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| Holder | Type | Held (Actual) | % of Outstanding | Market Value | Date Reported |
|---|---|---|---|---|---|
| OrbiMed Advisors LLC | Institution | 19,404,757 | 19.57% | US$ 95.28M | 2026-04-24 |
| OrbiMed Private Investments VI, LP | Institution | 17,405,831 | 17.55% | US$ 85.46M | 2026-04-24 |
| Baker Bros. Advisors LP | Institution | 17,293,897 | 17.44% | US$ 84.91M | 2026-04-21 |
| Baker Brothers Life Sciences, L.P. | Institution | 15,787,178 | 15.92% | US$ 77.52M | 2026-04-21 |
| RA Capital Management, L.P. | Institution | 6,475,882 | 6.53% | US$ 31.80M | 2026-04-27 |
| RA Capital Healthcare Fund, L.P. | Institution | 6,475,882 | 6.53% | US$ 31.80M | 2026-04-27 |
| Kynam Capital Management, LP | Institution | 1,592,551 | 1.61% | US$ 7.82M | 2026-03-31 |
| 667, L.P. | Institution | 1,501,531 | 1.51% | US$ 7.37M | 2026-04-21 |
| Vanguard Capital Management, LLC | Institution | 1,230,406 | 1.24% | US$ 6.04M | 2026-03-31 |
| OrbiMed Genesis Master Fund, L.P. | Institution | 1,126,126 | 1.14% | US$ 5.53M | 2026-04-24 |
| EcoR1 Capital, LLC | Institution | 947,049 | 0.95% | US$ 4.65M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 923,626 | 0.93% | US$ 4.54M | 2026-03-31 |
| Sphera Funds Management Ltd | Institution | 558,339 | 0.56% | US$ 2.74M | 2026-03-31 |
| Blue Sky Trust | Institution | 551,776 | 0.56% | US$ 2.71M | 2025-12-31 |
| OrbiMed Partners Master Fund Limited | Institution | 526,300 | 0.53% | US$ 2.58M | 2026-04-24 |
| Acadian Asset Management LLC | Institution | 511,519 | 0.52% | US$ 2.51M | 2026-03-31 |
| Dr. Paul Friedman | Insider | 500,098 | 0.50% | US$ 2.46M | 2025-03-31 |
| Dr. Andrew Combs | Insider | 480,123 | 0.48% | US$ 2.36M | 2025-03-31 |
| Millennium Management LLC | Institution | 382,737 | 0.39% | US$ 1.88M | 2026-03-31 |
| Marshall Wace LLP | Institution | 358,906 | 0.36% | US$ 1.76M | 2026-03-31 |
| Morgan Stanley | Institution | 322,161 | 0.32% | US$ 1.58M | 2026-03-31 |
| BlackRock, Inc. | Institution | 321,886 | 0.32% | US$ 1.58M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 302,458 | 0.30% | US$ 1.49M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 275,200 | 0.28% | US$ 1.35M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 267,788 | 0.27% | US$ 1.31M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 236,469 | 0.24% | US$ 1.16M | 2026-03-31 |
| SEI Investments Company | Institution | 213,586 | 0.22% | US$ 1.05M | 2026-05-31 |
| Jane Street Group, LLC | Institution | 192,963 | 0.19% | US$ 947.45k | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 157,380 | 0.16% | US$ 772.74k | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 152,825 | 0.15% | US$ 750.37k | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 138,231 | 0.14% | US$ 678.71k | 2026-03-31 |
| Citadel Advisors LLC | Institution | 124,378 | 0.13% | US$ 610.70k | 2026-03-31 |
| Connor, Clark & Lunn Investment Management Ltd. | Institution | 109,085 | 0.11% | US$ 535.61k | 2026-03-31 |
| Mr. Sean Brusky | Insider | 100,000 | 0.10% | US$ 491.00k | 2026-03-05 |
| UBS Asset Management AG | Institution | 64,505 | 0.07% | US$ 316.72k | 2026-03-31 |
| Hudson River Trading LLC | Institution | 58,699 | 0.06% | US$ 288.21k | 2026-03-31 |
| XTX Markets Limited | Institution | 57,190 | 0.06% | US$ 280.80k | 2026-03-31 |
| Bank of America Corporation | Institution | 56,525 | 0.06% | US$ 277.54k | 2026-03-31 |
| Bridgeway Capital Management, LLC | Institution | 53,500 | 0.05% | US$ 262.69k | 2026-03-31 |
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