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| Holder | Type | Held (Actual) | % of Outstanding | Market Value | Date Reported |
|---|---|---|---|---|---|
| FMR LLC | Institution | 8,757,571 | 6.88% | US$ 238.73M | 2026-06-10 |
| RA Capital Management, L.P. | Institution | 7,744,621 | 6.08% | US$ 211.12M | 2026-06-10 |
| RA Capital Healthcare Fund, L.P. | Institution | 6,556,740 | 5.15% | US$ 178.74M | 2026-06-10 |
| ARCH Venture Fund XII, L.P. | Institution | 6,412,780 | 5.04% | US$ 174.81M | 2026-06-10 |
| venBio LLC | Institution | 5,166,697 | 4.06% | US$ 140.84M | 2026-06-10 |
| GV Management Company, LLC | Institution | 4,833,248 | 3.80% | US$ 131.75M | 2026-06-10 |
| GV 2017, L.P. | Institution | 4,833,248 | 3.80% | US$ 131.75M | 2026-06-10 |
| Mwg Management Ltd. | Institution | 4,574,328 | 3.59% | US$ 124.70M | 2026-06-10 |
| Cormorant Asset Management, LP | Institution | 4,365,612 | 3.43% | US$ 119.01M | 2026-06-10 |
| Nextech Invest Ltd. | Institution | 4,163,176 | 3.27% | US$ 113.49M | 2026-06-10 |
| Nextech VII Oncology SCSp | Institution | 4,163,176 | 3.27% | US$ 113.49M | 2026-06-10 |
| venBio Global Strategic Fund III, L.P. | Institution | 3,058,416 | 2.40% | US$ 83.37M | 2026-06-10 |
| venBio Fund III SPV I, L.P.; | Institution | 2,108,281 | 1.66% | US$ 57.47M | 2026-06-10 |
| Cormorant Private Healthcare Fund Vi, Lp | Institution | 1,274,519 | 1.00% | US$ 34.74M | 2026-06-10 |
| RA Capital Nexus Fund III, L.P. | Institution | 1,187,881 | 0.93% | US$ 32.38M | 2026-06-10 |
| Cormorant Global Healthcare Master Fund, LP | Institution | 925,607 | 0.73% | US$ 25.23M | 2026-06-10 |
| Cormorant Private Healthcare Fund IV LP | Institution | 907,003 | 0.71% | US$ 24.72M | 2026-06-10 |
| Cormorant Private Healthcare Fund III LP | Institution | 772,906 | 0.61% | US$ 21.07M | 2026-06-10 |
| Cormorant Private Healthcare Fund V LP | Institution | 485,577 | 0.38% | US$ 13.24M | 2026-06-10 |
| Mr. Edward Fitzgerald | Insider | 14,688 | 0.01% | US$ 400.39k | 2026-06-10 |
| Mr. Alexis Borisy | Insider | 0 | 0.00% | - | 2026-06-10 |
| Dr. Richard Klausner | Insider | 0 | 0.00% | - | 2026-06-10 |
| Dr. Mathai Mammen | Insider | 0 | 0.00% | - | 2026-06-10 |
| Dr. Barbara Weber | Insider | 0 | 0.00% | - | 2026-06-10 |
| Dr. Rohin Mhatre | Insider | 0 | 0.00% | - | 2026-06-10 |
| Ms. Teresa Jurgensen | Insider | 0 | 0.00% | - | 2026-06-10 |
| Mr. Thomas Kotarakos | Insider | 0 | 0.00% | - | 2026-06-10 |
| Dr. Mohammed Benzaghou | Insider | 0 | 0.00% | - | 2026-06-10 |
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