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| Holder | Type | Held (Actual) | % of Outstanding | Market Value | Date Reported |
|---|---|---|---|---|---|
| Tang Capital Management, LLC | Institution | 16,790,809 | 9.32% | US$ 35.76M | 2026-03-31 |
| OrbiMed Advisors LLC | Institution | 15,219,994 | 8.45% | US$ 32.42M | 2026-03-31 |
| Caduceus Private Investments V, L.P. | Institution | 15,219,994 | 8.45% | US$ 32.42M | 2025-08-13 |
| Suvretta Capital Management, LLC | Institution | 14,307,379 | 7.94% | US$ 30.47M | 2026-03-31 |
| Averill Master Fund, Ltd. | Institution | 12,229,050 | 6.79% | US$ 26.05M | 2025-08-13 |
| Vivo Capital, LLC | Institution | 9,545,466 | 5.30% | US$ 20.33M | 2026-03-31 |
| BlackRock, Inc. | Institution | 9,505,653 | 5.28% | US$ 20.25M | 2026-03-31 |
| Vivo Opportunity Fund Holdings, L.P | Institution | 8,995,979 | 5.00% | US$ 19.16M | 2025-09-30 |
| Adage Capital Management, L.P. | Institution | 8,486,500 | 4.71% | US$ 18.08M | 2026-03-31 |
| Enavate Sciences | Institution | 7,788,150 | 4.32% | US$ 16.59M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 6,694,976 | 3.72% | US$ 14.26M | 2026-03-31 |
| Blackstone Inc. | Institution | 6,126,182 | 3.40% | US$ 13.05M | 2025-12-31 |
| Vanguard Capital Management, LLC | Institution | 6,037,175 | 3.35% | US$ 12.86M | 2026-03-31 |
| Adage Capital Partners, L.P. | Institution | 5,994,810 | 3.33% | US$ 12.77M | 2024-12-31 |
| Dr. Thomas Schuetz | Insider | 5,909,586 | 3.28% | US$ 12.59M | 2026-03-31 |
| Tang Capital Partners, LP | Institution | 4,669,934 | 2.59% | US$ 9.95M | 2025-01-08 |
| RTW Investments, LP | Institution | 4,186,599 | 2.32% | US$ 8.92M | 2026-03-31 |
| Mr. Mark Lampert | Insider | 4,142,020 | 2.30% | US$ 8.82M | 2026-03-31 |
| BVF Partners L.P. | Institution | 3,622,822 | 2.01% | US$ 7.72M | 2026-03-31 |
| Deerfield Management Company, L.P. | Institution | 3,606,000 | 2.00% | US$ 7.68M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 3,565,770 | 1.98% | US$ 7.60M | 2026-03-31 |
| Rock Springs Capital Management LP | Institution | 3,305,308 | 1.84% | US$ 7.04M | 2026-03-31 |
| Logos Global Management, L.P. | Institution | 3,150,000 | 1.75% | US$ 6.71M | 2026-03-31 |
| Biotechnology Value Fund II, L.P. | Institution | 3,028,951 | 1.68% | US$ 6.45M | 2026-03-31 |
| CHI Advisors LLC | Institution | 2,941,525 | 1.63% | US$ 6.27M | 2026-03-31 |
| Borealis Ventures | Institution | 2,749,256 | 1.53% | US$ 5.86M | 2026-03-31 |
| Qube Research & Technologies Ltd | Institution | 2,550,356 | 1.42% | US$ 5.43M | 2026-03-31 |
| UBS Asset Management AG | Institution | 2,530,975 | 1.41% | US$ 5.39M | 2026-03-31 |
| Borealis Granite Fund | Institution | 2,348,976 | 1.30% | US$ 5.00M | 2026-03-31 |
| Sofinnova Investments, Inc. | Institution | 2,056,161 | 1.14% | US$ 4.38M | 2026-03-31 |
| Braidwell LP | Institution | 1,965,106 | 1.09% | US$ 4.19M | 2026-03-31 |
| Blackstone Alternative Asset Management L.P. | Institution | 1,857,848 | 1.03% | US$ 3.96M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 1,824,357 | 1.01% | US$ 3.89M | 2026-03-31 |
| Impresa Management LLC | Institution | 1,710,498 | 0.95% | US$ 3.64M | 2026-03-31 |
| Royce & Associates, LP | Institution | 1,619,798 | 0.90% | US$ 3.45M | 2026-03-31 |
| Columbia Management Investment Advisers, LLC | Institution | 1,596,815 | 0.89% | US$ 3.40M | 2026-03-31 |
| Palo Alto Investors LP | Institution | 1,514,504 | 0.84% | US$ 3.23M | 2026-03-31 |
| Birchview Capital, LP | Institution | 1,465,867 | 0.81% | US$ 3.12M | 2026-03-31 |
| Great Point Partners, LLC | Institution | 1,350,000 | 0.75% | US$ 2.88M | 2026-03-31 |
| Fisher Asset Management, LLC | Institution | 1,348,259 | 0.75% | US$ 2.87M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 1,119,090 | 0.62% | US$ 2.38M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 1,082,651 | 0.60% | US$ 2.31M | 2026-03-31 |
| Schonfeld Strategic Advisors LLC | Institution | 1,076,004 | 0.60% | US$ 2.29M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 1,048,558 | 0.58% | US$ 2.23M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 998,140 | 0.55% | US$ 2.13M | 2026-03-31 |
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