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| Holder | Type | Held (Actual) | % of Outstanding | Market Value | Date Reported |
|---|---|---|---|---|---|
| FMR LLC | Institution | 15,379,377 | 13.93% | US$ 292.05M | 2026-03-31 |
| BlackRock, Inc. | Institution | 7,831,475 | 7.09% | US$ 148.72M | 2026-03-31 |
| Bellevue Asset Management AG | Institution | 6,726,144 | 6.09% | US$ 127.73M | 2026-03-31 |
| Paradigm Biocapital Advisors LP | Institution | 5,633,788 | 5.10% | US$ 106.99M | 2026-06-18 |
| Deep Track Capital, LP | Institution | 5,417,660 | 4.91% | US$ 102.88M | 2026-05-01 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 5,417,660 | 4.91% | US$ 102.88M | 2026-05-01 |
| Fairmount Funds Management LLC | Institution | 5,090,928 | 4.61% | US$ 96.68M | 2026-05-11 |
| Fairmount Healthcare Fund II L.P. | Institution | 5,090,928 | 4.61% | US$ 96.68M | 2026-05-11 |
| Paradigm BioCapital International Fund Ltd. | Institution | 4,942,532 | 4.48% | US$ 93.86M | 2026-06-18 |
| State Street Global Advisors, Inc. | Institution | 4,672,885 | 4.23% | US$ 88.74M | 2026-03-31 |
| Commodore Capital Master LP | Institution | 4,300,000 | 3.89% | US$ 81.66M | 2025-04-04 |
| Vanguard Capital Management, LLC | Institution | 4,167,201 | 3.77% | US$ 79.14M | 2026-03-31 |
| VR Management, LLC | Institution | 3,882,709 | 3.52% | US$ 73.73M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 3,206,035 | 2.90% | US$ 60.88M | 2026-03-31 |
| Wellington Management Group LLP | Institution | 3,078,554 | 2.79% | US$ 58.46M | 2026-03-31 |
| Kynam Capital Management, LP | Institution | 2,341,652 | 2.12% | US$ 44.47M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 2,333,213 | 2.11% | US$ 44.31M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 2,318,234 | 2.10% | US$ 44.02M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 2,315,957 | 2.10% | US$ 43.98M | 2026-03-31 |
| Novo Holdings A/S | Institution | 2,000,000 | 1.81% | US$ 37.98M | 2026-03-31 |
| Baker Bros. Advisors LP | Institution | 1,971,678 | 1.79% | US$ 37.44M | 2026-03-31 |
| Tang Capital Management, LLC | Institution | 1,792,626 | 1.62% | US$ 34.04M | 2026-03-31 |
| Fisher Asset Management, LLC | Institution | 1,768,295 | 1.60% | US$ 33.58M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 1,641,477 | 1.49% | US$ 31.17M | 2026-03-31 |
| Avoro Capital Advisors LLC | Institution | 1,500,000 | 1.36% | US$ 28.49M | 2026-03-31 |
| AllianceBernstein L.P. | Institution | 1,392,072 | 1.26% | US$ 26.44M | 2026-03-31 |
| D. E. Shaw & Co., L.P. | Institution | 1,262,540 | 1.14% | US$ 23.98M | 2026-03-31 |
| UBS Asset Management AG | Institution | 1,195,432 | 1.08% | US$ 22.70M | 2026-03-31 |
| Perceptive Advisors LLC | Institution | 1,170,829 | 1.06% | US$ 22.23M | 2026-03-31 |
| Bank of America Corporation | Institution | 1,134,710 | 1.03% | US$ 21.55M | 2026-03-31 |
| Deutsche Asset & Wealth Management | Institution | 1,032,316 | 0.93% | US$ 19.60M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 1,027,303 | 0.93% | US$ 19.51M | 2026-03-31 |
| JP Morgan Asset Management | Institution | 1,011,456 | 0.92% | US$ 19.21M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 970,018 | 0.88% | US$ 18.42M | 2026-03-31 |
| Loomis, Sayles & Company, L.P. | Institution | 927,717 | 0.84% | US$ 17.62M | 2026-03-31 |
| First Turn Management, LLC | Institution | 911,337 | 0.83% | US$ 17.31M | 2026-03-31 |
| Rice Hall James & Associates, LLC | Institution | 898,611 | 0.81% | US$ 17.06M | 2026-03-31 |
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