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| Holder | Type | Held (Actual) | % of Outstanding | Market Value | Date Reported |
|---|---|---|---|---|---|
| FMR LLC | Institution | 9,045,481 | 14.70% | US$ 245.04M | 2026-03-31 |
| Fairmount Funds Management LLC | Institution | 8,713,000 | 14.16% | US$ 236.04M | 2026-03-31 |
| Fairmount Healthcare Fund II L.P. | Institution | 5,809,000 | 9.44% | US$ 157.37M | 2026-02-09 |
| Avoro Capital Advisors LLC | Institution | 3,783,000 | 6.15% | US$ 102.48M | 2026-03-31 |
| VR Management, LLC | Institution | 3,603,595 | 5.85% | US$ 97.62M | 2026-03-31 |
| Venrock Healthcare Capital Partners EG, L.P. | Institution | 2,841,355 | 4.62% | US$ 76.97M | 2026-02-09 |
| Forbion Capital Partners B.V. | Institution | 2,441,000 | 3.97% | US$ 66.13M | 2026-03-31 |
| RA Capital Management, L.P. | Institution | 2,399,310 | 3.90% | US$ 65.00M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 2,362,696 | 3.84% | US$ 64.01M | 2026-03-31 |
| Viking Global Investors LP | Institution | 2,311,082 | 3.75% | US$ 62.61M | 2026-03-31 |
| Bellevue Asset Management AG | Institution | 2,298,000 | 3.73% | US$ 62.25M | 2026-03-31 |
| Remedium Capital Partners, LLC | Institution | 2,045,473 | 3.32% | US$ 55.41M | 2026-03-31 |
| Commodore Capital LP | Institution | 1,939,000 | 3.15% | US$ 52.53M | 2026-03-31 |
| Cormorant Asset Management, LP | Institution | 1,525,000 | 2.48% | US$ 41.31M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 1,448,000 | 2.35% | US$ 39.23M | 2026-03-31 |
| Andreessen Horowitz LLC | Institution | 1,236,157 | 2.01% | US$ 33.49M | 2026-03-31 |
| Perceptive Advisors LLC | Institution | 1,223,000 | 1.99% | US$ 33.13M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 1,193,708 | 1.94% | US$ 32.34M | 2026-03-31 |
| Wellington Management Group LLP | Institution | 1,058,000 | 1.72% | US$ 28.66M | 2026-03-31 |
| Artal Group S.A. | Institution | 900,000 | 1.46% | US$ 24.38M | 2026-03-31 |
| Braidwell LP | Institution | 894,846 | 1.45% | US$ 24.24M | 2026-03-31 |
| Venrock Healthcare Capital Partners III, L.P. | Institution | 692,909 | 1.13% | US$ 18.77M | 2026-02-09 |
| Vestal Point Capital, LP | Institution | 600,000 | 0.97% | US$ 16.25M | 2026-03-31 |
| Blackstone Alternative Asset Management L.P. | Institution | 503,522 | 0.82% | US$ 13.64M | 2026-03-31 |
| Millennium Management LLC | Institution | 471,646 | 0.77% | US$ 12.78M | 2026-03-31 |
| Affinity Asset Advisors, LLC | Institution | 450,000 | 0.73% | US$ 12.19M | 2026-03-31 |
| Ikarian Capital, LLC | Institution | 335,710 | 0.55% | US$ 9.09M | 2026-03-31 |
| Ikarian Healthcare Master Fund, L.P. | Institution | 285,710 | 0.46% | US$ 7.74M | 2025-11-30 |
| Qube Research & Technologies Ltd | Institution | 282,436 | 0.46% | US$ 7.65M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 279,000 | 0.45% | US$ 7.56M | 2026-03-31 |
| Nantahala Capital Management, LLC | Institution | 278,000 | 0.45% | US$ 7.53M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 241,126 | 0.39% | US$ 6.53M | 2026-03-31 |
| BlackRock, Inc. | Institution | 222,437 | 0.36% | US$ 6.03M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 201,847 | 0.33% | US$ 5.47M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 183,922 | 0.30% | US$ 4.98M | 2026-03-31 |
| Marshall Wace LLP | Institution | 169,818 | 0.28% | US$ 4.60M | 2026-03-31 |
| UBS Asset Management AG | Institution | 160,415 | 0.26% | US$ 4.35M | 2026-03-31 |
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