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| Holder | Type | Held (Actual) | % of Outstanding | Market Value | Date Reported |
|---|---|---|---|---|---|
| JPMorgan Chase & Co. | Institution | 29,702,468 | 10.04% | US$ 476.43M | 2026-06-02 |
| Adage Capital Management, L.P. | Institution | 27,178,192 | 9.18% | US$ 435.94M | 2026-03-31 |
| MPM BioImpact LLC | Institution | 26,066,805 | 8.81% | US$ 418.11M | 2026-03-31 |
| Baker Bros. Advisors LP | Institution | 23,468,163 | 7.93% | US$ 376.43M | 2026-03-31 |
| Suvretta Capital Management, LLC | Institution | 23,425,713 | 7.92% | US$ 375.75M | 2026-04-15 |
| Averill Master Fund, Ltd. | Institution | 23,425,713 | 7.92% | US$ 375.75M | 2026-04-15 |
| Artisan Partners Limited Partnership | Institution | 22,825,885 | 7.71% | US$ 366.13M | 2026-03-31 |
| Adage Capital Partners, L.P. | Institution | 21,996,097 | 7.43% | US$ 352.82M | 2026-03-31 |
| Baker Brothers Life Sciences, L.P. | Institution | 21,282,929 | 7.19% | US$ 341.38M | 2026-01-12 |
| Artal Group S.A. | Institution | 19,310,005 | 6.53% | US$ 309.73M | 2026-03-31 |
| Invus Public Equities, L.P. | Institution | 17,997,870 | 6.08% | US$ 288.69M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 15,459,843 | 5.22% | US$ 247.98M | 2026-01-29 |
| Vivo Capital, LLC | Institution | 13,337,845 | 4.51% | US$ 213.94M | 2026-03-31 |
| Vivo Opportunity Fund Holdings, L.P | Institution | 11,820,005 | 3.99% | US$ 189.59M | 2026-03-31 |
| Bpifrance Participations SA | Institution | 10,898,595 | 3.68% | US$ 174.81M | 2026-01-07 |
| The Goldman Sachs Group, Inc. | Institution | 7,165,123 | 2.42% | US$ 114.93M | 2025-11-10 |
| ADAR1 Capital Management, LLC | Institution | 5,064,330 | 1.71% | US$ 81.23M | 2026-03-31 |
| Syquant Capital SAS | Institution | 4,833,228 | 1.63% | US$ 77.52M | 2025-04-02 |
| Perceptive Advisors LLC | Institution | 4,821,955 | 1.63% | US$ 77.34M | 2026-03-31 |
| Yiheng Capital Management, L.P. | Institution | 4,132,210 | 1.40% | US$ 66.28M | 2026-03-31 |
| Braidwell LP | Institution | 3,899,300 | 1.32% | US$ 62.54M | 2024-12-31 |
| Patient Square Capital, LP | Institution | 3,467,670 | 1.17% | US$ 55.62M | 2026-03-31 |
| Octagon Capital Advisors LP | Institution | 2,871,000 | 0.97% | US$ 46.05M | 2026-03-31 |
| Redmile Group, LLC | Institution | 2,456,700 | 0.83% | US$ 39.41M | 2026-03-31 |
| Braidwell Partners Master Fund LP | Institution | 2,393,815 | 0.81% | US$ 38.40M | 2024-12-31 |
| 667, L.P. | Institution | 2,185,234 | 0.74% | US$ 35.05M | 2026-01-12 |
| Duquesne Family Office LLC | Institution | 1,916,815 | 0.65% | US$ 30.75M | 2026-03-31 |
| Averill Madison Master Fund, Ltd. | Institution | 1,783,701 | 0.60% | US$ 28.61M | 2025-10-13 |
| Millennium Management LLC | Institution | 1,594,795 | 0.54% | US$ 25.58M | 2026-03-31 |
| Vivo Opportunity Cayman Fund,L.P. | Institution | 1,517,840 | 0.51% | US$ 24.35M | 2026-03-31 |
| Atika Capital Management, LLC | Institution | 1,356,500 | 0.46% | US$ 21.76M | 2026-03-31 |
| BlackRock, Inc. | Institution | 1,349,738 | 0.46% | US$ 21.65M | 2026-05-31 |
| Elmind Capital, L.P. | Institution | 1,325,000 | 0.45% | US$ 21.25M | 2026-03-31 |
| Avicenna Life Sci Master Fund Lp | Institution | 1,312,135 | 0.44% | US$ 21.05M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 1,167,145 | 0.39% | US$ 18.72M | 2026-03-31 |
| Columbia Management Investment Advisers, LLC | Institution | 1,157,085 | 0.39% | US$ 18.56M | 2026-03-31 |
| New York State Common Retirement Fund | Institution | 840,900 | 0.28% | US$ 13.49M | 2026-03-31 |
| Boothbay Fund Management, LLC | Institution | 817,005 | 0.28% | US$ 13.10M | 2026-03-31 |
| Morgan Stanley | Institution | 730,580 | 0.25% | US$ 11.72M | 2026-03-31 |
| Russell Investment Management, LLC | Institution | 642,800 | 0.22% | US$ 10.31M | 2026-03-31 |
| Ikarian Capital, LLC | Institution | 525,000 | 0.18% | US$ 8.42M | 2026-03-31 |
| Dorsey, Wright & Associates, LLC | Institution | 512,750 | 0.17% | US$ 8.22M | 2026-03-31 |
| Ishara Investments, L.P. | Institution | 512,500 | 0.17% | US$ 8.22M | 2026-03-31 |
| Envestnet Asset Management, Inc. | Institution | 478,570 | 0.16% | US$ 7.68M | 2026-03-31 |
| UBS Asset Management AG | Institution | 397,685 | 0.13% | US$ 6.38M | 2026-03-31 |
| Polymer Capital Management (HK) Limited | Institution | 322,500 | 0.11% | US$ 5.17M | 2026-03-31 |
| Diversify Wealth Management, LLC | Institution | 318,360 | 0.11% | US$ 5.11M | 2026-03-31 |
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