee of the board of directors. As of September 30, 2023, there were 2,661,308 common shares available for issuance, 3,559,858 options outstanding, and 314,854 RSUs outstanding under the 2019 Plan.
Stock Options
Option awards under the 2019 Plan generally vest based on the grantee’s continued service with the Company during a specified period following a grant and expire ten years from the grant date. Awards typically vest in four years, but vesting conditions can vary based on the discretion of the Company’s board of directors.
A summary of the Company’s stock option activity and related information is as follows:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Number of Shares |
|
|
Weighted- Average Exercise Price Per Share |
|
|
Weighted- Average Remaining Contractual Term (Years) |
|
|
Aggregate Intrinsic Value (in thousands) |
|
Outstanding as of December 31, 2022 |
|
|
5,570,355 |
|
|
$ |
63.82 |
|
|
|
7.2 |
|
|
$ |
744,097 |
|
Granted |
|
|
636,014 |
|
|
|
195.44 |
|
|
|
|
|
|
|
Exercised |
|
|
(394,163 |
) |
|
|
68.62 |
|
|
|
|
|
|
|
Forfeited |
|
|
(268,382 |
) |
|
|
142.72 |
|
|
|
|
|
|
|
Expired |
|
|
(2,138 |
) |
|
|
123.63 |
|
|
|
|
|
|
|
Outstanding as of September 30, 2023 |
|
|
5,541,686 |
|
|
$ |
74.74 |
|
|
|
6.5 |
|
|
$ |
546,440 |
|
Options vested and expected to vest as of September 30, 2023 |
|
|
5,541,686 |
|
|
$ |
74.74 |
|
|
|
6.5 |
|
|
$ |
546,440 |
|
Options exercisable as of September 30, 2023 |
|
|
3,892,864 |
|
|
$ |
41.37 |
|
|
|
5.6 |
|
|
$ |
497,659 |
|
The aggregate intrinsic values of options outstanding, exercisable, vested and expected to vest were calculated as the difference between the exercise price of the options and the publicly traded stock price of the Company’s common stock as of September 30, 2023.
As of September 30, 2023, there was $132.2 million of unrecognized compensation cost, which is expected to be recognized over a weighted-average period of 2.8 years.
The weighted-average fair values of options granted during the nine months ended September 30, 2023 and 2022 was $114.69 and $70.59, respectively. The intrinsic value of options exercised during the nine months ended September 30, 2023 and 2022 was $54.5 million and $84.0 million, respectively.
Restricted Stock Units
RSUs are granted to certain employees and are payable in shares of the Company's common stock. RSU shares are accounted for at fair value based upon the closing stock price on the date of grant. The corresponding expense is amortized over the vesting period, which is typically four years.
12
A summary of the Company’s restricted stock unit activity and related information is as follows:
|
|
|
|
|
|
|
|
|
|
|
Number of Shares |
|
|
Weighted- Average Grant Date Fair Value |
|
Unvested as of December 31, 2022 |
|
|
— |
|
|
$ |
— |
|
Granted |
|
|
330,267 |
|
|
|
195.46 |
|
Vested |
|
|
— |
|
|
|
— |
|
Forfeited |
|
|
(15,413 |
) |
|
|
189.49 |
|
Unvested as of September 30, 2023 |
|
|
314,854 |
|
|
$ |
195.75 |
|
As of September 30, 2023, the total remaining unrecognized compensation cost related to nonvested RSUs was $53.6 million, which will be amortized over the weighted-average remaining requisite service period of 3.4 years.
Stock-based Compensation Expense
Stock-based compensation expense is classified in the statements of operations for the three and nine months ended September 30, 2023 and 2022 as follows (in thousands):
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended September 30, |
|
|
Nine Months Ended September 30, |
|
|
|
2023 |
|
|
2022 |
|
|
2023 |
|
|
2022 |
|
Research and development |
|
$ |
10,880 |
|
|
$ |
5,431 |
|
|
$ |
29,955 |
|
|
$ |
15,140 |
|
General and administrative |
|
|
7,416 |
|
|
|
6,590 |
|
|
|
21,851 |
|
|
|
19,649 |
|
Total stock-based compensation expense |
|
$ |
18,296 |
|
|
$ |
12,021 |
|
|
$ |
51,806 |
|
|
$ |
34,789 |
|
13
Note 9. Fair Value of Financial Assets and Liabilities
The following tables present information about the Company’s assets as of September 30, 2023 and December 31, 2022 that are measured at fair value on a recurring basis and indicate the level of the fair value hierarchy utilized to determine such fair values (in thousands):
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Fair Value Measurement |
|
|
|
at September 30, 2023 Using |
|
|
|
Level 1 |
|
|
Level 2 |
|
|
Level 3 |
|
|
Total |
|
Cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
Money market fund |
|
$ |
135,160 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
135,160 |
|
Commercial paper |
|
|
— |
|
|
|
29,422 |
|
|
|
— |
|
|
|
29,422 |
|
Short-term investments, other: |
|
|
|
|
|
|
|
|
|
|
|
|
Certificate of deposit |
|
|
— |
|
|
|
2,033 |
|
|
|
— |
|
|
|
2,033 |
|
Investment securities: |
|
|
|
|
|
|
|
|
|
|
|
|
US Treasuries |
|
|
689,176 |
|
|
|
— |
|
|
|
— |
|
|
|
689,176 |
|
US government agencies |
|
|
202,646 |
|
|
|
— |
|
|
|
— |
|
|
|
202,646 |
|
Corporate debt securities |
|
|
— |
|
|
|
33,120 |
|
|
|
— |
|
|
|
33,120 |
|
Commercial paper |
|
|
— |
|
|
|
230,064 |
|
|
|
— |
|
|
|
230,064 |
|
Total |
|
$ |
1,026,982 |
|
|
$ |
294,639 |
|
|
$ |
— |
|
|
$ |
1,321,621 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Fair Value Measurement |
|
|
|
at December 31, 2022 Using |
|
|
|
Level 1 |
|
|
Level 2 |
|
|
Level 3 |
|
|
Total |
|
Cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
Money market fund |
|
$ |
160,158 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
160,158 |
|
Commercial paper |
|
|
— |
|
|
|
61,277 |
|
|
|
— |
|
|
|
61,277 |
|
Investment securities: |
|
|
|
|
|
|
|
|
|
|
|
|
US Treasuries |
|
|
423,688 |
|
|
|
— |
|
|
|
— |
|
|
|
423,688 |
|
US government agencies |
|
|
210,188 |
|
|
|
— |
|
|
|
— |
|
|
|
210,188 |
|
Corporate debt securities |
|
|
— |
|
|
|
63,728 |
|
|
|
— |
|
|
|
63,728 |
|
Commercial paper |
|
|
— |
|
|
|
178,111 |
|
|
|
— |
|
|
|
178,111 |
|
Total |
|
$ |
794,034 |
|
|
$ |
303,116 |
|
|
$ |
— |
|
|
$ |
1,097,150 |
|
The fair values of the Company’s commercial paper and corporate debt securities are based on prices obtained from independent pricing sources. Securities with validated quotes from pricing services are reflected within Level 2, as they are primarily based on observable pricing for similar assets or other market observable inputs. Typical inputs used by these pricing services include, but are not limited to, reported trades, benchmark yields, issuer spreads, bids, offers or estimates of cash flow, prepayment spreads and default rates.
Certificates of deposit held for investment with an original maturity greater than three months and less than twelve months are carried at amortized cost and reported as short-term investments on the Company's consolidated balance sheet, which approximates their fair value based on Level 2 inputs.
The Company does not hold any securities classified as Level 3, which are securities valued using unobservable inputs. The Company has not transferred any investment securities between the classification levels.
14
The estimated fair value and amortized cost of the Company’s available-for-sale investments, by contractual maturity and security type, are summarized as follows (in thousands):
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
September 30, 2023 |
|
|
|
Amortized Cost |
|
|
Unrealized Gains |
|
|
Unrealized Losses |
|
|
Fair Value |
|
US Treasuries (due within one year) |
|
$ |
559,852 |
|
|
$ |
7 |
|
|
$ |
(1,193 |
) |
|
$ |
558,666 |
|
US Treasuries (due after one year and less than three years) |
|
|
131,249 |
|
|
|
2 |
|
|
|
(741 |
) |
|
|
130,510 |
|
US government agencies (due within one year) |
|
|
147,612 |
|
|
|
10 |
|
|
|
(296 |
) |
|
|
147,326 |
|
US government agencies (due after one year and less than three years) |
|
|
55,752 |
|
|
|
— |
|
|
|
(432 |
) |
|
|
55,320 |
|
Corporate debt securities (due within one year) |
|
|
30,361 |
|
|
|
— |
|
|
|
(138 |
) |
|
|
30,223 |
|
Corporate debt securities (due after one year and less than three years) |
|
|
2,948 |
|
|
|
— |
|
|
|
(51 |
) |
|
|
2,897 |
|
Commercial paper (due within one year) |
|
|
230,161 |
|
|
|
6 |
|
|
|
(103 |
) |
|
|
230,064 |
|
Total |
|
$ |
1,157,935 |
|
|
$ |
25 |
|
|
$ |
(2,954 |
) |
|
$ |
1,155,006 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
December 31, 2022 |
|
|
|
Amortized Cost |
|
|
Unrealized Gains |
|
|
Unrealized Losses |
|
|
Fair Value |
|
US Treasuries (due within one year) |
|
$ |
329,533 |
|
|
$ |
17 |
|
|
$ |
(2,044 |
) |
|
$ |
327,506 |
|
US Treasuries (due after one year and less than three years) |
|
|
96,802 |
|
|
|
— |
|
|
|
(620 |
) |
|
|
96,182 |
|
US government agencies (due within one year) |
|
|
178,319 |
|
|
|
54 |
|
|
|
(108 |
) |
|
|
178,265 |
|
US government agencies (due after one year and less than three years) |
|
|
32,104 |
|
|
|
— |
|
|
|
(181 |
) |
|
|
31,923 |
|
Corporate debt securities (due within one year) |
|
|
51,952 |
|
|
|
1 |
|
|
|
(170 |
) |
|
|
51,783 |
|
Corporate debt securities (due after one year and less than three years) |
|
|
11,983 |
|
|
|
— |
|
|
|
(38 |
) |
|
|
11,945 |
|
Commercial paper (due within one year) |
|
|
178,312 |
|
|
|
16 |
|
|
|
(217 |
) |
|
|
178,111 |
|
Total |
|
$ |
879,005 |
|
|
$ |
88 |
|
|
$ |
(3,378 |
) |
|
$ |
875,715 |
|
The Company has classified all of its available-for-sale investment securities, including those with maturities beyond one year, as current assets on its consolidated balance sheets based on the highly liquid nature of the investment securities and because these investment securities are considered available for use in current operations.
The Company is required to determine whether a decline in the fair value below the amortized cost basis of available-for-sale securities is due to credit-related factors. At each reporting date, the Company performs an evaluation of impairment to determine if any unrealized losses are the result of credit losses. Impairment is assessed at the individual security level. Factors considered in determining whether a loss resulted from a credit loss or other factors include the Company’s intent and ability to hold the investment until the recovery of its amortized cost basis, the extent to which the fair value is less than the amortized cost basis, the length of time and extent to which fair value has been less than the cost basis, the financial condition of the issuer, any historical failure of the issuer to make scheduled interest or principal payments, any changes to the rating of the security by a rating agency, any adverse legal or regulatory events affecting the issuer or issuer’s industry, and any significant deterioration in economic conditions.
Unrealized losses on available-for-sale securities presented in the previous table have not been recognized in the consolidated statements of operations because the securities are high credit quality, investment grade securities that the Company does not intend to sell and will not be required to sell prior to their anticipated recovery, and the decline in fair value is attributable to factors other than credit losses. Based on its evaluation, the Company determined its year-to-date credit losses related to its available-for-sale securities were immaterial at September 30, 2023 and December 31, 2022.
15
Note 10. Commitments and Contingencies
Leases
The Company has 25,445 square feet of office space on High Street in Boston, Massachusetts (“High Street Sublease”). The term of the High Street Sublease extends from April 1, 2021 through December 31, 2025 and provides for escalating annualized base rent payments starting at approximately $1.5 million and increasing to $1.6 million in the final year of the sublease.
In April 2023, the Company entered into an agreement ("High Street Lease") to lease approximately 50,890 square feet of additional office space located at 99 High Street in Boston, Massachusetts. The Company took possession of the premises in June 2023. The initial term of the lease is ten years from the date alterations are substantially complete, estimated to occur no later than April 2024, with the option to renew for an additional five-year term. Annual base rent under the lease is approximately $3.5 million and is subject to annual increases in accordance with the terms of the lease agreement. Lease payments begin on the earlier of January 1, 2025 or nine months from the date alterations are substantially complete. The Company recognized a right-of-use ("ROU") asset and corresponding lease liability of approximately $11.7 million and $11.4 million, respectively, on its consolidated balance sheet as of June 8, 2023 upon commencement of the High Street Lease. The lease provides for a tenant improvement allowance of $9.2 million, which was recognized as a reduction in the ROU asset and lease liability recognized at commencement, as the Company is reasonably certain to incur reimbursable costs related to alterations equal to or exceeding this amount. The option to renew the lease for an additional five-year term was excluded from the determination of lease liabilities arising from obtaining the ROU assets, as it was not considered reasonably certain of being exercised at commencement. Upon signing of the High Street Lease, the Company was also required to pay the first full monthly installment of base rent of $0.3 million, which was included as an adjustment to the ROU asset recognized upon commencement of the lease. The agreement requires a security deposit of $2.0 million, which is in the form of a line of credit collateralized by a certificate of deposit with a six month maturity which will be continually reinvested for the duration of the lease term. This certificate of deposit has been recorded within "short-term investments, other" on the consolidated balance sheet as of September 30, 2023.
The Company also has office space at 33 Arch Street in Boston, Massachusetts ("Arch Street Lease"), which expires in December 2023, as amended. The associated space is entirely subleased to third parties through the remainder of the current lease term ("Arch Street Subleases"). We additionally have office space in Carmel, Indiana.
For each of the lease agreements entered into or modified, the Company identified certain non-lease components. Lease and non-lease components were combined into a single lease component. In addition, all identified leases were assessed as operating leases.
As the Company’s leases do not provide an implicit rate, the Company used its incremental borrowing rate, which is the rate incurred to borrow on a collateralized basis over a term equal to the lease payments in a similar economic environment, in determining the present value of lease payments for each identified lease at the lease commencement date.
The components of lease cost were as follows (dollar amounts in thousands):
|
|
|
|
|
|
|
|
|
|
|
Nine Months Ended September 30, |
|
|
|
2023 |
|
|
2022 |
|
Lease Cost |
|
|
|
|
|
|
Operating lease cost |
|
$ |
2,506 |
|
|
$ |
1,613 |
|
Short-term lease cost |
|
|
— |
|
|
|
— |
|
Sublease income |
|
|
(441 |
) |
|
|
(433 |
) |
Total lease cost |
|
$ |
2,065 |
|
|
$ |
1,180 |
|
|
|
|
|
|
|
|
Other Information |
|
|
|
|
|
|
Cash paid for amounts included in the measurement of lease liabilities |
|
$ |
2,154 |
|
|
$ |
1,908 |
|
Operating lease liabilities arising from obtaining right-of-use assets |
|
|
11,820 |
|
|
|
— |
|
Weighted-average remaining lease term |
|
9.05 years |
|
|
2.85 years |
|
Weighted-average discount rate |
|
|
10.44 |
% |
|
|
5.88 |
% |
16
The following is a maturity analysis of the remaining annual undiscounted cash flows of the operating lease liabilities and a reconciliation to present value of lease liabilities as of September 30, 2023 (in thousands):
|
|
|
|
|
Year ended: |
|
|
|
December 31, 2023 |
|
$ |
649 |
|
December 31, 2024 |
|
|
1,704 |
|
December 31, 2025 |
|
|
4,818 |
|
December 31, 2026 |
|
|
3,591 |
|
December 31, 2027 |
|
|
3,698 |
|
Thereafter |
|
|
29,188 |
|
Total future minimum lease payments |
|
|
43,648 |
|
Less lease incentive |
|
|
(9,184 |
) |
Less imputed interest |
|
|
(18,855 |
) |
Present value of lease liabilities |
|
$ |
15,609 |
|
Cash inflows related to the $9.2 million lease incentive under the High Street Lease are expected to be received in the years ended December 31, 2023 and 2024 and are expected to exceed cash outflows relating to our operating leases during those years.
The annual undiscounted cash flows to be received from subleases is $0.2 million as of September 30, 2023. The Arch Street Lease and the Arch Street Subleases mature in December 2023 and will not be extended.
Indemnification
In the normal course of business, the Company enters into contracts and agreements that contain a variety of representations and warranties and provide for general indemnifications. The Company’s exposure under these agreements is unknown because it involves claims that may be made against the Company in the future but have not yet been made. To date, the Company has not paid any claims or been required to defend any action related to its indemnification obligations. However, the Company may incur charges in the future as a result of these indemnification obligations.
Contingencies
From time to time, the Company may have certain contingent liabilities that arise in the ordinary course of its business activities. The Company accrues a liability for such matters when it is probable that future expenditures will be made, and such expenditures can be reasonably estimated.
Litigation
The Company is not a party to any litigation and does not have contingency reserves established for any litigation liabilities as of September 30, 2023.
Note 11. 401(k) Savings Plan
The Company has a 401(k) retirement plan in which substantially all U.S. employees are eligible to participate. Eligible employees may elect to contribute up to the maximum limits, as set by the Internal Revenue Service, of their eligible compensation. The total contribution expense for the Company was $1.5 million and $0.7 million for the nine months ended September 30, 2023 and 2022, respectively.
17
Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations.
The following discussion and analysis of our financial condition and results of operations should be read in conjunction with our unaudited consolidated financial statements and related notes appearing elsewhere in this Quarterly Report on Form 10‑Q and our audited consolidated financial statements and related notes for the year ended December 31, 2022 included in our Annual Report on Form 10-K, or the Annual Report, filed with the Securities and Exchange Commission, or the SEC, on February 23, 2023. This Quarterly Report on Form 10-Q contains “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, or the Exchange Act. These statements are often identified by the use of words such as “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “plan,” “project,” “will,” “would” or the negative or plural of these words or similar expressions or variations. Such forward-looking statements are subject to a number of risks, uncertainties, assumptions and other factors that could cause actual results and the timing of certain events to differ materially from future results expressed or implied by the forward-looking statements. Factors that could cause or contribute to such differences include, but are not limited to, those identified and discussed in the section titled “Risk Factors,” set forth in Part II, Item 1A of this Quarterly Report on Form 10-Q, Part I, Item 1A of our Annual Report, and in subsequent SEC filings. You should not rely upon forward-looking statements as predictions of future events. Furthermore, such forward-looking statements speak only as of the date of this report. Except as required by law, we undertake no obligation to update any forward-looking statements to reflect events or circumstances after the date of such statements.
Overview
We are a clinical-stage biopharmaceutical company driven to discover, develop, and deliver transformative medicines for people living with psychiatric and neurological conditions. Our pipeline is primarily built on the broad therapeutic potential of our lead product candidate, KarXT (xanomeline-trospium), an oral modulator of muscarinic receptors that are located both in the central nervous system, or CNS, and various peripheral tissues. KarXT is our proprietary product candidate that combines xanomeline, a novel muscarinic agonist, with trospium, an approved muscarinic antagonist, to preferentially stimulate muscarinic receptors in the CNS.
We are initially developing KarXT for the treatment of schizophrenia in adults, as well as for the treatment of psychosis in Alzheimer's disease, or AD. KarXT combines xanomeline, a muscarinic receptor agonist that preferentially stimulates M1 and M4 muscarinic receptors, and trospium, an approved muscarinic receptor antagonist that does not measurably cross the blood-brain barrier, confining its effects to peripheral tissues. M1 and M4 muscarinic receptors are the receptor subtypes believed to mediate the antipsychotic and procognitive effects of xanomeline and other muscarinic agonists. Results from preclinical studies and clinical trials conducted by third parties support the hypothesis that xanomeline can reduce psychosis and improve cognition. To our knowledge, xanomeline is the only muscarinic orthosteric agonist that has demonstrated therapeutic benefit in clinical trials in both schizophrenia and AD. Like all muscarinic orthosteric agonists studied to date, however, xanomeline’s tolerability has been limited by side effects arising from muscarinic receptor stimulation in peripheral tissues, which leads to nausea, vomiting, diarrhea and increased salivation and sweating, collectively referred to as cholinergic adverse events. Trospium is a muscarinic receptor antagonist approved in the United States and Europe for the treatment of overactive bladder that inhibits all five muscarinic receptor subtypes in peripheral tissues. We believe that the combination of xanomeline and trospium in KarXT has the potential to preferentially stimulate M1 and M4 muscarinic receptors in the brain without stimulating muscarinic receptors in peripheral tissues in order to achieve meaningful therapeutic benefit in patients with psychotic and cognitive disorders.
The EMERGENT program is our clinical program evaluating KarXT for the treatment of schizophrenia as a monotherapy and includes our completed positive Phase 2 EMERGENT-1 and Phase 3 EMERGENT-2 and EMERGENT-3 trials evaluating the efficacy and safety of KarXT compared to placebo, as well as two Phase 3 trials, EMERGENT-4 and EMERGENT-5, evaluating the long-term safety of KarXT. Topline data from the EMERGENT-4 and EMERGENT-5 trials is anticipated in the second half of 2024
In September 2023, we submitted our New Drug Application, or NDA, for KarXT for the treatment of schizophrenia to the FDA. If approved, we are targeting a potential commercial launch of KarXT for the treatment of schizophrenia in the second half of 2024.
In the first quarter of 2023, we initiated a Phase 1b Ambulatory Blood Pressure Monitoring, or ABPM, trial to further characterize the impact of KarXT on blood pressure. Enrollment for this trial completed in the second quarter of 2023, and we expect topline data in the fourth quarter of 2023.
18
Given the unique mechanism of action of KarXT in comparison to existing standard of care therapies, we believe there is the potential for therapeutic benefit as both a monotherapy and as an adjunctive therapy for the treatment of schizophrenia. In November 2021, we initiated our Phase 3 ARISE trial evaluating the efficacy and safety of KarXT compared to placebo as an adjunctive treatment in adults with schizophrenia who have an inadequate response to their current antipsychotic therapy. This six-week, 1:1 randomized, double-blind, placebo-controlled Phase 3 outpatient trial is designed to enroll up to 400 adults with schizophrenia who have not achieved an adequate response to their current atypical antipsychotic treatment. The primary outcome measure of the trial is change in Positive and Negative Syndrome Scale, or PANSS, total score of KarXT compared to placebo at week 6. Upon completion of the trial at week 6, participants have the opportunity to enroll in our ARISE-2 trial, an ongoing 52-week outpatient, open-label extension trial evaluating the long-term safety and tolerability of KarXT when dosed with atypical antipsychotic treatment. We anticipate topline data from the ARISE trial in the second half of 2024.
We are also developing KarXT as a potential treatment for psychosis related to AD. The ADEPT program, which is the clinical program evaluating KarXT as a potential treatment for psychosis related to AD, consists of three Phase 3 trials: ADEPT-1, ADEPT-2 and ADEPT-3. The Phase 3 ADEPT-1 trial is evaluating the efficacy and safety of KarXT compared to placebo in adults with moderate to severe psychosis related to AD. Enrollment for this trial began in the third quarter of 2022 and topline data is anticipated in 2025. This trial consists of a 12-week, single-blind treatment period, followed by a 26-week, double-blind, randomized withdrawal period in which subjects who meet the response criteria will be randomized to receive KarXT or placebo. The single-blind treatment period is designed to enroll approximately 380 adults with AD between 55 and 90 years old, with moderate to severe hallucinations or delusions, who are living at home or at an assisted living facility. The primary objective of this trial is to evaluate relapse prevention as measured by time from randomization to relapse during the 26-week, double-blind period. Our Phase 3 ADEPT-2 trial is a 14-week, flexible-dose, double-blind, placebo-controlled trial evaluating the efficacy and safety of KarXT versus placebo in up to 400 patients. This trial initiated in the third quarter of 2023 and topline data is anticipated in 2025. Our Phase 3 ADEPT-3 trial is an open-label extension trial of ADEPT-1 and ADEPT-2 evaluating the long-term safety of KarXT in adults with psychosis related to AD. Enrollment for this trial commenced in the third quarter of 2023.
In January 2023, we entered into an exclusive global license agreement for Goldfinch Bio, Inc.’s, or Goldfinch Bio’s, investigational transient receptor potential canonical 4 and 5 (TRPC4/5) channel candidates, including the lead clinical-stage TRPC4/5 candidate, KAR-2618 (formerly GFB-887), after confirming select properties of KAR-2618 under a material transfer agreement. KAR-2618 has been dosed in over 100 humans across Goldfinch Bio’s clinical trials. We intend to evaluate KAR-2618 for the treatment of major depressive disorder, and plan to initiate a Phase 1b clinical trial in 2024. We expect to provide additional information regarding trial design and timing in early 2024.
Since our inception in 2009, we have focused substantially all of our efforts and financial resources on organizing and staffing our company, acquiring and developing our technology, raising capital, building our intellectual property portfolio, undertaking preclinical studies and clinical trials, preparing for the potential commercialization of KarXT, and providing general and administrative support for these activities.
19
We have never generated revenue from product sales and have incurred significant net losses since inception. Our net losses were $319.9 million and $200.1 million for the nine months ended September 30, 2023 and 2022, respectively. As of September 30, 2023, we had an accumulated deficit of $884.1 million. Our net losses may fluctuate significantly from quarter to quarter and year to year. We expect to incur significant expenses and increasing operating losses for the foreseeable future. We anticipate that our operating expenses and capital expenditures will increase substantially, particularly as we:
•invest significantly to further develop and potentially commercialize KarXT for our current and future indications;
•advance additional product candidates, such as KAR-2618, into preclinical and clinical development;
•seek regulatory approvals for any product candidates that successfully complete clinical trials;
•require the manufacture of larger quantities of our product candidates for clinical development and potential commercialization;
•hire additional clinical, scientific, management and administrative personnel;
•maintain, expand and protect our intellectual property portfolio;
•acquire or in-license other assets and technologies; and
•add additional operational, financial and management information systems and processes to support our ongoing development efforts, any future manufacturing or commercialization efforts and our ongoing operations as a public company.
We do not expect to generate revenue from product sales unless and until we successfully complete development and obtain regulatory approval for a product candidate, the outcome of which is subject to significant uncertainty. Additionally, we currently use third parties such as contract research organizations, or CROs, and contract manufacturing organizations, or CMOs, to carry out our preclinical, manufacturing and clinical development activities, and we do not yet have a sales organization. If we obtain regulatory approval for any product candidates, we expect to incur significant commercialization expenses related to product sales, marketing, manufacturing and distribution.
As a result, we may need substantial additional funding to support our continuing operations and pursue our growth strategy. Until such time as we can generate significant revenue from product sales, if ever, we expect to finance our operations through a combination of private and public equity offerings, debt financings, collaborations, strategic alliances and marketing, distribution, or licensing arrangements with third parties. We may be unable to raise additional funds or enter into such other agreements or arrangements when needed on favorable terms, or at all. If we fail to raise capital or enter into such agreements as and when needed, we may have to significantly delay, scale back or discontinue the development and commercialization of one or more of our product candidates.
As of September 30, 2023, we had cash, cash equivalents and available-for-sale investments of $1,339.5 million. We believe that our existing cash, cash equivalents and available-for-sale investments will be sufficient to meet our anticipated operating and capital expenditure requirements through the end of 2026. We have based this estimate on assumptions that may prove to be wrong, and we could exhaust our available capital resources sooner than we expect. See “Liquidity and Capital Resources.”
Components of Our Results of Operations
Revenue
To date, we have not generated any revenue from product sales. If our development efforts for our product candidates are successful and result in regulatory approval, we may generate revenue in the future from product sales. We cannot predict if, when, or to what extent we will generate revenue from the commercialization and sale of our product candidates. We may never succeed in obtaining regulatory approval for any of our product candidates.
20
Our revenue to date has been derived from payments under our license agreement, or the Zai License Agreement, with Zai Lab (Shanghai) Co., Ltd., or Zai. We may generate additional revenue in the future from payments under the Zai License Agreement or as a result of any other license or collaboration agreements we may enter into for any of our product candidates or intellectual property. For the nine months ended September 30, 2023, we recognized revenue of $0.7 million under the Zai License Agreement associated with the sale of clinical drug supply to Zai and did not recognize any revenue for the three months ended September 30, 2023. We cannot provide assurance as to the timing of future milestone or royalty payments under the Zai License Agreement, or that we will receive any of these payments at all. We generated $5.3 million of revenue under the Zai License Agreement in the nine months ended September 30, 2022 and recognized revenue of less than $0.1 million under the Zai License Agreement associated with the sale of clinical drug supply to Zai in the three months ended September 30, 2022.
Operating Expenses
Research and Development Expenses
Research and development expenses consist primarily of costs incurred for the development of our product candidates and our drug discovery efforts, which include:
•personnel costs, including salaries and the related costs, and stock-based compensation expense for employees engaged in research and development functions;
•expenses incurred in connection with the preclinical and clinical development of our product candidates, including under agreements with CROs;
•expenses incurred in connection with CMOs that manufacture drug products for use in our preclinical and clinical trials;
•formulation costs and chemistry, manufacturing and controls, or CMC, costs; and
•expenses incurred under license agreements related to in-process R&D or agreements with consultants who supplement our internal capabilities.
We expense all research and development costs in the periods in which they are incurred. Costs for certain development activities are recognized based on an evaluation of the progress to completion of specific tasks using information and data provided to us by our vendors and third-party service providers.
Research and development costs directly related to our clinical development activities, such as fees paid to consultants, central laboratories, contractors, CMOs and CROs, are tracked on an indication-by-indication basis. Other costs that are indirectly related to our clinical development activities, such as formulation and CMC, preclinical, discovery and other unallocated expenses in the table below, are not allocated on an indication-by-indication basis due to the overlap of the potential benefit of those efforts across multiple indications that utilize KarXT and future product and development candidates. Unallocated expenses primarily relate to personnel or other consulting costs which are deployed across multiple projects under development. For the nine months ended September 30, 2023, unallocated expenses also include $15.0 million in license fees related to the acquisition of KAR-2618 paid in February 2023. The following table summarizes our research and development expenses:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended September 30, |
|
|
Nine Months Ended September 30, |
|
|
|
2023 |
|
|
2022 |
|
|
2023 |
|
|
2022 |
|
|
|
(in thousands) |
|
|
(in thousands) |
|
Schizophrenia clinical trials |
|
$ |
35,764 |
|
|
$ |
27,792 |
|
|
$ |
93,859 |
|
|
$ |
72,791 |
|
Alzheimer's disease psychosis clinical trials |
|
|
8,925 |
|
|
|
1,854 |
|
|
|
23,063 |
|
|
|
3,802 |
|
CMC and formulation |
|
|
13,850 |
|
|
|
8,301 |
|
|
|
30,276 |
|
|
|
21,674 |
|
Preclinical |
|
|
3,913 |
|
|
|
526 |
|
|
|
10,107 |
|
|
|
1,522 |
|
Medical affairs |
|
|
2,164 |
|
|
|
555 |
|
|
|
7,453 |
|
|
|
1,238 |
|
Discovery |
|
|
5,013 |
|
|
|
5,979 |
|
|
|
13,117 |
|
|
|
14,328 |
|
Unallocated expenses |
|
|
34,323 |
|
|
|
16,943 |
|
|
|
104,034 |
|
|
|
42,888 |
|
Total research and development expense |
|
$ |
103,952 |
|
|
$ |
61,950 |
|
|
$ |
281,909 |
|
|
$ |
158,243 |
|
21
We expect our research and development expenses to continue to increase for the foreseeable future as we continue to invest in research and development activities related to developing our product candidates, as our programs advance into later stages of development and we continue to conduct clinical trials. The process of conducting the necessary clinical research to obtain regulatory approval is costly and time-consuming, and the successful development of our product candidates is highly uncertain.
Because of the numerous risks and uncertainties associated with conducting product development, we cannot determine with certainty the duration and completion costs of our current or future preclinical studies and clinical trials or if, when, or to what extent we will generate revenues from the commercialization and sale of our product candidates. We may never succeed in achieving regulatory approval for our product candidates. The duration, costs and timing of preclinical studies and clinical trials and development of our product candidates will depend on a variety of factors, if and as we:
•continue to develop and conduct clinical trials for KarXT for our current and future indications;
•initiate and continue research, preclinical and clinical development efforts for our early stage and future product candidates, such as KAR-2618;
•seek to identify additional product candidates;
•seek regulatory approvals for KarXT for our current and future indications as well as any other product candidates that successfully complete clinical development;
•manufacture larger quantities of KarXT and our other product candidates for clinical development and potential commercialization;
•add operational, financial and management information systems and personnel, including personnel to support our product development;
•hire and retain additional personnel, such as clinical, quality control, scientific, commercial and administrative personnel;
•maintain, expand and protect our intellectual property portfolio;
•continue to assess the impact of the effects of the COVID-19 pandemic on our ability to execute research and development activities;
•add equipment and physical infrastructure to support our research and development; and
•acquire or in-license other product candidates and technologies.
A change in the outcome of any of these variables with respect to the development of any of our product candidates would significantly change the costs and timing associated with the development of that product candidate. We may never succeed in obtaining regulatory approval for any of our product candidates.
We do not believe that it is possible at this time to accurately project total indication-specific expenses through commercialization. There are numerous factors associated with the successful commercialization of any of our product candidates, including future trial design and various regulatory requirements, many of which cannot be determined with accuracy at this time based on our stage of development. Additionally, future commercial and regulatory factors beyond our control will impact our clinical development programs and plans.
General and Administrative Expenses
General and administrative expenses consist primarily of employee-related costs for personnel in executive, commercial, finance and administrative functions, costs related to maintenance and filing of intellectual property, facility-related costs, insurance costs, and other expenses for outside professional services, including legal, human resources, data management, audit and accounting services, and costs incurred as we prepare for commercialization. Personnel costs consist of salaries, short-term incentive compensation, benefits, travel expense and stock-based compensation expense. The following table summarizes our general and administrative expenses:
22
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended September 30, |
|
|
Nine Months Ended September 30, |
|
|
|
2023 |
|
|
2022 |
|
|
2023 |
|
|
2022 |
|
|
|
(in thousands) |
|
|
(in thousands) |
|
Personnel related expenses (including stock-based compensation) |
|
$ |
17,910 |
|
|
$ |
11,548 |
|
|
$ |
45,254 |
|
|
$ |
32,306 |
|
Professional and consultant fees |
|
|
8,912 |
|
|
|
4,546 |
|
|
|
23,964 |
|
|
|
10,775 |
|
Other |
|
|
5,444 |
|
|
|
3,031 |
|
|
|
14,718 |
|
|
|
8,675 |
|
Total general and administrative expense |
|
$ |
32,266 |
|
|
$ |
19,125 |
|
|
$ |
83,936 |
|
|
$ |
51,756 |
|
We anticipate that our general and administrative expenses will continue to increase in the future as we increase our headcount to support our continued research activities and development of our product candidates, and, if we receive FDA approval, as we commercialize. We will also continue to incur increased accounting, audit, legal, regulatory, compliance and director and officer insurance costs as well as investor and public relations expenses associated with operating as a public company.
Other Income, Net
Other income, net, consists of interest income from our cash equivalents, available-for-sale investments and other short-term investments, and sublease income recognized in connection with the sublease of office space. The following table summarizes our other income, net:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended September 30, |
|
|
Nine Months Ended September 30, |
|
|
|
2023 |
|
|
2022 |
|
|
2023 |
|
|
2022 |
|
|
|
(in thousands) |
|
|
(in thousands) |
|
Interest income |
|
$ |
16,952 |
|
|
$ |
3,884 |
|
|
$ |
44,894 |
|
|
$ |
4,611 |
|
Sublease income |
|
|
147 |
|
|
|
147 |
|
|
|
441 |
|
|
|
433 |
|
Total other income, net |
|
$ |
17,099 |
|
|
$ |
4,031 |
|
|
$ |
45,335 |
|
|
$ |
5,044 |
|
Results of Operations
Comparison of the three months ended September 30, 2023 and 2022
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended September 30, |
|
|
|
|
|
|
2023 |
|
|
2022 |
|
|
Change |
|
|
|
(in thousands) |
|
|
|
|
License and other revenue |
|
$ |
— |
|
|
$ |
81 |
|
|
$ |
(81 |
) |
Operating expenses: |
|
|
|
|
|
|
|
|
|
Research and development |
|
|
103,952 |
|
|
|
61,950 |
|
|
|
42,002 |
|
General and administrative |
|
|
32,266 |
|
|
|
19,125 |
|
|
|
13,141 |
|
Total operating expenses |
|
|
136,218 |
|
|
|
81,075 |
|
|
|
55,143 |
|
Loss from operations |
|
|
(136,218 |
) |
|
|
(80,994 |
) |
|
|
(55,224 |
) |
Total other income, net |
|
|
17,099 |
|
|
|
4,031 |
|
|
|
13,068 |
|
Income tax provision |
|
|
— |
|
|
|
— |
|
|
|
— |
|
Net loss attributable to common stockholders |
|
$ |
(119,119 |
) |
|
$ |
(76,963 |
) |
|
$ |
(42,156 |
) |
23
Research and Development Expenses
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended September 30, |
|
|
|
|
|
|
2023 |
|
|
2022 |
|
|
Change |
|
|
|
(in thousands) |
|
|
|
|
Direct research and development expenses: |
|
|
|
|
|
|
|
|
|
Schizophrenia clinical trials |
|
$ |
35,764 |
|
|
$ |
27,792 |
|
|
$ |
7,972 |
|
Alzheimer's disease psychosis clinical trials |
|
|
8,925 |
|
|
|
1,854 |
|
|
|
7,071 |
|
CMC and formulation |
|
|
13,850 |
|
|
|
8,301 |
|
|
|
5,549 |
|
Preclinical |
|
|
3,913 |
|
|
|
526 |
|
|
|
3,387 |
|
Medical affairs |
|
|
2,164 |
|
|
|
555 |
|
|
|
1,609 |
|
Discovery |
|
|
5,013 |
|
|
|
5,979 |
|
|
|
(966 |
) |
Unallocated expenses: |
|
|
|
|
|
|
|
|
|
Personnel related expenses (including stock-based compensation) |
|
|
28,940 |
|
|
|
15,337 |
|
|
|
13,603 |
|
License fees |
|
|
— |
|
|
|
— |
|
|
|
— |
|
Consultant fees and other expenses |
|
|
5,383 |
|
|
|
1,606 |
|
|
|
3,777 |
|
Total research and development expense |
|
$ |
103,952 |
|
|
$ |
61,950 |
|
|
$ |
42,002 |
|
Expenses related to our schizophrenia clinical trials increased by $8.0 million, primarily due to expenses related to our ongoing EMERGENT and ARISE Phase 3 trials as well as our ABPM Phase 1b trial. The increase of $7.1 million in expenses related to our Alzheimer's disease psychosis, or ADP, clinical trials is primarily driven by our ongoing ADEPT-1 Phase 3 trial which initiated in the third quarter of 2022. The increase of $5.6 million in formulation and CMC expenses is primarily due to an increase in manufacturing activities in 2023 to obtain sufficient supply of KarXT to support our NDA submission and potential commercialization, as well as current and future clinical trial activities. The increase of $3.4 million in expenses related to preclinical activities is primarily due to the timing and execution of studies for KarXT and early pipeline candidates. The decrease of $1.0 million in discovery costs is due to the timing of activities associated with our portfolio of discovery programs. The increase of $13.6 million in personnel related costs was primarily a result of an increase in headcount and an increase of $5.4 million related to stock-based compensation expense. The increase of $3.8 million in consultant fees and other expenses was due to an increase in consulting costs not specifically allocated to discovery, preclinical, clinical, formulation and CMC activities.
General and Administrative Expenses
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended September 30, |
|
|
|
|
|
|
2023 |
|
|
2022 |
|
|
Change |
|
|
|
(in thousands) |
|
|
|
|
Personnel related expenses (including stock-based compensation) |
|
$ |
17,910 |
|
|
$ |
11,548 |
|
|
$ |
6,362 |
|
Professional and consultant fees |
|
|
8,912 |
|
|
|
4,546 |
|
|
|
4,366 |
|
Other |
|
|
5,444 |
|
|
|
3,031 |
|
|
|
2,413 |
|
Total general and administrative expense |
|
$ |
32,266 |
|
|
$ |
19,125 |
|
|
$ |
13,141 |
|
The increase of $6.4 million in personnel related costs was primarily a result of an increase in headcount and an increase of $0.8 million related to stock-based compensation expense. The increase of $4.4 million in professional and consultant fees was primarily due to an increase in pre-commercial costs, accounting fees, legal costs and consulting fees related to our ongoing business activities. The increase of $2.4 million in other costs was primarily due to infrastructure and administrative related costs to support increased headcount.
Other Income, Net
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended September 30, |
|
|
|
|
|
|
2023 |
|
|
2022 |
|
|
Change |
|
|
|
(in thousands) |
|
|
|
|
Interest income |
|
$ |
16,952 |
|
|
$ |
3,884 |
|
|
$ |
13,068 |
|
Sublease income |
|
|
147 |
|
|
|
147 |
|
|
|
— |
|
Total other income, net |
|
$ |
17,099 |
|
|
$ |
4,031 |
|
|
$ |
13,068 |
|
24
Interest income is attributable to interest earned on our cash equivalents and available-for-sale investments. The increase of $13.1 million in interest income is primarily due to an increase in our cash equivalents and investment securities held, as well as an increase in interest rates on such instruments, during the three months ended September 30, 2023 compared to the three months ended September 30, 2022.
Comparison of the nine months ended September 30, 2023 and 2022
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Nine Months Ended September 30, |
|
|
|
|
|
|
2023 |
|
|
2022 |
|
|
Change |
|
|
|
(in thousands) |
|
|
|
|
License and other revenue |
|
$ |
654 |
|
|
$ |
5,359 |
|
|
$ |
(4,705 |
) |
Operating expenses: |
|
|
|
|
|
|
|
|
|
Research and development |
|
|
281,909 |
|
|
|
158,243 |
|
|
|
123,666 |
|
General and administrative |
|
|
83,936 |
|
|
|
51,756 |
|
|
|
32,180 |
|
Total operating expenses |
|
|
365,845 |
|
|
|
209,999 |
|
|
|
155,846 |
|
Loss from operations |
|
|
(365,191 |
) |
|
|
(204,640 |
) |
|
|
(160,551 |
) |
Total other income, net |
|
|
45,335 |
|
|
|
5,044 |
|
|
|
40,291 |
|
Income tax provision |
|
|
— |
|
|
|
(528 |
) |
|
|
528 |
|
Net loss attributable to common stockholders |
|
$ |
(319,856 |
) |
|
$ |
(200,124 |
) |
|
$ |
(119,732 |
) |
Research and Development Expenses
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Nine Months Ended September 30, |
|
|
|
|
|
|
2023 |
|
|
2022 |
|
|
Change |
|
|
|
(in thousands) |
|
|
|
|
Direct research and development expenses: |
|
|
|
|
|
|
|
|
|
Schizophrenia clinical trials |
|
$ |
93,859 |
|
|
$ |
72,791 |
|
|
$ |
21,068 |
|
Alzheimer's disease psychosis clinical trials |
|
|
23,063 |
|
|
|
3,802 |
|
|
|
19,261 |
|
CMC and formulation |
|
|
30,276 |
|
|
|
21,674 |
|
|
|
8,602 |
|
Preclinical |
|
|
10,107 |
|
|
|
1,522 |
|
|
|
8,585 |
|
Medical affairs |
|
|
7,453 |
|
|
|
1,238 |
|
|
|
6,215 |
|
Discovery |
|
|
13,117 |
|
|
|
14,328 |
|
|
|
(1,211 |
) |
Unallocated expenses: |
|
|
|
|
|
|
|
|
|
Personnel related expenses (including stock-based compensation) |
|
|
73,785 |
|
|
|
38,594 |
|
|
|
35,191 |
|
License fees |
|
|
15,000 |
|
|
|
— |
|
|
|
15,000 |
|
Consultant fees and other expenses |
|
|
15,249 |
|
|
|
4,294 |
|
|
|
10,955 |
|
Total research and development expense |
|
$ |
281,909 |
|
|
$ |
158,243 |
|
|
$ |
123,666 |
|
Expenses related to our schizophrenia clinical trials increased by $21.1 million, primarily due to expenses related to close out costs for our EMERGENT-3 trial, and costs related to our ongoing EMERGENT and ARISE Phase 3 trials as well as our ABPM Phase 1b trial. The increase of $19.3 million in expenses related to our ADP clinical trials is primarily driven by our ongoing ADEPT-1 Phase 3 trial which initiated in the third quarter of 2022. The increase of $8.6 million in formulation and CMC expenses is primarily due to an increase in manufacturing activities in 2023 to obtain sufficient supply of KarXT to support our NDA submission and potential commercialization, as well as current and future clinical trial activities. The increase of $8.6 million in expenses related to preclinical activities is primarily due to the timing and execution of studies for KarXT and early pipeline candidates. The decrease of $1.2 million in discovery costs is due to the timing of activities associated with our portfolio of discovery programs. The increase of $35.2 million in personnel related costs was primarily a result of an increase in headcount and an increase of $14.8 million related to stock-based compensation expense. License fees of $15.0 million are due to the upfront payment made in connection with the license agreement for Goldfinch Bio’s TRPC4/5 channel candidates, including KAR-2618. The increase of $11.0 million in consultant fees and other expenses was due to an increase in consulting costs not specifically allocated to discovery, preclinical, clinical, formulation and CMC activities.
25
General and Administrative Expenses
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Nine Months Ended September 30, |
|
|
|
|
|
|
2023 |
|
|
2022 |
|
|
Change |
|
|
|
(in thousands) |
|
|
|
|
Personnel related expenses (including stock-based compensation) |
|
$ |
45,254 |
|
|
$ |
32,306 |
|
|
$ |
12,948 |
|
Professional and consultant fees |
|
|
23,964 |
|
|
|
10,775 |
|
|
|
13,189 |
|
Other |
|
|
14,718 |
|
|
|
8,675 |
|
|
|
6,043 |
|
Total general and administrative expense |
|
$ |
83,936 |
|
|
$ |
51,756 |
|
|
$ |
32,180 |
|
The increase of $13.0 million in personnel related costs was primarily a result of an increase in headcount and an increase of $2.2 million related to stock-based compensation expense. The increase of $13.2 million in professional and consultant fees was primarily due to an increase in pre-commercial costs, accounting fees, legal costs and consulting fees related to our ongoing business activities. The increase of $6.0 million in other costs was primarily due to other infrastructure and administrative related costs to support increased headcount.
Other Income (Loss), Net
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Nine Months Ended September 30, |
|
|
|
|
|
|
2023 |
|
|
2022 |
|
|
Change |
|
|
|
(in thousands) |
|
|
|
|
Interest income |
|
$ |
44,894 |
|
|
$ |
4,611 |
|
|
$ |
40,283 |
|
Sublease income |
|
|
441 |
|
|
|
433 |
|
|
|
8 |
|
Total other income, net |
|
$ |
45,335 |
|
|
$ |
5,044 |
|
|
$ |
40,291 |
|
Interest income is attributable to interest earned on our cash equivalents, available-for-sale investments and short-term investments. The increase of $40.3 million in interest income is primarily due to an increase in our cash equivalents and investment securities held, as well as an increase in interest rates on such instruments, during the nine months ended September 30, 2023 compared to the nine months ended September 30, 2022.
Liquidity and Capital Resources
Since our inception, we have incurred significant operating losses. We have not yet commercialized any of our product candidates and we do not expect to generate revenue from sales of any product candidates until we receive FDA approval, which may take longer than we anticipate, or may not occur at all. Through September 30, 2023, our operations have been financed by net proceeds of $25.7 million from the issuance of convertible notes, $91.0 million from the sale of shares of our redeemable convertible preferred stock, $93.0 million from the sale of our common stock in our initial public offering in June 2019, $234.2 million from the sale of our common stock in a follow-on public offering in November 2019, $270.0 million from the sale of our common stock in a follow-on public offering in March 2021, $819.1 million from the sale of our common stock in a follow-on public offering in August 2022, $436.7 million from the sale of our common stock in a follow-on public offering in March 2023, and $45.0 million from the Zai License Agreement, as well as interest income from our cash equivalents and investment portfolio. As of September 30, 2023, we had $1,339.5 million in cash, cash equivalents and available-for-sale investments, and an accumulated deficit of $884.1 million.
On June 21, 2023, we filed an automatically effective registration statement on Form S-3, or the 2023 Registration Statement, with the SEC which registers the offering, issuance and sale of an unspecified amount of common stock, preferred stock, debt securities, warrants and/or units of any combination thereof. We simultaneously entered into an equity distribution agreement, or the 2023 Distribution Agreement, with Goldman Sachs & Co. LLC and Leerink Partners (f/k/a SVB Securities LLC), as sales agents, to provide for the issuance and sale by the Company of up to $400.0 million of common stock from time to time in “at-the-market” offerings under the 2023 Registration Statement and related prospectus, or the 2023 ATM Program. We may sell common stock pursuant to the 2023 Distribution Agreement from time to time in varying amounts, which may be limited, based upon factors including (among others) market conditions, investor demand, the trading price of our common stock, and determinations by us of our need for, and appropriate sources of, additional capital. As of September 30, 2023, no sales had been made pursuant to the 2023 ATM Program.
26
Our primary use of cash has been to fund operating expenses, which consist of research and development and general and administrative expenditures. Cash used to fund operating expenses is impacted by the timing of when we pay these expenses, as reflected in the change in our outstanding prepaid expenses, accounts payable and accrued expenses.
Cash Flows
The following table summarizes our sources and uses of cash for each of the periods presented:
|
|
|
|
|
|
|
|
|
|
|
Nine Months Ended September 30, |
|
|
|
2023 |
|
|
2022 |
|
|
|
(in thousands) |
|
Net cash used in operating activities |
|
$ |
(274,760 |
) |
|
$ |
(149,249 |
) |
Net cash used in investing activities |
|
|
(252,761 |
) |
|
|
(279,779 |
) |
Net cash provided by financing activities |
|
|
463,506 |
|
|
|
850,392 |
|
Net (decrease) increase in cash, cash equivalents and restricted cash |
|
$ |
(64,015 |
) |
|
$ |
421,364 |
|
Cash Flows from Operating Activities
Cash used in operating activities for the nine months ended September 30, 2023 was $274.8 million, consisting of a net loss of $319.9 million, partially offset by non-cash items, including stock-based compensation expense of $51.8 million and interest income resulting from the amortization of premiums and accretion of discounts on our available-for-sale investments of $27.6 million. The change in our net operating assets and liabilities was mainly due to an increase in accrued expense of $14.3 million and a decrease in prepaid expenses of $16.2 million, primarily driven by timing of payments made and services rendered by CROs and CMOs in connection with our clinical trials. These amounts were partially offset by an increase in other current assets of $9.1 million, due primarily to payment of a refundable regulatory fee and a receivable arising in connection with the acquisition of rights to a general unsecured claim against Goldfinch Bio, and an increase in accrued interest on investment securities of $2.8 million.
Cash used in operating activities for the nine months ended September 30, 2022 was $149.2 million, consisting of a net loss of $200.1 million, partially offset by non-cash items, including stock-based compensation expense of $34.8 million. The change in our net operating assets and liabilities was mainly due to increases in prepaid expenses and other current assets of $5.9 million, accounts payable of $13.8 million, and accrued expenses of $6.6 million, primarily driven by timing of payments made and services rendered by CROs and CMOs in connection with our clinical trials, and a decrease in accounts receivable of $1.7 million pursuant to cash collected under the Zai License Agreement.
Cash Flows from Investing Activities
Cash used in investing activities for the nine months ended September 30, 2023 was $252.8 million, primarily attributable to purchases of investment securities of $1,292.3 million, which were partially offset by maturities of investment securities of $1,043.7 million.
Cash used by investing activities for the nine months ended September 30, 2022 was $279.8 million, primarily attributable to purchases of investment securities of $459.4 million, which were partially offset by maturities of investment securities of $180.2 million.
Cash Flows from Financing Activities
Cash provided by financing activities for the nine months ended September 30, 2023 was $463.5 million, which was primarily attributable to $436.7 million in net proceeds received from the sale of common stock in our March 2023 follow-on public offering, and $27.0 million in proceeds received from the exercise of stock options.
Cash provided by financing activities for the nine months ended September 30, 2022 was $850.4 million, which was primarily attributable to $819.1 million net proceeds received from the sale of common stock in our August 2022 follow-on public offering, and $31.4 million attributable to proceeds received from the exercise of stock options.
27
Future Funding Requirements
We expect our expenses to increase substantially in connection with our ongoing activities, in particular as we continue to advance our product candidates through clinical trials and prepare for potential commercialization of KarXT for schizophrenia. In addition, we expect to incur additional costs associated with our ongoing operations as a public company.
As of September 30, 2023, we had cash and cash equivalents and available-for-sale investments of $1,339.5 million. Based on our current plans, we believe that our existing cash, cash equivalents and available-for-sale investments will be sufficient to meet our anticipated operating and capital expenditure requirements through the end of 2026.
We have based this estimate on assumptions that may prove to be wrong, and we could utilize our available capital resources sooner than we currently expect. Because of the numerous risks and uncertainties associated with research, development and commercialization of pharmaceutical product candidates, we are unable to estimate the exact amount of our working capital requirements. Our future funding requirements will depend on and could increase significantly as a result of many factors, including:
•the scope, progress, results and costs of researching and developing KarXT for our current and future indications as well as other product candidates we may develop, including KAR-2618;
•the timing of, and the costs involved in, obtaining marketing approvals for KarXT for our current and future indications as well as other product candidates we may develop and pursue, including KAR-2618;
•if approved, the costs of commercialization activities for KarXT for the approved indication, or any other product candidate that receives regulatory approval to the extent such costs are not the responsibility of any future collaborators, including the costs and timing of establishing product sales, marketing, distribution and manufacturing capabilities;
•subject to receipt of regulatory approval, the revenue received, if any, from commercial sales of KarXT for any program or revenues received from any other product candidates;
•the extent to which we in-license or acquire rights to other products, product candidates or technologies;
•our headcount growth and associated costs as we expand our research and development and commercial infrastructure;
•the costs of preparing, filing and prosecuting patent applications, and maintaining and protecting our intellectual property rights, including enforcing and defending intellectual property related claims; and
•the ongoing costs of operating as a public company.
A change in the outcome of any of these or other variables with respect to the development of any of our product candidates could significantly change the costs and timing associated with the development of that product candidate. Further, our operating plans may change in the future, and we may need additional funds to meet operational needs and capital requirements associated with such operating plans.
Until such time, if ever, as we can generate substantial product revenue, we expect to finance our operations through a combination of equity financings, debt financings, collaborations with other companies or other strategic transactions. We do not currently have any committed external source of funds. To the extent that we raise additional capital through the sale of equity or convertible debt securities, our stockholders’ ownership interest will be diluted, and the terms of these securities may include liquidation or other preferences that adversely affect their rights as common stockholders. Debt financing and preferred equity financing, if available, may involve agreements that include covenants limiting or restricting our ability to take specific actions, such as incurring additional debt, making acquisitions or capital expenditures or declaring dividends. If we raise additional funds through collaborations, strategic alliances or marketing, distribution or licensing arrangements with third parties, we may have to relinquish valuable rights to our technologies, future revenue streams, research programs or product candidates or grant licenses on terms that may not be favorable to us. If we are unable to raise additional funds through equity or debt financings or other arrangements when needed, we may be required to delay, limit, reduce or terminate our research, product development or future commercialization efforts or grant rights to develop and market product candidates that we would otherwise prefer to develop and market ourselves.
28
Further, our operating plans may change, and we may need additional funds to meet operational needs and capital requirements for clinical trials and other research and development activities. We currently have no credit facility or committed sources of capital. Because of the numerous risks and uncertainties associated with the development and commercialization of our product candidates, we are unable to estimate the amounts of increased capital outlays and operating expenditures associated with our current and anticipated product development programs.
Cash Requirements due to Contractual Obligations and Other Commitments
We are currently under agreements to lease our Arch Street office space through December 2023. Remaining lease payments from October 1, 2023 through the end of the lease term total $0.2 million. As of January 21, 2022, all leases at our Arch Street office space in Boston, Massachusetts have been subleased through the end of their lease terms.
We are also under agreement to lease office space in Carmel, Indiana through August 2024. Remaining lease payments total $0.1 million through the end of the lease term.
In March 2021, we entered into an agreement to sublease approximately 25,445 square feet of office space, or the High Street Premises, from a third party in Boston, Massachusetts as part of the relocation of our corporate headquarters. The term of the sublease extends from April 1, 2021 through December 31, 2025 and provides for escalating annualized base rent payments starting at approximately $1.5 million and increasing to $1.6 million in the final year of the sublease. Remaining lease payments from October 1, 2023 through the end of the lease term total $3.6 million.
In April 2023, we entered into an agreement to lease approximately 50,890 square feet of additional office space located at 99 High Street in Boston, MA. We took possession of the premises in June 2023. The initial term of the lease is ten years from the date alterations are substantially complete, estimated to occur no later than April 2024, with the option to renew for an additional five-year term. Annual base rent under the lease is approximately $3.5 million and is subject to annual increases in accordance with the terms of the lease agreement. Lease payments begin on the earlier of January 1, 2025 or nine months from the date alterations are substantially complete and total $39.7 million through the end of the lease term. The lease provides for a tenant improvement allowance of $9.2 million.
We enter into contracts in the normal course of business with CROs, CMOs and other third parties for clinical trials, preclinical research studies and testing and manufacturing services. These contracts are generally cancelable by us upon prior written notice. Payments due upon cancellation consist of payments for services provided or expenses incurred, including noncancelable obligations of our service providers, up to the date of cancellation, and may also include termination penalties. As of September 30, 2023 the timing, amount or likelihood of such payments are not known.
We are also party to certain license and collaboration agreements with PureTech Health, Eli Lilly and Company, and GFB (ABC) LLC, assignee of the assignment estate of Goldfinch Bio. We may be obligated to make certain future payments which are contingent upon future events such as our achievement of specified regulatory and commercial milestones, or royalties on net product sales under these agreements. As of September 30, 2023, we were unable to estimate the timing or likelihood of achieving these milestones or generating future product sales.
Critical Accounting Polices and Estimates
Our consolidated financial statements are prepared in accordance with generally accepted accounting principles in the United States. The preparation of our consolidated financial statements and related disclosures requires us to make estimates, assumptions and judgments that affect the reported amount of assets, liabilities, revenue, costs and expenses, and related disclosures. We believe that of our critical accounting policies described under the heading “Management’s Discussion and Analysis of Financial Condition and Results of Operations—Critical Accounting Policies and Estimates” in our Annual Report, the following involves the most judgment and complexity:
•Research and development contract costs and accruals
Accordingly, we believe the policies set forth above are critical to fully understand and evaluate our financial condition and results of operations. If actual results or events differ materially from the estimates, judgments and assumptions used by us in applying these policies, our reported financial condition and results of operations could be materially affected.
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Recently Issued or Adopted Accounting Pronouncements
New pronouncements issued but not effective until after September 30, 2023 are not expected to have a material impact on the Company’s consolidated financial statements.
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Item 3. Quantitative and Qualitative Disclosures About Market Risk.
We are exposed to market risk related to changes in interest rates. We had cash, cash equivalents and available-for-sale investment securities of $1,339.5 million as of September 30, 2023, which consisted primarily of money market funds and investment securities, largely composed of U.S. Treasuries and Agencies and investment grade, short to intermediate term fixed income securities. Short-term investments consisted of a certificate of deposit with a maturity of less than twelve months.
The primary objective of our investment activities is to preserve capital to fund our operations. We also seek to maximize income from our investments without assuming significant risk. To achieve our objectives, we maintain a portfolio of investments in a variety of securities of high credit quality and short-term duration, according to our board-approved investment policy. Our investments are subject to interest rate risk and could fall in value if market interest rates increase. We intend and have the ability to hold those investments to maturity and, should interest rates rise, there would be no recognition of impairment required. Declines in interest rates, however, could reduce future investment income. A hypothetical 10% relative change in interest rates during any of the periods presented would not have had a material impact on our consolidated financial statements.
We are not currently exposed to significant market risk related to changes in foreign currency exchange rates; however, we have contracted with and may continue to contract with vendors that are located outside of the United States. As a result, our operations may be subject to fluctuations in foreign currency exchange rates in the future.
We do not believe that inflation had a material effect on our business, financial condition, or results of operations during the three and nine months ended September 30, 2023 and 2022. However, inflation has had, and may continue to have, an impact on the labor costs we incur to attract and retain qualified personnel.
Item 4. Limitations on Effectiveness of Controls and Procedures.
The term “disclosure controls and procedures,” as defined in Rules 13a-15(e) and 15d-15(e) under the Exchange Act, refers to controls and procedures that are designed to ensure that information required to be disclosed by a company in the reports that it files or submits under the Exchange Act is recorded, processed, summarized and reported, within the time periods specified in the SEC’s rules and forms. Disclosure controls and procedures include, without limitation, controls and procedures designed to ensure that information required to be disclosed by a company in the reports that it files or submits under the Exchange Act is accumulated and communicated to the company’s management, including its principal executive and principal financial officers, or persons performing similar functions, as appropriate, to allow timely decisions regarding required disclosure.
In designing and evaluating our disclosure controls and procedures, management recognizes that any controls and procedures, no matter how well designed and operated, can provide only reasonable assurance of achieving the desired control objectives. In addition, the design of disclosure controls and procedures must reflect the fact that there are resource constraints and that management is required to apply judgment in evaluating the benefits of possible controls and procedures relative to their costs.
Evaluation of Disclosure Controls and Procedures
Our management, with the participation of our principal executive officer and principal financial officer, evaluated, as of the end of the period covered by this Quarterly Report on Form 10-Q, the effectiveness of our disclosure controls and procedures (as defined in Rules 13a-15(e) and 15d-15(e) under the Exchange Act of 1934). Based on that evaluation, our principal executive officer and principal financial officer concluded that our disclosure controls and procedures were effective at the reasonable assurance level as of September 30, 2023.
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Changes in Internal Control Over Financial Reporting
During the second fiscal quarter, we completed the implementation of an enterprise resource planning (“ERP”) system, with which we expect to improve the efficiency of certain financial and transactional processes. As a result, we have updated the design and documentation of internal controls related to processes and procedures which were impacted following the ERP implementation to ensure we continue to maintain effective internal control over financial reporting.
Except as described in the previous paragraph, there was no change in our internal control over financial reporting (as defined in Rules 13a-15(f) and 15d-15(f) under the Exchange Act) which occurred during the three and nine months ended September 30, 2023 that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting.
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PART II—OTHER INFORMATION
Item 1. Legal Proceedings.
We are not currently subject to any material legal proceedings.
Item 1A. Risk Factors.
In addition to the risks described in our Annual Report, you should carefully consider the other information set forth in this Form 10-Q and the information in our other filings with the SEC, as they could materially affect our business, financial condition or future results of operations. There have been no material changes to the risk factors previously disclosed in Part I, Item 1A (Risk Factors) of our Annual Report.
Item 2. Unregistered Sales of Equity Securities and Use of Proceeds.
None.
Item 3. Defaults Upon Senior Securities.
None.
Item 4. Mine Safety Disclosures.
Not applicable.
Item 5. Other Information.
(c) Trading Arrangements
During the three months ended September 30, 2023, none of our directors or officers (as defined in Rule 16a-1(f) under the Exchange Act) adopted or terminated (1) a contract, instruction or written plan for the purchase or sale of Company securities intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) or (2) a "non-Rule 10b5-1 trading arrangement" (as defined in Item 408(c) of Regulation S-K).
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Item 6. Exhibits.
The exhibits listed on the Exhibit Index immediately preceding such exhibits, which is incorporated herein by reference, are filed or furnished as part of this Quarterly Report on Form 10‑Q.
# Indicates a management contract or any compensatory plan, contract or arrangement.
+ The certification furnished in Exhibit 32.1 hereto is deemed to accompany this Quarterly Report on Form 10‑Q and will not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, except to the extent that the Registrant specifically incorporates it by reference. Such certification will not be deemed to be incorporated by reference into any filings under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended, except to the extent that the Registrant specifically incorporates it by reference.
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SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.
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KARUNA THERAPEUTICS, INC. |
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Date: November 2, 2023 |
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By: |
/s/ William Meury |
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William Meury |
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President and Chief Executive Officer (Principal Executive Officer) |
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Date: November 2, 2023 |
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By: |
/s/ Jason Brown |
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Jason Brown |
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Chief Financial Officer (Principal Financial and Accounting Officer) |
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Exhibit 10.1
AMENDED AND RESTATED EMPLOYMENT AGREEMENT
This Amended and Restated Employment Agreement (“Agreement”) is made between Karuna Therapeutics, Inc., a Delaware corporation (the “Company”), and Jason Brown (the “Executive”) and is made effective as of September 29, 2023 (the “Effective Date”).
WHEREAS, the Company (formerly, Karuna Pharmaceuticals, Inc.) and the Executive are parties to an employment offer letter, dated September 17, 2018 (the “Prior Agreement”), which the Company and the Executive intend to amend and restate in its entirety; and
WHEREAS, the Company desires to continue to employ the Executive and the Executive desires to continue to be employed by the Company on the terms and conditions contained herein.
NOW, THEREFORE, in consideration of the mutual covenants and agreements herein contained and other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the parties hereby agree to amend and restate the Prior Agreement as follows:
(a)Term. The term of this Agreement shall commence on the Effective Date and continue until terminated in accordance with the provisions hereof (the “Term”). The Executive’s employment with the Company shall be “at will,” meaning that the Executive’s employment may be terminated by the Company or the Executive at any time and for any reason, subject to the terms of this Agreement.
(b)Position and Duties. During the Term, the Executive shall serve as the Chief Financial Officer of the Company and shall have such powers and duties as may from time to time be prescribed by the Board of Directors (the “Board”) or the Chief Executive Officer of the Company (the “CEO”). The Executive shall devote his full working time and attention to the business and affairs of the Company, and he will be required to travel as necessary for business-related purposes. Notwithstanding the foregoing, the Executive may serve on other boards of directors, with the advance written approval of the Board, or engage in religious, charitable or other community activities or other business activities as long as such services and activities are disclosed to the Board in advance and do not interfere with the Executive’s performance of his duties to the Company, provided the Executive shall not perform an operational or fundraising role for another for-profit entity or provide services for any other for-profit entity whose business activities conflict with the business activities of the Company.
2.Compensation and Related Matters.
(a)Base Salary. During the Term, the Executive’s initial base salary shall be paid at the rate of $505,000 per year. The Executive’s base salary shall be reviewed annually by the Board or the Compensation Committee of the Board (the “Compensation Committee”). The base salary in effect at any given time is referred to herein as “Base Salary.” The Base Salary
shall be payable in a manner that is consistent with the Company’s usual payroll practices for executive officers and subject to applicable withholdings and deductions.
(b)Incentive Compensation. During the Term, the Executive shall be eligible to receive cash incentive compensation as determined by the Board or the Compensation Committee from time to time. The Executive’s initial target annual incentive compensation shall be 45% percent of his Base Salary (the “Target Bonus”) and be based on predetermined metrics as determined by the Board or the Compensation Committee. The actual amount of the Executive’s annual incentive compensation, if any, shall be determined in the sole discretion of the Board or the Compensation Committee, subject to the terms of any applicable incentive compensation plan that may be in effect from time to time. Except as otherwise provided herein, to earn incentive compensation, the Executive must be employed by the Company on the day such incentive compensation is paid.
(c)Expenses. The Executive shall be entitled to receive prompt reimbursement for all reasonable expenses incurred by him during the Term in performing services hereunder, in accordance with the policies and procedures then in effect and established by the Company for its executive officers.
(d)Other Benefits. During the Term, the Executive shall be eligible to participate in or receive benefits under the Company’s employee benefit plans in effect from time to time, subject to the terms of such plans.
(e)Vacations. During the Term, the Executive shall be entitled to take paid time off in accordance with the Company’s applicable paid time off policy for executives as may be in effect from time to time. The Executive shall also be entitled to all paid holidays given by the Company to its executive officers subject to applicable policies of the Company as may be in effect from time to time.
(f)Equity. The Executive’s equity compensation shall be governed by the terms and conditions of the Company’s Stock Option and Incentive Plan, as many be amended, and the applicable award agreement(s) (collectively, the “Equity Documents”). In connection with the commencement of the Executive’s employment, subject to execution of this Agreement and as of the Effective Date, the Board has granted to the Executive (i) an option to purchase a number of shares of the Company’s common stock having an aggregate value equal to $796,775, rounded down to the nearest share number, which will vest over four years, with 25% vesting on the one-year anniversary of the Effective Date and the balance vesting in 12 equal quarterly installments thereafter, and (ii) a number of restricted stock units with an aggregate value of $796,775, rounded down to the nearest share number, which will vest in four equal installments over four years, with 25% vesting on each one-year anniversary of the Effective Date; provided in each case that the Executive remains an employee or other service provider of the Company on such vesting dates. In the event of any conflict between the Equity Documents and this Agreement, the Equity Documents shall control.
3.Termination. During the Term, the Executive’s employment hereunder may be terminated without any breach of this Agreement under the following circumstances:
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(a)Death. The Executive’s employment hereunder shall terminate upon his death.
(b)Disability. The Company may terminate the Executive’s employment if he is disabled and unable to perform the essential functions of the Executive’s then existing position or positions under this Agreement with or without reasonable accommodation for a period of 180 days (which need not be consecutive) in any 12-month period. If any question shall arise as to whether during any period the Executive is disabled so as to be unable to perform the essential functions of the Executive’s then existing position or positions with or without reasonable accommodation, the Executive may, and at the request of the Company shall, submit to the Company a certification in reasonable detail by a physician selected by the Company to whom the Executive or the Executive’s guardian has no reasonable objection as to whether the Executive is so disabled or how long such disability is expected to continue, and such certification shall for the purposes of this Agreement be conclusive of the issue. The Executive shall cooperate with any reasonable request of the physician in connection with such certification. If such question shall arise and the Executive shall fail to submit such certification, the Company’s determination of such issue shall be binding on the Executive. Nothing in this Section 3(b) shall be construed to waive the Executive’s rights, if any, under existing law including, without limitation, the Family and Medical Leave Act of 1993, 29 U.S.C. §2601 et seq. and the Americans with Disabilities Act, 42 U.S.C. §12101 et seq.
(c)Termination by Company for Cause. The Company may terminate the Executive’s employment hereunder for Cause. For purposes of this Agreement, “Cause” shall mean: (i) conduct by the Executive constituting a material act of misconduct in connection with the performance of his duties, including, without limitation, willful failure or refusal to perform material responsibilities that have been requested by the Board, misappropriation of funds or property of the Company or any of its subsidiaries or affiliates other than the occasional, customary and de minimis use of Company property for personal purposes, or dishonesty to the Board with respect to any material matter; (ii) the commission by the Executive of any acts satisfying the elements of felony or a misdemeanor involving moral turpitude, deceit, dishonesty or fraud, or any conduct by the Executive that would reasonably be expected to result in material injury or reputational harm to the Company or any of its subsidiaries or affiliates if he were retained in his position; (iii) continued non-performance by the Executive of his duties hereunder (other than by reason of the Executive’s physical or mental illness, incapacity or disability) which has continued for more than 30 days following written notice of such non-performance from the CEO; (iv) a breach by the Executive of any of the provisions contained in Section 8 of this Agreement or the Restrictive Covenants Agreements; (v) a material violation by the Executive of the Company’s written employment policies; or (vi) failure to cooperate with a bona fide internal investigation or an investigation by regulatory or law enforcement authorities, after being instructed by the Company to cooperate, or the willful destruction or failure to preserve documents or other materials known to be relevant to such investigation or the inducement of others to fail to cooperate or to produce documents or other materials in connection with such investigation.
(d)Termination without Cause. The Company may terminate the Executive’s employment hereunder at any time without Cause. Any termination by the Company of the
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Executive’s employment under this Agreement which does not constitute a termination for Cause under Section 3(c) and does not result from the death or disability of the Executive under Section 3(a) or (b) shall be deemed a termination without Cause.
(e)Termination by the Executive. The Executive may terminate his employment hereunder at any time for any reason, including but not limited to Good Reason. For purposes of this Agreement, “Good Reason” shall mean that the Executive has complied with the “Good Reason Process” (hereinafter defined) following the occurrence of any of the following events: (i) a material diminution in the Executive’s responsibilities, authority or duties; (ii) a material diminution in the Executive’s Base Salary except for across-the-board salary reductions based on the Company’s financial performance similarly affecting all or substantially all senior management employees of the Company; (iii) a material change in the geographic location at which the Executive provides services to the Company; or (iv) the material breach of this Agreement by the Company. “Good Reason Process” shall mean that (i) the Executive reasonably determines in good faith that a “Good Reason” condition has occurred; (ii) the Executive notifies the Company in writing of the first occurrence of the Good Reason condition within 60 days of the first occurrence of such condition; (iii) the Executive cooperates in good faith with the Company’s efforts, for a period not less than 30 days following such notice (the “Cure Period”), to remedy the condition; (iv) notwithstanding such efforts, the Good Reason condition continues to exist; and (v) the Executive terminates his employment within 60 days after the end of the Cure Period. If the Company cures the Good Reason condition during the Cure Period, Good Reason shall be deemed not to have occurred.
4.Notice and Date of Termination.
(a)Notice of Termination. Except for termination as specified in Section 3(a), any termination of the Executive’s employment by the Company or any such termination by the Executive shall be communicated by written Notice of Termination to the other party hereto. For purposes of this Agreement, a “Notice of Termination” shall mean a notice which shall indicate the specific termination provision in this Agreement relied upon.
(b)Date of Termination. “Date of Termination” shall mean: (i) if the Executive’s employment is terminated by his death, the date of his death; (ii) if the Executive’s employment is terminated on account of disability under Section 3(b) or by the Company for Cause under Section 3(c), the date on which Notice of Termination is given; (iii) if the Executive’s employment is terminated by the Company under Section 3(d), the date on which a Notice of Termination is given or another date as specified in the Notice of Termination; (iv) if the Executive’s employment is terminated by the Executive under Section 3(e) without Good Reason, 30 days after the date on which a Notice of Termination is given, and (v) if the Executive’s employment is terminated by the Executive under Section 3(e) for Good Reason, the date on which a Notice of Termination is given after the end of the Cure Period. Notwithstanding the foregoing, in the event that the Executive gives a Notice of Termination to the Company, the Company may unilaterally accelerate the Date of Termination and such acceleration shall not result in a termination by the Company for purposes of this Agreement.
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5.Compensation Upon Termination.
(a)Termination Generally. If the Executive’s employment with the Company is terminated for any reason, the Company shall pay or provide to the Executive (or to his authorized representative or estate) (i) any Base Salary earned through the Date of Termination, unpaid expense reimbursements (subject to, and in accordance with, Section 2(c) of this Agreement) and unused vacation that accrued through the Date of Termination on or before the time required by law but in no event more than 30 days after the Executive’s Date of Termination; and (ii) any vested benefits the Executive may have under any employee benefit plan of the Company through the Date of Termination, which vested benefits shall be paid and/or provided in accordance with the terms of such employee benefit plans (collectively, the “Accrued Benefit”).
(b)Termination by the Company without Cause or by the Executive with Good Reason. During the Term, if the Executive’s employment is terminated by the Company without Cause as provided in Section 3(d), or the Executive terminates his employment for Good Reason as provided in Section 3(e), then the Company shall pay the Executive his Accrued Benefit. In addition, subject to (i) the Executive signing a separation agreement in a form and manner satisfactory to the Company, which shall contain, among other provisions, a general release of claims in favor of the Company and related persons and entities, confidentiality, return of property and non-disparagement and a reaffirmation of all of the Executive’s Continuing Obligations (as defined below) (the “Separation Agreement and Release”) and (ii) the Separation Agreement and Release becoming fully irrevocable, all within 60 days after the Date of Termination (or such shorter period as set forth in the Separation Agreement and Release), which shall include a seven (7) business day revocation period:
(i)the Company shall pay the Executive an amount equal to nine (9) months of the Executive’s then current Base Salary; and
(ii)the Company shall pay the Executive a pro-rata amount of the Executive’s Target Bonus based on the performance of the Company and consistent with bonuses paid to other Company executives, both as determined by the Board in its reasonable good faith discretion; and
(iii)if the Executive was participating in the Company’s group health plan immediately prior to the Date of Termination and elects COBRA health continuation, then the Company shall pay to the Executive a monthly cash payment for nine (9) months or the Executive’s COBRA health continuation period, whichever ends earlier, in an amount equal to the monthly employer contribution that the Company would have made to provide health insurance to the Executive if the Executive had remained employed by the Company.
The amounts payable under Sections 5(b)(i) and (iii) shall be paid out in substantially equal installments in accordance with the Company’s payroll practice over nine (9) months commencing within 60 days after the Date of Termination; provided, however, that if the 60-day period begins in one calendar year and ends in a second calendar year, such payments, to the extent they qualify as “non-qualified deferred compensation” within the meaning of Section
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409A of the Internal Revenue Code of 1986, as amended (the “Code”), shall begin to be paid in the second calendar year by the last day of such 60-day period; provided, further, that the initial payment shall include a catch-up payment to cover amounts retroactive to the day immediately following the Date of Termination. Each payment pursuant to this Agreement is intended to constitute a separate payment for purposes of Treasury Regulation Section 1.409A-2(b)(2). The amount payable under Section 4(b)(ii) shall be paid on the date bonuses are paid to the Company’s other executives but no later than March 15 following the year in which the Date of Termination occurs.
Notwithstanding the foregoing, if the Executive breaches any of the provisions contained in Section 8 of this Agreement or the Restrictive Covenants Agreements (as defined below), all payments under this Section 5(b) shall immediately cease.
6.Change in Control Payment. The provisions of this Section 6 set forth certain terms of an agreement reached between the Executive and the Company regarding the Executive’s rights and obligations upon the occurrence of a Change in Control of the Company. These provisions are intended to assure and encourage in advance the Executive’s continued attention and dedication to his assigned duties and his objectivity during the pendency and after the occurrence of any such event. These provisions shall apply in lieu of, and expressly supersede, the provisions of Section 5(b) regarding severance pay and benefits upon a termination of employment, if such termination of employment occurs within twelve (12) months after the occurrence of the first event constituting a Change in Control (the “Change in Control Period”). These provisions shall terminate and be of no further force or effect beginning after the Change in Control Period.
(a)Change in Control. During the Term, if during the Change in Control Period, the Executive’s employment is terminated by the Company without Cause as provided in Section 3(d) or the Executive terminates his employment for Good Reason as provided in Section 3(e), then, subject to the Executive signing a Separation Agreement and Release that conforms with the requirements of Section 5(b)(i) and the Separation Agreement and Release becoming fully irrevocable, all within 60 days after the Date of Termination (or such shorter period as set forth in the Separation Agreement and Release), which shall include a seven (7) business day revocation period:
(i)the Company shall pay the Executive a lump sum in cash in an amount equal to one times the sum of (A) the Executive’s then current Base Salary (or the Executive’s Base Salary in effect immediately prior to the Change in Control, if higher) plus (B) the Executive’s Target Bonus for the then current year; and
(ii)notwithstanding anything to the contrary in any applicable option agreement or other equity award agreement, all outstanding equity grants subject to time-based vesting held by the Executive shall immediately accelerate and become fully exercisable or nonforfeitable as of the Date of Termination; and
(iii)if the Executive was participating in the Company’s group health plan immediately prior to the Date of Termination and elects COBRA health continuation, then the Company shall pay to the Executive a monthly cash payment for twelve (12)
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months or the Executive’s COBRA health continuation period, whichever ends earlier, in an amount equal to the monthly employer contribution that the Company would have made to provide health insurance to the Executive if the Executive had remained employed by the Company.
The amounts payable under Sections 6(a)(i) and (iii) shall be paid or commence to be paid within 60 days after the Date of Termination; provided, however, that if the 60-day period begins in one calendar year and ends in a second calendar year, such payments, to the extent they qualify as “non-qualified deferred compensation” within the meaning of Section 409A of the Code, shall be paid or commence to be paid in the second calendar year by the last day of such 60-day period. Notwithstanding the foregoing, if the Executive breaches any of the provisions contained in Section 8 of this Agreement, all payments under this Section 6(a) shall immediately cease.
(b)Additional Limitation.
(i)Anything in this Agreement to the contrary notwithstanding, in the event that the amount of any compensation, payment or distribution by the Company to or for the benefit of the Executive, whether paid or payable or distributed or distributable pursuant to the terms of this Agreement or otherwise, calculated in a manner consistent with Section 280G of the Code and the applicable regulations thereunder (the “Aggregate Payments”), would be subject to the excise tax imposed by Section 4999 of the Code, then the Aggregate Payments shall be reduced (but not below zero) so that the sum of all of the Aggregate Payments shall be $1.00 less than the amount at which the Executive becomes subject to the excise tax imposed by Section 4999 of the Code; provided that such reduction shall only occur if it would result in the Executive receiving a higher After Tax Amount (as defined below) than the Executive would receive if the Aggregate Payments were not subject to such reduction. In such event, the Aggregate Payments shall be reduced in the following order, in each case, in reverse chronological order beginning with the Aggregate Payments that are to be paid the furthest in time from consummation of the transaction that is subject to Section 280G of the Code: (1) cash payments not subject to Section 409A of the Code; (2) cash payments subject to Section 409A of the Code; (3) equity-based payments and acceleration; and (4) non-cash forms of benefits; provided that in the case of all the foregoing Aggregate Payments all amounts or payments that are not subject to calculation under Treas. Reg. §1.280G-1, Q&A-24(b) or (c) shall be reduced before any amounts that are subject to calculation under Treas. Reg. §1.280G-1, Q&A-24(b) or (c).
(ii)For purposes of this Section 6(b), the “After Tax Amount” means the amount of the Aggregate Payments less all federal, state, and local income, excise and employment taxes imposed on the Executive as a result of the Executive’s receipt of the Aggregate Payments. For purposes of determining the After Tax Amount, the Executive shall be deemed to pay federal income taxes at the highest marginal rate of federal income taxation applicable to individuals for the calendar year in which the determination is to be made, and state and local income taxes at the highest marginal rates of individual taxation in each applicable state and locality, net of the maximum reduction in federal income taxes which could be obtained from deduction of such state and local taxes.
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(iii)The determination as to whether a reduction in the Aggregate Payments shall be made pursuant to Section 6(b)(i) shall be made by a nationally recognized accounting firm selected by the Company (the “Accounting Firm”), which shall provide detailed supporting calculations both to the Company and the Executive within 15 business days of the Date of Termination, if applicable, or at such earlier time as is reasonably requested by the Company or the Executive. Any determination by the Accounting Firm shall be binding upon the Company and the Executive.
(c)Definitions. For purposes of this Section 5, the following terms shall have the following meanings:
“Change in Control” shall mean any of the following:
(i)any “person,” as such term is used in Sections 13(d) and 14(d) of the Securities Exchange Act of 1934, as amended (the “Act”) (other than the Company, any of its subsidiaries, or any trustee, fiduciary or other person or entity holding securities under any employee benefit plan or trust of the Company or any of its subsidiaries), together with all “affiliates” and “associates” (as such terms are defined in Rule 12b-2 under the Act) of such person, shall become the “beneficial owner” (as such term is defined in Rule 13d-3 under the Act), directly or indirectly, of securities of the Company representing 50 percent or more of the combined voting power of the Company’s then outstanding securities having the right to vote in an election of the Board (“Voting Securities”) (in such case other than as a result of an acquisition of securities directly from the Company); or
(ii)the date a majority of the members of the Board is replaced during any 12-month period by directors whose appointment or election is not endorsed by a majority of the members of the Board before the date of the appointment or election; or
(iii)the consummation of (A) any consolidation or merger of the Company where the stockholders of the Company, immediately prior to the consolidation or merger, would not, immediately after the consolidation or merger, beneficially own (as such term is defined in Rule 13d-3 under the Act), directly or indirectly, shares representing in the aggregate more than 50 percent of the voting shares of the Company issuing cash or securities in the consolidation or merger (or of its ultimate parent corporation, if any), or (B) any sale or other transfer (in one transaction or a series of transactions contemplated or arranged by any party as a single plan) of all or substantially all of the assets of the Company.
Notwithstanding the foregoing, a “Change in Control” shall not be deemed to have occurred for purposes of the foregoing clause (i) solely as the result of an acquisition of securities by the Company which, by reducing the number of shares of Voting Securities outstanding, increases the proportionate number of Voting Securities beneficially owned by any person to 50 percent or more of the combined voting power of all of the then outstanding Voting Securities; provided, however, that if any person referred to in this sentence shall thereafter become the beneficial owner of any additional shares of Voting Securities (other than pursuant to a stock split, stock dividend, or similar transaction or as a result of an acquisition of securities
8
directly from the Company) and immediately thereafter beneficially owns 50 percent or more of the combined voting power of all of the then outstanding Voting Securities, then a “Change in Control” shall be deemed to have occurred for purposes of the foregoing clause (i).
(a)Anything in this Agreement to the contrary notwithstanding, if at the time of the Executive’s separation from service within the meaning of Section 409A of the Code, the Company determines that the Executive is a “specified employee” within the meaning of Section 409A(a)(2)(B)(i) of the Code, then to the extent any payment or benefit that the Executive becomes entitled to under this Agreement on account of the Executive’s separation from service would be considered deferred compensation otherwise subject to the 20 percent additional tax imposed pursuant to Section 409A(a) of the Code as a result of the application of Section 409A(a)(2)(B)(i) of the Code, such payment shall not be payable and such benefit shall not be provided until the date that is the earlier of (A) six months and one day after the Executive’s separation from service, or (B) the Executive’s death. If any such delayed cash payment is otherwise payable on an installment basis, the first payment shall include a catch-up payment covering amounts that would otherwise have been paid during the six-month period but for the application of this provision, and the balance of the installments shall be payable in accordance with their original schedule.
(b)All in-kind benefits provided and expenses eligible for reimbursement under this Agreement shall be provided by the Company or incurred by the Executive during the time periods set forth in this Agreement. All reimbursements shall be paid as soon as administratively practicable, but in no event shall any reimbursement be paid after the last day of the taxable year following the taxable year in which the expense was incurred. The amount of in-kind benefits provided or reimbursable expenses incurred in one taxable year shall not affect the in-kind benefits to be provided or the expenses eligible for reimbursement in any other taxable year (except for any lifetime or other aggregate limitation applicable to medical expenses). Such right to reimbursement or in-kind benefits is not subject to liquidation or exchange for another benefit.
(c)To the extent that any payment or benefit described in this Agreement constitutes “non-qualified deferred compensation” under Section 409A of the Code, and to the extent that such payment or benefit is payable upon the Executive’s termination of employment, then such payments or benefits shall be payable only upon the Executive’s “separation from service.” The determination of whether and when a separation from service has occurred shall be made in accordance with the presumptions set forth in Treasury Regulation Section 1.409A‑1(h).
(d)The parties intend that this Agreement will be administered in accordance with Section 409A of the Code. To the extent that any provision of this Agreement is ambiguous as to its compliance with Section 409A of the Code, the provision shall be read in such a manner so that all payments hereunder comply with Section 409A of the Code. Each payment pursuant to this Agreement is intended to constitute a separate payment for purposes of Treasury Regulation Section 1.409A‑2(b)(2). The parties agree that this Agreement may be amended, as reasonably requested by either party, and as may be necessary to fully comply with Section 409A
9
of the Code and all related rules and regulations in order to preserve the payments and benefits provided hereunder without additional cost to either party.
(e)The Company makes no representation or warranty and shall have no liability to the Executive or any other person if any provisions of this Agreement are determined to constitute deferred compensation subject to Section 409A of the Code but do not satisfy an exemption from, or the conditions of, such Section.
8.Continuing Obligations.
(a)Restrictive Covenants Agreements. On or around the date hereof, the Executive will enter into the Amended and Restated Employee Invention and Non-Disclosure Agreement, attached hereto as Exhibit A, and the Amended and Restated Non-Competition and Non-Solicitation Agreement, attached hereto as Exhibit B (together, the “Restrictive Covenants Agreements”). The Executive acknowledges and agrees that the Executive received the Restrictive Covenants Agreement with this Agreement at least ten (10) business days before the commencement of the Executive’s employment. For purposes of this Agreement, the obligations in this Section 8 and those that arise in the Restrictive Covenants Agreements and any other agreement relating to confidentiality, assignment of inventions, or other restrictive covenants shall collectively be referred to as the “Continuing Obligations.”
(b)Protected Disclosures and Other Protected Action. Nothing in this Agreement shall be interpreted or applied to prohibit the Executive from making any good faith report to any governmental agency or other governmental entity (a “Government Agency”) concerning any act or omission that the Executive reasonably believes constitutes a possible violation of federal or state law or making other disclosures that are protected under the anti-retaliation or whistleblower provisions of applicable federal or state law or regulation. In addition, nothing contained in this Agreement limits the Executive’s ability to communicate with any Government Agency or otherwise participate in any investigation or proceeding that may be conducted by any Government Agency, including the Executive’s ability to provide documents or other information, without notice to the Company. In addition, for the avoidance of doubt, pursuant to the federal Defend Trade Secrets Act of 2016, the Executive shall not be held criminally or civilly liable under any federal or state trade secret law or under this Agreement or the Restrictive Covenants Agreements for the disclosure of a trade secret that (a) is made (i) in confidence to a federal, state, or local government official, either directly or indirectly, or to an attorney; and (ii) solely for the purpose of reporting or investigating a suspected violation of law; or (b) is made in a complaint or other document filed in a lawsuit or other proceeding, if such filing is made under seal.
9.Consent to Jurisdiction. The parties hereby consent to the jurisdiction of the state and federal courts of the Commonwealth of Massachusetts. Accordingly, with respect to any such court action, the Executive (a) submits to the personal jurisdiction of such courts; (b) consents to service of process; and (c) waives any other requirement (whether imposed by statute, rule of court, or otherwise) with respect to personal jurisdiction or service of process.
10.Integration. This Agreement, along with the Restrictive Covenants Agreements and the Equity Documents, constitutes the entire agreement between the parties with respect to
10
the subject matter hereof and supersedes all prior agreements between the parties concerning such subject matter, including without limitation the Prior Agreement.
11.Withholding; Tax Effect. All payments made by the Company to the Executive under this Agreement shall be net of any tax or other amounts required to be withheld by the Company under applicable law. Nothing in this Agreement shall be construed to require the Company to make any payments to compensate the Executive for any adverse tax effect associated with any payments or benefits or for any deduction or withholding from any payment or benefit.
12.Successor to the Executive. This Agreement shall inure to the benefit of and be enforceable by the Executive’s personal representatives, executors, administrators, heirs, distributees, devisees and legatees. In the event of the Executive’s death after his termination of employment but prior to the completion by the Company of all payments due to his under this Agreement, the Company shall continue such payments to the Executive’s beneficiary designated in writing to the Company prior to his death (or to his estate, if the Executive fails to make such designation).
13.Enforceability. If any portion or provision of this Agreement (including, without limitation, any portion or provision of any section of this Agreement) shall to any extent be declared illegal or unenforceable by a court of competent jurisdiction, then the remainder of this Agreement, or the application of such portion or provision in circumstances other than those as to which it is so declared illegal or unenforceable, shall not be affected thereby, and each portion and provision of this Agreement shall be valid and enforceable to the fullest extent permitted by law.
14.Survival. The provisions of this Agreement shall survive the termination of this Agreement and/or the termination of the Executive’s employment to the extent necessary to effectuate the terms contained herein.
15.Waiver. No waiver of any provision hereof shall be effective unless made in writing and signed by the waiving party. The failure of any party to require the performance of any term or obligation of this Agreement, or the waiver by any party of any breach of this Agreement, shall not prevent any subsequent enforcement of such term or obligation or be deemed a waiver of any subsequent breach.
16.Notices. Any notices, requests, demands and other communications provided for by this Agreement shall be sufficient if in writing and delivered in person or sent by a nationally recognized overnight courier service or by registered or certified mail, postage prepaid, return receipt requested, to the Executive at the last address the Executive has filed in writing with the Company or, in the case of the Company, at its main offices, attention of the Board.
17.Amendment. This Agreement may be amended or modified only by a written instrument signed by the Executive and by a duly authorized representative of the Company.
18.Effect on Other Plans and Agreements. An election by the Executive to resign for Good Reason under the provisions of this Agreement shall not be deemed a voluntary
11
termination of employment by the Executive for the purpose of interpreting the provisions of any of the Company's benefit plans, programs or policies. Nothing in this Agreement shall be construed to limit the rights of the Executive under the Company’s benefit plans, programs or policies except as otherwise provided in Section 8 hereof, and except that the Executive shall have no rights to any severance benefits under any Company severance pay plan, offer letter or otherwise. In the event that the Executive is party to an agreement with the Company providing for payments or benefits under such agreement and this Agreement, the terms of this Agreement shall govern and the Executive may receive payment under this Agreement only and not both. Further, Section 5 and Section 6 of this Agreement are mutually exclusive and in no event shall the Executive be entitled to payments or benefits pursuant to Section 5 and Section 6 of this Agreement.
19.Governing Law. This is a Massachusetts contract and shall be construed under and be governed in all respects by the laws of the Commonwealth of Massachusetts, without giving effect to the conflict of laws principles thereof. With respect to any disputes concerning federal law, such disputes shall be determined in accordance with the law as it would be interpreted and applied by the United States Court of Appeals for the First Circuit.
20.Counterparts. This Agreement may be executed in any number of counterparts, each of which when so executed and delivered shall be taken to be an original; but such counterparts shall together constitute one and the same document.
21.Successor to Company. The Company shall require any successor (whether direct or indirect, by purchase, merger, consolidation or otherwise) to all or substantially all of the business or assets of the Company expressly to assume and agree to perform this Agreement to the same extent that the Company would be required to perform it if no succession had taken place. Failure of the Company to obtain an assumption of this Agreement at or prior to the effectiveness of any succession shall be a material breach of this Agreement.
22.Gender Neutral. Wherever used herein, a pronoun in the masculine gender shall be considered as including the feminine gender unless the context clearly indicates otherwise.
[Remainder of Page Intentionally Left Blank]
12
IN WITNESS WHEREOF, the parties have executed this Agreement effective on the date and year first above written.
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Karuna Therapeutics, Inc. |
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By: /s/ Bill Meury Name: Bill Meury Title: President and Chief Executive Officer |
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EXECUTIVE |
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/s/ Jason Brown Jason Brown |
13
Exhibit 31.1
CERTIFICATION OF PRINCIPAL EXECUTIVE OFFICER PURSUANT TO RULES 13A-14(A) AND 15D-14(A) UNDER THE SECURITIES EXCHANGE ACT OF 1934, AS ADOPTED PURSUANT TO SECTION 302 OF SARBANES-OXLEY ACT OF 2002
I, William Meury, certify that:
1. I have reviewed this Quarterly Report on Form 10-Q of Karuna Therapeutics, Inc.;
2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
4. The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report), that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and
5. The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):
a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and
b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.
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Dated: November 2, 2023 |
/s/ William Meury |
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William Meury |
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Chief Executive Officer and President |
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(Principal Executive Officer) |
Exhibit 31.2
CERTIFICATION OF PRINCIPAL FINANCIAL OFFICER PURSUANT TO RULES 13A-14(A) AND 15D-14(A) UNDER THE SECURITIES EXCHANGE ACT OF 1934, AS ADOPTED PURSUANT TO SECTION 302 OF SARBANES-OXLEY ACT OF 2002
I, Jason Brown, certify that:
1. I have reviewed this Quarterly Report on Form 10-Q of Karuna Therapeutics, Inc.;
2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
4. The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
c) Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
d) Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report), that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and
5. The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):
a) All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and
b) Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.
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Dated: November 2, 2023 |
/s/ Jason Brown |
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Jason Brown |
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Chief Financial Officer |
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(Principal Financial and Accounting Officer) |
Exhibit 32.1
CERTIFICATION OF PRINCIPAL EXECUTIVE OFFICER AND PRINCIPAL FINANCIAL OFFICER
PURSUANT TO 18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002
In connection with the Quarterly Report on Form 10-Q of Karuna Therapeutics, Inc. (the “Company”) for the quarterly period ended September 30, 2023, as filed with the Securities and Exchange Commission on the date hereof (the “Report”), the undersigned, William Meury and Jason Brown, Chief Executive Officer of the Company and Chief Financial Officer of the Company, respectively, hereby certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that to their knowledge:
(1) the Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and
(2) the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.
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Dated: November 2, 2023 |
/s/ William Meury |
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William Meury |
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Chief Executive Officer and President |
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(Principal Executive Officer) |
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Dated: November 2, 2023 |
/s/ Jason Brown |
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Jason Brown |
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Chief Financial Officer |
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(Principal Financial and Accounting Officer) |
v3.23.3
Document and Entity Information - shares
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9 Months Ended |
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Sep. 30, 2023 |
Oct. 31, 2023 |
Cover [Abstract] |
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Document Type |
10-Q
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Amendment Flag |
false
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Document Period End Date |
Sep. 30, 2023
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Document Fiscal Year Focus |
2023
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Document Fiscal Period Focus |
Q3
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Trading Symbol |
KRTX
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Entity Registrant Name |
Karuna Therapeutics, Inc.
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Entity Central Index Key |
0001771917
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Current Fiscal Year End Date |
--12-31
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Entity File Number |
001-38958
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Entity Tax Identification Number |
27-0605902
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Entity Address, Address Line One |
99 High Street
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Entity Address, Address Line Two |
26th Floor
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Boston
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Entity Address, State or Province |
MA
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02110
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857
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449-2244
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Yes
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v3.23.3
CONSOLIDATED BALANCE SHEETS (Unaudited) - USD ($) $ in Thousands |
Sep. 30, 2023 |
Dec. 31, 2022 |
Current assets: |
|
|
Cash and cash equivalents |
$ 184,471
|
$ 248,329
|
Restricted cash |
104
|
0
|
Investment securities, available-for-sale |
1,155,006
|
875,715
|
Short-term investments, other |
2,033
|
0
|
Accounts receivable |
0
|
57
|
Prepaid expenses |
12,876
|
29,106
|
Deferred offering costs |
829
|
568
|
Other current assets |
10,078
|
994
|
Total current assets |
1,365,397
|
1,154,769
|
Restricted cash, net of current portion |
0
|
261
|
Right-of-use lease assets - operating, net |
14,603
|
4,674
|
Property and equipment, net |
4,715
|
3,201
|
Other non-current assets |
382
|
429
|
Total assets |
1,385,097
|
1,163,334
|
Current liabilities: |
|
|
Accounts payable |
2,939
|
2,379
|
Accrued expenses |
44,129
|
29,285
|
Current portion of operating lease liability |
1,796
|
2,282
|
Other current liabilities |
104
|
0
|
Total current liabilities |
48,968
|
33,946
|
Operating lease liability, net of current portion |
13,813
|
3,046
|
Other non-current liabilities |
0
|
104
|
Total liabilities |
62,781
|
37,096
|
Commitments and Contingencies (Note 10) |
|
|
Stockholders’ equity: |
|
|
Preferred stock, value |
0
|
0
|
Common Stock, value |
4
|
3
|
Additional paid-in capital |
2,209,304
|
1,693,732
|
Accumulated deficit |
(884,063)
|
(564,207)
|
Accumulated other comprehensive loss |
(2,929)
|
(3,290)
|
Total stockholders’ equity |
1,322,316
|
1,126,238
|
Total liabilities and stockholders’ equity |
$ 1,385,097
|
$ 1,163,334
|
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v3.23.3
CONSOLIDATED BALANCE SHEETS (Unaudited) (Parenthetical) - $ / shares
|
Sep. 30, 2023 |
Dec. 31, 2022 |
Statement of Financial Position [Abstract] |
|
|
Preferred stock, par value |
$ 0.0001
|
$ 0.0001
|
Preferred stock, shares authorized |
10,000,000
|
10,000,000
|
Preferred stock, shares outstanding |
0
|
0
|
Common stock, par value |
$ 0.0001
|
$ 0.0001
|
Common stock, shares authorized |
150,000,000
|
150,000,000
|
Common stock, shares issued |
37,719,367
|
34,473,905
|
Common stock, shares outstanding |
37,719,367
|
34,473,905
|
X |
- DefinitionFace amount or stated value per share of common stock.
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v3.23.3
CONSOLIDATED STATEMENTS OF OPERATIONS (Unaudited) - USD ($) $ in Thousands |
3 Months Ended |
9 Months Ended |
Sep. 30, 2023 |
Sep. 30, 2022 |
Sep. 30, 2023 |
Sep. 30, 2022 |
Income Statement [Abstract] |
|
|
|
|
License and other revenue |
$ 0
|
$ 81
|
$ 654
|
$ 5,359
|
Operating expenses: |
|
|
|
|
Research and development |
103,952
|
61,950
|
281,909
|
158,243
|
General and administrative |
32,266
|
19,125
|
83,936
|
51,756
|
Total operating expenses |
136,218
|
81,075
|
365,845
|
209,999
|
Loss from operations |
(136,218)
|
(80,994)
|
(365,191)
|
(204,640)
|
Other income, net: |
|
|
|
|
Interest income |
16,952
|
3,884
|
44,894
|
4,611
|
Sublease income |
147
|
147
|
441
|
433
|
Total other income, net |
17,099
|
4,031
|
45,335
|
5,044
|
Net loss before income taxes |
(119,119)
|
(76,963)
|
(319,856)
|
(199,596)
|
Income tax provision |
|
|
|
(528)
|
Net loss attributable to common stockholders |
$ (119,119)
|
$ (76,963)
|
$ (319,856)
|
$ (200,124)
|
Net loss per share, basic |
$ (3.16)
|
$ (2.38)
|
$ (8.72)
|
$ (6.52)
|
Net loss per share, diluted |
$ (3.16)
|
$ (2.38)
|
$ (8.72)
|
$ (6.52)
|
Weighted Average Number of Shares Outstanding, Basic |
37,689,144
|
32,349,111
|
36,682,056
|
30,693,117
|
Weighted Average Number of Shares Outstanding, Diluted |
37,689,144
|
32,349,111
|
36,682,056
|
30,693,117
|
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v3.23.3
CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS (Unaudited) - USD ($) $ in Thousands |
3 Months Ended |
9 Months Ended |
Sep. 30, 2023 |
Sep. 30, 2022 |
Sep. 30, 2023 |
Sep. 30, 2022 |
Statement of Comprehensive Income [Abstract] |
|
|
|
|
Net Income (Loss) |
$ (119,119)
|
$ (76,963)
|
$ (319,856)
|
$ (200,124)
|
Other comprehensive loss: |
|
|
|
|
Unrealized gains (losses) on available-for-sale investments |
713
|
(703)
|
361
|
(3,201)
|
Comprehensive loss |
$ (118,406)
|
$ (77,666)
|
$ (319,495)
|
$ (203,325)
|
X |
- DefinitionAmount after tax of increase (decrease) in equity from transactions and other events and circumstances from net income and other comprehensive income, attributable to parent entity. Excludes changes in equity resulting from investments by owners and distributions to owners.
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v3.23.3
CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (Unaudited) - USD ($) $ in Thousands |
Total |
Common Stock |
Additional Paid In Capital |
Accumulated Deficit |
Accumulated Other Comprehensive Loss |
Beginning balance at Dec. 31, 2021 |
$ 502,026
|
$ 3
|
$ 790,391
|
$ (287,871)
|
$ (497)
|
Beginning balance, shares at Dec. 31, 2021 |
|
29,770,558
|
|
|
|
Stock-based compensation expense |
22,768
|
|
22,768
|
|
|
Exercise of common options |
6,274
|
|
6,274
|
|
|
Exercise of common options, shares |
|
162,545
|
|
|
|
Other comprehensive income (loss) |
(2,498)
|
|
|
|
(2,498)
|
Net Income (Loss) |
(123,161)
|
|
|
(123,161)
|
|
Ending balance at Jun. 30, 2022 |
405,409
|
$ 3
|
819,433
|
(411,032)
|
(2,995)
|
Ending balance, shares at Jun. 30, 2022 |
|
29,933,103
|
|
|
|
Beginning balance at Dec. 31, 2021 |
502,026
|
$ 3
|
790,391
|
(287,871)
|
(497)
|
Beginning balance, shares at Dec. 31, 2021 |
|
29,770,558
|
|
|
|
Net Income (Loss) |
(200,124)
|
|
|
|
|
Ending balance at Sep. 30, 2022 |
1,183,955
|
$ 3
|
1,675,645
|
(487,995)
|
(3,698)
|
Ending balance, shares at Sep. 30, 2022 |
|
34,345,991
|
|
|
|
Beginning balance at Jun. 30, 2022 |
405,409
|
$ 3
|
819,433
|
(411,032)
|
(2,995)
|
Beginning balance, shares at Jun. 30, 2022 |
|
29,933,103
|
|
|
|
Issuance of common stock |
819,047
|
|
819,047
|
|
|
Issuance of common stock, shares |
|
4,011,628
|
|
|
|
Stock-based compensation expense |
12,021
|
|
12,021
|
|
|
Exercise of common options |
25,144
|
|
25,144
|
|
|
Exercise of common options, shares |
|
401,260
|
|
|
|
Other comprehensive income (loss) |
(703)
|
|
|
|
(703)
|
Net Income (Loss) |
(76,963)
|
|
|
(76,963)
|
|
Ending balance at Sep. 30, 2022 |
1,183,955
|
$ 3
|
1,675,645
|
(487,995)
|
(3,698)
|
Ending balance, shares at Sep. 30, 2022 |
|
34,345,991
|
|
|
|
Beginning balance at Dec. 31, 2022 |
1,126,238
|
$ 3
|
1,693,732
|
(564,207)
|
(3,290)
|
Beginning balance, shares at Dec. 31, 2022 |
|
34,473,905
|
|
|
|
Issuance of common stock |
436,720
|
$ 1
|
436,719
|
|
|
Issuance of common stock, shares |
|
2,851,299
|
|
|
|
Stock-based compensation expense |
33,510
|
|
33,510
|
|
|
Exercise of common options |
24,184
|
|
24,184
|
|
|
Exercise of common options, shares |
|
319,090
|
|
|
|
Other comprehensive income (loss) |
(352)
|
|
|
|
(352)
|
Net Income (Loss) |
(200,737)
|
|
|
(200,737)
|
|
Ending balance at Jun. 30, 2023 |
1,419,563
|
$ 4
|
2,188,145
|
(764,944)
|
(3,642)
|
Ending balance, shares at Jun. 30, 2023 |
|
37,644,294
|
|
|
|
Beginning balance at Dec. 31, 2022 |
$ 1,126,238
|
$ 3
|
1,693,732
|
(564,207)
|
(3,290)
|
Beginning balance, shares at Dec. 31, 2022 |
|
34,473,905
|
|
|
|
Exercise of common options, shares |
394,163
|
|
|
|
|
Net Income (Loss) |
$ (319,856)
|
|
|
|
|
Ending balance at Sep. 30, 2023 |
1,322,316
|
$ 4
|
2,209,304
|
(884,063)
|
(2,929)
|
Ending balance, shares at Sep. 30, 2023 |
|
37,719,367
|
|
|
|
Beginning balance at Jun. 30, 2023 |
1,419,563
|
$ 4
|
2,188,145
|
(764,944)
|
(3,642)
|
Beginning balance, shares at Jun. 30, 2023 |
|
37,644,294
|
|
|
|
Exercise of common options |
2,863
|
|
2,863
|
|
|
Exercise of common options, shares |
|
75,073
|
|
|
|
Other comprehensive income (loss) |
713
|
|
|
|
713
|
Net Income (Loss) |
(119,119)
|
|
|
(119,119)
|
|
Ending balance at Sep. 30, 2023 |
$ 1,322,316
|
$ 4
|
$ 2,209,304
|
$ (884,063)
|
$ (2,929)
|
Ending balance, shares at Sep. 30, 2023 |
|
37,719,367
|
|
|
|
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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (Unaudited) (Parenthetical) - Public Offering - USD ($) $ in Thousands |
3 Months Ended |
6 Months Ended |
Sep. 30, 2022 |
Jun. 30, 2023 |
Underwriting discounts and commissions |
$ 43,125
|
$ 23,000
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Offering cost |
$ 328
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$ 281
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CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($) $ in Thousands |
9 Months Ended |
Sep. 30, 2023 |
Sep. 30, 2022 |
Cash flows from operating activities |
|
|
Net loss |
$ (319,856)
|
$ (200,124)
|
Adjustments to reconcile net loss to net cash used in operating activities: |
|
|
Stock-based compensation expense |
51,806
|
34,789
|
Amortization of premiums and accretion of discounts on investment securities |
(27,567)
|
(327)
|
Depreciation and amortization expense |
1,254
|
807
|
Changes in operating assets and liabilities: |
|
|
Accrued interest on investment securities |
(2,753)
|
(399)
|
Accounts receivable |
57
|
1,669
|
Prepaid expenses |
16,230
|
(4,454)
|
Other current assets |
(9,084)
|
(1,443)
|
Right-of-use assets |
1,891
|
1,322
|
Other non-current assets |
47
|
108
|
Accounts payable |
413
|
13,777
|
Accrued expenses |
14,341
|
6,643
|
Other current liabilities |
104
|
0
|
Operating lease liability |
(1,539)
|
(1,617)
|
Other non-current liabilities |
(104)
|
0
|
Net cash used in operating activities |
(274,760)
|
(149,249)
|
Cash flows from investing activities |
|
|
Purchases of investment securities |
(1,292,308)
|
(459,353)
|
Purchase of short-term investments (certificates of deposit) |
(2,033)
|
0
|
Maturities of investment securities |
1,043,698
|
180,199
|
Acquisition of property and equipment |
(2,118)
|
(625)
|
Net cash (used in) provided by investing activities |
(252,761)
|
(279,779)
|
Cash flows from financing activities |
|
|
Proceeds from public offering, net of underwriting discounts and commissions |
436,720
|
819,375
|
Payment of offering costs |
(261)
|
(401)
|
Proceeds from exercise of stock options |
27,047
|
31,418
|
Net cash provided by financing activities |
463,506
|
850,392
|
Net (decrease) increase in cash, cash equivalents and restricted cash |
(64,015)
|
421,364
|
Cash, cash equivalents and restricted cash at beginning of period |
248,590
|
207,214
|
Cash, cash equivalents and restricted cash at end of period |
184,575
|
628,578
|
Supplemental disclosures of cash flows information |
|
|
Lease liabilities arising from obtaining right-of-use assets |
11,820
|
0
|
Purchases of property and equipment included in accounts payable and accrued expenses |
$ 650
|
$ 9
|
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v3.23.3
Pay vs Performance Disclosure - USD ($) $ in Thousands |
3 Months Ended |
6 Months Ended |
9 Months Ended |
Sep. 30, 2023 |
Sep. 30, 2022 |
Jun. 30, 2023 |
Jun. 30, 2022 |
Sep. 30, 2023 |
Sep. 30, 2022 |
Pay vs Performance Disclosure |
|
|
|
|
|
|
Net Income (Loss) |
$ (119,119)
|
$ (76,963)
|
$ (200,737)
|
$ (123,161)
|
$ (319,856)
|
$ (200,124)
|
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X |
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v3.23.3
Nature of the Business and Basis of Presentation
|
9 Months Ended |
Sep. 30, 2023 |
Organization, Consolidation and Presentation of Financial Statements [Abstract] |
|
Nature of the Business and Basis of Presentation |
Note 1. Nature of the Business and Basis of Presentation Description of the Business Karuna Therapeutics, Inc. (the “Company”) was incorporated under the laws of the State of Delaware in July 2009 as Karuna Pharmaceuticals, Inc. and is headquartered in Boston, Massachusetts. In March 2019, the Company changed its name to Karuna Therapeutics, Inc. The Company is a clinical-stage biopharmaceutical company driven to discover, develop, and deliver transformative medicines for people living with psychiatric and neurological conditions. Since the Company’s inception, it has focused substantially all of its efforts and financial resources on organizing and staffing the Company, acquiring and developing its technology, raising capital, building its intellectual property portfolio, undertaking preclinical studies and clinical trials, preparing for the potential commercialization of KarXT, and providing general and administrative support for these activities. The Company has not generated any product revenue related to its primary business purpose to date and is subject to a number of risks similar to those of other early stage companies, including dependence on key individuals, regulatory approval of products, uncertainty of market acceptance of products, competition from substitute products and larger companies, compliance with government regulations, protection of proprietary technology, dependence on third parties, product liability, the impact of the effects of the COVID-19 coronavirus pandemic, and the need to obtain adequate additional financing to fund the development of its product candidates. In March 2023, the Company completed a follow-on public offering under an effective registration statement on Form S-3 (File No. 333-239657) and a related prospectus supplement in which it issued and sold 2,851,299 shares of common stock, which included the full exercise of the underwriters’ option to purchase an additional 371,908 shares of common stock, at a public offering price of $161.33 per share. The aggregate net proceeds to the Company from the offering, inclusive of proceeds from the option exercise, were $436.7 million after deducting underwriting discounts and commissions of $23.0 million and offering expenses of $0.3 million. On June 21, 2023, the Company filed an automatically effective registration statement on Form S-3 (File No. 333- 272813) with the Securities and Exchange Commission (the “SEC"), which registers the offering, issuance and sale of an unspecified amount of common stock, preferred stock, debt securities, warrants and/or units of any combination thereof. The Company’s consolidated financial statements have been prepared on the basis of continuity of operations, realization of assets and the satisfaction of liabilities in the ordinary course of business. The Company experienced negative operating cash flows of $274.8 million for the nine months ended September 30, 2023 and had an accumulated deficit of $884.1 million as of September 30, 2023. The Company expects to continue to generate operating losses for the foreseeable future. The Company expects that its cash, cash equivalents and available-for-sale investments of $1,339.5 million as of September 30, 2023 will be sufficient to fund its operating expenses and capital expenditure requirements through at least 12 months from the date of issuance of these consolidated financial statements. Basis of Presentation The accompanying consolidated financial statements have been prepared in conformity with accounting principles generally accepted in the United States of America (“U.S. GAAP”). Any reference in these notes to applicable guidance is meant to refer to the authoritative U.S. GAAP as found in the Accounting Standards Codification (“ASC”) and Accounting Standards Updates (“ASUs”) of the Financial Accounting Standards Board (“FASB”). The consolidated financial statements include the accounts of Karuna Therapeutics, Inc. and its wholly owned subsidiary, Karuna Securities Corporation, a Massachusetts corporation. All inter-company transactions and balances have been eliminated in consolidation. The accompanying consolidated balance sheet as of September 30, 2023 and the consolidated statements of operations, comprehensive loss, and stockholders’ equity for the three and nine months ended September 30, 2023 and 2022, and the statements of cash flow for the nine months ended September 30, 2023 and 2022, are unaudited. The unaudited interim consolidated financial statements have been prepared on the same basis as the audited annual consolidated financial statements and, in the opinion of management, reflect all adjustments, which include only normal recurring adjustments, necessary for the fair statement of the Company’s financial position as of September 30, 2023 and the results of its operations for the three and nine months ended September 30, 2023 and 2022 and cash flows for the nine months ended September 30, 2023 and 2022. Certain information and footnote disclosures typically included in annual financial statements prepared in accordance with U.S. GAAP have been condensed or omitted. Accordingly, these unaudited consolidated interim financial statements should be read in conjunction with the Company’s consolidated financial statements as of and for the year ended December 31, 2022. The results for the three and nine months ended September 30, 2023 are not necessarily indicative of results to be expected for the year ending December 31, 2023, any other interim periods, or any future year or period.
|
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- DefinitionThe entire disclosure for the nature of an entity's business, major products or services, principal markets including location, and the relative importance of its operations in each business and the basis for the determination, including but not limited to, assets, revenues, or earnings. For an entity that has not commenced principal operations, disclosures about the risks and uncertainties related to the activities in which the entity is currently engaged and an understanding of what those activities are being directed toward.
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v3.23.3
Summary of Significant Accounting Policies
|
9 Months Ended |
Sep. 30, 2023 |
Accounting Policies [Abstract] |
|
Summary of Significant Accounting Policies |
Note 2. Summary of Significant Accounting Policies The significant accounting policies and estimates used in preparation of the consolidated financial statements are described in the Company’s audited consolidated financial statements as of and for the year ended December 31, 2022, and the notes thereto, which are included in the Company’s Annual Report on Form 10-K. During the three and nine months ended September 30, 2023, there were no material changes to the Company’s significant accounting policies, except for the addition of the following policy: Policy Regarding Acquired In-Process Research and Development (IPR&D) and Development Milestones Acquired IPR&D and development milestones include the initial costs of externally developed IPR&D projects, acquired directly in a transaction other than a business combination, that do not have an alternative future use. Prior to regulatory approval of the compound, initial costs are expensed when incurred, and milestone payment obligations related to these transactions are expensed when the event triggering an obligation to pay the milestone occurs. Milestone payments made upon or after regulatory approval are capitalized and amortized over the remaining useful life of the related asset. Recently Issued Accounting Pronouncements New pronouncements issued but not effective until after September 30, 2023 are not expected to have a material impact on the Company’s consolidated financial statements.
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- DefinitionThe entire disclosure for all significant accounting policies of the reporting entity.
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v3.23.3
Prepaid Expenses and Other Current Assets and Accrued Expenses
|
9 Months Ended |
Sep. 30, 2023 |
Prepaid Expenses And Other Assets And Accrued Expenses [Abstract] |
|
Prepaid Expenses and Other Assets and Accrued Expenses |
Note 3. Prepaid Expenses, Other Current Assets, and Accrued Expenses Prepaid expenses consisted of the following (in thousands):
|
|
|
|
|
|
|
|
|
|
|
September 30, 2023 |
|
|
December 31, 2022 |
|
Research and development expenses |
|
$ |
8,881 |
|
|
$ |
25,285 |
|
Insurance |
|
|
2,581 |
|
|
|
2,472 |
|
Other |
|
|
1,414 |
|
|
|
1,349 |
|
Total prepaid expenses |
|
$ |
12,876 |
|
|
$ |
29,106 |
|
The Company also had other current assets totaling $10.1 million as of September 30, 2023 and $1.0 million as of December 31, 2022, respectively. As of September 30, 2023, other current assets included a refundable regulatory fee of $3.2 million paid in connection with the Company's New Drug Application ("NDA") submission and a receivable of $4.9 million in connection with the acquisition of rights to a general unsecured claim against Goldfinch Bio, Inc. ("Goldfinch Bio"). As of December 31, 2022, other current assets included interest receivable on our investment securities of $0.7 million. Accrued expenses consisted of the following (in thousands):
|
|
|
|
|
|
|
|
|
|
|
September 30, 2023 |
|
|
December 31, 2022 |
|
Research and development expenses |
|
$ |
22,821 |
|
|
$ |
11,962 |
|
Payroll and related expenses |
|
|
14,717 |
|
|
|
11,950 |
|
Professional fees |
|
|
4,593 |
|
|
|
2,943 |
|
Other |
|
|
1,998 |
|
|
|
2,430 |
|
Total accrued expenses |
|
$ |
44,129 |
|
|
$ |
29,285 |
|
|
X |
- DefinitionPrepaid expenses and other assets and accrued expenses.
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v3.23.3
Stockholders' Equity
|
9 Months Ended |
Sep. 30, 2023 |
Equity [Abstract] |
|
Stockholders' Equity |
Note 4. Stockholders’ Equity Preferred Stock On July 2, 2019, in connection with the closing of the Company’s initial public offering of its common stock ("IPO"), the Company filed its amended and restated Certificate of Incorporation, which authorizes the Company to issue up to 10,000,000 shares of preferred stock, $0.0001 par value per share. Through September 30, 2023, no preferred stock has been issued. Common Stock As of September 30, 2023, the Company’s amended and restated Certificate of Incorporation authorized the Company to issue 150,000,000 shares of common stock, $0.0001 par value per share. Holders of the common stock are entitled to one vote for each share of common stock held at all meetings of stockholders and written actions in lieu of meetings. The holders of common stock are entitled to receive dividends out of funds legally available, as declared by the board of directors. These dividends are subject to the preferential dividend rights of the holders of the Company’s preferred stock. Through September 30, 2023, no cash dividends have been declared or paid. As of September 30, 2023, there were 37,719,367 shares of common stock outstanding.
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v3.23.3
Zai License Agreement
|
9 Months Ended |
Sep. 30, 2023 |
Research and Development [Abstract] |
|
Zai License Agreement |
Note 5. Zai License Agreement Terms of Agreement On November 8, 2021, the Company and Zai Lab (Shanghai) Co., Ltd. ("Zai") entered into a license agreement (the "Zai License Agreement"), pursuant to which Karuna granted to Zai the right to exclusively develop, manufacture and commercialize KarXT in Greater China, including mainland China, Hong Kong, Macau, and Taiwan (the “Licensed Territory”). Zai will fund substantially all development, regulatory, and commercialization activities in the Licensed Territory. Under the terms of the Zai License Agreement, the Company received a non-refundable $35.0 million upfront payment and payment of certain taxes on its behalf. The Zai License Agreement also provides that the Company is eligible to receive total development and regulatory milestone payments of up to $80.0 million, total sales milestone payments of up to $72.0 million and low double-digit to high-teens tiered royalties based on annual net sales of KarXT in the Licensed Territory, subject to reduction under specified circumstances. Receipt of sales milestone payments and royalties are not contingent on any further participation by the Company in the development of KarXT in the Licensed Territory. The Zai License Agreement will expire upon the latest of the following dates with respect to the last licensed product in any region in the Licensed Territory: (i) the date of expiration of the last valid claim covering such licensed product in such region, (ii) the date that is a specific period after the date of the first commercial sale of such licensed product in such region and (iii) the expiration date of any regulatory exclusivity for such licensed product in such region. Zai may terminate the Zai License Agreement for convenience, subject to the terms thereto, by providing written notice to the Company, which termination will be effective following a prescribed notice period. In addition, the Company may terminate the Zai License Agreement under specified circumstances if Zai or certain other parties challenge the Company’s patent rights or if Zai or its affiliates fail to complete certain development activities with respect to the licensed product for a specified period of time, subject to specified exceptions. Either party may terminate the Zai License Agreement for the other party’s uncured material breach, with a customary notice and cure period, or insolvency. After termination or expiration, the Company is entitled to retain a worldwide, exclusive, and perpetual license from Zai to exploit the licensed product, which license would be non-exclusive after expiration (but not termination), subject to a reasonable royalty to be agreed by the parties if terminated for the Company’s uncured material breach. Revenue Recognition The Company concluded that the distinct units of account within the agreement are reflective of a vendor-customer relationship and therefore within the scope of ASC 606, Revenue From Contracts with Customers. Under the provisions of ASC 606, the Company identified one performance obligation. The Company provided an exclusive license to intellectual property, bundled with the associated know-how and certain professional services that are not substantive. Under the terms of the Zai License Agreement, Zai has the sole right to manufacture, or have manufactured, KarXT for use in development and commercialization in the Licensed Territory. At the election of Zai, the Company may supply KarXT to Zai at the fully burdened manufacturing cost plus a specified margin, as defined within the Zai License Agreement. This provision was determined to be an option to acquire additional goods or services at a price that approximates the stand-alone selling price for that good or service, and therefore does not represent a material right, or separate performance obligation, within the context of the Zai License Agreement. For the nine months ended September 30, 2023, the Company recognized $0.7 million in revenue associated with sales of clinical drug supply to Zai. No revenue associated with sales of clinical drug supply was recognized during the three months ended September 30, 2023. For the three and nine months ended September 30, 2022, less than $0.1 million revenue was recognized for sales of clinical drug supply to Zai. The Company determined the transaction price of the Zai License Agreement was equal to $37.0 million, which includes the upfront fee of $35.0 million and payments to taxing authorities on the Company’s behalf. In estimating the stand-alone selling price, the Company determined that there were no significant financing components, noncash consideration or amounts that may be refunded to the customer, and as such the total unconstrained consideration of $37.0 million was included in the total transaction price. License of Intellectual Property. The license to the Company's intellectual property represents a distinct performance obligation. The license and associated know-how was transferred to Zai in the fourth quarter of 2021 to satisfy this performance obligation. The Company allocated the full transaction price to the license of the Company's intellectual property and accordingly recognized revenue of $37.0 million as license revenue in its Consolidated Statement of Operations for the year ended December 31, 2021. Milestone Payments. The potential development and regulatory milestone payments, as well as sales milestone payments, are paid upon achievement of certain milestones as defined in the Zai License Agreement. For the three and nine months ended September 30, 2023, there was no revenue related to milestone payments recognized pursuant to the Zai License Agreement. For the nine months ended September 30, 2022, the Company recognized $5.3 million in license revenue for certain development milestones and related payments to taxing authorities on the Company's behalf, and recorded $0.5 million in foreign tax expense to income tax provision. For the three months ended September 30, 2022, there was no revenue related to milestone payments recognized pursuant to the Zai License Agreement. For all remaining development and regulatory milestones, which, as of September 30, 2023, can total up to $70.0 million, it was determined that their achievement is highly dependent on factors outside of the Company's control. These payments have been fully constrained until the Company concludes that achievement of the milestone is probable, and that recognition of revenue related to the milestone will not result in a significant reversal in amounts recognized in future periods, and as such have been excluded from the transaction price. At the end of each subsequent reporting period, the Company will re-evaluate the probability of achievement of each milestone and any related constraint and, if necessary, adjust its estimate of the overall transaction price. As of September 30, 2023, the Company has not recognized any revenue associated with sales milestones. Royalties. Any consideration related to royalties will be recognized if and when the related sales occur, as they were determined to relate predominantly to the license granted to Zai and, therefore, have also been excluded from the transaction price. As of September 30, 2023, the Company has not recognized any revenue associated with royalties. There was no deferred revenue as of September 30, 2023 or December 31, 2022 related to the Zai License Agreement.
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v3.23.3
Net Loss per Share
|
9 Months Ended |
Sep. 30, 2023 |
Earnings Per Share [Abstract] |
|
Net Loss per Share |
Note 6. Net Loss per Share The following table sets forth the computation of basic and diluted net loss per share of common stock for the three and nine months ended September 30, 2023 and 2022 (in thousands, except share and per share data):
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended September 30, |
|
|
Nine Months Ended September 30, |
|
|
|
2023 |
|
|
2022 |
|
|
2023 |
|
|
2022 |
|
Net Loss |
|
$ |
(119,119 |
) |
|
$ |
(76,963 |
) |
|
$ |
(319,856 |
) |
|
$ |
(200,124 |
) |
Weighted-average shares used in computing net loss per share |
|
|
37,689,144 |
|
|
|
32,349,111 |
|
|
|
36,682,056 |
|
|
|
30,693,117 |
|
Net loss per share, basic and diluted |
|
$ |
(3.16 |
) |
|
$ |
(2.38 |
) |
|
$ |
(8.72 |
) |
|
$ |
(6.52 |
) |
The Company’s potentially dilutive securities, which consist of stock options and restricted stock units ("RSUs"), have been excluded from the computation of diluted net loss per share because including them would have had an anti-dilutive impact. Therefore, the weighted average number of common shares outstanding used to calculate both basic and diluted net loss per share attributable to common stockholders is the same. The following common stock equivalents, presented based on amounts outstanding at each period end, have been excluded from the calculation of diluted net loss per share:
|
|
|
|
|
|
|
|
|
|
|
September 30, |
|
|
|
2023 |
|
|
2022 |
|
Stock options to purchase common stock |
|
|
5,541,686 |
|
|
|
5,561,493 |
|
Restricted stock units |
|
|
314,854 |
|
|
|
— |
|
|
|
|
5,856,540 |
|
|
|
5,561,493 |
|
|
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v3.23.3
License Agreements
|
9 Months Ended |
Sep. 30, 2023 |
Asset Acquisition [Abstract] |
|
License Agreements |
Note 7. License Agreements Acquisition of KAR-2618 and other TRPC4/5 candidates In January 2023, the Company entered into an exclusive license agreement (the "GFB Agreement"), with GFB (ABC), LLC ("GFB"), assignee of the assignment estate of Goldfinch Bio, pursuant to which GFB granted to the Company the exclusive right and license to develop, manufacture, and commercialize GFB’s TRPC4/5 candidates (the "GFB Compounds"), including the lead clinical-stage candidate known as KAR-2618 (formerly GFB-887). The Company agreed to use commercially reasonable efforts to develop, obtain regulatory approval for, and commercialize at least one licensed product that contains or comprises a GFB Compound in at least two indications in the United States. Under the terms of the GFB Agreement, the Company paid to GFB a $15.0 million upfront payment, and agreed to pay a total of up to $520.0 million for each GFB Compound upon the achievement of certain development, regulatory and commercial milestones with respect to such GFB Compound, of which $110.0 million, $150.0 million, and $260.0 million are related to development, regulatory, and commercial sales milestones, respectively. The Company also agreed to pay GFB a flat low-single digit royalty on aggregate net sales of each licensed product on a country-by-country basis until the expiration of the applicable royalty term, which ends on the later of (i) the expiration date of the last valid claim covering the licensed product in such country, (ii) the expiration date of regulatory exclusivity with respect to such licensed product in such country, and (iii) the date that is a specific period after the first commercial sale of such licensed product in such country. The royalty rate is subject to reduction on a licensed product-by-licensed product and country-by-country basis under certain circumstances. In the event that the Company sublicenses to a third party any of the rights to the licensed intellectual property granted under the GFB Agreement, the Company will be obligated to pay GFB royalties within the range of 25% to 35% on any consideration the Company receives from the sublicensee, excluding royalties and certain other payments. Unless earlier terminated, the GFB Agreement will expire on the expiration of the last to expire royalty term. Unless the GFB Agreement is earlier terminated, on expiration of each applicable royalty term, the Company will have a fully paid-up, irrevocable and perpetual license to develop, manufacture and commercialize each applicable licensed product in the applicable country. Either party may terminate the GFB Agreement for the other party’s material breach, following a customary notice and cure period, or insolvency. The Company may terminate the GFB Agreement for any reason upon 90 days written notice to GFB. The upfront payment of $15.0 million was accounted for as an asset acquisition and recorded within research and development expense in the consolidated statement of operations for the nine months ended September 30, 2023, as KAR-2618 is prior to regulatory approval and has no alternative future use. The Company did not incur or recognize any milestone payments under the GFB Agreement during the three and nine months ended September 30, 2023. Intellectual Property License with Eli Lilly and Company In May 2012, the Company entered into an exclusive license agreement (the “Lilly License Agreement”), with Eli Lilly and Company (“Eli Lilly”), pursuant to which Eli Lilly assigned to the Company all of its rights to certain patents (now expired), regulatory documentation, data records and materials related to xanomeline. The Company is also entitled to sublicense or otherwise transfer the rights granted in connection with the Lilly License Agreement. Under the Lilly License Agreement, the Company is obligated to use commercially reasonable efforts to develop, manufacture, commercialize and seek and maintain regulatory approval for xanomeline, in any formulation, for use in humans. The Company paid Eli Lilly an upfront payment of $0.1 million and has agreed to make milestone payments to Eli Lilly of up to an aggregate of $16.0 million upon the achievement of specified regulatory milestones and up to an aggregate of $54.0 million in commercial milestones. In addition, the Company is obligated to pay Eli Lilly tiered royalties, at rates in the low to mid single-digit percentages, on the worldwide net sales of any commercialized product on a country-by-country basis until the expiration of the applicable royalty term, which is the longer of six years from the date of first commercial sale of each licensed product within a country or data package exclusivity in such country. During the royalty term, Eli Lilly is prohibited from granting any third party rights to the patents, regulatory documentation, data records and materials that have been licensed to the Company under the Lilly License Agreement. The Lilly License Agreement will expire on the later of (i) the expiration of the last-to-expire royalty term on a licensed product-by-licensed product basis or (ii) the date on which the Company has made all milestone payments pursuant to the terms of the Lilly License Agreement, unless terminated earlier by the parties. In no event will the term of the Lilly License Agreement exceed 15 years past the anniversary of the first commercial sale of a xanomeline product. The Company may terminate the Lilly License Agreement for any reason with proper prior notice to Eli Lilly. Either party may terminate the Lilly License Agreement upon an uncured material breach by the other party. The initial upfront payment of $0.1 million was expensed when incurred in May 2012. As of September 30, 2023, no regulatory or commercial milestones have been reached and, accordingly, no milestone payments have been made. Intellectual Property License with PureTech Health In March 2011, the Company entered into an exclusive license agreement (the “Patent License Agreement”) with PureTech Health, pursuant to which PureTech Health granted the Company an exclusive license to patent rights relating to combinations of a muscarinic activator with a muscarinic inhibitor for the treatment of central nervous system disorders. In connection with the Patent License Agreement, the Company has agreed to make milestone payments to PureTech Health of up to an aggregate of $10.0 million upon the achievement of specified development and regulatory milestones. In addition, the Company is obligated to pay PureTech Health low single-digit royalties on the worldwide net sales of any commercialized product covered by the licenses granted under the Patent License Agreement. In the event that the Company sublicenses any of the patent rights granted under the Patent License Agreement, the Company will be obligated to pay PureTech Health royalties within the range of 15% to 25% on any income the Company receives from the sublicensee, excluding royalties. The Company may terminate the Patent License Agreement for any reason with proper prior notice to PureTech Health. Either party may terminate the Patent License Agreement upon an uncured material breach by the other party. The Company incurred no expenses related to the Patent License Agreement during the three and nine months ended September 30, 2023 and 2022. As of September 30, 2023, the remaining development and regulatory milestone payments under the Patent License Agreement total up to $8.0 million. The Company had no outstanding liabilities to PureTech Health related to the Patent License Agreement as of September 30, 2023 and December 31, 2022.
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v3.23.3
Stock-based Compensation
|
9 Months Ended |
Sep. 30, 2023 |
Share-Based Payment Arrangement [Abstract] |
|
Stock-based Compensation |
Note 8. Stock-based Compensation In September 2009, the Company’s board of directors approved the 2009 Stock Incentive Plan (the “2009 Plan”) which provided for the grant of incentive stock options to employees and non-statutory stock options to directors, consultants, and non-employees of the Company. The 2009 Plan terminated in July 2019 effective upon the completion of the Company’s IPO. No additional options will be granted under the 2009 Plan. As of September 30, 2023, there were 1,981,828 options outstanding under the 2009 Plan. In May 2019, the Company’s board of directors approved the 2019 Stock Option and Incentive Plan (the “2019 Plan”) which became effective on June 26, 2019, the date immediately prior to the date on which the registration statement related to the IPO was declared effective by the SEC. The 2019 Plan will expire in May 2029. Under the 2019 Plan, the Company may grant incentive stock options, non-statutory stock options, restricted stock awards, RSUs, and other stock-based awards. There were 1,709,832 shares of the Company’s common stock initially reserved for issuance under the 2019 Plan. The number of shares of common stock underlying awards that expire, or are terminated, surrendered, canceled or forfeited without having been fully exercised under the 2009 Plan will be added to the shares of common stock available for issuance under the 2019 Plan. In addition, the number of shares of common stock that may be issued under the 2019 Plan automatically increases on January 1 of each calendar year, commencing on January 1, 2020, by 4% of the number of shares of common stock outstanding on the immediately preceding December 31 or such lesser amount determined by the Company’s board of directors or the compensation committee of the board of directors. As of September 30, 2023, there were 2,661,308 common shares available for issuance, 3,559,858 options outstanding, and 314,854 RSUs outstanding under the 2019 Plan. Stock Options Option awards under the 2019 Plan generally vest based on the grantee’s continued service with the Company during a specified period following a grant and expire ten years from the grant date. Awards typically vest in four years, but vesting conditions can vary based on the discretion of the Company’s board of directors. A summary of the Company’s stock option activity and related information is as follows:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Number of Shares |
|
|
Weighted- Average Exercise Price Per Share |
|
|
Weighted- Average Remaining Contractual Term (Years) |
|
|
Aggregate Intrinsic Value (in thousands) |
|
Outstanding as of December 31, 2022 |
|
|
5,570,355 |
|
|
$ |
63.82 |
|
|
|
7.2 |
|
|
$ |
744,097 |
|
Granted |
|
|
636,014 |
|
|
|
195.44 |
|
|
|
|
|
|
|
Exercised |
|
|
(394,163 |
) |
|
|
68.62 |
|
|
|
|
|
|
|
Forfeited |
|
|
(268,382 |
) |
|
|
142.72 |
|
|
|
|
|
|
|
Expired |
|
|
(2,138 |
) |
|
|
123.63 |
|
|
|
|
|
|
|
Outstanding as of September 30, 2023 |
|
|
5,541,686 |
|
|
$ |
74.74 |
|
|
|
6.5 |
|
|
$ |
546,440 |
|
Options vested and expected to vest as of September 30, 2023 |
|
|
5,541,686 |
|
|
$ |
74.74 |
|
|
|
6.5 |
|
|
$ |
546,440 |
|
Options exercisable as of September 30, 2023 |
|
|
3,892,864 |
|
|
$ |
41.37 |
|
|
|
5.6 |
|
|
$ |
497,659 |
|
The aggregate intrinsic values of options outstanding, exercisable, vested and expected to vest were calculated as the difference between the exercise price of the options and the publicly traded stock price of the Company’s common stock as of September 30, 2023. As of September 30, 2023, there was $132.2 million of unrecognized compensation cost, which is expected to be recognized over a weighted-average period of 2.8 years. The weighted-average fair values of options granted during the nine months ended September 30, 2023 and 2022 was $114.69 and $70.59, respectively. The intrinsic value of options exercised during the nine months ended September 30, 2023 and 2022 was $54.5 million and $84.0 million, respectively. Restricted Stock Units RSUs are granted to certain employees and are payable in shares of the Company's common stock. RSU shares are accounted for at fair value based upon the closing stock price on the date of grant. The corresponding expense is amortized over the vesting period, which is typically four years. A summary of the Company’s restricted stock unit activity and related information is as follows:
|
|
|
|
|
|
|
|
|
|
|
Number of Shares |
|
|
Weighted- Average Grant Date Fair Value |
|
Unvested as of December 31, 2022 |
|
|
— |
|
|
$ |
— |
|
Granted |
|
|
330,267 |
|
|
|
195.46 |
|
Vested |
|
|
— |
|
|
|
— |
|
Forfeited |
|
|
(15,413 |
) |
|
|
189.49 |
|
Unvested as of September 30, 2023 |
|
|
314,854 |
|
|
$ |
195.75 |
|
As of September 30, 2023, the total remaining unrecognized compensation cost related to nonvested RSUs was $53.6 million, which will be amortized over the weighted-average remaining requisite service period of 3.4 years. Stock-based Compensation Expense Stock-based compensation expense is classified in the statements of operations for the three and nine months ended September 30, 2023 and 2022 as follows (in thousands):
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended September 30, |
|
|
Nine Months Ended September 30, |
|
|
|
2023 |
|
|
2022 |
|
|
2023 |
|
|
2022 |
|
Research and development |
|
$ |
10,880 |
|
|
$ |
5,431 |
|
|
$ |
29,955 |
|
|
$ |
15,140 |
|
General and administrative |
|
|
7,416 |
|
|
|
6,590 |
|
|
|
21,851 |
|
|
|
19,649 |
|
Total stock-based compensation expense |
|
$ |
18,296 |
|
|
$ |
12,021 |
|
|
$ |
51,806 |
|
|
$ |
34,789 |
|
|
X |
- DefinitionThe entire disclosure for share-based payment arrangement.
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v3.23.3
Fair Value of Financial Assets and Liabilities
|
9 Months Ended |
Sep. 30, 2023 |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Abstract] |
|
Fair Value of Financial Assets and Liabilities |
Note 9. Fair Value of Financial Assets and Liabilities The following tables present information about the Company’s assets as of September 30, 2023 and December 31, 2022 that are measured at fair value on a recurring basis and indicate the level of the fair value hierarchy utilized to determine such fair values (in thousands):
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Fair Value Measurement |
|
|
|
at September 30, 2023 Using |
|
|
|
Level 1 |
|
|
Level 2 |
|
|
Level 3 |
|
|
Total |
|
Cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
Money market fund |
|
$ |
135,160 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
135,160 |
|
Commercial paper |
|
|
— |
|
|
|
29,422 |
|
|
|
— |
|
|
|
29,422 |
|
Short-term investments, other: |
|
|
|
|
|
|
|
|
|
|
|
|
Certificate of deposit |
|
|
— |
|
|
|
2,033 |
|
|
|
— |
|
|
|
2,033 |
|
Investment securities: |
|
|
|
|
|
|
|
|
|
|
|
|
US Treasuries |
|
|
689,176 |
|
|
|
— |
|
|
|
— |
|
|
|
689,176 |
|
US government agencies |
|
|
202,646 |
|
|
|
— |
|
|
|
— |
|
|
|
202,646 |
|
Corporate debt securities |
|
|
— |
|
|
|
33,120 |
|
|
|
— |
|
|
|
33,120 |
|
Commercial paper |
|
|
— |
|
|
|
230,064 |
|
|
|
— |
|
|
|
230,064 |
|
Total |
|
$ |
1,026,982 |
|
|
$ |
294,639 |
|
|
$ |
— |
|
|
$ |
1,321,621 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Fair Value Measurement |
|
|
|
at December 31, 2022 Using |
|
|
|
Level 1 |
|
|
Level 2 |
|
|
Level 3 |
|
|
Total |
|
Cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
Money market fund |
|
$ |
160,158 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
160,158 |
|
Commercial paper |
|
|
— |
|
|
|
61,277 |
|
|
|
— |
|
|
|
61,277 |
|
Investment securities: |
|
|
|
|
|
|
|
|
|
|
|
|
US Treasuries |
|
|
423,688 |
|
|
|
— |
|
|
|
— |
|
|
|
423,688 |
|
US government agencies |
|
|
210,188 |
|
|
|
— |
|
|
|
— |
|
|
|
210,188 |
|
Corporate debt securities |
|
|
— |
|
|
|
63,728 |
|
|
|
— |
|
|
|
63,728 |
|
Commercial paper |
|
|
— |
|
|
|
178,111 |
|
|
|
— |
|
|
|
178,111 |
|
Total |
|
$ |
794,034 |
|
|
$ |
303,116 |
|
|
$ |
— |
|
|
$ |
1,097,150 |
|
The fair values of the Company’s commercial paper and corporate debt securities are based on prices obtained from independent pricing sources. Securities with validated quotes from pricing services are reflected within Level 2, as they are primarily based on observable pricing for similar assets or other market observable inputs. Typical inputs used by these pricing services include, but are not limited to, reported trades, benchmark yields, issuer spreads, bids, offers or estimates of cash flow, prepayment spreads and default rates. Certificates of deposit held for investment with an original maturity greater than three months and less than twelve months are carried at amortized cost and reported as short-term investments on the Company's consolidated balance sheet, which approximates their fair value based on Level 2 inputs. The Company does not hold any securities classified as Level 3, which are securities valued using unobservable inputs. The Company has not transferred any investment securities between the classification levels. The estimated fair value and amortized cost of the Company’s available-for-sale investments, by contractual maturity and security type, are summarized as follows (in thousands):
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
September 30, 2023 |
|
|
|
Amortized Cost |
|
|
Unrealized Gains |
|
|
Unrealized Losses |
|
|
Fair Value |
|
US Treasuries (due within one year) |
|
$ |
559,852 |
|
|
$ |
7 |
|
|
$ |
(1,193 |
) |
|
$ |
558,666 |
|
US Treasuries (due after one year and less than three years) |
|
|
131,249 |
|
|
|
2 |
|
|
|
(741 |
) |
|
|
130,510 |
|
US government agencies (due within one year) |
|
|
147,612 |
|
|
|
10 |
|
|
|
(296 |
) |
|
|
147,326 |
|
US government agencies (due after one year and less than three years) |
|
|
55,752 |
|
|
|
— |
|
|
|
(432 |
) |
|
|
55,320 |
|
Corporate debt securities (due within one year) |
|
|
30,361 |
|
|
|
— |
|
|
|
(138 |
) |
|
|
30,223 |
|
Corporate debt securities (due after one year and less than three years) |
|
|
2,948 |
|
|
|
— |
|
|
|
(51 |
) |
|
|
2,897 |
|
Commercial paper (due within one year) |
|
|
230,161 |
|
|
|
6 |
|
|
|
(103 |
) |
|
|
230,064 |
|
Total |
|
$ |
1,157,935 |
|
|
$ |
25 |
|
|
$ |
(2,954 |
) |
|
$ |
1,155,006 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
December 31, 2022 |
|
|
|
Amortized Cost |
|
|
Unrealized Gains |
|
|
Unrealized Losses |
|
|
Fair Value |
|
US Treasuries (due within one year) |
|
$ |
329,533 |
|
|
$ |
17 |
|
|
$ |
(2,044 |
) |
|
$ |
327,506 |
|
US Treasuries (due after one year and less than three years) |
|
|
96,802 |
|
|
|
— |
|
|
|
(620 |
) |
|
|
96,182 |
|
US government agencies (due within one year) |
|
|
178,319 |
|
|
|
54 |
|
|
|
(108 |
) |
|
|
178,265 |
|
US government agencies (due after one year and less than three years) |
|
|
32,104 |
|
|
|
— |
|
|
|
(181 |
) |
|
|
31,923 |
|
Corporate debt securities (due within one year) |
|
|
51,952 |
|
|
|
1 |
|
|
|
(170 |
) |
|
|
51,783 |
|
Corporate debt securities (due after one year and less than three years) |
|
|
11,983 |
|
|
|
— |
|
|
|
(38 |
) |
|
|
11,945 |
|
Commercial paper (due within one year) |
|
|
178,312 |
|
|
|
16 |
|
|
|
(217 |
) |
|
|
178,111 |
|
Total |
|
$ |
879,005 |
|
|
$ |
88 |
|
|
$ |
(3,378 |
) |
|
$ |
875,715 |
|
The Company has classified all of its available-for-sale investment securities, including those with maturities beyond one year, as current assets on its consolidated balance sheets based on the highly liquid nature of the investment securities and because these investment securities are considered available for use in current operations. The Company is required to determine whether a decline in the fair value below the amortized cost basis of available-for-sale securities is due to credit-related factors. At each reporting date, the Company performs an evaluation of impairment to determine if any unrealized losses are the result of credit losses. Impairment is assessed at the individual security level. Factors considered in determining whether a loss resulted from a credit loss or other factors include the Company’s intent and ability to hold the investment until the recovery of its amortized cost basis, the extent to which the fair value is less than the amortized cost basis, the length of time and extent to which fair value has been less than the cost basis, the financial condition of the issuer, any historical failure of the issuer to make scheduled interest or principal payments, any changes to the rating of the security by a rating agency, any adverse legal or regulatory events affecting the issuer or issuer’s industry, and any significant deterioration in economic conditions. Unrealized losses on available-for-sale securities presented in the previous table have not been recognized in the consolidated statements of operations because the securities are high credit quality, investment grade securities that the Company does not intend to sell and will not be required to sell prior to their anticipated recovery, and the decline in fair value is attributable to factors other than credit losses. Based on its evaluation, the Company determined its year-to-date credit losses related to its available-for-sale securities were immaterial at September 30, 2023 and December 31, 2022.
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v3.23.3
Commitments and Contingencies
|
9 Months Ended |
Sep. 30, 2023 |
Commitments and Contingencies Disclosure [Abstract] |
|
Commitments and Contingencies |
Note 10. Commitments and Contingencies Leases The Company has 25,445 square feet of office space on High Street in Boston, Massachusetts (“High Street Sublease”). The term of the High Street Sublease extends from April 1, 2021 through December 31, 2025 and provides for escalating annualized base rent payments starting at approximately $1.5 million and increasing to $1.6 million in the final year of the sublease. In April 2023, the Company entered into an agreement ("High Street Lease") to lease approximately 50,890 square feet of additional office space located at 99 High Street in Boston, Massachusetts. The Company took possession of the premises in June 2023. The initial term of the lease is ten years from the date alterations are substantially complete, estimated to occur no later than April 2024, with the option to renew for an additional five-year term. Annual base rent under the lease is approximately $3.5 million and is subject to annual increases in accordance with the terms of the lease agreement. Lease payments begin on the earlier of January 1, 2025 or nine months from the date alterations are substantially complete. The Company recognized a right-of-use ("ROU") asset and corresponding lease liability of approximately $11.7 million and $11.4 million, respectively, on its consolidated balance sheet as of June 8, 2023 upon commencement of the High Street Lease. The lease provides for a tenant improvement allowance of $9.2 million, which was recognized as a reduction in the ROU asset and lease liability recognized at commencement, as the Company is reasonably certain to incur reimbursable costs related to alterations equal to or exceeding this amount. The option to renew the lease for an additional five-year term was excluded from the determination of lease liabilities arising from obtaining the ROU assets, as it was not considered reasonably certain of being exercised at commencement. Upon signing of the High Street Lease, the Company was also required to pay the first full monthly installment of base rent of $0.3 million, which was included as an adjustment to the ROU asset recognized upon commencement of the lease. The agreement requires a security deposit of $2.0 million, which is in the form of a line of credit collateralized by a certificate of deposit with a six month maturity which will be continually reinvested for the duration of the lease term. This certificate of deposit has been recorded within "short-term investments, other" on the consolidated balance sheet as of September 30, 2023. The Company also has office space at 33 Arch Street in Boston, Massachusetts ("Arch Street Lease"), which expires in December 2023, as amended. The associated space is entirely subleased to third parties through the remainder of the current lease term ("Arch Street Subleases"). We additionally have office space in Carmel, Indiana. For each of the lease agreements entered into or modified, the Company identified certain non-lease components. Lease and non-lease components were combined into a single lease component. In addition, all identified leases were assessed as operating leases. As the Company’s leases do not provide an implicit rate, the Company used its incremental borrowing rate, which is the rate incurred to borrow on a collateralized basis over a term equal to the lease payments in a similar economic environment, in determining the present value of lease payments for each identified lease at the lease commencement date. The components of lease cost were as follows (dollar amounts in thousands):
|
|
|
|
|
|
|
|
|
|
|
Nine Months Ended September 30, |
|
|
|
2023 |
|
|
2022 |
|
Lease Cost |
|
|
|
|
|
|
Operating lease cost |
|
$ |
2,506 |
|
|
$ |
1,613 |
|
Short-term lease cost |
|
|
— |
|
|
|
— |
|
Sublease income |
|
|
(441 |
) |
|
|
(433 |
) |
Total lease cost |
|
$ |
2,065 |
|
|
$ |
1,180 |
|
|
|
|
|
|
|
|
Other Information |
|
|
|
|
|
|
Cash paid for amounts included in the measurement of lease liabilities |
|
$ |
2,154 |
|
|
$ |
1,908 |
|
Operating lease liabilities arising from obtaining right-of-use assets |
|
|
11,820 |
|
|
|
— |
|
Weighted-average remaining lease term |
|
9.05 years |
|
|
2.85 years |
|
Weighted-average discount rate |
|
|
10.44 |
% |
|
|
5.88 |
% |
The following is a maturity analysis of the remaining annual undiscounted cash flows of the operating lease liabilities and a reconciliation to present value of lease liabilities as of September 30, 2023 (in thousands):
|
|
|
|
|
Year ended: |
|
|
|
December 31, 2023 |
|
$ |
649 |
|
December 31, 2024 |
|
|
1,704 |
|
December 31, 2025 |
|
|
4,818 |
|
December 31, 2026 |
|
|
3,591 |
|
December 31, 2027 |
|
|
3,698 |
|
Thereafter |
|
|
29,188 |
|
Total future minimum lease payments |
|
|
43,648 |
|
Less lease incentive |
|
|
(9,184 |
) |
Less imputed interest |
|
|
(18,855 |
) |
Present value of lease liabilities |
|
$ |
15,609 |
|
Cash inflows related to the $9.2 million lease incentive under the High Street Lease are expected to be received in the years ended December 31, 2023 and 2024 and are expected to exceed cash outflows relating to our operating leases during those years. The annual undiscounted cash flows to be received from subleases is $0.2 million as of September 30, 2023. The Arch Street Lease and the Arch Street Subleases mature in December 2023 and will not be extended. Indemnification In the normal course of business, the Company enters into contracts and agreements that contain a variety of representations and warranties and provide for general indemnifications. The Company’s exposure under these agreements is unknown because it involves claims that may be made against the Company in the future but have not yet been made. To date, the Company has not paid any claims or been required to defend any action related to its indemnification obligations. However, the Company may incur charges in the future as a result of these indemnification obligations. Contingencies From time to time, the Company may have certain contingent liabilities that arise in the ordinary course of its business activities. The Company accrues a liability for such matters when it is probable that future expenditures will be made, and such expenditures can be reasonably estimated. Litigation The Company is not a party to any litigation and does not have contingency reserves established for any litigation liabilities as of September 30, 2023.
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v3.23.3
401(k) Savings Plan
|
9 Months Ended |
Sep. 30, 2023 |
Retirement Benefits [Abstract] |
|
401(k) Savings Plan |
Note 11. 401(k) Savings Plan The Company has a 401(k) retirement plan in which substantially all U.S. employees are eligible to participate. Eligible employees may elect to contribute up to the maximum limits, as set by the Internal Revenue Service, of their eligible compensation. The total contribution expense for the Company was $1.5 million and $0.7 million for the nine months ended September 30, 2023 and 2022, respectively.
|
X |
- DefinitionThe entire disclosure for an entity's employee compensation and benefit plans, including, but not limited to, postemployment and postretirement benefit plans, defined benefit pension plans, defined contribution plans, non-qualified and supplemental benefit plans, deferred compensation, share-based compensation, life insurance, severance, health care, unemployment and other benefit plans.
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v3.23.3
Summary of Significant Accounting Policies (Policies)
|
9 Months Ended |
Sep. 30, 2023 |
Accounting Policies [Abstract] |
|
Basis of Presentation |
Basis of Presentation The accompanying consolidated financial statements have been prepared in conformity with accounting principles generally accepted in the United States of America (“U.S. GAAP”). Any reference in these notes to applicable guidance is meant to refer to the authoritative U.S. GAAP as found in the Accounting Standards Codification (“ASC”) and Accounting Standards Updates (“ASUs”) of the Financial Accounting Standards Board (“FASB”). The consolidated financial statements include the accounts of Karuna Therapeutics, Inc. and its wholly owned subsidiary, Karuna Securities Corporation, a Massachusetts corporation. All inter-company transactions and balances have been eliminated in consolidation. The accompanying consolidated balance sheet as of September 30, 2023 and the consolidated statements of operations, comprehensive loss, and stockholders’ equity for the three and nine months ended September 30, 2023 and 2022, and the statements of cash flow for the nine months ended September 30, 2023 and 2022, are unaudited. The unaudited interim consolidated financial statements have been prepared on the same basis as the audited annual consolidated financial statements and, in the opinion of management, reflect all adjustments, which include only normal recurring adjustments, necessary for the fair statement of the Company’s financial position as of September 30, 2023 and the results of its operations for the three and nine months ended September 30, 2023 and 2022 and cash flows for the nine months ended September 30, 2023 and 2022. Certain information and footnote disclosures typically included in annual financial statements prepared in accordance with U.S. GAAP have been condensed or omitted. Accordingly, these unaudited consolidated interim financial statements should be read in conjunction with the Company’s consolidated financial statements as of and for the year ended December 31, 2022. The results for the three and nine months ended September 30, 2023 are not necessarily indicative of results to be expected for the year ending December 31, 2023, any other interim periods, or any future year or period.
|
Policy Regarding Acquired In-Process Research and Development (IPR&D) and Development Milestones |
Policy Regarding Acquired In-Process Research and Development (IPR&D) and Development Milestones Acquired IPR&D and development milestones include the initial costs of externally developed IPR&D projects, acquired directly in a transaction other than a business combination, that do not have an alternative future use. Prior to regulatory approval of the compound, initial costs are expensed when incurred, and milestone payment obligations related to these transactions are expensed when the event triggering an obligation to pay the milestone occurs. Milestone payments made upon or after regulatory approval are capitalized and amortized over the remaining useful life of the related asset.
|
Recently Issued Accounting Pronouncements |
Recently Issued Accounting Pronouncements New pronouncements issued but not effective until after September 30, 2023 are not expected to have a material impact on the Company’s consolidated financial statements.
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v3.23.3
Prepaid Expenses and Other Current Assets and Accrued Expenses (Tables)
|
9 Months Ended |
Sep. 30, 2023 |
Prepaid Expenses And Other Assets And Accrued Expenses [Abstract] |
|
Schedule of Prepaid Expenses and Other Current Assets |
Prepaid expenses consisted of the following (in thousands):
|
|
|
|
|
|
|
|
|
|
|
September 30, 2023 |
|
|
December 31, 2022 |
|
Research and development expenses |
|
$ |
8,881 |
|
|
$ |
25,285 |
|
Insurance |
|
|
2,581 |
|
|
|
2,472 |
|
Other |
|
|
1,414 |
|
|
|
1,349 |
|
Total prepaid expenses |
|
$ |
12,876 |
|
|
$ |
29,106 |
|
|
Schedule of Accrued Expenses |
Accrued expenses consisted of the following (in thousands):
|
|
|
|
|
|
|
|
|
|
|
September 30, 2023 |
|
|
December 31, 2022 |
|
Research and development expenses |
|
$ |
22,821 |
|
|
$ |
11,962 |
|
Payroll and related expenses |
|
|
14,717 |
|
|
|
11,950 |
|
Professional fees |
|
|
4,593 |
|
|
|
2,943 |
|
Other |
|
|
1,998 |
|
|
|
2,430 |
|
Total accrued expenses |
|
$ |
44,129 |
|
|
$ |
29,285 |
|
|
X |
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v3.23.3
Net Loss per Share (Tables)
|
9 Months Ended |
Sep. 30, 2023 |
Earnings Per Share [Abstract] |
|
Schedule of Computation of Basic and Diluted Net Loss Per Share of Common Stock |
The following table sets forth the computation of basic and diluted net loss per share of common stock for the three and nine months ended September 30, 2023 and 2022 (in thousands, except share and per share data):
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended September 30, |
|
|
Nine Months Ended September 30, |
|
|
|
2023 |
|
|
2022 |
|
|
2023 |
|
|
2022 |
|
Net Loss |
|
$ |
(119,119 |
) |
|
$ |
(76,963 |
) |
|
$ |
(319,856 |
) |
|
$ |
(200,124 |
) |
Weighted-average shares used in computing net loss per share |
|
|
37,689,144 |
|
|
|
32,349,111 |
|
|
|
36,682,056 |
|
|
|
30,693,117 |
|
Net loss per share, basic and diluted |
|
$ |
(3.16 |
) |
|
$ |
(2.38 |
) |
|
$ |
(8.72 |
) |
|
$ |
(6.52 |
) |
|
Schedule of Anti-Dilutive Securities Excluded from Calculation of Diluted Net Loss Per Share |
The following common stock equivalents, presented based on amounts outstanding at each period end, have been excluded from the calculation of diluted net loss per share:
|
|
|
|
|
|
|
|
|
|
|
September 30, |
|
|
|
2023 |
|
|
2022 |
|
Stock options to purchase common stock |
|
|
5,541,686 |
|
|
|
5,561,493 |
|
Restricted stock units |
|
|
314,854 |
|
|
|
— |
|
|
|
|
5,856,540 |
|
|
|
5,561,493 |
|
|
X |
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v3.23.3
Stock-based Compensation (Tables)
|
9 Months Ended |
Sep. 30, 2023 |
Share-Based Payment Arrangement [Abstract] |
|
Summary of Stock Option Activity |
A summary of the Company’s stock option activity and related information is as follows:
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Number of Shares |
|
|
Weighted- Average Exercise Price Per Share |
|
|
Weighted- Average Remaining Contractual Term (Years) |
|
|
Aggregate Intrinsic Value (in thousands) |
|
Outstanding as of December 31, 2022 |
|
|
5,570,355 |
|
|
$ |
63.82 |
|
|
|
7.2 |
|
|
$ |
744,097 |
|
Granted |
|
|
636,014 |
|
|
|
195.44 |
|
|
|
|
|
|
|
Exercised |
|
|
(394,163 |
) |
|
|
68.62 |
|
|
|
|
|
|
|
Forfeited |
|
|
(268,382 |
) |
|
|
142.72 |
|
|
|
|
|
|
|
Expired |
|
|
(2,138 |
) |
|
|
123.63 |
|
|
|
|
|
|
|
Outstanding as of September 30, 2023 |
|
|
5,541,686 |
|
|
$ |
74.74 |
|
|
|
6.5 |
|
|
$ |
546,440 |
|
Options vested and expected to vest as of September 30, 2023 |
|
|
5,541,686 |
|
|
$ |
74.74 |
|
|
|
6.5 |
|
|
$ |
546,440 |
|
Options exercisable as of September 30, 2023 |
|
|
3,892,864 |
|
|
$ |
41.37 |
|
|
|
5.6 |
|
|
$ |
497,659 |
|
|
Share-Based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity |
A summary of the Company’s restricted stock unit activity and related information is as follows:
|
|
|
|
|
|
|
|
|
|
|
Number of Shares |
|
|
Weighted- Average Grant Date Fair Value |
|
Unvested as of December 31, 2022 |
|
|
— |
|
|
$ |
— |
|
Granted |
|
|
330,267 |
|
|
|
195.46 |
|
Vested |
|
|
— |
|
|
|
— |
|
Forfeited |
|
|
(15,413 |
) |
|
|
189.49 |
|
Unvested as of September 30, 2023 |
|
|
314,854 |
|
|
$ |
195.75 |
|
|
Summary of Stock-based Compensation Expense |
Stock-based compensation expense is classified in the statements of operations for the three and nine months ended September 30, 2023 and 2022 as follows (in thousands):
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Three Months Ended September 30, |
|
|
Nine Months Ended September 30, |
|
|
|
2023 |
|
|
2022 |
|
|
2023 |
|
|
2022 |
|
Research and development |
|
$ |
10,880 |
|
|
$ |
5,431 |
|
|
$ |
29,955 |
|
|
$ |
15,140 |
|
General and administrative |
|
|
7,416 |
|
|
|
6,590 |
|
|
|
21,851 |
|
|
|
19,649 |
|
Total stock-based compensation expense |
|
$ |
18,296 |
|
|
$ |
12,021 |
|
|
$ |
51,806 |
|
|
$ |
34,789 |
|
|
X |
- DefinitionTabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.
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v3.23.3
Fair Value of Financial Assets and Liabilities (Tables)
|
9 Months Ended |
Sep. 30, 2023 |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Abstract] |
|
Schedule of Fair Value Measurement on Recurring Basis and Indicates the level of Fair Value Hierarchy Utilized |
The following tables present information about the Company’s assets as of September 30, 2023 and December 31, 2022 that are measured at fair value on a recurring basis and indicate the level of the fair value hierarchy utilized to determine such fair values (in thousands):
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Fair Value Measurement |
|
|
|
at September 30, 2023 Using |
|
|
|
Level 1 |
|
|
Level 2 |
|
|
Level 3 |
|
|
Total |
|
Cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
Money market fund |
|
$ |
135,160 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
135,160 |
|
Commercial paper |
|
|
— |
|
|
|
29,422 |
|
|
|
— |
|
|
|
29,422 |
|
Short-term investments, other: |
|
|
|
|
|
|
|
|
|
|
|
|
Certificate of deposit |
|
|
— |
|
|
|
2,033 |
|
|
|
— |
|
|
|
2,033 |
|
Investment securities: |
|
|
|
|
|
|
|
|
|
|
|
|
US Treasuries |
|
|
689,176 |
|
|
|
— |
|
|
|
— |
|
|
|
689,176 |
|
US government agencies |
|
|
202,646 |
|
|
|
— |
|
|
|
— |
|
|
|
202,646 |
|
Corporate debt securities |
|
|
— |
|
|
|
33,120 |
|
|
|
— |
|
|
|
33,120 |
|
Commercial paper |
|
|
— |
|
|
|
230,064 |
|
|
|
— |
|
|
|
230,064 |
|
Total |
|
$ |
1,026,982 |
|
|
$ |
294,639 |
|
|
$ |
— |
|
|
$ |
1,321,621 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Fair Value Measurement |
|
|
|
at December 31, 2022 Using |
|
|
|
Level 1 |
|
|
Level 2 |
|
|
Level 3 |
|
|
Total |
|
Cash equivalents: |
|
|
|
|
|
|
|
|
|
|
|
|
Money market fund |
|
$ |
160,158 |
|
|
$ |
— |
|
|
$ |
— |
|
|
$ |
160,158 |
|
Commercial paper |
|
|
— |
|
|
|
61,277 |
|
|
|
— |
|
|
|
61,277 |
|
Investment securities: |
|
|
|
|
|
|
|
|
|
|
|
|
US Treasuries |
|
|
423,688 |
|
|
|
— |
|
|
|
— |
|
|
|
423,688 |
|
US government agencies |
|
|
210,188 |
|
|
|
— |
|
|
|
— |
|
|
|
210,188 |
|
Corporate debt securities |
|
|
— |
|
|
|
63,728 |
|
|
|
— |
|
|
|
63,728 |
|
Commercial paper |
|
|
— |
|
|
|
178,111 |
|
|
|
— |
|
|
|
178,111 |
|
Total |
|
$ |
794,034 |
|
|
$ |
303,116 |
|
|
$ |
— |
|
|
$ |
1,097,150 |
|
|
Summary of Estimated Fair Value and Amortized Cost of Available-for-Sale Investments by Contractual Maturity |
The estimated fair value and amortized cost of the Company’s available-for-sale investments, by contractual maturity and security type, are summarized as follows (in thousands):
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
September 30, 2023 |
|
|
|
Amortized Cost |
|
|
Unrealized Gains |
|
|
Unrealized Losses |
|
|
Fair Value |
|
US Treasuries (due within one year) |
|
$ |
559,852 |
|
|
$ |
7 |
|
|
$ |
(1,193 |
) |
|
$ |
558,666 |
|
US Treasuries (due after one year and less than three years) |
|
|
131,249 |
|
|
|
2 |
|
|
|
(741 |
) |
|
|
130,510 |
|
US government agencies (due within one year) |
|
|
147,612 |
|
|
|
10 |
|
|
|
(296 |
) |
|
|
147,326 |
|
US government agencies (due after one year and less than three years) |
|
|
55,752 |
|
|
|
— |
|
|
|
(432 |
) |
|
|
55,320 |
|
Corporate debt securities (due within one year) |
|
|
30,361 |
|
|
|
— |
|
|
|
(138 |
) |
|
|
30,223 |
|
Corporate debt securities (due after one year and less than three years) |
|
|
2,948 |
|
|
|
— |
|
|
|
(51 |
) |
|
|
2,897 |
|
Commercial paper (due within one year) |
|
|
230,161 |
|
|
|
6 |
|
|
|
(103 |
) |
|
|
230,064 |
|
Total |
|
$ |
1,157,935 |
|
|
$ |
25 |
|
|
$ |
(2,954 |
) |
|
$ |
1,155,006 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
December 31, 2022 |
|
|
|
Amortized Cost |
|
|
Unrealized Gains |
|
|
Unrealized Losses |
|
|
Fair Value |
|
US Treasuries (due within one year) |
|
$ |
329,533 |
|
|
$ |
17 |
|
|
$ |
(2,044 |
) |
|
$ |
327,506 |
|
US Treasuries (due after one year and less than three years) |
|
|
96,802 |
|
|
|
— |
|
|
|
(620 |
) |
|
|
96,182 |
|
US government agencies (due within one year) |
|
|
178,319 |
|
|
|
54 |
|
|
|
(108 |
) |
|
|
178,265 |
|
US government agencies (due after one year and less than three years) |
|
|
32,104 |
|
|
|
— |
|
|
|
(181 |
) |
|
|
31,923 |
|
Corporate debt securities (due within one year) |
|
|
51,952 |
|
|
|
1 |
|
|
|
(170 |
) |
|
|
51,783 |
|
Corporate debt securities (due after one year and less than three years) |
|
|
11,983 |
|
|
|
— |
|
|
|
(38 |
) |
|
|
11,945 |
|
Commercial paper (due within one year) |
|
|
178,312 |
|
|
|
16 |
|
|
|
(217 |
) |
|
|
178,111 |
|
Total |
|
$ |
879,005 |
|
|
$ |
88 |
|
|
$ |
(3,378 |
) |
|
$ |
875,715 |
|
|
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v3.23.3
Commitments and Contingencies (Tables)
|
9 Months Ended |
Sep. 30, 2023 |
Commitments and Contingencies Disclosure [Abstract] |
|
Schedule of Components of Lease Cost |
The components of lease cost were as follows (dollar amounts in thousands):
|
|
|
|
|
|
|
|
|
|
|
Nine Months Ended September 30, |
|
|
|
2023 |
|
|
2022 |
|
Lease Cost |
|
|
|
|
|
|
Operating lease cost |
|
$ |
2,506 |
|
|
$ |
1,613 |
|
Short-term lease cost |
|
|
— |
|
|
|
— |
|
Sublease income |
|
|
(441 |
) |
|
|
(433 |
) |
Total lease cost |
|
$ |
2,065 |
|
|
$ |
1,180 |
|
|
|
|
|
|
|
|
Other Information |
|
|
|
|
|
|
Cash paid for amounts included in the measurement of lease liabilities |
|
$ |
2,154 |
|
|
$ |
1,908 |
|
Operating lease liabilities arising from obtaining right-of-use assets |
|
|
11,820 |
|
|
|
— |
|
Weighted-average remaining lease term |
|
9.05 years |
|
|
2.85 years |
|
Weighted-average discount rate |
|
|
10.44 |
% |
|
|
5.88 |
% |
|
Schedule of Maturity Analysis of Annual Undiscounted Cash Flows of Operating Lease Liabilities and Reconciliation to Present Value of Lease Liabilities |
The following is a maturity analysis of the remaining annual undiscounted cash flows of the operating lease liabilities and a reconciliation to present value of lease liabilities as of September 30, 2023 (in thousands):
|
|
|
|
|
Year ended: |
|
|
|
December 31, 2023 |
|
$ |
649 |
|
December 31, 2024 |
|
|
1,704 |
|
December 31, 2025 |
|
|
4,818 |
|
December 31, 2026 |
|
|
3,591 |
|
December 31, 2027 |
|
|
3,698 |
|
Thereafter |
|
|
29,188 |
|
Total future minimum lease payments |
|
|
43,648 |
|
Less lease incentive |
|
|
(9,184 |
) |
Less imputed interest |
|
|
(18,855 |
) |
Present value of lease liabilities |
|
$ |
15,609 |
|
|
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v3.23.3
Nature of the Business and Basis of Presentation - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands |
3 Months Ended |
6 Months Ended |
9 Months Ended |
|
Mar. 31, 2023 |
Sep. 30, 2022 |
Jun. 30, 2023 |
Sep. 30, 2023 |
Sep. 30, 2022 |
Dec. 31, 2022 |
Subsidiary Sale Of Stock [Line Items] |
|
|
|
|
|
|
Shares issued and sold |
2,851,299
|
|
|
|
|
|
Purchase of additional shares |
371,908
|
|
|
|
|
|
Proceeds from issuance of public offering |
$ 436,700
|
|
|
|
|
|
Underwriting discounts and commissions |
23,000
|
|
|
|
|
|
Stock issuance costs incurred |
$ 300
|
|
|
|
|
|
Cash flows from operating activities |
|
|
|
$ 274,760
|
$ 149,249
|
|
Accumulated deficit |
|
|
|
884,063
|
|
$ 564,207
|
Cash and cash equivalents and available-for-sale investments |
|
|
|
$ 1,339,500
|
|
|
Common Stock |
|
|
|
|
|
|
Subsidiary Sale Of Stock [Line Items] |
|
|
|
|
|
|
Shares issued and sold |
|
4,011,628
|
2,851,299
|
|
|
|
Initial Public Offering |
|
|
|
|
|
|
Subsidiary Sale Of Stock [Line Items] |
|
|
|
|
|
|
Public offering price pre share |
$ 161.33
|
|
|
|
|
|
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v3.23.3
Prepaid Expenses and Other Current Assets and Accrued Expenses - Schedule of Prepaid Expenses and Other Current Assets (Details) - USD ($) $ in Thousands |
Sep. 30, 2023 |
Dec. 31, 2022 |
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract] |
|
|
Research and development expenses |
$ 8,881
|
$ 25,285
|
Insurance |
2,581
|
2,472
|
Other |
1,414
|
1,349
|
Total prepaid expenses and other current assets |
$ 12,876
|
$ 29,106
|
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v3.23.3
Prepaid Expenses and Other Current Assets and Accrued Expenses - Schedule of Accrued Expenses (Details) - USD ($) $ in Thousands |
Sep. 30, 2023 |
Dec. 31, 2022 |
Payables and Accruals [Abstract] |
|
|
Research and development expenses |
$ 22,821
|
$ 11,962
|
Payroll and related expenses |
14,717
|
11,950
|
Professional fees |
4,593
|
2,943
|
Other |
1,998
|
2,430
|
Total accrued expenses |
$ 44,129
|
$ 29,285
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v3.23.3
Stockholders' Equity - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands |
9 Months Ended |
|
|
Sep. 30, 2023 |
Dec. 31, 2022 |
Jul. 02, 2019 |
Class Of Stock [Line Items] |
|
|
|
Preferred stock, shares authorized |
10,000,000
|
10,000,000
|
|
Preferred stock, par value |
$ 0.0001
|
$ 0.0001
|
|
Preferred stock, shares outstanding |
0
|
0
|
|
Common Stock, Shares, Outstanding |
37,719,367
|
34,473,905
|
|
Common stock, shares authorized |
150,000,000
|
150,000,000
|
|
Common stock, par value |
$ 0.0001
|
$ 0.0001
|
|
Dividends declared |
$ 0
|
|
|
Initial Public Offering |
|
|
|
Class Of Stock [Line Items] |
|
|
|
Preferred stock, shares authorized |
|
|
10,000,000
|
Preferred stock, par value |
|
|
$ 0.0001
|
Preferred Stock, Shares Issued |
0
|
|
|
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v3.23.3
Zai License Agreement (Additional Information) (Details) - USD ($)
|
|
3 Months Ended |
9 Months Ended |
12 Months Ended |
|
Nov. 08, 2021 |
Sep. 30, 2023 |
Sep. 30, 2022 |
Sep. 30, 2023 |
Sep. 30, 2022 |
Dec. 31, 2021 |
Dec. 31, 2022 |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |
|
|
|
|
|
|
|
License and other revenue |
|
$ 0
|
$ 81,000
|
$ 654,000
|
$ 5,359,000
|
|
|
Zai License Agreement [Member] |
|
|
|
|
|
|
|
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |
|
|
|
|
|
|
|
Upfront Payment for License Agreement |
$ 35,000,000
|
|
|
|
|
|
|
Development and Regulatory Milestone Payments Under License Agreement |
80,000,000
|
|
|
70,000,000
|
|
|
|
Other Revenue |
|
0
|
100,000
|
700,000
|
100,000
|
|
|
Sales Milestone Payments Under License Agreement |
72,000,000
|
|
|
|
|
|
|
Transaction Price of License Agreement |
37,000,000
|
|
|
|
|
|
|
Initial payment |
$ 35,000,000
|
|
|
|
|
|
|
License and other revenue |
|
|
|
|
5,300,000
|
|
|
Income tax provision Include Foreign Tax Expenses |
|
0
|
$ 0
|
0
|
0
|
|
|
Deferred revenue |
|
$ 0
|
|
$ 0
|
|
|
$ 0
|
Zai License Agreement [Member] | Intellectual Property License Agreement [Member] |
|
|
|
|
|
|
|
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |
|
|
|
|
|
|
|
License and other revenue |
|
|
|
|
|
$ 37,000,000
|
|
Zai License Agreement [Member] | General and Administrative Expense [Member] |
|
|
|
|
|
|
|
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |
|
|
|
|
|
|
|
Income tax provision Include Foreign Tax Expenses |
|
|
|
|
$ 500,000
|
|
|
X |
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v3.23.3
Net Loss Per Share - Schedule of Computation of Basic and Diluted Net Loss Per Share of Common Stock (Details) - USD ($) $ / shares in Units, $ in Thousands |
3 Months Ended |
6 Months Ended |
9 Months Ended |
Sep. 30, 2023 |
Sep. 30, 2022 |
Jun. 30, 2023 |
Jun. 30, 2022 |
Sep. 30, 2023 |
Sep. 30, 2022 |
Earnings Per Share [Abstract] |
|
|
|
|
|
|
Net Loss |
$ (119,119)
|
$ (76,963)
|
$ (200,737)
|
$ (123,161)
|
$ (319,856)
|
$ (200,124)
|
Weighted-average shares used in computing net loss per share, Basic |
37,689,144
|
32,349,111
|
|
|
36,682,056
|
30,693,117
|
Weighted-average shares used in computing net loss per share, Diluted |
37,689,144
|
32,349,111
|
|
|
36,682,056
|
30,693,117
|
Net loss per share, basic |
$ (3.16)
|
$ (2.38)
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|
|
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v3.23.3
Net Loss Per Share - Schedule of Diluted net loss per share (Details) - shares
|
9 Months Ended |
Sep. 30, 2023 |
Sep. 30, 2022 |
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] |
|
|
Anti-dilutive securities excluded from computation of earnings per share, amount |
5,856,540
|
5,561,493
|
Employee Stock Option |
|
|
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] |
|
|
Anti-dilutive securities excluded from computation of earnings per share, amount |
5,541,686
|
5,561,493
|
Restricted Stock Units (RSUs) [Member] |
|
|
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] |
|
|
Anti-dilutive securities excluded from computation of earnings per share, amount |
314,854
|
0
|
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v3.23.3
License Agreements (Additional Information) (Details)
|
1 Months Ended |
9 Months Ended |
|
Jan. 31, 2023
USD ($)
|
May 31, 2012
USD ($)
|
Mar. 31, 2011
USD ($)
|
Sep. 30, 2023
USD ($)
Milestone
|
Dec. 31, 2022
USD ($)
|
GFB Agreement [Member] |
|
|
|
|
|
Business Acquisition [Line Items] |
|
|
|
|
|
Upfront Payment for License Agreement |
$ 15,000,000
|
|
|
$ 15,000,000
|
|
Maximum future payments under license agreement |
520,000,000
|
|
|
|
|
Development Milestone Payments |
110,000,000
|
|
|
|
|
Regulatory Milestone Payments |
150,000,000
|
|
|
|
|
Commercial sales milestones |
$ 260,000,000
|
|
|
|
|
GFB Agreement [Member] | Minimum [Member] |
|
|
|
|
|
Business Acquisition [Line Items] |
|
|
|
|
|
Payments for royalties, percentage |
25.00%
|
|
|
|
|
GFB Agreement [Member] | Maximum [Member] |
|
|
|
|
|
Business Acquisition [Line Items] |
|
|
|
|
|
Payments for royalties, percentage |
35.00%
|
|
|
|
|
Intellectual Property License Agreement [Member] | Eli Lilly And Company [Member] |
|
|
|
|
|
Business Acquisition [Line Items] |
|
|
|
|
|
Upfront Payment for License Agreement |
|
$ 100,000
|
|
|
|
Royalty Expiration Term |
|
6 years
|
|
|
|
License Agreement Maximum Term |
|
|
|
15 years
|
|
Number Of Milestones Reached | Milestone |
|
|
|
0
|
|
Milestone Payment |
|
|
|
$ 0
|
|
Intellectual Property License Agreement [Member] | Eli Lilly And Company [Member] | Maximum [Member] |
|
|
|
|
|
Business Acquisition [Line Items] |
|
|
|
|
|
Contingent Milestone Payments Payable |
|
$ 16,000,000
|
|
|
|
Commercial Milestone Payments Payable |
|
$ 54,000,000
|
|
|
|
Patent License Agreement [Member] | Pure Tech Health [Member] |
|
|
|
|
|
Business Acquisition [Line Items] |
|
|
|
|
|
Contingent Milestone Payments Payable |
|
|
$ 10,000,000
|
|
|
Development and Regulatory Milestone Payments Under License Agreement |
|
|
|
8,000,000
|
|
Related Party Deposit Liabilities |
|
|
|
$ 0
|
$ 0
|
Patent License Agreement [Member] | Pure Tech Health [Member] | Minimum [Member] |
|
|
|
|
|
Business Acquisition [Line Items] |
|
|
|
|
|
Percentage Of Royalties Payable On Income From Sublicensee Excluding Royalties |
|
|
15.00%
|
|
|
Patent License Agreement [Member] | Pure Tech Health [Member] | Maximum [Member] |
|
|
|
|
|
Business Acquisition [Line Items] |
|
|
|
|
|
Percentage Of Royalties Payable On Income From Sublicensee Excluding Royalties |
|
|
25.00%
|
|
|
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v3.23.3
Stock-based Compensation - Additional Information (Details) - USD ($) $ / shares in Units, $ in Millions |
1 Months Ended |
9 Months Ended |
12 Months Ended |
|
May 30, 2019 |
Sep. 30, 2023 |
Sep. 30, 2022 |
Dec. 31, 2020 |
Dec. 31, 2022 |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
|
|
Number of shares outstanding |
|
5,541,686
|
|
|
5,570,355
|
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition |
|
2 years 9 months 18 days
|
|
|
|
Unrecognized compensation cost |
|
$ 132.2
|
|
|
|
Unrecognized compensation costs, weighted average recognition period |
|
2 years 9 months 18 days
|
|
|
|
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value |
|
$ 114.69
|
$ 70.59
|
|
|
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value |
|
$ 54.5
|
$ 84.0
|
|
|
Restricted Stock [Member] |
|
|
|
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
|
|
Number of shares outstanding |
|
314,854
|
|
|
0
|
Employee service share based compensation nonvested awards total compensation cost not yet recognized Restricted Stock Units Shares |
|
$ 53.6
|
|
|
|
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition |
|
3 years 4 months 24 days
|
|
|
|
Unrecognized compensation costs, weighted average recognition period |
|
3 years 4 months 24 days
|
|
|
|
2009 Plan |
|
|
|
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
|
|
Number of shares outstanding |
|
1,981,828
|
|
|
|
Share based compensation arrangement by share based payment award termination date |
|
Jul. 02, 2019
|
|
|
|
2019 Plan |
|
|
|
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
|
|
Aggregate common shares issuable |
|
2,661,308
|
|
|
|
Number of shares outstanding |
|
3,559,858
|
|
|
|
Common stock reserved for future issuance |
1,709,832
|
|
|
|
|
Automatic increase in stock issuance as percentage on outstanding stock |
|
|
|
4.00%
|
|
Stock option and incentive plan expiration month and year |
2029-05
|
|
|
|
|
Expiration period |
|
10 years
|
|
|
|
Vesting period |
|
4 years
|
|
|
|
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v3.23.3
Stock-based Compensation - Summary of Stock Option Activity (Details) $ / shares in Units, $ in Thousands |
9 Months Ended |
12 Months Ended |
Sep. 30, 2023
USD ($)
$ / shares
shares
|
Dec. 31, 2022
USD ($)
$ / shares
shares
|
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table] |
|
|
Number of Shares, Outstanding, beginning of period | shares |
5,570,355
|
|
Number of Shares, Granted | shares |
636,014
|
|
Number of Shares, Exercised | shares |
(394,163)
|
|
Number of Shares, Forfeited | shares |
(268,382)
|
|
Number of Shares,Expired | shares |
2,138
|
|
Number of Shares, Outstanding, end of period | shares |
5,541,686
|
5,570,355
|
Number of Shares, Options vested and expected to vest | shares |
5,541,686
|
|
Number of Shares, Options exercisable | shares |
3,892,864
|
|
Weighted-Average Exercise Price Per Share, Outstanding, beginning of period | $ / shares |
$ 63.82
|
|
Weighted-Average Exercise Price Per Share, Outstanding, Granted | $ / shares |
195.44
|
|
Weighted-Average Exercise Price Per Share, Outstanding, Exercised | $ / shares |
68.62
|
|
Weighted-Average Exercise Price Per Share, Outstanding, Forfeited | $ / shares |
142.72
|
|
Weighted-Average Exercise Price Per Share, Outstanding,Expired | $ / shares |
123.63
|
|
Weighted-Average Exercise Price Per Share, Outstanding, end of period | $ / shares |
74.74
|
$ 63.82
|
Weighted-Average Exercise Price Per Share, Options vested and expected to vest | $ / shares |
74.74
|
|
Weighted-Average Exercise Price Per Share, Options exercisable | $ / shares |
$ 41.37
|
|
Weighted-Average Remaining Contractual Term, Outstanding (Years) |
6 years 6 months
|
7 years 2 months 12 days
|
Weighted-Average Remaining Contractual Term, Options vested and expected to vest |
6 years 6 months
|
|
Weighted-Average Remaining Contractual Term, Options exercisable |
5 years 7 months 6 days
|
|
Aggregate Intrinsic Value, Outstanding | $ |
$ 546,440
|
$ 744,097
|
Aggregate Intrinsic Value, Options vested and expected to vest | $ |
546,440
|
|
Aggregate Intrinsic Value, Options exercisable | $ |
$ 497,659
|
|
Restricted Stock [Member] |
|
|
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table] |
|
|
Number of Shares, Outstanding, beginning of period | shares |
0
|
|
Number of Shares, Granted | shares |
330,267
|
|
Number of Shares, Forfeited | shares |
(15,413)
|
|
Number of Shares, Outstanding, end of period | shares |
314,854
|
0
|
Weighted-Average Exercise Price Per Share, Outstanding, beginning of period | $ / shares |
$ 0
|
|
Weighted-Average Exercise Price Per Share, Outstanding, Granted | $ / shares |
195.46
|
|
Weighted-Average Exercise Price Per Share, Outstanding, Forfeited | $ / shares |
189.49
|
|
Weighted-Average Exercise Price Per Share, Outstanding, end of period | $ / shares |
$ 195.75
|
$ 0
|
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Stock-based Compensation - Summary of Stock-based Compensation Expense (Details) - USD ($) $ in Thousands |
3 Months Ended |
9 Months Ended |
Sep. 30, 2023 |
Sep. 30, 2022 |
Sep. 30, 2023 |
Sep. 30, 2022 |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
|
Total stock based compensation expense |
$ 18,296
|
$ 12,021
|
$ 51,806
|
$ 34,789
|
General and Administrative |
|
|
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
|
Total stock based compensation expense |
7,416
|
6,590
|
21,851
|
19,649
|
Research and Development |
|
|
|
|
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
|
|
|
|
Total stock based compensation expense |
$ 10,880
|
$ 5,431
|
$ 29,955
|
$ 15,140
|
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v3.23.3
Fair Value of Financial Assets and Liabilities - Schedule of Fair Value Measurement on Recurring Basis and Indicates the level of Fair Value Hierarchy Utilized (Details) - Recurring - USD ($) $ in Thousands |
Sep. 30, 2023 |
Dec. 31, 2022 |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Total fair value assets |
$ 1,321,621
|
$ 1,097,150
|
Corporate Debt Securities |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Investment securities |
33,120
|
63,728
|
Money Market Funds |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Cash equivalents |
135,160
|
160,158
|
US Treasury Securities |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Investment securities |
689,176
|
423,688
|
Commercial Paper |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Cash equivalents |
230,064
|
61,277
|
Investment securities |
29,422
|
178,111
|
US Government Agencies |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Cash equivalents |
202,646
|
210,188
|
Certificate of deposit |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Certificate of deposit |
2,033
|
|
Fair Value, Inputs, Level 1 |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Total fair value assets |
1,026,982
|
794,034
|
Fair Value, Inputs, Level 1 | Corporate Debt Securities |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Investment securities |
0
|
0
|
Fair Value, Inputs, Level 1 | Money Market Funds |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Cash equivalents |
135,160
|
160,158
|
Fair Value, Inputs, Level 1 | US Treasury Securities |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Investment securities |
689,176
|
423,688
|
Fair Value, Inputs, Level 1 | Commercial Paper |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Cash equivalents |
0
|
0
|
Investment securities |
0
|
0
|
Fair Value, Inputs, Level 1 | US Government Agencies |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Cash equivalents |
202,646
|
210,188
|
Fair Value, Inputs, Level 1 | Certificate of deposit |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Certificate of deposit |
0
|
|
Fair Value, Inputs, Level 2 |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Total fair value assets |
294,639
|
303,116
|
Fair Value, Inputs, Level 2 | Corporate Debt Securities |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Investment securities |
33,120
|
63,728
|
Fair Value, Inputs, Level 2 | Money Market Funds |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Cash equivalents |
0
|
0
|
Fair Value, Inputs, Level 2 | US Treasury Securities |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Investment securities |
0
|
0
|
Fair Value, Inputs, Level 2 | Commercial Paper |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Cash equivalents |
230,064
|
61,277
|
Investment securities |
29,422
|
178,111
|
Fair Value, Inputs, Level 2 | US Government Agencies |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Cash equivalents |
0
|
0
|
Fair Value, Inputs, Level 2 | Certificate of deposit |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Certificate of deposit |
2,033
|
|
Fair Value, Inputs, Level 3 |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Total fair value assets |
0
|
0
|
Fair Value, Inputs, Level 3 | Corporate Debt Securities |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Investment securities |
0
|
0
|
Fair Value, Inputs, Level 3 | Money Market Funds |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Cash equivalents |
0
|
0
|
Fair Value, Inputs, Level 3 | US Treasury Securities |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Investment securities |
0
|
0
|
Fair Value, Inputs, Level 3 | Commercial Paper |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Cash equivalents |
0
|
0
|
Investment securities |
0
|
0
|
Fair Value, Inputs, Level 3 | US Government Agencies |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Cash equivalents |
0
|
$ 0
|
Fair Value, Inputs, Level 3 | Certificate of deposit |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Certificate of deposit |
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|
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v3.23.3
Fair Value of Financial Assets and Liabilities - Summary of Estimated Fair Value and Amortized Cost of Available-for-Sale Investments by Contractual Maturity (Details) - USD ($) $ in Thousands |
Sep. 30, 2023 |
Dec. 31, 2022 |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Amortized Cost |
$ 1,157,935
|
$ 879,005
|
Available For Sale Securities Accumulated Gross Unrealized Gains Before Tax |
25
|
88
|
Available For Sale Securities Accumulated Gross Unrealized Losses Before Tax |
(2,954)
|
(3,378)
|
Fair Value |
1,155,006
|
875,715
|
Corporate Debt Securities |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Due within in one year, Amortized cost |
30,361
|
51,952
|
Due within one year, Amortized cost, Unrealized gains |
0
|
1
|
Due within one year , Amortized cost, Unrealized losses |
(138)
|
(170)
|
Due in one year or less, Fair value |
30,223
|
51,783
|
Due after one year and less than two years, Amortized cost |
2,948
|
11,983
|
Due after one year and less than two years, Amortized cost, Unrealized gains |
0
|
0
|
Due after one year and less than two years, Amortized cost, Unrealized losses |
(51)
|
(38)
|
Due after one year and less than two years, Fair value |
2,897
|
11,945
|
US Treasury Securities |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Due after one year and less than two years, Amortized cost |
131,249
|
96,802
|
Due after one year and less than two years, Amortized cost, Unrealized losses |
(741)
|
(620)
|
Due after one year and less than two years, Fair value |
130,510
|
96,182
|
Due within in one year, Amortized cost |
559,852
|
329,533
|
Due within one year, Amortized cost, Unrealized gains |
7
|
17
|
Due within one year, Amortized cost, Unrealized losses |
(1,193)
|
(2,044)
|
Due in one year or less, Fair value |
558,666
|
327,506
|
Due after one year and less than two years, Amortized cost, Unrealized gains |
2
|
0
|
US Government Agencies |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Due within in one year, Amortized cost |
147,612
|
178,319
|
Due within one year, Amortized cost, Unrealized gains |
10
|
54
|
Due within one year, Amortized cost, Unrealized losses |
(296)
|
(108)
|
Due in one year or less, Fair value |
147,326
|
178,265
|
Due after one year and less than two years, Amortized cost |
55,752
|
32,104
|
Due after one year and less than two years, Amortized cost, Unrealized gains |
0
|
0
|
Due after one year and less than two years, Amortized cost, Unrealized losses |
(432)
|
(181)
|
Due after one year and less than two years, Fair value |
55,320
|
31,923
|
Commercial Paper |
|
|
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] |
|
|
Due within in one year, Amortized cost |
230,161
|
178,312
|
Due within one year, Amortized cost, Unrealized gains |
6
|
16
|
Due within one year , Amortized cost, Unrealized losses |
(103)
|
(217)
|
Due in one year or less, Fair value |
$ 230,064
|
$ 178,111
|
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v3.23.3
Commitments and Contingencies - Additional Information (Details)
|
1 Months Ended |
9 Months Ended |
|
|
Apr. 30, 2023
USD ($)
ft²
|
May 31, 2012
USD ($)
|
Mar. 31, 2011
USD ($)
|
Sep. 30, 2023
USD ($)
ft²
Milestone
|
Jun. 08, 2023
USD ($)
|
Dec. 31, 2022
USD ($)
|
Commitments And Contingencies [Line Items] |
|
|
|
|
|
|
Restricted cash, net of current portion |
|
|
|
$ 0
|
|
$ 261,000
|
Right-of-use lease assets - operating, net |
|
|
|
14,603,000
|
|
$ 4,674,000
|
Lease liability |
|
|
|
15,609,000
|
|
|
Contingency reserves for litigation |
|
|
|
$ 0
|
|
|
Intellectual Property License Agreement | Eli Lilly and Company |
|
|
|
|
|
|
Commitments And Contingencies [Line Items] |
|
|
|
|
|
|
Royalty expiration term |
|
6 years
|
|
|
|
|
Number of milestones reached | Milestone |
|
|
|
0
|
|
|
Milestone payments |
|
|
|
$ 0
|
|
|
License agreement term |
|
|
|
15 years
|
|
|
Patent License | PureTech Health |
|
|
|
|
|
|
Commitments And Contingencies [Line Items] |
|
|
|
|
|
|
Contingent milestone payments payable |
|
|
$ 10,000,000
|
|
|
|
Development and Regulatory Milestone Payments Under License Agreement |
|
|
|
$ 8,000,000
|
|
|
Maximum | Intellectual Property License Agreement | Eli Lilly and Company |
|
|
|
|
|
|
Commitments And Contingencies [Line Items] |
|
|
|
|
|
|
Contingent milestone payments payable |
|
$ 16,000,000
|
|
|
|
|
Commercial milestone payments payable |
|
$ 54,000,000
|
|
|
|
|
Maximum | Patent License | PureTech Health |
|
|
|
|
|
|
Commitments And Contingencies [Line Items] |
|
|
|
|
|
|
Percentage of royalties payable on income from sublicensee, excluding royalties |
|
|
25.00%
|
|
|
|
Minimum | Patent License | PureTech Health |
|
|
|
|
|
|
Commitments And Contingencies [Line Items] |
|
|
|
|
|
|
Percentage of royalties payable on income from sublicensee, excluding royalties |
|
|
15.00%
|
|
|
|
Boston, Massachusetts | High Street Lease Agreement [Member] |
|
|
|
|
|
|
Commitments And Contingencies [Line Items] |
|
|
|
|
|
|
Lease base rent |
$ 3,500,000
|
|
|
|
|
|
Base rent, first rent due date |
Jan. 01, 2025
|
|
|
|
|
|
Right-of-use lease assets - operating, net |
|
|
|
|
$ 11,700,000
|
|
Lease liability |
|
|
|
|
$ 11,400,000
|
|
Tenant Improvement Allowance |
$ 9,200,000
|
|
|
|
|
|
Monthly installment of base rental |
$ 300,000
|
|
|
|
|
|
Area of land | ft² |
50,890
|
|
|
|
|
|
Lease initial term |
10 years
|
|
|
|
|
|
Boston, Massachusetts | High Street Lease Agreement [Member] | Years Ended December 31, 2023 [Member] |
|
|
|
|
|
|
Commitments And Contingencies [Line Items] |
|
|
|
|
|
|
Lease incentive receivables |
|
|
|
9,200,000
|
|
|
Boston, Massachusetts | High Street Lease Agreement [Member] | Years Ended December 31, 2024 [Member] |
|
|
|
|
|
|
Commitments And Contingencies [Line Items] |
|
|
|
|
|
|
Lease incentive receivables |
|
|
|
9,200,000
|
|
|
The Arch Street Lease Agreement Member |
|
|
|
|
|
|
Commitments And Contingencies [Line Items] |
|
|
|
|
|
|
Annual undiscounted cash flows from Sublease |
|
|
|
200,000
|
|
|
Office Space | High Street Lease Agreement [Member] |
|
|
|
|
|
|
Commitments And Contingencies [Line Items] |
|
|
|
|
|
|
Security deposit |
|
|
|
$ 2,000,000
|
|
|
Office Space | Boston, Massachusetts |
|
|
|
|
|
|
Commitments And Contingencies [Line Items] |
|
|
|
|
|
|
Sublease area of office space | ft² |
|
|
|
25,445
|
|
|
Sublease commencement date |
|
|
|
Apr. 01, 2021
|
|
|
Sublease expiring date |
|
|
|
Dec. 31, 2025
|
|
|
Annualized Base Rent Payments |
|
|
|
$ 1,500,000
|
|
|
Final year of the sublease. |
|
|
|
$ 1,600,000
|
|
|
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v3.23.3
Commitments and Contingencies - Components of Lease Cost (Details) - USD ($) $ in Thousands |
3 Months Ended |
9 Months Ended |
Sep. 30, 2023 |
Sep. 30, 2022 |
Sep. 30, 2023 |
Sep. 30, 2022 |
Lease Cost |
|
|
|
|
Operating lease cost |
|
|
$ 2,506
|
$ 1,613
|
Short-term lease cost |
|
|
0
|
0
|
Sublease income |
$ (147)
|
$ (147)
|
(441)
|
(433)
|
Total lease cost |
|
|
2,065
|
1,180
|
Cash paid for amounts included in the measurement of lease liabilities |
|
|
2,154
|
1,908
|
Operating lease liabilities arising from obtaining right-of-use assets |
|
|
$ 11,820
|
$ 0
|
Weighted-average remaining lease term |
9 years 18 days
|
2 years 10 months 6 days
|
9 years 18 days
|
2 years 10 months 6 days
|
Weighted-average discount rate |
10.44%
|
5.88%
|
10.44%
|
5.88%
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v3.23.3
Commitments and Contingencies - Schedule of Maturity Analysis of Annual Undiscounted Cash Flows of Operating Lease Liabilities and Reconciliation to Present Value of Lease Liabilities (Details) $ in Thousands |
Sep. 30, 2023
USD ($)
|
Commitments and Contingencies Disclosure [Abstract] |
|
December 31, 2023 |
$ 649
|
December 31, 2024 |
1,704
|
December 31, 2025 |
4,818
|
December 31, 2026 |
3,591
|
December 31, 2027 |
3,698
|
Thereafter |
29,188
|
Total future minimum lease payments |
43,648
|
Less Lease Incentive |
(9,184)
|
Less imputed interest |
(18,855)
|
Present value of lease liabilities |
$ 15,609
|
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