axelvento
2 days ago
When Donald Trump unveiled a $500bn plan to spearhead a cancer vaccine, many greeted it as another of his grandiose proposals.
But not Anna Bochenski.
The 53-year-old New Yorker is one of the few people in the world who knows how life-changing the shots can be.
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The administrative worker was told she had just months to live in January 2021 after her aggressive breast cancer returned and stopped responding to treatment.
After a six-year battle with the disease, which included numerous surgeries and 32 brutal rounds of radiation, the cancer had spread to her ribs and spine, where it had become virtually incurable, known as 'metastatic'.
As a last resort, she was enrolled in a clinical trial for an experimental cancer vaccine developed at the famous Mount Sinai hospital in Manhattan.
The vaccine works by melting away the primary tumor and teaches the body to hunt and kill the cells that have spread elsewhere. Within weeks, the tumors in her back and a tennis ball-sized tumor under her armpit disappeared, while a third in her chest shrunk.
Speaking to DailyMail.com this month, almost exactly four years after the vaccine, she said: 'It saved my life. At that time, there was nothing I could do. There was nothing that could treat my cancer.'
Hundreds of experimental cancer vaccines are in production around the world, but President Trump's newly announced artificial intelligence project could be the catalyst that finally brings these shots to the public.
https://www.dailymail.co.uk/health/article-14322495/cancer-vaccine-donald-trump-mrna-cure-tumors.html
axelvento
2 days ago
Fetterman: RFK Jr.’s nomination in trouble after rocky hearing
Sen. John Fetterman (D-Pa.), who was thought to be open to voting for Robert F. Kennedy Jr.’s nomination to head the Department of Health and Human Services, now says the nominee is in serious trouble after his rocky confirmation hearing.
“I don’t think it went well for him today. I don’t think that was a good one,” he said after Kennedy sparred with Democrats on the Senate Finance Committee over his past statements and stance on vaccines.
Fetterman said after the bruising hearing that he thinks Kennedy’s nomination may be “moot.”
“It’s moot,” he said when asked if he’s still open to voting for Kennedy. “I’m not really sure how much support’s going to emerge after that.”
The Pennsylvania Democrat noted that he’s met with Kennedy twice already.
“I think we can all agree that was really a difficult performance,” he said. “I’m not sure he’ll even make it out of the committee.”
Sen. Michael Bennet (D-Colo.), one of the Democrats who grilled Kennedy at his hearing Wednesday, asked him pointedly about his comments on a podcast that exposure to pesticides could be causing more children to identify as transgender.
Kennedy acknowledged under Bennet’s cross-examination that he “probably did say” that Lyme Disease was a militarily-engineered bioweapon.
Sen. Ron Wyden (D-Ore.), meanwhile, tried to pin down Kennedy on his past views and statements on vaccines in a combative back-and-forth.
“You have a history of trying to take vaccines away from people,” Wyden told him.
RFJ, Jr.’s nomination will be voted on by the Senate Finance Committee, but before that happens, he will appear before the Senate Health, Education, Labor and Pensions Committee for a second round of questioning Thursday.
Sen. Susan Collins (R-Maine), a member of the HELP Committee and a key Senate swing vote, said it’s “premature” for her to say how she will vote.
“I do not make decisions on nominees prior to the public hearings,” she said.
“It’s totally premature to make a decision prior to the [public hearing,]” she added.
https://thehill.com/homenews/senate/5114271-fetterman-rfk-jr-nomination-hearing/
axelvento
3 days ago
As the Senate committee hearings over Robert F. Kennedy Jr.’s nomination to serve as secretary of Health and Human Services kick off Wednesday, opposition to his bid is mounting.
"All we need is a handful of senators," says Dr. Rob Davidson, executive director of Committee to Protect Health Care, a progressive advocacy group that reports gathering more than 18,000 signatures from physicians (though the list hasn't been made public). "They should look at his record and it will absolutely confirm that he is a danger."
let's see what will happen
https://www.npr.org/sections/shots-health-news/2025/01/28/nx-s1-5274744/rfk-confirmation-vaccines-health-secretary
MartinLutherKing
6 days ago
The cure to cancer brother🚀🚀🚀
TransCode Therapeutics, Inc. (NASDAQ: RNAZ), a leading clinical-stage oncology company committed to using its proprietary platform delivery system to defeat cancer, today announced a strategic expansion of its diverse product portfolio. New capabilities for TransCode’s TTX delivery platform are embodied in the new provisional patent application entitled, “Nanoparticles Comprising Payloads and Their In Vivo Delivery” (U.S. patent application 63/456,602 or the ‘602 application).
The therapeutic potential of RNA in oncology has remained an unrealized promise due to what is believed to be the difficulty in safely and effectively delivering oligonucleotides to tumors. Despite well documented targets that have been shown to be important for cancer onset, progression and recurrence, delivery mechanisms have fallen short in delivering RNA therapeutic payloads due to systemic inflammation, toxicity and the inability to efficiently reach their targets. Additionally, targeted delivery of therapeutic agents outside of RNA approaches has also remained a significant challenge for treatment of many other diseases besides cancer.
The technology disclosed in the ‘602 application represents an expansion of TransCode’s therapeutic delivery platform to include applicability to gene editing by repairing and/or replacement of genes using CRISPR technology and cancer vaccines using messenger RNA (mRNA).
TransCode’s said, “Our scientists have been working to expand the potential of our nanoparticle delivery system for some time in order to overcome the challenges of targeted delivery of therapies in oncology. We believe that by expanding our delivery platform and our resulting product portfolio including CRISPR, mRNA vaccines and potentially other targeted therapies outside of RNA positions the company as a platform delivery company.”
The filing of the ‘602 application directly supports TransCode’s goal of deploying the right therapy for individual cancer patients. If issued, the proposed patent would join other granted patents controlled by TransCode, including US 9,629,812 and EP 2 961 386. As part of its overall patent strategy, TransCode is actively pursuing intellectual property protection for additional components of its discovery engine built around its TTX delivery platform. The TTX platform currently comprises a hemodynamic and metabolic targeting delivery system suitable for deploying a variety of therapeutic candidates including RNAi, pattern recognition receptors, mRNA, gene repair/replacement and radiolabeled therapeutics.
“While our major focus is on advancing TTX-MC138, our lead therapeutic candidate targeting miR-10b, shown to be a master regulator of metastatic cell viability in a number of solid tumor types, we are excited by our platform’s expanded potential to be used more broadly for a variety of therapeutic approaches to relevant documented targets responsible for cancer onset, progression and recurrence. The approach represented by the ’602 application, if successful in development, could expand our ability to deploy the right therapy for individual patients using the therapeutic capabilities our platform offers.”
axelvento
1 week ago
Norovirus-A large phase three trial of the shot is underway, with results expected as soon as later this year or 2026. Moderna needs to see a certain number of cases before it can analyze the data and determine how well its vaccine works, putting the timeline in flux. The 25,000-person study is enrolling ahead of schedule, said Doran Fink, Moderna’s clinical therapeutic area head for gastrointestinal and bacterial pathogens.
https://www.modernatx.com/en-US/media-center/all-media/blogs/understanding-norovirus