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| Holder | Type | Held (Actual) | % of Outstanding | Market Value | Date Reported |
|---|---|---|---|---|---|
| Morgan Stanley Investment Management Inc. | Institution | 9,442,785 | 10.01% | US$ 36.64M | 2026-03-31 |
| Empery Asset Management, LP | Institution | 8,944,118 | 9.48% | US$ 34.70M | 2026-03-31 |
| FMR LLC | Institution | 8,103,400 | 8.59% | US$ 31.44M | 2026-03-31 |
| Bain Capital Life Sciences Investors, LLC | Institution | 7,967,454 | 8.45% | US$ 30.91M | 2026-03-31 |
| Perceptive Advisors LLC | Institution | 6,737,648 | 7.14% | US$ 26.14M | 2026-03-31 |
| Perceptive Life Sciences Master Fund, Ltd. | Institution | 6,737,648 | 7.14% | US$ 26.14M | 2026-03-31 |
| Saturn V Capital Management LP | Institution | 6,456,646 | 6.85% | US$ 25.05M | 2026-03-31 |
| Deep Track Capital, LP | Institution | 6,339,535 | 6.72% | US$ 24.60M | 2026-03-31 |
| Kalehua Capital Management LLC | Institution | 3,722,840 | 3.95% | US$ 14.44M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 3,497,612 | 3.71% | US$ 13.57M | 2026-03-31 |
| Braidwell LP | Institution | 3,272,954 | 3.47% | US$ 12.70M | 2026-03-31 |
| NEA 18 Venture Growth Equity, L.P. | Institution | 3,233,744 | 3.43% | US$ 12.55M | 2025-10-27 |
| New Enterprise Associates, Inc. | Institution | 3,233,743 | 3.43% | US$ 12.55M | 2026-03-31 |
| Rosalind Advisors, Inc. | Institution | 3,214,766 | 3.41% | US$ 12.47M | 2026-03-31 |
| Blackstone Alternative Asset Management L.P. | Institution | 2,681,922 | 2.84% | US$ 10.41M | 2026-03-31 |
| Trails Edge Capital Partners, LP | Institution | 2,571,478 | 2.73% | US$ 9.98M | 2026-03-31 |
| Nantahala Capital Management, LLC | Institution | 2,449,468 | 2.60% | US$ 9.50M | 2026-03-31 |
| BVF Partners L.P. | Institution | 2,233,742 | 2.37% | US$ 8.67M | 2026-03-31 |
| Samsara BioCapital LLC | Institution | 1,832,566 | 1.94% | US$ 7.11M | 2026-03-31 |
| BlackRock, Inc. | Institution | 1,211,794 | 1.28% | US$ 4.70M | 2026-03-31 |
| Millennium Management LLC | Institution | 1,210,514 | 1.28% | US$ 4.70M | 2026-03-31 |
| Biotechnology Value Fund L.P. | Institution | 1,158,732 | 1.23% | US$ 4.50M | 2025-08-20 |
| Woodline Partners LP | Institution | 1,001,095 | 1.06% | US$ 3.88M | 2026-03-31 |
| Coastlands Capital LP | Institution | 999,709 | 1.06% | US$ 3.88M | 2026-03-01 |
| Susquehanna International Group, LLP | Institution | 958,821 | 1.02% | US$ 3.72M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 939,726 | 1.00% | US$ 3.65M | 2026-03-31 |
| Biotechnology Value Fund II, L.P. | Institution | 906,855 | 0.96% | US$ 3.52M | 2025-08-20 |
| The Goldman Sachs Group, Inc. | Institution | 882,134 | 0.94% | US$ 3.42M | 2026-03-31 |
| StemPoint Capital LP | Institution | 850,742 | 0.90% | US$ 3.30M | 2026-03-31 |
| Bain Capital Life Sciences Fund II, L.P. | Institution | 607,832 | 0.64% | US$ 2.36M | 2025-12-31 |
| Vanguard Fiduciary Trust Company | Institution | 480,733 | 0.51% | US$ 1.87M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 403,534 | 0.43% | US$ 1.57M | 2026-03-31 |
| Marshall Wace LLP | Institution | 336,834 | 0.36% | US$ 1.31M | 2026-03-31 |
| Stonepine Capital Management LLC | Institution | 335,309 | 0.36% | US$ 1.30M | 2026-03-31 |
| VR Management, LLC | Institution | 330,525 | 0.35% | US$ 1.28M | 2026-03-31 |
| UBS Asset Management AG | Institution | 267,340 | 0.28% | US$ 1.04M | 2026-03-31 |
| Acorn Bioventures | Institution | 234,039 | 0.25% | US$ 908.07k | 2026-03-31 |
| Qube Research & Technologies Ltd | Institution | 218,954 | 0.23% | US$ 849.54k | 2026-03-31 |
| Northern Trust Global Investments | Institution | 178,235 | 0.19% | US$ 691.55k | 2026-03-31 |
| Mr. David Kirske | Insider | 176,293 | 0.19% | US$ 684.02k | 2026-05-12 |
| Pale Fire Capital SE | Institution | 167,590 | 0.18% | US$ 650.25k | 2026-03-31 |
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