RNS Number:1099U
Amersham PLC
12 January 2004




                                  SCHEDULE 10

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES


1)  Name of company

Amersham plc


2)  Name of shareholder having a major interest

Franklin Resources Inc and its direct and indirect subsidiaries


3)  Please state whether notification indicates that it is in respect
of holding of the shareholder named in 2 above or in respect of a non-beneficial
interest or in the case of an individual holder if it is a holding of that
person's spouse or children under the age of 18

Non Beneficial interest


4)  Name of the registered holder(s) and, if more than one holder, the
number of shares held by each of them

Franklin Resources Inc and its direct and indirect subsidiaries


5)  Number of shares/amount of stock acquired

Not advised


6)  Percentage of issued class

N/A


7)  Number of shares/amount of stock disposed

N/A


8)  Percentage of issued class

N/A


9)  Class of security

Ordinary shares of 5 pence each


10) Date of transaction

10 December 2003


11) Date company informed

12 December 2003


12) Total holding following this notification

19,938,175 Ordinary Shares of 5p each



13) Total percentage holding of issued class following this notification

2.823%


14) Any additional information

The interest of Franklin Resources Inc and its direct and indirect subsidiaries
in the share capital of Amersham plc has fallen below 3% and accordingly they no
longer have a notifiable interest under ss198-202 of the Companies Act 1985


15) Name of contact and telephone number for queries

Susan Henderson, Deputy Company Secretary Tel 01494 542063


16) Name and signature of authorised company official responsible for
making this notification

Susan M Henderson,


Date of notification 23 December 2003



                      This information is provided by RNS
            The company news service from the London Stock Exchange

END
HOLSFAFFESLSEIF