Form 6-K - Report of foreign issuer [Rules 13a-16 and 15d-16]

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

FORM 6-K

REPORT OF FOREIGN PRIVATE ISSUER

PURSUANT TO RULE 13a-16 OR 15d-16

UNDER THE SECURITIES EXCHANGE ACT OF 1934

For the Month of July 2024

Commission File Number: 001-38097

ARGENX SE

(Translation of registrant’s name into English)

Laarderhoogtweg 25
1101 EB Amsterdam, the Netherlands

(Address of principal executive offices)

Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F.

Form 20-F ⌧ Form 40-F ◻

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1): ◻

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7): ◻

argenx SE

On July 25, 2024, argenx SE (the “Company) issued a press release and unaudited first half-year financial results for 2024, which are further described in an Unaudited Interim Report for the Six Months Ended June 30, 2024, copies of which are attached hereto as Exhibits 99.1 and 99.2, respectively, and are incorporated by reference herein.

The information contained in this Current Report on Form 6-K, including Exhebit 99.1 and Exhebit 99.2, shall be deemed to be incorporated by reference into the Company’s Registration Statements on Forms F-3 (File No. 333-258251 and S-8 (File Nos. 333-225375, 333-258253, and 333-274721), and to be part thereof from the date on which this Current Report on Form 6-K is filed, to the extent not superseded by documents or reports subsequently filed or furnished.

EXHIBITS


Exhibit		Description

99.1		Press Release dated July 25, 2024

99.2		Unaudited Interim Report for the Six Months Ended June 30, 2024

101.INS		Inline XBRL Instance Document

101.SCH		Inline XBRL Taxonomy Extension Schema Document

101.CAL		Inline XBRL Taxonomy Extension Calculation Linkbase Document

101.DEF		Inline XBRL Taxonomy Extension Definition Linkbase Document

101.LAB		Inline XBRL Taxonomy Extension Label Linkbase Document

101.PRE		Inline XBRL Taxonomy Extension Presentation Linkbase Document

104		Cover Page Interactive Data File (formatted as Inline XBRL)

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.


	ARGENX SE

Date: July 25, 2024	By:	/s/ Hemamalini (Malini) Moorthy
		Hemamalini (Malini) Moorthy
		General Counsel

Ex* reflects cash, cash equivalents and current financial assets

hibit 99.1

argenx Reports Half Year 2024 Financial Results and Provides Second Quarter Business Update

$478 million in second quarter global net product sales

First CIDP patients treated with VYVGART^® Hytrulo following June 21^st FDA approval

On track to begin four additional registrational studies across efgartigimod and empasiprubart by end of 2024

Management to host conference call today at 2:30 PM CET (8:30 AM ET)

July 25, 7:00 AM CET

Amsterdam, the Netherlands – argenx SE (Euronext & Nasdaq: ARGX), a global immunology company committed to improving the lives of people suffering from severe autoimmune diseases, today announced its half year 2024 results and provided a second quarter business update.

“We were excited to unveil our ambition for the future of argenx – Vision 2030 – last week, outlining our plan to develop and deliver continued and sustainable innovation for patients,” said Tim Van Hauwermeiren, Chief Executive Officer, argenx. “We are already delivering on this promise with impressive commercial execution throughout the first half of the year, expanding our patient reach in MG, and launching in CIDP with our broad FDA label. Our development pipeline is stronger than ever, driven by our unique innovation engine. And we are well-positioned to capture the sizeable growth opportunity before us as we seek to reach earlier-line MG patients over the next 12-18 months with potential label expansions and a pre-filled syringe.”

Vision 2030

During its R&D Day on July 16, 2024, argenx unveiled its ‘Vision 2030’ as part of its long-term commitment to transform the treatment of autoimmune diseases by strengthening its leadership in neonatal Fc receptor (FcRn) biology, investing in its continuous pipeline of differentiated antibody candidates, and scaling in a disciplined way to ensure innovation remains core to the argenx mission. ‘Vision 2030’ includes the following goals:

●

50,000 patients globally on treatment with an argenx medicine

●

10 labeled indications across all approved assets, including VYVGART franchise and potentially empasiprubart and ARGX-119

●

Five new molecules in Phase 3 development indicating ongoing investment in internal discovery engine, the Immunology Innovation Program

Reaching 50,000 Patients Globally

VYVGART (efgartigimod alfa-fcab) is a first-in-class antibody fragment targeting FcRn and is now approved for both intravenous use and subcutaneous injection (SC) (efgartigimod alfa and hyaluronidase-qvfc) in three indications, including generalized myasthenia gravis (gMG) globally, primary immune thrombocytopenia (ITP) in Japan, and chronic inflammatory demyelinating polyneuropathy (CIDP) in the U.S.

●

Generated global net product sales (inclusive of both VYVGART and VYVGART SC) of $478 million in second quarter of 2024

●

National Medical Products Administration (NMPA) approved VYVGART SC for treatment of gMG in China through Zai Lab on July 16, 2024

●

Additional VYVGART regulatory decisions on approval expected for gMG in 2024, including in Switzerland, Australia, and Saudi Arabia

●

Launched VYVGART Hytrulo in CIDP in U.S. with first patients injected in July

●

Multiple VYVGART SC regulatory submissions under review or planned for CIDP, including:

o

Regulatory submissions completed in China, Japan, and Europe with decisions on approval expected in 2025

o

Regulatory submission filing in Canada by end of 2024

●

Announced plan to evaluate VYVGART in ocular MG with registrational study (ADAPT OCULUS) to start by end of year; OCULUS to support label-expansion strategy into broader MG populations along with ongoing ADAPT SERON study in seronegative MG

●

Regulatory submission filed and under regulatory review for VYVGART SC pre-filled syringe (PFS) for gMG and and CIDP

Advancing Pipeline to Achieve 10 Labeled Indications by 2030

argenx continues to demonstrate breadth and depth within its immunology pipeline, advancing multiple pipeline-in-a-product candidates. argenx is solidifying its leadership in FcRn biology, with efgartigimod currently in development in 15 indications. argenx is also advancing its first-in-class C2 inhibitor, empasiprubart, which is being evaluated in multifocal motor neuropathy (MMN), delayed graft function (DGF), dermatomyositis (DM), and CIDP. In addition, argenx is evaluating ARGX-119, a muscle-specific kinase (MuSK) agonist in both congenital myasthenic syndrome (CMS) and amyotrophic lateral sclerosis (ALS).

●

Registrational studies ongoing of efgartigimod in thyroid eye disease (TED)

●

Advancing development of efgartigimod in primary Sjogren’s disease (SjD) with Phase 3 study to begin by end of 2024

●

Following alignment meeting with FDA, confirmatory study of VYVGART (IV) in primary ITP to start by end of 2024 to enable registration in U.S.

●

Topline data from seamless Phase 2/3 ALKIVIA study evaluating efgartigimod across three myositis subsets (immune-mediated necrotizing myopathy (IMNM), anti-synthetase syndrome (ASyS), and DM expected in fourth quarter of 2024

●

Update on BALLAD study development plan evaluating efgartigimod in bullous pemphigoid (BP) expected by end of 2024

●

Proof-of-concept studies ongoing with efgartigimod in membranous nephropathy (MN) and lupus nephritis (LN) with studies expected to initiate this year in antibody mediated rejection (AMR) and systemic sclerosis (SSc)

●

Phase 3 study of empasiprubart for MMN to initiate in fourth quarter of 2024

●

CIDP nominated as fourth empasiprubart indication, recognizing opportunity to bring multiple innovative treatments to patients

●

Phase 1b/2a studies of ARGX-119 to assess early signal detection in patients with CMS and ALS to start by end of 2024

Investing in Immunology Innovation Program to Support Five New Molecules in Phase 3 by 2030

argenx continues to invest in its Immunology Innovation Program (IIP) to drive long-term sustainable pipeline growth. Through the IIP, four new pipeline candidates have been nominated, including: ARGX-213, targeting FcRn and further solidifying argenx’s leadership in this new class of medicine; ARGX-121, a first-in-class molecule targeting IgA; ARGX-109, targeting IL-6, which plays an important role in inflammation, and ARGX-220, a first-in-class sweeping antibody for which the target has not yet been disclosed.

●

Phase 1 studies of ARGX-213 and ARGX-121 expected to start in second half of 2025

●

Investigational new drug (IND) applications for ARGX-220 and ARGX-109 on track to be filed by end of 2025

SECOND QUARTER 2024 FINANCIAL RESULTS

argenx SE

UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF PROFIT OR LOSS

		Three Months Ended				Six Months Ended
		June 30,				June 30,
(in thousands of $ except for shares and EPS)	2024		2023		2024		2023
Product net sales	$	477,635	$	269,313	$	875,918	$	487,335
Collaboration revenue		-		1,237		2,718		2,355
Other operating income		11,793		10,485		23,305		21,225
Total operating income	$	489,428	$	281,035	$	901,941	$	510,915

Cost of sales	$	(52,383)	$	(24,024)	$	(95,561)	$	(42,359)
Research and development expenses		(225,286)		(195,509)		(450,255)		(361,364)
Selling, general and administrative expenses		(255,699)		(161,977)		(491,694)		(311,149)
Loss from investment in joint venture		(1,521)		(1,619)		(3,313)		(1,880)
Total operating expenses	$	(534,889)	$	(383,129)	$	(1,040,823)		(716,752)

Operating loss	$	(45,461)	$	(102,094)	$	(138,882)	$	(205,837)

Financial income	$	38,933	$	20,441	$	77,828	$	37,029
Financial expense		(572)		(207)		(1,084)		(395)
Exchange gains/(losses)		(7,903)		(2,001)		(27,215)		9,164

Loss for the period before taxes	$	(15,003)	$	(83,861)	$	(89,353)	$	(160,039)
Income tax benefit/(expense)	$	44,069	$	(10,507)	$	56,822	$	36,800
Profit/(loss) for the period	$	29,066	$	(94,368)	$	(32,531)	$	(123,239)
Profit/(loss) for the period attributable to:
Owners of the parent	$	29,066	$	(94,368)	$	(32,531)	$	(123,239)
Weighted average number of shares outstanding		59,490,437		55,828,239		59,400,217		55,690,873
Basic profit/(loss) per share (in $)		0.49		(1.69)		(0.55)		(2.21)
Diluted profit/(loss) per share (in $)		0.45		(1.69)		(0.55)		(2.21)
Net increase/(decrease) in cash, cash equivalents and current financial assets compared to year-end 2022 and 2023						(77,497)	$	(195,580)
Cash and cash equivalents and current financial assets at the end of the period						3,102,347	$	1,996,968

DETAILS OF THE FINANCIAL RESULTS

Total operating income for the three and six months ended June 30, 2024 was $489 million and $902 million compared to $281 million and $511 million for the same periods in 2023, and mainly consists of:

●Product net sales of VYVGART and VYVGART SC for the three and six months ended June 30, 2024, were $478 million and $876 million compared to $269 million and $487 million for the same periods in 2023.

●Other operating income for the three and six months ended June 30, 2024 was $12 million and $23 million compared to $10 million and $21 million for the same periods in 2023. The other operating income for the three and six months ended June 30, 2024 and 2023, primarily relates to research and development tax incentives.

Total operating expenses for the three and six months ended June 30, 2024 were $535 million and $1,041 million compared to $383 million and $717 million for the same periods in 2023, and mainly consists of:

●	Cost of sales for the three and six months ended June 30, 2024 was $52 million and $96 million compared to $24 million and $42 million for the same periods in 2023. The cost of sales was recognized with respect to the sale of VYVGART and VYVGART SC.

●

Research and development expenses for the three and six months ended June 30, 2024 were $225 million and $450 million compared to $196 million and $361 million for the same periods in 2023. The research and development expenses mainly relate to external research and development expenses and personnel expenses incurred in the clinical development of efgartigimod in various indications and the expansion of other clinical and preclinical pipeline candidates.

●

Selling, general and administrative expenses for the three and six months ended June 30, 2024 were $256 million and $492 million compared to $162 million and $311 million for the same periods in 2023. The selling, general and administrative expenses mainly relate to professional and marketing fees linked to the commercialization of VYVGART and VYVGART SC, and personnel expenses.

Financial income for the three and six months ended June 30, 2024, was $39 million and $78 million compared to $20 million and $37 million for the same periods in 2023. The increase in financial income is mainly due to an increase in interest income coming from an increase of cash, cash equivalents and current financial assets as a result of the July 2023 financing round.

Exchange losses for the three and six months ended June 30, 2024, were $8 million and $27 million compared to $2 million exchange losses and $9 million of exchange gains for the same periods in 2023. Exchange gains/losses are mainly attributable to unrealized exchange rate gains or losses on the cash, cash equivalents and current financial assets denominated in Euro.

Income tax for the three and six months ended June 30, 2024, was $44 million and $57 million of income tax benefit, respectively, compared to $11 million of income tax expense and $37 million of income tax benefit for the same periods in 2023.

Net Result for the three and six months ended June 30, 2024, was $29 million profit and $33 million loss compared to $94 million and $123 million loss for the same periods in 2023. On a per weighted average share basis, the basic profit was $0.49 and diluted profit was $0.45 for the three months ended June 30, 2024, compared to a basic and diluted loss of $1.69 for the same period in 2023. On a per weighted average share basis, the basic and diluted loss was $0.55 for the six months ended June 30, 2024, compared to a basic and diluted loss of $2.21 for the same period in 2023.

Cash, cash equivalents and current financial assets totalled $3.1 billion as of June 30, 2024, compared to $3.2 billion as of December 31, 2023. The decrease in cash and cash equivalents and current financial assets result from a net cash flows used in operating activities.

FINANCIAL GUIDANCE

Based on its current operating plans, argenx expects its combined research and development and selling, general and administrative expenses in 2024 to be less than $2 billion. argenx updated its cash burn guidance and now expects to utilize less than $500 million of net cash* ⁱin 2024 on anticipated operating expenses as well as working capital and capital expenditures.

EXPECTED 2024 FINANCIAL CALENDAR

●

October 31, 2024: 3Q 2024 financial results and business update

●

February 27, 2025: Full-year 2024 financial results and 4Q 2024 business update

CONFERENCE CALL DETAILS

The half-year 2024 financial results and second quarter business update will be discussed during a conference call and webcast presentation today at 2:30 PM CET/8:30 AM ET. A webcast of the live call and replay may be accessed on the Investors section of the argenx website at argenx.com/investors.

Dial-in numbers:

Please dial in 15 minutes prior to the live call.

Belgium32 800 50 201

France33 800 943355

Netherlands31 20 795 1090

United Kingdom44 800 358 0970

United States 1 800 715 9871

Japan81 3 4578 9081

Switzerland41 43 210 11 32

About argenx

argenx is a global immunology company committed to improving the lives of people suffering from severe autoimmune diseases. Partnering with leading academic researchers through its Immunology Innovation Program (IIP), argenx aims to translate immunology breakthroughs into a world-class portfolio of novel antibody-based medicines. argenx developed and is commercializing the first approved neonatal Fc receptor (FcRn) blocker, globally in the U.S., Japan, Israel, the EU, the UK, China and Canada. The Company is evaluating efgartigimod in multiple serious autoimmune diseases and advancing several earlier stage experimental medicines within its therapeutic franchises. For more information, visit www.argenx.com and follow us on LinkedIn, X/Twitter, Instagram, Facebook, and YouTube.

For further information, please contact:

Media:

Ben Petok

bpetok@argenx.com

Investors:

Alexandra Roy (US)

aroy@argenx.com

Lynn Elton (EU)

lelton@argenx.com

Forward-looking Statements

The contents of this announcement include statements that are, or may be deemed to be, “forward-looking statements.” These forward-looking statements can be identified by the use of forward-looking terminology, including the terms “advance,” “aim,” “anticipates,” “continue,” “expect,” “expand,” “plan,” or “seek” and include statements argenx makes regarding its Vision 2030 plan to develop and deliver continued and sustainable innovation for patients; its long-term commitments; its Vision 2030 goals, including having 50,000 patients globally on treatment with an argenx medicine, 10 labeled indications across all approved assets, including VYVGART franchise and potentially empasiprubart and ARGX-119, and five new molecules in Phase 3 development indicating ongoing investment in the immunology innovation program; its growth opportunity; its plans to reach earlier-line MG patients over the next 12-18 months with potential label expansions and a pre-filled syringe; the advancement of, and anticipated clinical development, data readouts and regulatory milestones and plans, including the anticipated timing of four additional Phase 3 registrational studies across efgartigimod and empasiprubart, the expected timing of additional VYVGART regulatory decisions on approval for gMG, including in Switzerland, Australia, and Saudi Arabia, the expected timing of additional VYVGART SC regulatory submissions under review or planned for CIDP, including decisions on approval in China, Japan, and Europe and a regulatory submission filing in Canada, the anticipated timing of the initiation of a Phase 3 study for efgartigimod in primary Sjogren’s disease (SjD), the anticipated timing of a confirmatory study of VYVGART (IV) in primary ITP, the anticipated timing of topline data from Phase 2/3 ALKIVIA study evaluating efgartigimod across three myositis subsets, the anticipated timing of an update on BALLAD study development plan evaluating efgartigimod in BP, the anticipated timing of proof-of-concept studies for efgartigimod in AMR and SSc, the anticipated timing of the initiation of a Phase 3 study of empasiprubart for MMN, the anticipated timing of the initiation of Phase 1b/2a studies of ARGX-119 to assess early signal detection in patients with CMS and ALS, the anticipated timing of the initiation of Phase 1 studies of ARGX-213 and ARGX-121; its investigational new drug applications for ARGX-2220 and ARGX-109 expected to be filed by the end of 2025; its 2024 research and development and selling, general and administrative expenses and operating expenses; its 2024 cash burn; and its goal of translating immunology breakthroughs into a world-class portfolio of novel antibody-based medicines. By their nature, forward-looking statements involve risks and uncertainties and readers are cautioned that any such forward-looking statements are not guarantees of future performance. argenx’s actual results may differ materially from those predicted by the forward-looking statements as a result of various important factors, including the results of argenx's clinical trials; expectations regarding the inherent uncertainties associated with the development of novel drug therapies; preclinical and clinical trial and product development activities and regulatory approval requirements in products and product candidates; the acceptance of argenx's products and product candidates by patients as safe, effective and cost-effective; the impact of governmental laws and regulations on our business; disruptions caused on our reliance of third parties suppliers, service provides and manufacturing; inflation and deflation and the corresponding fluctuations in interest rates; and regional instability and conflicts. A further list and description of these risks, uncertainties and other risks can be found in argenx’s U.S. Securities and Exchange Commission (SEC) filings and reports, including in argenx’s most recent annual report on Form 20-F filed with the SEC as well as subsequent filings and reports filed by argenx with the SEC. Given these uncertainties, the reader is advised not to place any undue reliance on such forward-looking statements. These forward-looking statements speak only as of the date of publication of this document. argenx undertakes no obligation to publicly update or revise the information in this press release, including any forward-looking statements, except as may be required by law.

ⁱ reflects cash, cash equivalents and current financial assets

Table of Contents

TABLE OF CONTENTS

MANAGEMENT REPORT
1. MAIN EVENTS IN THE SIX MONTHS OF 2024	2
2. FINANCIAL HIGHLIGHTS	3
3. RISK FACTORS	4
4. FORWARD-LOOKING STATEMENTS	4
UNAUDITED CONDENSED CONSOLIDATED INTERIM STATEMENTS OF FINANCIAL POSITION	6
UNAUDITED CONDENSED CONSOLIDATED INTERIM STATEMENTS OF PROFIT OR LOSS	8
UNAUDITED CONDENSED CONSOLIDATED INTERIM STATEMENTS OF COMPREHENSIVE INCOME (LOSS)	9
UNAUDITED CONDENSED CONSOLIDATED INTERIM STATEMENTS OF CASH FLOWS	10
UNAUDITED CONDENSED CONSOLIDATED INTERIM STATEMENTS OF CHANGES IN EQUITY	11
NOTES TO THE UNAUDITED CONDENSED CONSOLIDATED INTERIM FINANCIAL STATEMENTS	12

Table of Contents

MANAGEMENT REPORT

1.	MAIN EVENTS IN THE SIX MONTHS OF 2024

FIRST QUARTER OF 2024

See refer to our Q1 2024 press release

SECOND QUARTER OF 2024 AND RECENT BUSINESS UPDATE

Vision 2030

●

50,000 patients globally on treatment with an argenx medicine

●

10 labeled indications across all approved assets, including VYVGART franchise and potentially empasiprubart and ARGX-119

●

Five new molecules in Phase 3 development indicating ongoing investment in internal discovery engine, the Immunology Innovation Program

Reaching 50,000 Patients Globally

●

Generated global net product sales (inclusive of both VYVGART and VYVGART SC) of $876 million in the first six months of 2024

●

National Medical Products Administration (NMPA) approved VYVGART SC for treatment of gMG in China through Zai Lab on July 16, 2024

●

Additional VYVGART regulatory decisions on approval expected for gMG in 2024, including in Switzerland, Australia, and Saudi Arabia

●

Launched VYVGART Hytrulo in CIDP in U.S. with first patients injected in July

●

Multiple VYVGART SC regulatory submissions under review or planned for CIDP, including:

o

Regulatory submissions completed in China, Japan, and Europe with decisions on approval expected in 2025

o

Regulatory submission filing in Canada by end of 2024

●

Regulatory submission filed and under regulatory review for VYVGART SC pre-filled syringe (PFS) for gMG and CIDP

Table of Contents

Advancing Pipeline to Achieve 10 Labeled Indications by 2030

●

Registrational studies ongoing of efgartigimod in thyroid eye disease (TED)

●

Advancing development of efgartigimod in primary Sjogren’s disease (SjD) with Phase 3 study to begin by end of 2024

●

Following alignment meeting with FDA, confirmatory study of VYVGART (IV) in primary ITP to start by end of 2024 to enable registration in U.S.

●

Update on BALLAD study development plan evaluating efgartigimod in bullous pemphigoid (BP) expected by end of 2024

●

Phase 3 study of empasiprubart for MMN to initiate in fourth quarter of 2024

●

CIDP nominated as fourth empasiprubart indication, recognizing opportunity to bring multiple innovative treatments to patients

●

Phase 1b/2a studies of ARGX-119 to assess early signal detection in patients with CMS and ALS to start by end of 2024

Investing in Immunology Innovation Program to Support Five New Molecules in Phase 3 by 2030

●

Phase 1 studies of ARGX-213 and ARGX-121 expected to start in second half of 2025

●

Investigational new drug (IND) applications for ARGX-220 and ARGX-109 on track to be filed by end of 2025

2.	FINANCIAL HIGHLIGHTS

Total operating income for the six months ended June 30, 2024, was $902 million compared to $511 million for the same period in 2023, and mainly consists of:

●

Product net sales of VYVGART and VYVGART SC for the six months ended June 30, 2024, were $876 million compared to $487 million for the same period in 2023.

●

Other operating income for the six months ended June 30, 2024, was $23 million compared to $21 million for the same period in 2023. The other operating income for the six months ended June 30, 2024 and 2023, primarily relates to research and development tax incentives.

Total operating expenses for the six months ended June 30, 2024 were $1,041 million compared to $717 million for the same period in 2023, and mainly consists of:

●

Cost of sales for the six months ended June 30, 2024, was $96 million compared to $42 million for the same period in 2023. The cost of sales was recognized with respect to the sale of VYVGART and VYVGART SC.

Table of Contents

●

Research and development expenses for the six months ended June 30, 2024, were $450 million compared to $361 million for the same period in 2023. The research and development expenses mainly relate to external research and development expenses and personnel expenses incurred in the clinical development of efgartigimod in various indications and the expansion of other clinical and preclinical pipeline candidates.

●

Selling, general and administrative expenses for the six months ended June 30, 2024, were $492 million compared to $311 million for the same period in 2023. The selling, general and administrative expenses mainly relate to professional and marketing fees linked to the commercialization of VYVGART and VYVGART SC, and personnel expenses.

Financial income for the six months ended June 30, 2024, was $78 million compared to $37 million for the same period in 2023. The increase in financial income is mainly due to an increase in interest income coming from an increase of cash, cash equivalents and current financial assets as a result of the July 2023 financing round.

Exchange losses for the six months ended June 30, 2024, were $27 million compared to $9 million of exchange gains for the same period in 2023. Exchange gains/losses are mainly attributable to unrealized exchange rate gains or losses on the cash, cash equivalents and current financial assets denominated in Euro.

Income tax for the six months ended June 30, 2024, was $57 million of income tax benefit compared to $37 million of income tax benefit for the same period in 2023. Income tax benefit for the six months ended June 30, 2024, consists of $16 million of current income tax expense and $73 million of deferred tax benefit, compared to $23 million of current income tax expense and $59 million of deferred tax benefit for the comparable prior period.

Loss for the six months ended June 30, 2024 was $33 million compared to $123 million for the same period in 2023. On a per weighted average share basis, the basic loss per share was $0.55 and $2.21 for the six months ended June 30, 2024 and 2023, respectively.

Cash, cash equivalents and current financial assets totalled $3.1 billion as of June 30, 2024, compared to $3.2 billion as of December 31, 2023. The decrease in cash and cash equivalents and current financial assets result from net cash flows used in operating activities.

3.	RISK FACTORS

We refer to the description of risk factors in the 2023 annual report, pp. 97-143 as supplemented by the description of risk factors in our annual report on Form 20-F filed with the U.S. Securities and Exchange Commission, pp. 1-39. In summary, the principal risks and uncertainties faced by us relate to: our financial position and need for additional capital, commercialization of our products and product candidates, including new indications, government regulations, development and clinical testing of our products and product candidates, dependence on third parties, business and industry, intellectual property, our organization and operations.

We also refer to the description of our financial risk management given in the 2023 annual report, pp. F40-F44, which remains valid.

4.	FORWARD-LOOKING STATEMENTS

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including VYVGART franchise and potentially empasiprubart and ARGX-119, and five new molecules in Phase 3 development indicating ongoing investment in the immunology innovation program; its growth opportunity; its plans to reach earlier-line MG patients over the next 12-18 months with potential label expansions and a pre-filled syringe; the advancement of, and anticipated clinical development, data readouts and regulatory milestones and plans, including the anticipated timing of four additional Phase 3 registrational studies across efgartigimod and empasiprubart, the expected timing of additional VYVGART regulatory decisions on approval for gMG, including in Switzerland, Australia, and Saudi Arabia, the expected timing of additional VYVGART SC regulatory submissions under review or planned for CIDP, including decisions on approval in China, Japan, and Europe and a regulatory submission filing in Canada, the anticipated timing of the initiation of a Phase 3 study for efgartigimod in primary Sjogren’s disease (SjD), the anticipated timing of a confirmatory study of VYVGART (IV) in primary ITP, the anticipated timing of topline data from Phase 2/3 ALKIVIA study evaluating efgartigimod across three myositis subsets, the anticipated timing of an update on BALLAD study development plan evaluating efgartigimod in BP, the anticipated timing of proof-of-concept studies for efgartigimod in AMR and SSc, the anticipated timing of the initiation of a Phase 3 study of empasiprubart for MMN, the anticipated timing of the initiation of Phase 1b/2a studies of ARGX-119 to assess early signal detection in patients with CMS and ALS, the anticipated timing of the initiation of Phase 1 studies of ARGX-213 and ARGX-121; its investigational new drug applications for ARGX-2220 and ARGX-109 expected to be filed by the end of 2025; its 2024 research and development and selling, general and administrative expenses and operating expenses; its 2024 cash burn; and its goal of translating immunology breakthroughs into a world-class portfolio of novel antibody-based medicines. By their nature, forward-looking statements involve risks and uncertainties and readers are cautioned that any such forward-looking statements are not guarantees of future performance. argenx’s actual results may differ materially from those predicted by the forward-looking statements as a result of various important factors, including the results of argenx's clinical trials; expectations regarding the inherent uncertainties associated with the development of novel drug therapies; preclinical and clinical trial and product development activities and regulatory approval requirements in products and product candidates; the acceptance of argenx's products and product candidates by patients as safe, effective and cost-effective; the impact of governmental laws and regulations on our business; disruptions caused on our reliance of third parties suppliers, service provides and manufacturing; inflation and deflation and the corresponding fluctuations in interest rates; and regional instability and conflicts. A further list and description of these risks, uncertainties and other risks can be found in argenx’s U.S. Securities and Exchange Commission (SEC) filings and reports, including in argenx’s most recent annual report on Form 20-F filed with the SEC as well as subsequent filings and reports filed by argenx with the SEC. Given these uncertainties, the reader is advised not to place any undue reliance on such forward-looking statements. These forward-looking statements speak only as of the date of publication of this document. argenx undertakes no obligation to publicly update or revise the information in this press release, including any forward-looking statements, except as may be required by law.

STATEMENT OF THE BOARD OF DIRECTORS

We hereby certify that, to the best of our knowledge, the unaudited condensed consolidated interim financial statements of argenx SE as of and for the six months ended June 30, 2024, prepared in accordance with IAS 34 “Interim Financial Reporting” as issued by the IASB and as adopted by the European Union, gives a true and fair view of the assets, liabilities, financial position and total comprehensive income of the Company and the undertakings included in the consolidation as a whole, and that the management report includes a fair review of the development and performance of the business and the position of the Company and the undertakings included in the consolidation taken as a whole, together with a description of the principal risks and uncertainties that they face.

On behalf of the Board of Directors

Tim van Hauwermeiren, CEO

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UNAUDITED CONDENSED CONSOLIDATED INTERIM FINANCIAL STATEMENTS

ARGENX SE

UNAUDITED CONDENSED CONSOLIDATED INTERIM STATEMENTS OF FINANCIAL POSITION


		As of
		June 30,		December 31,
(in thousands of $)	Note	2024		2023
ASSETS
Non‑current assets
Property, plant and equipment		$	36,931	$	22,675
Intangible assets			141,774		125,228
Deferred tax asset	14		174,626		97,211
Research and development incentive receivables			91,237		76,706
Investment in joint venture			6,599		9,912
Prepaid expenses			47,327		47,327
Other non-current assets	4		34,276		39,662
Total non‑current assets			532,770		418,721

Current assets
Inventories	5	$	326,460	$	310,550
Prepaid expenses			179,420		134,072
Trade and other receivables	6		652,875		496,687
Research and development incentive receivables			2,686		2,584
Financial assets			1,664,100		1,131,000
Cash and cash equivalents	7		1,438,247		2,048,844
Total current assets			4,263,788		4,123,737

TOTAL ASSETS		$	4,796,558	$	4,542,458

The accompanying notes form an integral part of these unaudited condensed consolidated interim financial statements

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		As of
		June 30,		December 31,
(in thousands of $)	Note	2024		2023
EQUITY AND LIABILITIES
Equity	8
Equity attributable to owners of the parent
Share capital		$	7,118	$	7,058
Share premium			5,747,441		5,651,497
Translation differences			128,935		131,543
Accumulated losses			(2,437,375)		(2,404,844)
Other reserves			816,128		712,253
Total equity		$	4,262,247	$	4,097,507

Non-current liabilities
Provisions for employee benefits			1,581		1,449
Lease liabilities			28,107		15,354
Deferred tax liabilities	14		4,994		5,155
Total non-current liabilities			34,682		21,958

Current liabilities
Lease liabilities			5,853		4,646
Trade and other payables	10		479,829		414,013
Tax liabilities			13,947		4,334
Total current liabilities			499,629		422,993

Total liabilities		$	534,311	$	444,951

TOTAL EQUITY AND LIABILITIES		$	4,796,558	$	4,542,458

The accompanying notes form an integral part of these unaudited condensed consolidated interim financial statements.

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ARGENX SE

UNAUDITED CONDENSED CONSOLIDATED INTERIM STATEMENTS OF PROFIT OR LOSS


		Six Months Ended
		June 30,
(in thousands of $ except for shares and EPS)	Note	2024		2023
Product net sales	11	$	875,918	$	487,335
Collaboration revenue			2,718		2,355
Other operating income			23,305		21,225
Total operating income			901,941		510,915

Cost of sales			(95,561)		(42,359)
Research and development expenses	12		(450,255)		(361,364)
Selling, general and administrative expenses	13		(491,694)		(311,149)
Loss from investment in joint venture			(3,313)		(1,880)
Total operating expenses			(1,040,823)		(716,752)

Operating loss		$	(138,882)	$	(205,837)

Financial income			77,828		37,029
Financial expense			(1,084)		(395)
Exchange gains/(losses)			(27,215)		9,164

Loss for the period before taxes		$	(89,353)	$	(160,039)
Income tax benefit	14	$	56,822	$	36,800
Loss for the period		$	(32,531)	$	(123,239)
Loss for the period attributable to:
Owners of the parent			(32,531)	$	(123,239)
Weighted average number of shares outstanding			59,400,217		55,690,873
Basic and diluted (loss) per share (in $)			(0.55)		(2.21)

The accompanying notes are an integral part of these unaudited condensed consolidated interim financial statements.

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ARGENX SE

UNAUDITED CONDENSED CONSOLIDATED INTERIM STATEMENTS OF COMPREHENSIVE INCOME (LOSS)


		Six Months Ended
		June 30,
(in thousands of $)	Note	2024		2023
Loss for the period		$	(32,531)	$	(123,239)

Items that may be reclassified subsequently to profit or loss, net of tax
Currency translation differences, arisen from translating foreign activities			(2,608)		762
Items that will not be reclassified to profit or loss, net of tax
Fair value gain/(loss) on investments in equity instruments designated as at FVTOCI	4		(5,682)		(1,688)

Other comprehensive loss, net of income tax			(8,290)		(926)

Total comprehensive loss attributable to:
Owners of the parent		$	(40,821)	$	(124,165)

The accompanying notes form an integral part of these unaudited condensed consolidated interim financial statements.

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ARGENX SE

UNAUDITED CONDENSED CONSOLIDATED INTERIM STATEMENTS OF CASH FLOWS


		Six Months Ended
		June 30,
(in thousands of $)	Note	2024		2023
Operating loss		$	(138,882)	$	(205,837)
Adjustments for non-cash items
Amortization of intangible assets			4,956		43
Depreciation of property, plant and equipment			3,667		2,661
Provisions for employee benefits			143		138
Expense recognized in respect of share-based payments	9		102,381		102,083
Fair value gains on financial assets at fair value through profit or loss			(445)		—
Loss from investment in joint venture			3,313		1,880
Other non-cash expenses			8		—
		$	(24,859)	$	(99,032)
Movements in current assets/liabilities
(Increase)/decrease in trade and other receivables	6		(97,612)		(68,057)
(Increase)/decrease in inventories	5		(16,072)		27,240
(Increase)/decrease in other current assets			(45,821)		(62,500)
Increase/(decrease) in trade and other payables	10		76,710		(616)
Movements in non-current assets/liabilities
(Increase)/decrease in other non‑current assets	4		(18,139)		(11,603)
(Increase)/decrease in non-current prepaid expense			—		(47,327)

Net cash flows used in operating activities, before interest and taxes			(125,793)		(261,894)

Interest paid			(157)		(78)
Income taxes received/(paid)			1,294		(23,465)

Net cash flows used in operating activities		$	(124,656)	$	(285,436)

Purchase of intangible assets			(21,500)		—
Purchase of property, plant and equipment			(811)		(479)
Purchase of current financial assets	7		(1,108,410)		(267,196)
Sale of current financial assets	7		568,410		780,331
Interest received			48,552		27,361
Investment in joint venture			—		(13,000)

Net cash flows from / (used in) investing activities		$	(513,759)	$	527,017

Principal elements of lease payments			(3,604)		(2,182)
Payment of employee withholding taxes relating to restricted stock unit awards			(1,792)		(604)
Proceeds from exercise of stock options	8		45,470		65,074

Net cash flows from financing activities		$	40,074	$	62,288

Increase/(decrease) in cash and cash equivalents		$	(598,341)	$	303,868

Cash and cash equivalents at the beginning of the period		$	2,048,844	$	800,740
Exchange gains/(losses) on cash and cash equivalents		$	(12,256)	$	5,960
Cash and cash equivalents at the end of the period		$	1,438,247	$	1,110,567

The accompanying notes form an integral part of these unaudited condensed consolidated interim financial statements.

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ARGENX SE

UNAUDITED CONDENSED CONSOLIDATED INTERIM STATEMENTS OF CHANGES IN EQUITY


	Attributable to owners of the parent
									Share-based				Total
									payment and				equity
									income tax		Fair value movement on		attributable
									deduction on		investment in equity		to owners
	Share		Share		Accumulated		Translation		share-based		instruments designated		of the		Total
(in thousands of $)	capital		premium		losses		differences		payments		as at FVTOCI		parent		equity
Balance year ended December 31, 2022	$	6,640		4,309,880		(2,109,791)		129,280		535,247		(57,557)		2,813,699		2,813,699

Loss for the year						(123,239)								(123,239)		(123,239)
Other comprehensive income / (loss)								762				(1,688)		(926)		(926)
Total comprehensive income / (loss) for the year		—		—		(123,239)		762		—		(1,688)		(124,165)		(124,165)
Income tax benefit from excess tax deductions related to share-based payments										1,396				1,396		1,396
Share-based payment										102,651				102,651		102,651
Exercise of stock options		58		65,016										65,074		65,074
Ordinary shares withheld for payment of employees’ withholding tax liability				(604)										(604)		(604)

Balance year ended June 30, 2023	$	6,698	$	4,374,291	$	(2,233,029)	$	130,042	$	639,294	$	(59,245)	$	2,858,051	$	2,858,051

Balance year ended December 31, 2023	$	7,058	$	5,651,497	$	(2,404,844)	$	131,543	$	771,725	$	(59,472)	$	4,097,507	$	4,097,507

Loss for the period						(32,531)								(32,531)		(32,531)
Other comprehensive income / (loss)								(2,608)				(5,682)		(8,290)		(8,290)
Total comprehensive income / (loss) for the period		—		—		(32,531)		(2,608)		—		(5,682)		(40,821)		(40,821)
Income tax benefit from excess tax deductions related to share-based payments										7,013				7,013		7,013
Share-based payment										102,544				102,544		102,544
Exercise of stock options		60		97,736										97,796		97,796
Ordinary shares withheld for payment of employees’ withholding tax liability				(1,792)										(1,792)		(1,792)

Balance year ended June 30, 2024	$	7,118	$	5,747,441	$	(2,437,375)	$	128,935	$	881,282	$	(65,154)	$	4,262,247	$	4,262,247

Please refer to note 8 for more information on the share capital.

The accompanying notes form an integral part of these unaudited condensed consolidated interim financial statements.

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ARGENX SE

NOTES TO THE UNAUDITED CONDENSED CONSOLIDATED INTERIM FINANCIAL STATEMENTS

1. General information about the company

argenx SE (the Company) is a Dutch European public company with limited liability incorporated under the laws of the Netherlands. The Company (COC 24435214) has its official seat in Rotterdam, the Netherlands, and its registered office is at Laarderhoogteweg 25, 1101 EB Amsterdam, the Netherlands.

argenx SE is a publicly traded company with ordinary shares listed on Euronext Brussels under the symbol “ARGX” since July 2014 and with American Depositary Shares listed on Nasdaq under the symbol “ARGX” since May 2017.

2. Basis of preparation

The unaudited condensed consolidated interim financial statements for the six months ended June 30, 2024 have been prepared in accordance with IAS 34 ‘Interim Financial Reporting’ as issued by the IASB and as adopted by the European Union. The unaudited condensed consolidated interim financial statements should be read in conjunction with the annual financial statements for the year ended December 31, 2023.

All amounts herein are presented in thousands of $, unless otherwise indicated, rounded to the nearest $ ‘000.

The unaudited condensed consolidated financial statements have been approved for issue by the Company’s Board of Directors (the “Board”) on July 23, 2024.

3. Material accounting policy information

There were no significant changes in the material accounting policies, critical accounting judgements and key sources of estimation uncertainty applied by us in these unaudited condensed consolidated interim financial statements compared to those used in the annual consolidated financial statements as of December 31, 2023.

4. Other non-current assets


	At June 30,		At December 31,
(in thousands of $)	2024		2023
Non-current restricted cash	$	2,269	$	2,419
Non-current financial assets held at fair value through profit or loss		22,160		21,715
Non-current financial assets held at fair value through OCI		9,847		15,528
Total other non-current assets	$	34,276	$	39,662

Please also refer to note 15 for more information on the financial instruments.

5. Inventories


	At June 30,		At December 31,
(in thousands of $)	2024		2023
Raw materials and consumables	$	250,891	$	240,836
Inventories in process		37,158		47,074
Finished goods		38,411		22,640
Total inventories	$	326,460	$	310,550

The cost of inventories, which is recognized under “Cost of sales” on the unaudited condensed consolidated statements of profit or loss, amounted to $76 million for the six months ended June 30, 2024 (compared to $42 million for the six months ended June 30, 2023).

On June 30, 2024, pre-launch inventory awaiting facility approval amounted to $84 million.

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6. Trade and other receivables

Trade and other receivables are composed of receivables which are detailed below:


	At June 30,		At December 31,
(in thousands of $)	2024		2023
Trade receivable	$	515,960	$	417,994
Interest receivable		33,295		13,126
Tax receivables		46,107		63,605
Other receivables		57,513		1,962
Total trade and other receivables	$	652,875	$	496,687

The carrying amounts of trade and other receivables approximate their respective fair values. On June 30, 2024 and December 31, 2023, the Company did not have any provision for expected credit losses.

On June 30, 2024, Other receivables include $52 million related to proceeds of exercise of stock options.

7. Cash and cash equivalents


	At June 30,		At December 31,
(in thousands of $)	2024		2023
Money market funds	$	1,307,197	$	1,678,100
Term accounts		100,000		350,000
Cash and bank balances		31,050		20,744
Total cash and cash equivalents	$	1,438,247	$	2,048,844

On June 30, 2024, Cash and cash equivalents amounted to $1,438 million, compared to $2,049 million on December 31, 2023 and comprise of cash and bank balances, term accounts with an original maturity not exceeding 3 months and money market funds that are readily convertible to cash and are subject to an insignificant risk of changes in value.

Please also refer to note 15 for more information on the financial instruments.

8. Shareholders’ capital

On June 30, 2024, the Company’s share capital was represented by 59,796,273 shares. All shares were issued, fully paid and of the same class. The table below summarizes the share issuances as a result of the exercise of stock options and vesting of restricted stock units under the Company’s Employee Stock Option Plan, for the period ended June 30, 2024.


Number of shares outstanding on December 31, 2023		59,194,488
Exercise of stock options		555,392
Vesting of RSUs		46,393
Number of shares outstanding on June 30, 2024		59,796,273

9. Share based payments

The Company has an equity incentive plan for the employees, key consultants, board members, senior managers and key outside advisors (“key persons”) of the Company and its subsidiaries. In accordance with the term of the plan, as approved by shareholders, employees may be granted stock options and/or restricted stock units.

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9.1 Stock options

The stock options are granted to key persons of the Company and its subsidiaries. The stock options may be granted to purchase ordinary shares at an exercise price. The stock options have been granted free of charge. Each employee’s stock option converts into one ordinary share of the Company upon exercise. The stock options carry neither rights to dividends nor voting rights. Stock options may be exercised at any time from the date of vesting to the date of their expiry.

The stock options granted vest, in principle, as follows:

●

1/3^rd of the total stock options granted on the first anniversary of the granting of the stock options; and

●

1/36^th of the total grant on the first day of each month following the first anniversary of the date of grant of the stock options.

Stock options granted to non-executive directors vest on the third anniversary of the date of grant.

Upon leave of the key persons, stock options must be exercised before the later of (i) 90 days after the last working day at argenx, or (ii) March 31 of the 4th year following the date of grant of those stock options, and in any case no later than the expiration date of the option.

Below is an overview of the parameters used in relation to the new grant during the six months ended June 30, 2024:


Stock options granted in	April 2024			June 2024 (1)
Number of options granted		42,243			660,166
Average Fair value of options (in $) (2)	$	112.14 - 156.49		$	158.50
Share price (in $) (2)	$	365.56 - 396.30		$	437.41
Exercise price (in $) (2)	$	396.30		$	445.76
Expected volatility		35.53 - 39.04	%		35.17	%
Average Expected option life (in years)		4.30 - 6.49			5.34
Risk‑free interest rate		2.66 - 3.02	%		2.87	%
Expected dividends		—	%		—	%

(1)

In June 2024, the Company granted a total of 660,166 stock options of which 188,606 stock options to Belgian taxed beneficiaries. Belgian taxed beneficiaries can choose between a contractual term of five or ten years. The expected option life ranges between 4.16 and 6.35 years. The fair value per option granted to Belgian taxed beneficiaries at grant date would range from $ 137.63 (for the stock options of Belgian taxed beneficiaries with a contractual term of five years) to $174.78 (for the stock options of Belgian taxed beneficiaries with a contractual term of ten years). This estimate will be reassessed once the acceptance period of 60 days has passed and the beneficiaries will have made a choice between a contractual term of five or ten years.

(2)	amounts have been converted to USD at the applicable rate prevailing at the grant date.

The total share-based payment expense related to stock options recognized in the unaudited condensed consolidated statement of profit or loss totaled $70 million for the six months ended June 30, 2024 compared to $72 million for the six months ended June 30, 2023.

9.2 Restricted Stock Units (RSUs)

The RSUs are granted to key persons of the Company and its subsidiaries. The RSUs have been granted free of charge. Each employee’s RSUs converts into one ordinary share of the Company upon vesting. The RSUs carry neither rights to dividends nor voting rights. RSUs once converted into ordinary shares, may be sold at any time from the date of vesting, have no expiry date and may be held by the participant without limitation. The fair value of RSUs is based on the closing sale price of our Company’s common stock on the day prior to the date of issuance. RSUs vest over a period of 4 years with 1/4^th of the total grant vesting at each anniversary of the date of grant.

The total share-based payment expense related to RSUs recognized in the unaudited condensed consolidated interim statements of profit or loss totaled $33 million for the six months ended June 30, 2024 compared to $30 million for six months ended June 30, 2023.

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10. Trade and other payables


	At June 30,		At December 31,
(in thousands of $)	2024		2023
Trade payables	$	280,633	$	245,557
Gross-to-net accruals		84,236		55,788
Short‑term employee benefits		106,708		95,104
Other		8,252		17,564
Total trade and other payables	$	479,829	$	414,013

The carrying amounts of trade and other payables approximate their respective fair values.

Trade payables correspond primarily to clinical and manufacturing activities and include accrued expenses related to these activities.

Short-term employee benefits include payables and accruals for compensation and bonuses to be paid to the employees of the Company.

The following table summerizes the movement in the Gross-to-net accruals for the period ended June 30, 2024:


(in thousands of $)	Rebates and chargebacks		Distribution fees, product returns and other		Total Gross-to-net accruals
Balance at December 31, 2022	$	15,398	$	4,079	$	19,478
Estimate related to the sales made in the current year		123,542		26,427		149,969
Adjustment for prior year sales		(4,041)		(883)		(4,924)
(Credits or payments)		(85,237)		(23,497)		(108,734)
Balance at December 31, 2023	$	49,662	$	6,126	$	55,788
Estimate related to the sales made in the current period		111,669		19,101		130,770
Adjustment for prior year sales		(5,391)		(40)		(5,431)
(Credits or payments)		(77,627)		(19,264)		(96,891)
Balance at June 30, 2024	$	78,313	$	5,923	$	84,236

11. Segment reporting

The Company manages its activities and operates as one business unit which is reflected in its organizational structure and internal reporting. The Company’s information on different segments or geographical segments is not used by management in making operating decisions.

The following table summarizes the product net sales by region of sales:


	Six Months Ended
	June 30,
(in thousands of $)	2024		2023
North America	$	755,536	$	440,853
Japan		38,114		23,645
EMEA		66,072		22,836
China		16,196		—
Total product net sales	$	875,918	$	487,335

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We sell our products through a limited number of distributors and wholesalers. Four U.S. customers represent approximately 88% of the product net sales in the U.S. during six months ended June 30, 2024 (compared to 88% for the same period in 2023).

12. Research and development expenses


	Six Months Ended
	June 30,
(in thousands of $)	2024		2023
Personnel expenses	$	132,903	$	99,482
External research and development expenses		286,038		233,868
Materials and consumables		2,309		2,044
Depreciation and amortization		2,769		3,498
IT expenses		16,493		13,441
Other expenses		9,743		9,031
Total Research and development expenses	$	450,255	$	361,364

13. Selling, general and administrative expenses


	Six Months Ended
	June 30,
(in thousands of $)	2024		2023
Personnel expenses	$	194,026	$	134,862
Marketing services		150,341		90,436
Professional fees		86,406		42,796
Supervisory board		4,267		3,978
Depreciation and amortization		1,424		1,083
IT expenses		11,647		5,496
Other expenses		43,583		32,499
Total Selling, general and administrative expenses	$	491,694	$	311,149

14. Income taxes

The Company recorded an income tax benefit of $57 million (compared to $37 million for the same period in 2023) in relation to a loss of the period before taxes of $89 million for the six months ended June 30, 2024 (compared to $160 million for the same period in 2023). The effective tax rate for the six months ended June 30, 2024 and June 30, 2023 was primarily impacted by the following items: (i) the mix of income generated among the jurisdictions in which the Company operates, (ii) certain deferred tax assets not recognized mainly due to the history of losses, and (iii) a $64 million deferred tax benefit due to intra-group inventory transfers (compared to $44 million for the same period in 2023).

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15. Financial instruments and financial risk management

The Company carried the following assets at fair value on June 30, 2024 and December 31, 2023, respectively:


	At June 30, 2024
(in thousands of $)	Level 1		Level 2		Level 3
Non-current financial assets	$	10,293	$	—	$	21,715
Cash and cash equivalents		1,307,197		—		—
Assets carried at fair value	$	1,317,490	$	—	$	21,715


	At December 31, 2023
(in thousands of $)	Level 1		Level 2		Level 3
Non-current financial assets	$	15,528	$	—	$	21,715
Cash and cash equivalents		1,678,100		—		—
Assets carried at fair value	$	1,693,628	$	—	$	21,715

Non-current financial assets – Level 3

The Company has a profit share in AgomAb Therapeutics NV. Since AgomAb Therapeutics NV is a private company, the valuation of the profit is based on level 3 assumptions.

In October 2023, AgomAb Therapeutics NV secured $100 million as a result of a Series C financing round. The Company’s profit share diluted as the number of shares held by the company stayed stable where the post-money valuation of AgomAb increased, which results in unchanged fair value of the non-current asset.

Non-current financial assets – Level 1

As part of the license agreement for the development and commercialization for efgartigimod in Greater China, the Company obtained, amongst others, 568,182 newly issued Zai Lab shares calculated at a price of $132 per share. The fair value of the equity instrument at period-end is determined by reference to the closing price of such securities at each reporting date (classified as level 1 in the fair value hierarchy), resulting in a change in fair value. The Company made the irrevocable election to recognize subsequent changes in fair value through OCI.

16. Related party transaction

The Company has a joint venture agreement with the University of Colorado Anschutz Medical Campus and UCHealth as a separate legal entity, OncoVerity, Inc. The Company contributed $13 million in 2023 towards the joint venture to fund its operations. The share of net loss resulting from investment in joint ventures is presented in the unaudited condensed consolidated statements of profit or loss and other comprehensive income (loss) in line “Loss from investment in joint ventures”.

During the six months ended June 30, 2024 a total of 98,306 stock options and 36,365 restricted stock units were granted to senior management members as a group. During the six months ended June 30, 2024 a total of 10,118 restricted stock units were granted to non-executive board members.

17. Contractual obligations and commitments

At balance sheet date, there were no commitments signed for the acquisition of property, plant and equipment.

In February 2019, and as amended in September 2020, the Company entered into a global collaboration and license agreement with Halozyme Therapeutics, Inc. Under the terms of the agreement as of June 30, 2024, the Company will pay up to $110 million to achievement of specific regulatory and sales-based milestones related to VYVGART SC. This amount represents the maximum amount that would be paid if all milestones would be achieved but excludes variable royalty payments based on unit sales. Further, the Company will pay $12.5 million per target for future target nominations and potential future payments of up to $160 million per selected target subject to achievement of specified development, regulatory and sales-based milestones and up to $40 million subject to the achievement of additional, specified sales-based milestones. This amount represents the

Table of Contents

maximum amount that would be paid if all milestones would be achieved but excludes variable royalty payments based on unit sales.

The Company’s manufacturing commitments with Lonza, its drug substance manufacturing contractor, relate to the ongoing execution of the biologic license application (BLA) services for efgartigimod and its manufacturing activities related to the commercialization or potential future commercialization. In December 2018, the Company signed its first commercial supply agreement with Lonza related to the reservation of commercial drug substance supply capacity for efgartigimod. In the aggregate, as of June 30, 2024, the Company has outstanding commitments for efgartigimod under the first commercial supply agreement of $330 million.

As of June 30, 2024, the Company had a line of credit totalling to $11 million (€ 10 million) with the banks.

18. Events after the balance sheet date

No events have occurred after the balance sheet date that could have a material impact on the unaudited condensed consolidated financial statements.

Document and Entity Information	6 Months Ended
Document and Entity Information	Jun. 30, 2024
Cover [Abstract]
Document Type	6-K
Document Period End Date	Jun. 30, 2024
Entity Registrant Name	ARGENX SE
Entity Central Index Key	0001697862
Current Fiscal Year End Date	--12-31
Document Fiscal Year Focus	2024
Document Fiscal Period Focus	Q2
Amendment Flag	false

UNAUDITED CONDENSED CONSOLIDATED INTERIM STATEMENTS OF FINANCIAL POSITION - USD ($) $ in Thousands	Jun. 30, 2024	Dec. 31, 2023
Non-current assets
Property, plant and equipment	$ 36,931	$ 22,675
Intangible assets	141,774	125,228
Deferred tax asset	174,626	97,211
Research and development incentive receivables	91,237	76,706
Investment in joint venture	6,599	9,912
Prepaid expenses	47,327	47,327
Other non-current assets	34,276	39,662
Total non-current assets	532,770	418,721
Current assets
Inventories	326,460	310,550
Prepaid expenses	179,420	134,072
Trade and other receivables	652,875	496,687
Research and development incentive receivables	2,686	2,584
Financial assets	1,664,100	1,131,000
Cash and cash equivalents	1,438,247	2,048,844
Total current assets	4,263,788	4,123,737
TOTAL ASSETS	4,796,558	4,542,458
Equity
Share capital	7,118	7,058
Share premium	5,747,441	5,651,497
Translation differences	128,935	131,543
Accumulated losses	(2,437,375)	(2,404,844)
Other reserves	816,128	712,253
Total equity	4,262,247	4,097,507
Non-current liabilities
Provisions for employee benefits	1,581	1,449
Lease liabilities	28,107	15,354
Deferred tax liabilities	4,994	5,155
Total non-current liabilities	34,682	21,958
Current liabilities
Lease liabilities	5,853	4,646
Trade and other payables	479,829	414,013
Tax liabilities	13,947	4,334
Total current liabilities	499,629	422,993
Total liabilities	534,311	444,951
TOTAL EQUITY AND LIABILITIES	$ 4,796,558	$ 4,542,458

UNAUDITED CONDENSED CONSOLIDATED INTERIM STATEMENTS OF PROFIT OR LOSS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023
UNAUDITED CONDENSED CONSOLIDATED INTERIM STATEMENTS OF PROFIT OR LOSS
Product net sales	$ 875,918	$ 487,335
Collaboration revenue	2,718	2,355
Other operating income	23,305	21,225
Total operating income	901,941	510,915
Cost of sales	(95,561)	(42,359)
Research and development expenses	(450,255)	(361,364)
Selling, general and administrative expenses	(491,694)	(311,149)
Loss from investment in joint venture	(3,313)	(1,880)
Total operating expenses	(1,040,823)	(716,752)
Operating loss	(138,882)	(205,837)
Financial income	77,828	37,029
Financial expense	(1,084)	(395)
Exchange gains/(losses)	(27,215)	9,164
Loss for the period before taxes	(89,353)	(160,039)
Income tax benefit	56,822	36,800
Loss for the period	(32,531)	(123,239)
Owners of the parent	$ (32,531)	$ (123,239)
Weighted average number of shares outstanding	59,400,217	55,690,873
Basic (loss) per share (in $)	$ (0.55)	$ (2.21)
Diluted (loss) per share (in $)	$ (0.55)	$ (2.21)

UNAUDITED CONDENSED CONSOLIDATED INTERIM STATEMENTS OF COMPREHENSIVE INCOME (LOSS) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023
UNAUDITED CONDENSED CONSOLIDATED INTERIM STATEMENTS OF COMPREHENSIVE INCOME (LOSS)
Loss for the period	$ (32,531)	$ (123,239)
Currency translation differences, arisen from translating foreign activities	(2,608)	762
Fair value gain/(loss) on investments in equity instruments designated as at FVTOCI	(5,682)	(1,688)
Other comprehensive loss, net of income tax	(8,290)	(926)
Owners of the parent	$ (40,821)	$ (124,165)

UNAUDITED CONDENSED CONSOLIDATED INTERIM STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023
CASH FLOWS (USED IN) / FROM OPERATING ACTIVITIES
Operating loss	$ (138,882)	$ (205,837)
Adjustments for non-cash items
Amortization of intangible assets	4,956	43
Depreciation of property, plant and equipment	3,667	2,661
Provisions for employee benefits	143	138
Expense recognized in respect of share-based payments	102,381	102,083
Fair value gains on financial assets at fair value through profit or loss	(445)
Loss from investment in joint venture	3,313	1,880
Other non-cash expenses	8
Adjustments for non-cash items	(24,859)	(99,032)
Movements in current assets/liabilities
(Increase)/decrease in trade and other receivables	(97,612)	(68,057)
(Increase)/decrease in inventories	(16,072)	27,240
(Increase)/decrease in other current assets	(45,821)	(62,500)
Increase/(decrease) in trade and other payables	76,710	(616)
Movements in non-current assets/liabilities
(Increase)/decrease in other non-current assets	(18,139)	(11,603)
(Increase)/decrease in non-current prepaid expense		(47,327)
Net cash flows used in operating activities, before interest and taxes	(125,793)	(261,894)
Interest paid	(157)	(78)
Income taxes received/(paid)	1,294	(23,465)
Net cash flows used in operating activities	(124,656)	(285,436)
CASH FLOWS (USED IN) / FROM INVESTING ACTIVITIES
Purchase of intangible assets	(21,500)
Purchase of property, plant and equipment	(811)	(479)
Purchase of current financial assets	(1,108,410)	(267,196)
Sale of current financial assets	568,410	780,331
Interest received	48,552	27,361
Investment in joint venture		(13,000)
Net cash flows from / (used in) investing activities	(513,759)	527,017
CASH FLOWS (USED IN) / FROM FINANCING ACTIVITIES
Principal elements of lease payments	(3,604)	(2,182)
Payment of employee withholding taxes relating to restricted stock unit awards	(1,792)	(604)
Proceeds from exercise of stock options	45,470	65,074
Net cash flows from financing activities	40,074	62,288
Increase/(decrease) in cash and cash equivalents	(598,341)	303,868
Cash and cash equivalents at the beginning of the period	2,048,844	800,740
Exchange gains/(losses) on cash and cash equivalents	(12,256)	5,960
Cash and cash equivalents at the end of the period	$ 1,438,247	$ 1,110,567

UNAUDITED CONDENSED CONSOLIDATED INTERIM STATEMENTS OF CHANGES IN EQUITY - USD ($) $ in Thousands	Share Capital	Share Premium	Accumulated Losses	Translation Difference	Share-based payment and income tax deduction on share-based payments	Fair value movement on investment in equity instruments designated as at FVTOCI	Total Equity Attributable to Owners of the Parent	Total
Equity at beginning of period at Dec. 31, 2022	$ 6,640	$ 4,309,880	$ (2,109,791)	$ 129,280	$ 535,247	$ (57,557)	$ 2,813,699	$ 2,813,699
Loss for the period			(123,239)				(123,239)	(123,239)
Other comprehensive income / (loss)				762		(1,688)	(926)	(926)
Total comprehensive income / (loss) for the year			(123,239)	762		(1,688)	(124,165)	(124,165)
Income tax benefit from excess tax deductions related to share-based payments					1,396		1,396	1,396
Share-based payment					102,651		102,651	102,651
Exercise of stock options	58	65,016					65,074	65,074
Ordinary shares withheld for payment of employees' withholding tax liability		(604)					(604)	(604)
Equity at end of period at Jun. 30, 2023	6,698	4,374,291	(2,233,029)	130,042	639,294	(59,245)	2,858,051	2,858,051
Equity at beginning of period at Dec. 31, 2023	7,058	5,651,497	(2,404,844)	131,543	771,725	(59,472)	4,097,507	4,097,507
Loss for the period			(32,531)				(32,531)	(32,531)
Other comprehensive income / (loss)				(2,608)		(5,682)	(8,290)	(8,290)
Total comprehensive income / (loss) for the year			(32,531)	(2,608)		(5,682)	(40,821)	(40,821)
Income tax benefit from excess tax deductions related to share-based payments					7,013		7,013	7,013
Share-based payment					102,544		102,544	102,544
Exercise of stock options	60	97,736					97,796	97,796
Ordinary shares withheld for payment of employees' withholding tax liability		(1,792)					(1,792)	(1,792)
Equity at end of period at Jun. 30, 2024	$ 7,118	$ 5,747,441	$ (2,437,375)	$ 128,935	$ 881,282	$ (65,154)	$ 4,262,247	$ 4,262,247

General information about the company

6 Months Ended

Jun. 30, 2024

General information about the company

General information about the company

1. General information about the company

Basis of preparation

6 Months Ended

Jun. 30, 2024

Basis of preparation

Basis of preparation

2. Basis of preparation

All amounts herein are presented in thousands of $, unless otherwise indicated, rounded to the nearest $ ‘000.

The unaudited condensed consolidated financial statements have been approved for issue by the Company’s Board of Directors (the “Board”) on July 23, 2024.

Material accounting policy information

6 Months Ended

Jun. 30, 2024

Material accounting policy information

Material accounting policy information

3. Material accounting policy information

Other non-current assets

6 Months Ended

Jun. 30, 2024

Other non-current assets

Other non-current assets

4. Other non-current assets


	At June 30,		At December 31,
(in thousands of $)	2024		2023
Non-current restricted cash	$	2,269	$	2,419
Non-current financial assets held at fair value through profit or loss		22,160		21,715
Non-current financial assets held at fair value through OCI		9,847		15,528
Total other non-current assets	$	34,276	$	39,662

Please also refer to note 15 for more information on the financial instruments.

Inventories

6 Months Ended

Jun. 30, 2024

Inventories

Inventories

5. Inventories


	At June 30,		At December 31,
(in thousands of $)	2024		2023
Raw materials and consumables	$	250,891	$	240,836
Inventories in process		37,158		47,074
Finished goods		38,411		22,640
Total inventories	$	326,460	$	310,550

On June 30, 2024, pre-launch inventory awaiting facility approval amounted to $84 million.

Trade and other receivables

6 Months Ended

Jun. 30, 2024

Trade and other receivables.

Trade and other receivables

6. Trade and other receivables

Trade and other receivables are composed of receivables which are detailed below:


	At June 30,		At December 31,
(in thousands of $)	2024		2023
Trade receivable	$	515,960	$	417,994
Interest receivable		33,295		13,126
Tax receivables		46,107		63,605
Other receivables		57,513		1,962
Total trade and other receivables	$	652,875	$	496,687

On June 30, 2024, Other receivables include $52 million related to proceeds of exercise of stock options.

Cash and cash equivalents

6 Months Ended

Jun. 30, 2024

Cash and cash equivalents

Cash and cash equivalents

7. Cash and cash equivalents


	At June 30,		At December 31,
(in thousands of $)	2024		2023
Money market funds	$	1,307,197	$	1,678,100
Term accounts		100,000		350,000
Cash and bank balances		31,050		20,744
Total cash and cash equivalents	$	1,438,247	$	2,048,844

Please also refer to note 15 for more information on the financial instruments.

Shareholders' capital

6 Months Ended

Jun. 30, 2024

Shareholders' capital

Shareholders' capital

8. Shareholders’ capital


Number of shares outstanding on December 31, 2023		59,194,488
Exercise of stock options		555,392
Vesting of RSUs		46,393
Number of shares outstanding on June 30, 2024		59,796,273

Share based payments

6 Months Ended

Jun. 30, 2024

Share based payments

Share based payments

9. Share based payments

9.1 Stock options

The stock options granted vest, in principle, as follows:

●

1/3^rd of the total stock options granted on the first anniversary of the granting of the stock options; and

●

1/36^th of the total grant on the first day of each month following the first anniversary of the date of grant of the stock options.

Stock options granted to non-executive directors vest on the third anniversary of the date of grant.

Below is an overview of the parameters used in relation to the new grant during the six months ended June 30, 2024:


Stock options granted in	April 2024			June 2024 (1)
Number of options granted		42,243			660,166
Average Fair value of options (in $) (2)	$	112.14 - 156.49		$	158.50
Share price (in $) (2)	$	365.56 - 396.30		$	437.41
Exercise price (in $) (2)	$	396.30		$	445.76
Expected volatility		35.53 - 39.04	%		35.17	%
Average Expected option life (in years)		4.30 - 6.49			5.34
Risk‑free interest rate		2.66 - 3.02	%		2.87	%
Expected dividends		—	%		—	%

(1)

(2)	amounts have been converted to USD at the applicable rate prevailing at the grant date.

9.2 Restricted Stock Units (RSUs)

Trade and other payables

6 Months Ended

Jun. 30, 2024

Trade and other payables.

Trade and other payables

10. Trade and other payables


	At June 30,		At December 31,
(in thousands of $)	2024		2023
Trade payables	$	280,633	$	245,557
Gross-to-net accruals		84,236		55,788
Short‑term employee benefits		106,708		95,104
Other		8,252		17,564
Total trade and other payables	$	479,829	$	414,013

The carrying amounts of trade and other payables approximate their respective fair values.

Trade payables correspond primarily to clinical and manufacturing activities and include accrued expenses related to these activities.

Short-term employee benefits include payables and accruals for compensation and bonuses to be paid to the employees of the Company.

The following table summerizes the movement in the Gross-to-net accruals for the period ended June 30, 2024:


(in thousands of $)	Rebates and chargebacks		Distribution fees, product returns and other		Total Gross-to-net accruals
Balance at December 31, 2022	$	15,398	$	4,079	$	19,478
Estimate related to the sales made in the current year		123,542		26,427		149,969
Adjustment for prior year sales		(4,041)		(883)		(4,924)
(Credits or payments)		(85,237)		(23,497)		(108,734)
Balance at December 31, 2023	$	49,662	$	6,126	$	55,788
Estimate related to the sales made in the current period		111,669		19,101		130,770
Adjustment for prior year sales		(5,391)		(40)		(5,431)
(Credits or payments)		(77,627)		(19,264)		(96,891)
Balance at June 30, 2024	$	78,313	$	5,923	$	84,236

Segment reporting

6 Months Ended

Jun. 30, 2024

Segment reporting

Segment reporting

11. Segment reporting

The following table summarizes the product net sales by region of sales:


	Six Months Ended
	June 30,
(in thousands of $)	2024		2023
North America	$	755,536	$	440,853
Japan		38,114		23,645
EMEA		66,072		22,836
China		16,196		—
Total product net sales	$	875,918	$	487,335

Research and development expenses

6 Months Ended

Jun. 30, 2024

Research and development expenses

Research and development expenses

12. Research and development expenses


	Six Months Ended
	June 30,
(in thousands of $)	2024		2023
Personnel expenses	$	132,903	$	99,482
External research and development expenses		286,038		233,868
Materials and consumables		2,309		2,044
Depreciation and amortization		2,769		3,498
IT expenses		16,493		13,441
Other expenses		9,743		9,031
Total Research and development expenses	$	450,255	$	361,364

Selling, general and administrative expenses

6 Months Ended

Jun. 30, 2024

Selling, general and administrative expenses

Selling, general and administrative expenses

13. Selling, general and administrative expenses


	Six Months Ended
	June 30,
(in thousands of $)	2024		2023
Personnel expenses	$	194,026	$	134,862
Marketing services		150,341		90,436
Professional fees		86,406		42,796
Supervisory board		4,267		3,978
Depreciation and amortization		1,424		1,083
IT expenses		11,647		5,496
Other expenses		43,583		32,499
Total Selling, general and administrative expenses	$	491,694	$	311,149

Income taxes

6 Months Ended

Jun. 30, 2024

Income taxes

Income taxes

14. Income taxes

Financial instruments and financial risk management

6 Months Ended

Jun. 30, 2024

Financial instruments and financial risk management

Financial instruments and financial risk management

15. Financial instruments and financial risk management

The Company carried the following assets at fair value on June 30, 2024 and December 31, 2023, respectively:


	At June 30, 2024
(in thousands of $)	Level 1		Level 2		Level 3
Non-current financial assets	$	10,293	$	—	$	21,715
Cash and cash equivalents		1,307,197		—		—
Assets carried at fair value	$	1,317,490	$	—	$	21,715


	At December 31, 2023
(in thousands of $)	Level 1		Level 2		Level 3
Non-current financial assets	$	15,528	$	—	$	21,715
Cash and cash equivalents		1,678,100		—		—
Assets carried at fair value	$	1,693,628	$	—	$	21,715

Non-current financial assets – Level 3

The Company has a profit share in AgomAb Therapeutics NV. Since AgomAb Therapeutics NV is a private company, the valuation of the profit is based on level 3 assumptions.

Non-current financial assets – Level 1

Related party transaction

6 Months Ended

Jun. 30, 2024

Related party transaction

Related party transaction

16. Related party transaction

Contractual obligations and commitments

6 Months Ended

Jun. 30, 2024

Contractual obligations and commitments

Contractual obligations and commitments

17. Contractual obligations and commitments

At balance sheet date, there were no commitments signed for the acquisition of property, plant and equipment.

maximum amount that would be paid if all milestones would be achieved but excludes variable royalty payments based on unit sales.

As of June 30, 2024, the Company had a line of credit totalling to $11 million (€ 10 million) with the banks.

Events after the balance sheet date

6 Months Ended

Jun. 30, 2024

Events after the balance sheet date

Events after the balance sheet date

18. Events after the balance sheet date

No events have occurred after the balance sheet date that could have a material impact on the unaudited condensed consolidated financial statements.

Basis of preparation (Policies)

6 Months Ended

Jun. 30, 2024

Basis of preparation

Basis of preparation

All amounts herein are presented in thousands of $, unless otherwise indicated, rounded to the nearest $ ‘000.

The unaudited condensed consolidated financial statements have been approved for issue by the Company’s Board of Directors (the “Board”) on July 23, 2024.

Other non-current assets (Tables)

6 Months Ended

Jun. 30, 2024

Other non-current assets

Schedule of other non-current assets


	At June 30,		At December 31,
(in thousands of $)	2024		2023
Non-current restricted cash	$	2,269	$	2,419
Non-current financial assets held at fair value through profit or loss		22,160		21,715
Non-current financial assets held at fair value through OCI		9,847		15,528
Total other non-current assets	$	34,276	$	39,662

Inventories (Tables)

6 Months Ended

Jun. 30, 2024

Inventories

Schedule of inventories


	At June 30,		At December 31,
(in thousands of $)	2024		2023
Raw materials and consumables	$	250,891	$	240,836
Inventories in process		37,158		47,074
Finished goods		38,411		22,640
Total inventories	$	326,460	$	310,550

Trade and other receivables (Tables)

6 Months Ended

Jun. 30, 2024

Trade and other receivables.

Schedule of trade and other receivables


	At June 30,		At December 31,
(in thousands of $)	2024		2023
Trade receivable	$	515,960	$	417,994
Interest receivable		33,295		13,126
Tax receivables		46,107		63,605
Other receivables		57,513		1,962
Total trade and other receivables	$	652,875	$	496,687

Cash and cash equivalents (Tables)

6 Months Ended

Jun. 30, 2024

Cash and cash equivalents

Schedule of cash and cash equivalents


	At June 30,		At December 31,
(in thousands of $)	2024		2023
Money market funds	$	1,307,197	$	1,678,100
Term accounts		100,000		350,000
Cash and bank balances		31,050		20,744
Total cash and cash equivalents	$	1,438,247	$	2,048,844

Shareholders' capital (Tables)

6 Months Ended

Jun. 30, 2024

Shareholders' capital

Schedule of number of share outstanding


Number of shares outstanding on December 31, 2023		59,194,488
Exercise of stock options		555,392
Vesting of RSUs		46,393
Number of shares outstanding on June 30, 2024		59,796,273

Share based payments (Tables)

6 Months Ended

Jun. 30, 2024

Share based payments

Schedule of parameters used in relation to the new grants


Stock options granted in	April 2024			June 2024 (1)
Number of options granted		42,243			660,166
Average Fair value of options (in $) (2)	$	112.14 - 156.49		$	158.50
Share price (in $) (2)	$	365.56 - 396.30		$	437.41
Exercise price (in $) (2)	$	396.30		$	445.76
Expected volatility		35.53 - 39.04	%		35.17	%
Average Expected option life (in years)		4.30 - 6.49			5.34
Risk‑free interest rate		2.66 - 3.02	%		2.87	%
Expected dividends		—	%		—	%

(1)

(2)	amounts have been converted to USD at the applicable rate prevailing at the grant date.

Trade and other payables (Tables)

6 Months Ended

Jun. 30, 2024

Trade and other payables.

Schedule of trade and other payables


	At June 30,		At December 31,
(in thousands of $)	2024		2023
Trade payables	$	280,633	$	245,557
Gross-to-net accruals		84,236		55,788
Short‑term employee benefits		106,708		95,104
Other		8,252		17,564
Total trade and other payables	$	479,829	$	414,013

Schedule of movement in gross to net accruals


(in thousands of $)	Rebates and chargebacks		Distribution fees, product returns and other		Total Gross-to-net accruals
Balance at December 31, 2022	$	15,398	$	4,079	$	19,478
Estimate related to the sales made in the current year		123,542		26,427		149,969
Adjustment for prior year sales		(4,041)		(883)		(4,924)
(Credits or payments)		(85,237)		(23,497)		(108,734)
Balance at December 31, 2023	$	49,662	$	6,126	$	55,788
Estimate related to the sales made in the current period		111,669		19,101		130,770
Adjustment for prior year sales		(5,391)		(40)		(5,431)
(Credits or payments)		(77,627)		(19,264)		(96,891)
Balance at June 30, 2024	$	78,313	$	5,923	$	84,236

Segment reporting (Tables)

6 Months Ended

Jun. 30, 2024

Segment reporting

Schedule of product net sales by country of sales


	Six Months Ended
	June 30,
(in thousands of $)	2024		2023
North America	$	755,536	$	440,853
Japan		38,114		23,645
EMEA		66,072		22,836
China		16,196		—
Total product net sales	$	875,918	$	487,335

Research and development expenses (Tables)

6 Months Ended

Jun. 30, 2024

Research and development expenses

Schedule of research and development expenses


	Six Months Ended
	June 30,
(in thousands of $)	2024		2023
Personnel expenses	$	132,903	$	99,482
External research and development expenses		286,038		233,868
Materials and consumables		2,309		2,044
Depreciation and amortization		2,769		3,498
IT expenses		16,493		13,441
Other expenses		9,743		9,031
Total Research and development expenses	$	450,255	$	361,364

Selling, general and administrative expenses (Tables)

6 Months Ended

Jun. 30, 2024

Selling, general and administrative expenses

Schedule of selling, general and administrative expenses


	Six Months Ended
	June 30,
(in thousands of $)	2024		2023
Personnel expenses	$	194,026	$	134,862
Marketing services		150,341		90,436
Professional fees		86,406		42,796
Supervisory board		4,267		3,978
Depreciation and amortization		1,424		1,083
IT expenses		11,647		5,496
Other expenses		43,583		32,499
Total Selling, general and administrative expenses	$	491,694	$	311,149

Financial instruments and financial risk management (Tables)

6 Months Ended

Jun. 30, 2024

Financial instruments and financial risk management

Schedule of assets at fair value


	At June 30, 2024
(in thousands of $)	Level 1		Level 2		Level 3
Non-current financial assets	$	10,293	$	—	$	21,715
Cash and cash equivalents		1,307,197		—		—
Assets carried at fair value	$	1,317,490	$	—	$	21,715


	At December 31, 2023
(in thousands of $)	Level 1		Level 2		Level 3
Non-current financial assets	$	15,528	$	—	$	21,715
Cash and cash equivalents		1,678,100		—		—
Assets carried at fair value	$	1,693,628	$	—	$	21,715

Other non-current assets - (Details) - USD ($) $ in Thousands	Jun. 30, 2024	Dec. 31, 2023
Other non-current assets
Non-current restricted cash	$ 2,269	$ 2,419
Non-current financial assets held at fair value through profit or loss	22,160	21,715
Non-current financial assets held at fair value through OCI	9,847	15,528
Total other non-current assets	$ 34,276	$ 39,662

Inventories (Details) - USD ($) $ in Thousands	6 Months Ended
Inventories (Details) - USD ($) $ in Thousands	Jun. 30, 2024	Jun. 30, 2023	Dec. 31, 2023
Inventories
Raw materials and consumables	$ 250,891		$ 240,836
Inventories in process	37,158		47,074
Finished goods	38,411		22,640
Total inventories	326,460		$ 310,550
Cost of merchandise sold	76,000	$ 42,000
Pre-launch inventory awaiting facility approval
Inventories
Total inventories	$ 84,000

Trade and other receivables (Details) - USD ($) $ in Thousands	Jun. 30, 2024	Dec. 31, 2023
Trade and other receivables.
Trade receivable	$ 515,960	$ 417,994
Interest receivable	33,295	13,126
Tax receivables	46,107	63,605
Other receivables	57,513	1,962
Total trade and other receivables	652,875	$ 496,687
Proceeds of exercise of stock options receivable included in other receivables	$ 52,000

Cash and cash equivalents (Details) - USD ($) $ in Thousands	Jun. 30, 2024	Dec. 31, 2023	Jun. 30, 2023	Dec. 31, 2022
Cash and cash equivalents
Money market funds	$ 1,307,197	$ 1,678,100
Term accounts	100,000	350,000
Cash and bank balances	31,050	20,744
Total cash and cash equivalents	$ 1,438,247	$ 2,048,844	$ 1,110,567	$ 800,740

Shareholders' capital (Details)	6 Months Ended
Shareholders' capital (Details)	Jun. 30, 2024 shares
Shareholders' capital
Number of shares outstanding at beginning of period	59,194,488
Exercise of stock options	555,392
Vesting of RSUs	46,393
Number of shares outstanding at end of period	59,796,273

Share based payments - Outstanding stock options (Details) - USD ($) $ in Millions	6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023
Disclosure of terms and conditions of share-based payment arrangement [line items]
Number of shares on conversion	1
Total share based payment expense	$ 70	$ 72
Tranche One
Disclosure of terms and conditions of share-based payment arrangement [line items]
Vesting percentage	33.33%
Tranche Two
Disclosure of terms and conditions of share-based payment arrangement [line items]
Vesting percentage	2.78%

Share based payments - Overview (Details)	1 Months Ended		6 Months Ended
Share based payments - Overview (Details)	Jun. 30, 2024 USD ($) EquityInstruments Y $ / shares	Apr. 30, 2024 Y EquityInstruments $ / shares	Jun. 30, 2024 USD ($) EquityInstruments Y $ / shares
Disclosure of terms and conditions of share-based payment arrangement [line items]
Number of options granted \| EquityInstruments	660,166	42,243	660,166
Average Fair value of options	$ 158.50
Share price	437.41
Exercise price	$ 445.76	$ 396.30	$ 445.76
Expected volatility	35.17%
Average Expected option life (in years) \| Y	5.34
Risk-free interest rate	2.87%
Belgian taxed beneficiaries
Disclosure of terms and conditions of share-based payment arrangement [line items]
Number of options granted \| EquityInstruments			188,606
Minimum
Disclosure of terms and conditions of share-based payment arrangement [line items]
Average Fair value of options		112.14
Share price		$ 365.56
Expected volatility		35.53%
Average Expected option life (in years) \| Y		4.30	4.16
Risk-free interest rate		2.66%
Time period for beneficiaries to choose contractual term	5 years
Minimum \| Belgian taxed beneficiaries
Disclosure of terms and conditions of share-based payment arrangement [line items]
Time period for beneficiaries to choose contractual term	5 years
Fair value of options \| $	$ 137,630		$ 137,630
Maximum
Disclosure of terms and conditions of share-based payment arrangement [line items]
Average Fair value of options		$ 156.49
Share price		$ 396.30
Expected volatility		39.04%
Average Expected option life (in years) \| Y	6.35	6.49
Risk-free interest rate		3.02%
Time period for beneficiaries to choose contractual term	10 years
Maximum \| Belgian taxed beneficiaries
Disclosure of terms and conditions of share-based payment arrangement [line items]
Time period for beneficiaries to choose contractual term	10 years
Fair value of options \| $	$ 174,780		$ 174,780

Share based payments - Restricted Stock Units (Details) - USD ($) $ in Millions	6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023
Disclosure of terms and conditions of share-based payment arrangement [line items]
Number of shares on conversion	1
Total share based payment expense	$ 70	$ 72
Restricted Stock Units (RSUs)
Disclosure of terms and conditions of share-based payment arrangement [line items]
Number of shares on conversion	1
Vesting period	4 years
Vesting percentage	25.00%
Total share based payment expense	$ 33	$ 30

Trade and other payables (Details) - USD ($) $ in Thousands	Jun. 30, 2024	Dec. 31, 2023	Dec. 31, 2022
Trade and other payables.
Trade payables	$ 280,633	$ 245,557
Gross-to-net accruals	84,236	55,788	$ 19,478
Short-term employee benefits	106,708	95,104
Other	8,252	17,564
Total trade and other payables	$ 479,829	$ 414,013

Trade and other payables - Movement in the gross-to-net accruals (Details) - USD ($) $ in Thousands	6 Months Ended	12 Months Ended
	Jun. 30, 2024	Dec. 31, 2023
Disclosure of subsidiaries [line items]
Gross-to-net accruals	$ 55,788	$ 19,478
Estimate related to the sales made in the current year	130,770	149,969
Adjustment for prior year sales	(5,431)	(4,924)
(Credits or payments)	(96,891)	(108,734)
Gross-to-net accruals	84,236	55,788
Rebates and charge backs
Disclosure of subsidiaries [line items]
Gross-to-net accruals	49,662	15,398
Estimate related to the sales made in the current year	111,669	123,542
Adjustment for prior year sales	(5,391)	(4,041)
(Credits or payments)	(77,627)	(85,237)
Gross-to-net accruals	78,313	49,662
Distribution fees, product returns and other
Disclosure of subsidiaries [line items]
Gross-to-net accruals	6,126	4,079
Estimate related to the sales made in the current year	19,101	26,427
Adjustment for prior year sales	(40)	(883)
(Credits or payments)	(19,264)	(23,497)
Gross-to-net accruals	$ 5,923	$ 6,126

Segment reporting - Product net sales by country of sales (Details) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023
Segment reporting
Total product net sales	$ 875,918	$ 487,335
North-America
Segment reporting
Total product net sales	755,536	440,853
Japan
Segment reporting
Total product net sales	38,114	23,645
EMEA
Segment reporting
Total product net sales	66,072	$ 22,836
China
Segment reporting
Total product net sales	$ 16,196

Segment reporting - Major distributor or whole sellers (Details)	6 Months Ended
	Jun. 30, 2024 customer item	Jun. 30, 2023
Segment reporting
Number of operating segments \| item	1
Number of major customers from U.S. \| customer	4
Percentage of product net sales from major customers from United States	88.00%	88.00%

Research and development expenses (Details) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023
Research and development expenses
Personnel expenses	$ 132,903	$ 99,482
External research and development expenses	286,038	233,868
Materials and consumables	2,309	2,044
Depreciation and amortization	2,769	3,498
IT expenses	16,493	13,441
Other expenses	9,743	9,031
Total research and development expenses	$ 450,255	$ 361,364

Selling, general and administrative expenses (Details) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2024	Jun. 30, 2023
Selling, general and administrative expenses
Personnel expenses	$ 194,026	$ 134,862
Marketing services	150,341	90,436
Professional fees	86,406	42,796
Supervisory board	4,267	3,978
Depreciation and amortization	1,424	1,083
IT expenses	11,647	5,496
Other expenses	43,583	32,499
Total Selling, general and administrative expenses	$ 491,694	$ 311,149

Income tax benefit (Details) - USD ($) $ in Thousands	6 Months Ended
Income tax benefit (Details) - USD ($) $ in Thousands	Jun. 30, 2024	Jun. 30, 2023
Income taxes
Income tax benefit	$ (56,822)	$ (36,800)
Pretax loss	(89,353)	(160,039)
Deferred tax impact	$ 64,000	$ 44,000

Financial instruments and financial risk management - Fair value (Details) - USD ($) $ in Thousands	Jun. 30, 2024	Dec. 31, 2023
Level 1
Financial instruments and financial risk management
Non-current financial assets	$ 10,293	$ 15,528
Cash and cash equivalents	1,307,197	1,678,100
Assets carried at fair value	1,317,490	1,693,628
Level 3
Financial instruments and financial risk management
Non-current financial assets	21,715	21,715
Assets carried at fair value	$ 21,715	$ 21,715

Financial instruments and financial risk management - License agreement (Details) - USD ($) $ / shares in Units, $ in Millions	1 Months Ended	6 Months Ended
	Oct. 31, 2023	Jun. 30, 2024
AgomAb \| Preferred Class C Shares
Financial instruments and financial risk management
Proceeds from issue of shares	$ 100
Zai Lab
Financial instruments and financial risk management
Number of equity instruments obtained		568,182
Price of equity instrument		$ 132

Related party transaction (Details) $ in Millions	1 Months Ended		6 Months Ended
Related party transaction (Details) $ in Millions	Jun. 30, 2024 USD ($) EquityInstruments	Apr. 30, 2024 EquityInstruments	Jun. 30, 2024 USD ($) shares EquityInstruments
Compensation of key management personnel
Numbers of stock options granted in the year \| EquityInstruments	660,166	42,243	660,166
Onco Verity Inc. Joint Venture
Compensation of key management personnel
Contractual capital commitments \| $	$ 13		$ 13
Senior management
Compensation of key management personnel
Numbers of stock options granted in the year			98,306
Numbers of restricted stock units granted in the year			36,365
Non-executive Directors
Compensation of key management personnel
Numbers of restricted stock units granted in the year			10,118

Contractual obligations and commitments (Details) € in Millions	1 Months Ended
	Feb. 28, 2019 USD ($)	Jun. 30, 2024 USD ($)	Jun. 30, 2024 EUR (€)
Commitments [Line Items]
Commitments to acquire property, plant and equipment		$ 0
Borrowings		11,000,000	€ 10
Efgartigimod
Commitments [Line Items]
Outstanding commitment		$ 330,000,000
Halozyme \| Global Collaboration and License Agreement
Commitments [Line Items]
Outstanding commitment	$ 110,000,000
Payment for each future target	12,500,000
Future milestone payments	160,000,000
Payment for additional milestones	$ 40,000,000

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