Bruker AXS SMART(TM) X2S Automated Chemical Crystallography System Wins Prestigious R&D 100 AwardBruker AXS SMART(TM) X2S Automa
July 23 2008 - 8:21AM
Business Wire
Bruker AXS today announced that its SMART X2S automated chemical
X-ray crystallography system has been awarded a R&D 100 award,
recognizing it as one of the 100 most technologically significant
products introduced in the past year. The R&D 100 Award winners
are selected by an independent panel of judges and the editors of
R&D Magazine. �The winning of an R&D 100 Award provides a
mark of excellence known to industry, government, and academia as
proof that the product is one of the most innovative ideas of the
year,� explained Martha Walz, R&D Magazine Editor-in-Chief.
Traditional X-ray systems for 3D molecular structure determination
are floor-standing, require significant infrastructure and
typically are installed in specialist crystallography centers.
While molecular structure information is of tremendous benefit for
chemists, the need for trained crystallographers has made access to
structural information unavailable for many chemists. Often they
need to send samples away to an off-site crystallography service
laboratory and wait days for the results, or they simply forego
structural confirmation at certain stages of research. The SMART
X2S for the first time allows inorganic and organic chemists to
produce atomic resolution, 3D molecular structures in their own
laboratories quickly and easily at the touch of a button. The SMART
X2S takes small molecule structure determination to the next level
of convenience by automating the previously difficult aspects of
X-ray structure determination, from sample loading and alignment
through data collection all the way to the mathematical structure
solution, structure verification and report generation. With its
small footprint, a weight of less than�150 kg and a requirement of
only 0.5 kW of standard single-phase AC power, the benchtop SMART
X2S can be installed easily in any academic or industrial chemistry
laboratory. The system is air cooled and easily moveable. The
Analytical and Biological Chemistry Research Facility (ABCRF) at
University College Cork (UCC) in Ireland, home to almost 100
researchers at UCC�s Chemistry-Biology interface working on areas
such as drug discovery, process development, synthetic chemistry,
bioanalytical sciences etc., is looking forward to the arrival of
the Bruker SMART X2S, adding significant new capability in the
characterisation of the solid state structure of pharmaceutical
materials. As the ABCRF is uniquely situated at the heart of a
major cluster of pharmaceutical companies focused on the
development and manufacture of pharmaceutical API's and drug
product, extensive interaction and collaboration exists with many
of these companies. Four research teams within the ABCRF are
members of a national Solid State Pharmaceuticals Strategic
Research Cluster, funded by Science Foundation Ireland, linking
five universities and ten pharmaceutical companies in Ireland in a
major research programme focused on development of a fundamental
understanding of crystallisation of pharmaceuticals and learning
how this process can be controlled to lead to materials with the
desired solid state properties to act as effective therapeutic
agents. Prof. Anita Maguire, Director of the ABCRF, highlighted the
strategic opportunity presented by securing the new SMART X2S
system, which will enable hands-on routine access to X-ray
crystallography to a large and diverse team of researchers focused
on synthetic inorganic, organic, medicinal and pharmaceutical
chemistry, thereby enabling them to secure structural data on their
compounds much more rapidly than would be possible through a
traditional service provided by a dedicated X-ray crystallographer.
This high throughput approach will provide the opportunity to study
the physical properties of a very wide range of organic materials
synthesised in the ABCRF. From the perspective of the researchers,
this will ensure that PhD graduates in synthetic chemistry will
gain hands-on experience in X-ray crystallography which would not
have been possible without this walk-up desktop instrument,
providing them with a very valuable skill and insight which will
underpin their future careers in the pharmaceutical sectors. One of
the key attractions of this instrument is that it will enhance our
research collaborations with the pharmaceutical industry as the
area of crystallisation is a very high priority in the sector. Dr.
Simon Lawrence, X-ray crystallography in UCC, stated that with the
new SMART X2S instrument X-ray crystallography enters the hands-on
analytical realm already well established in relation to NMR and
LC-MS, and therefore becomes much more accessible to the wider
chemical community of researchers than heretofore. For the first
time, the SMART X2S allows undergraduate students hands-on access
to X-ray crystallography, thereby demystifying this technique and
bringing it to the fore as a key analytical tool. Dr. Michael Ruf,
Director of Marketing for Chemical Crystallography and Development
Manager for the SMART X2S stated: "Winning the R&D 100 award is
a tremendous recognition for our development team. The SMART X2S
departs from traditional crystallographic instrumentation with the
integration of innovative robotics, X-ray detector, source and
software development. This instrument will add x-ray
crystallography to the collection of standard research tools for
synthetic chemists.� Since its introduction at Pittcon 2008, Bruker
AXS has equipped its demonstration laboratories in Madison,
Wisconsin (USA) and Yokohama (Japan) with SMART X2S systems, and
has performed numerous successful customer demonstrations. To
schedule a live demo, please contact: x2slivedemo@bruker-axs.nl
Bruker AXS will also demonstrate a fully functional SMART X2S at
IUCr 2008 (XXI Congress of International Union of Crystallography,
www.iucr.org) in Osaka in late August 2008. ABOUT BRUKER AXS: For
more information about Bruker AXS and Bruker Corporation (NASDAQ:
BRKR), please visit www.bruker-axs.com and www.bruker.com.
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