ME 23andMe Holding Company

23andMe Holding Co. (Nasdaq: ME), a leading human genetics company with a mission to help people access, understand, and benefit from the human genome, today released a new polygenic risk score (PRS) report* on the genetics of osteoporosis for 23andMe+ Premium members. The report informs customers if they are at a higher likelihood of developing osteoporosis based on a statistical model developed by 23andMe through its proprietary research database, along with actionable lifestyle factors that can reduce their risk.

Osteoporosis is a condition in which bone density becomes too low, which makes bones more fragile and prone to breaks (fractures). It's estimated that 12.3 million Americans have osteoporosis, and an additional 40+ million have osteopenia (a less severe form of low bone density).

Osteoporosis becomes more common with age, and women are more likely to develop the condition than men. Other risk factors include having a family history of the condition, having a small body frame, taking certain medications (such as corticosteroids), and having certain other health conditions. Often called a "silent" disease, osteoporosis usually has no symptoms until people break a bone — most commonly in the spine, hip, or wrist and often as a result of minor falls or normal activities.

If diagnosed early, osteoporosis is highly actionable. There are medications that can help slow bone loss, and strategies that can help prevent falls. Importantly, healthy lifestyle habits such as exercise, diet and avoiding smoking and heavy alcohol consumption can help lower one’s risk of developing the condition. Despite its actionability and health impacts, osteoporosis is often underdiagnosed and undertreated. According to the International Osteoporosis Foundation, about half of women and up to a quarter of men in the U.S. will break a bone due to low bone density, but ~80% of these individuals are never tested or treated for osteoporosis.

“Predominantly diagnosed in women, there are around 2 million new osteoporosis-related fractures in the U.S. each year, which is more than the number of new cases of heart attacks, breast cancer, and prostate cancer combined,” said Dr. Noura Abul-Husn, MD, PhD, Vice President of Genomic Health at 23andMe. “We’re proud to continue our commitment to developing genetic reports that impact women’s health, adding osteoporosis to our existing slate of offerings that include breast cancer, gestational diabetes, polycystic ovary syndrome (PCOS), uterine fibroids, among others.”

23andMe’s Osteoporosis PRS report* is based on a statistical model developed by 23andMe through its proprietary research database. The report takes into account an individual’s genetic results at many genetic markers, along with their genetic ancestry and birth sex to estimate the likelihood of developing osteoporosis. According to published data, it's estimated that genetics explains ~60-80% of the variability in bone density.

The Osteoporosis PRS report was developed by 23andMe scientists and clinical experts using 23andMe’s database of genetic and health information contributed by consented research participants. A published white paper provides full details on the science and methodology behind 23andMe’s PRS technology.

While 23andMe's new report provides an estimate of one's likelihood of developing osteoporosis, it does not account for every possible genetic variant that could impact a person’s likelihood of developing the condition, nor does it account for non-genetic factors. To learn more about the new Osteoporosis PRS report and how to become a 23andMe+ Premium member, visit https://www.23andme.com/membership/.

About 23andMe23andMe is a genetics-led consumer healthcare and research company empowering a healthier future. For more information, please visit investors.23andme.com.

Forward-Looking StatementsThis press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, including. All statements, other than statements of historical fact, included or incorporated in this press release are forward-looking statements. The words "believes," "anticipates," "estimates," "plans," "expects," "intends," "may," "could," "should," "potential," "likely," "projects," “predicts,” "continue," "will," “schedule,” and "would" or, in each case, their negative or other variations or comparable terminology, are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. These forward-looking statements are predictions based on 23andMe’s current expectations and projections about future events and various assumptions. 23andMe cannot guarantee that it will actually achieve the plans, intentions, or expectations disclosed in its forward-looking statements and you should not place undue reliance on 23andMe’s forward-looking statements. These forward-looking statements involve a number of risks, uncertainties (many of which are beyond the control of 23andMe), or other assumptions that may cause actual results or performance to differ materially from those expressed or implied by these forward-looking statements. The forward-looking statements contained herein are also subject generally to other risks and uncertainties that are described from time to time in the Company’s filings with the Securities and Exchange Commission, including under Item 1A, “Risk Factors” in the Company’s most recent Annual Report on Form 10-K, as filed with the Securities and Exchange Commission, and as revised and updated by our Quarterly Reports on Form 10-Q and Current Reports on Form 8-K. The statements made herein are made as of the date of this press release and, except as may be required by law, 23andMe undertakes no obligation to update them, whether as a result of new information, developments, or otherwise.

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*The 23andMe PRS reports are based on genetic models that include data from 23andMe consented research participants and incorporate thousands of genetic variants to describe if a person has a certain likelihood of developing a condition, but do not describe a person’s overall likelihood. The PRS reports do not account for lifestyle or family history and have not been reviewed by the US Food and Drug Administration. The PRS reports are not intended to tell you anything about your current state of health, or to be used to make medical decisions or determine any treatment.