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| Holder | Type | Held (Actual) | % of Outstanding | Market Value | Date Reported |
|---|---|---|---|---|---|
| T. Rowe Price Group, Inc. | Institution | 7,981,978 | 12.15% | US$ 214.48M | 2026-03-31 |
| RA Capital Management, L.P. | Institution | 7,255,993 | 11.04% | US$ 194.97M | 2026-03-31 |
| Vestal Point Capital, LP | Institution | 5,425,000 | 8.26% | US$ 145.77M | 2026-03-31 |
| Invus Public Equities, L.P. | Institution | 5,216,969 | 7.94% | US$ 140.18M | 2026-04-15 |
| Artal Group S.A. | Institution | 5,216,969 | 7.94% | US$ 140.18M | 2026-04-15 |
| RA Capital Healthcare Fund, L.P. | Institution | 4,603,418 | 7.01% | US$ 123.69M | 2026-02-26 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 4,062,500 | 6.18% | US$ 109.16M | 2026-03-31 |
| Deep Track Capital, LP | Institution | 4,062,500 | 6.18% | US$ 109.16M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 3,339,218 | 5.08% | US$ 89.72M | 2026-03-31 |
| Red Tree Venture Capital | Institution | 3,170,509 | 4.83% | US$ 85.19M | 2026-03-31 |
| TPG Capital, L.P. | Institution | 3,010,425 | 4.58% | US$ 80.89M | 2026-03-31 |
| RA Capital Nexus Fund III, L.P. | Institution | 2,652,575 | 4.04% | US$ 71.27M | 2026-02-26 |
| Omega Fund Management, LLC | Institution | 2,392,150 | 3.64% | US$ 64.28M | 2026-03-31 |
| RP Management, LLC | Institution | 2,388,150 | 3.63% | US$ 64.17M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 1,659,342 | 2.53% | US$ 44.59M | 2026-03-31 |
| Jones Hill Capital LP | Institution | 1,260,136 | 1.92% | US$ 33.86M | 2026-03-31 |
| Impresa Management LLC | Institution | 1,022,389 | 1.56% | US$ 27.47M | 2026-03-31 |
| OrbiMed Advisors LLC | Institution | 667,300 | 1.02% | US$ 17.93M | 2026-03-31 |
| Acorn Bioventures | Institution | 643,382 | 0.98% | US$ 17.29M | 2026-03-31 |
| Aisling Capital Management LP | Institution | 568,919 | 0.87% | US$ 15.29M | 2026-03-31 |
| Palo Alto Investors LP | Institution | 550,408 | 0.84% | US$ 14.79M | 2026-03-31 |
| Rock Springs Capital Management LP | Institution | 489,095 | 0.74% | US$ 13.14M | 2026-03-31 |
| Nan Fung Trinity (HK) Limited | Institution | 427,885 | 0.65% | US$ 11.50M | 2026-03-31 |
| Dafna Capital Management, LLC | Institution | 421,733 | 0.64% | US$ 11.33M | 2026-03-31 |
| Algert Global LLC | Institution | 330,833 | 0.50% | US$ 8.89M | 2026-03-31 |
| ClearBridge Investments, LLC | Institution | 289,221 | 0.44% | US$ 7.77M | 2026-03-31 |
| D. E. Shaw & Co., L.P. | Institution | 276,943 | 0.42% | US$ 7.44M | 2026-03-31 |
| Candriam, Société En Commandite Par Actions | Institution | 238,822 | 0.36% | US$ 6.42M | 2026-03-31 |
| Hudson Bay Capital Management LP | Institution | 233,703 | 0.36% | US$ 6.28M | 2026-03-31 |
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