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Halozyme Therapeutics Incorporated

Halozyme Therapeutics Incorporated (HALO)

48.03
0.49
(1.03%)
At close: December 26 3:00PM
48.03
0.01
( 0.02% )
After Hours: 4:00PM

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HALO News

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HALO Discussion

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biotecholdguy biotecholdguy 2 days ago
This is the season...the birth of Jesus the reason !
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maumar maumar 2 days ago
And the same to all. Thank you.
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Roger1 Roger1 2 days ago
Thank you and same to all.
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Fred Kadiddlehopper Fred Kadiddlehopper 2 days ago
To all who post and lurk here, if you celebrate Christmas or Chanukah or another or none at all, I wish you and yours a peaceful and loving holiday season.
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biotechinvestor1 biotechinvestor1 2 days ago
This BARGAIN will not last forever:

2024 PE Estimates 12.41
2025 PE Estimates 10.34
2026 PE Estimates 7.8
PEG .43
https://www.nasdaq.com/market-activity/stocks/halo/price-earnings-peg-ratios


Institutional ownership 98.8%
https://www.nasdaq.com/market-activity/stocks/halo/institutional-holdings

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maumar maumar 6 days ago
Agreed, but biotechs were pretty strong today, xbi up 1.64%, and high volume on option expiration day doesn’t necessarily lead to a lower stock price. Part of the selling is hopefully tax loss harvesting.
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Fred Kadiddlehopper Fred Kadiddlehopper 6 days ago
We're coming to the end of yet another year in which Helen Torley has utterly failed to deliver on any of her promises, so I'm not prone to seeing good news in the current state of Halozyme, Inc.
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biotechinvestor1 biotechinvestor1 6 days ago
Today was option expiration day. Always with large volumes. Nothing unexpected. 
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halofan halofan 6 days ago
What’s interesting is that with the thin trading in HALO stock, a sell off of this magnitude would normally have caused the stock to fall $2 or $3. So, maybe the fact that it only fell $.36 might be a good sign?
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Fred Kadiddlehopper Fred Kadiddlehopper 6 days ago
I'm guessing it's the last options expiry of the year that caused part of the volume, along with the fact that it is really the last true trading day of the year because all the trading bosses are heading out to their ski chalets until after New Years.
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maumar maumar 6 days ago
4.22M shares traded today and another 577k in after hours so far. The biggest risk is that halo doesn’t get the US patent extension, imho. Hopefully, whoever sold today did it for other reasons.
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Minninv Minninv 6 days ago
Looks like someone dumped a lot of share in the last 9 minutes of trading.
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biotechinvestor1 biotechinvestor1 1 week ago
Ask yourself what would be the shareprice be when:

1) HVAI deal is announced
2) US Enhanze patent is extended to 2029
3) Alteogen agrees (or is compelled to) pay licensing fees to Halo
4) OPDIVO SC is approved

North of $80
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biotechinvestor1 biotechinvestor1 1 week ago
Loading up more. Current PE is 15. Forward PE is 10. PEG OF 0.4

https://finviz.com/quote.ashx?t=HALO&p=d

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biotechinvestor1 biotechinvestor1 1 week ago
Halozyme Therapeutics Price Target Maintained With a $68.00/Share by HC
Wainwright & Co.
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biotecholdguy biotecholdguy 1 week ago
Stupid judge!
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Hero Car Hero Car 1 week ago
Law360, London (December 16, 2024, 8:35 PM GMT) -- A London judge on Monday rejected Halozyme's bid to protect an active ingredient in two breast cancer drugs with a supplementary protection certificate, after finding that it was actually an inactive substance used to enhance other therapeutic effects
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Minninv Minninv 1 week ago
In the table below, we summarize the PDUFA and advisory committee dates for several notable FDA approvals that could happen in 2024 and 2025. In the following sections, we’ll review each one in greater detail.


Opdivo (nivolumab)

Subcutaneous (under the skin) administration

December 29, 2024
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biotechinvestor1 biotechinvestor1 1 week ago
Higher volune today than normal. News brewing?
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biotechinvestor1 biotechinvestor1 2 weeks ago
"In Halozyme Therapeutics, the short percent of float has declined by 18.07%, a notable shift in sentiment. Such a sharp reduction in bearish positions might indicate improving fundamentals or positive expectations among investors. It may also suggest that recent developments have alleviated concerns that previously drove traders to short the stock."


https://stocksrunner.com/posts/2024-12-12-Short-Interest-Shifts
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stockrafter stockrafter 2 weeks ago
Thanks for the reminder......
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MysticalGladiator72 MysticalGladiator72 2 weeks ago
He's upset that B1 got 2 thumbs up.🤣😂😂
You just can't make this up.
He used to be a great poster. Perma Bears got to him.
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biotechinvestor1 biotechinvestor1 2 weeks ago
... I wonder if he was amused by the volumes; 10, 20, 30 all the way up to 50ml given in short duration without an on-body wearable pump. No one else (other than halo) can do this. Truly innovative.
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GreedyG1 GreedyG1 2 weeks ago
What’s perplexing? Looks like a possible solution to the limits of spring powered large volume injections.
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stockrafter stockrafter 2 weeks ago
Yes, they never get it.....

Need to encourage not discourage........never know what arises from some of those hidden crumbs, and some are hidden way down there, but why down there of all places....

This one is perplexing, to say the least........what are they up to now.....

https://worldwide.espacenet.com/patent/search/family/093429904/publication/AU2023430176B1?q=pn%3DAU2023430176B1
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stockrafter stockrafter 2 weeks ago
Interesting......

bi1 gets two thumbs for a twisted reply to some incredible bread crumbs, in which it was clearly stated info wasn't competition related...."for a break from the old competition, and MDASE stuff......... "

Time will definitely tell on this big one.....
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biotecholdguy biotecholdguy 2 weeks ago
Greg Frost was CEO when I bought my shares...BOTH Greg & Helen are AWESOME CEOs !!!
THEY know who is infringing !!
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MysticalGladiator72 MysticalGladiator72 2 weeks ago
Very nice day.
Considering the markets were down including the XBI
this was a solid day. Hope the momentum continues.
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Fred Kadiddlehopper Fred Kadiddlehopper 3 weeks ago
Correct, he was CEO before Helen Torley.
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biotechinvestor1 biotechinvestor1 3 weeks ago
This is no competition. Greg Frost is one of the co-founders of Halozyme, co-inventor of human hyaluronidase and former CEO of halozyme.
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stockrafter stockrafter 3 weeks ago
This weekends breadcrumb leads an investor on a whole new interesting path, for a break from the old competition, and MDASE stuff.........

"Exuma Biotech".......the possibilities........ "The use of claim 2, wherein the modified lymphocytes are administered subcutaneously in the presence of hyaluronidase." ...... bi1 looks like the Frost character you mentioned has been keeping busy.........
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biotechinvestor1 biotechinvestor1 3 weeks ago
Nearly everyting you post is either misinformed or incorrect. I never asked for a patent number from you. Show me the post (the message number) where you claim ai asked for it.
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PaladinConqueror59 PaladinConqueror59 3 weeks ago
I mean there was a fraudulent accounting news on one of the dates I listed, where do you focus on it?
In the end, it was all falsehood articles, and it will be the same this time.

I wonder if Goldman Sachs' analyst really has knowledge of the patent field.

I am referring to Sanofi v AMGEN's lawsuit as it relates to a violation of activation requirements.
It's very close with this case. You really don't know?

I can see your level when you say it's not related and sarcastically say martial law 2.0 lol

I am a shareholder of Alteogen and a shareholder of Halozyme. I'm just a regular person who wants to know the truth.

Previously, you asked me to bring the patent document number, but when I mentioned the patent document number and claim, I saw your level of answering with stock price. BI1 rofl.

At your level, it's only a mocking level of conversation, and I don't think it's going to be an in-depth conversation related to patents, so I'll end it now.

FAREWELL!
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biotechinvestor1 biotechinvestor1 3 weeks ago
None of the dates you mentioned show a 33% drop in a span of few days with no real/material news and purely based on drevitives manipulations (or martial law) as you initially postulated on this board. Now you have changed your story to "fradulant accounting"!!! By whom? Alteogen? Of course Alteogen's stock should have gone down if there were concerns about "fraudulant accounting." That would be significant/material news/concern.

And "malicious news"!!! Get real! We don't need conspiracy theories. The simplest explanation tends to be the real truth. Here is the simple truth: right after the market learned about Alteogen's patent viloation through Goldman Sacs, alteogen dropped 33%. No consoiracy theory needed. The market participants believe Alteogen will lose. You can come up with all the comical alternatives explanations you want!

Also, news of halo buying Evotec broke out and Halo's stock dropped immediately. No conspiracy theory needed. Simple and perfect explanation.

The news of Meck patent challenge against halo was not made PUBLIC for many days after the filing. So agian nice try, but you are wrong.

You keep referring to another patent dispute with two other companies (Amgen and Sanofi) with different merits that has little relevence to the matter between Halo and Alteos. 

You keep repeating the nonsensical argument from alteo's CEO. Do you work for Alteogen? 

You will have the answers you seek for the merits of halozyme patent arguments once halo's attorney file their response. 

In the meantime, keep entertaining us with your conspiry theories! Martial law 2.0?
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PaladinConqueror59 PaladinConqueror59 3 weeks ago
Answer the patent document & violation of enablement requirement.
(If you don't understand, search Amgen v Sanofi. i told you this so many time.)

Your answer is tied only to the stock price view.

And, find chart
09/20/20 ~ 05/20/21
12/13/21 ~ 01/27/22
08/22/22 ~ 10/13/22
03/26/24 ~ 04/05/24
and recent days.

Every time that fell, there was always malicious news, like termination of his contract with Merck and malicious - fraudulent accounting news.

According to your logic, the date Merck requested USTPO to judge is the 12th. Since then, Halozyme has fallen 30%, and the stock has not returned.

Judging by the stock price is only fragmentary, and it is correct to judge by the scope of patent rights.

Leaving aside the facts of the patent, it is rather silliness to judge only in the direction of the stock price.

MDASE's scope of a patent claim(distinct polypeptide is 1.50 x 10^63 and 1.35 x 10^66) is so large.
That scope of the claim is the scope that another inventor cannot complete even if he studies for life.
-----> this is violation of enablement requirement.


MDASE US9,447,401's claim seq id no:3 / 204 F replace to P
---> Alteogen's not use seq id no;3 and do not replace them

US 11,952,600 claim 1, at least 95% of the residues of the amino acid sequence of the modified PH20 polypeptide are identical to the residues in an amino acid sequence selected from the group consisting of SEQ ID NOs: 3
and 32-66 the modification at position 320 is a replacement selected from among H, K, R and S.

It is almost impossible for competitors to choose the best sequence, truncate position, and replacement targets while experimenting with such a large number of cases.
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CelestialSage6 CelestialSage6 3 weeks ago
I wonder who will laugh in the end haha
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biotechinvestor1 biotechinvestor1 3 weeks ago
For the true halo investors on this board: I hope you are getting the same sense of confidence as I am when you see how the bears have to resort to silly arguments to explain their position. Just in the past 24 hours we have read about Martial Law and deravatives causing alteogen's 33% drop, company size determining patent outcomes, etc etc.

This level of silliness is reassuring. They have no good arguments.
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biotecholdguy biotecholdguy 3 weeks ago
Which do you want in your body at this time? Altogen's testing is about 15 years behind FDA proven HALO. Why doesn't Alteogen need testing? Because they've copied HALO? (Merek knows!)
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biotechinvestor1 biotechinvestor1 3 weeks ago
Alteogen has many other profitable products. The fact that it's market cap is larger than halozyme has nothing to do with the patent issue or even with hyaluronidases.

I have a feeling you already knew this.


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CelestialSage6 CelestialSage6 3 weeks ago
You are saying that Alteogen's stock price has fallen 30%.

Alteogen's market capitalization is twice that of Halozyme. Since Alteogen's market capitalization is high, does this mean that Alteogen is better than Halozyme?
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biotechinvestor1 biotechinvestor1 3 weeks ago
No. Halo was at $62 right when the idiotic Evotec acquisition news came out. It hasn't fully recovered because some of the investors who left the stock lost trust in Helen and have not come back. Others are still worried that she might try to buy another company prematurely.

Of course you already knew all this, but as our permabear moderator try to confuse the readers heres.
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Fred Kadiddlehopper Fred Kadiddlehopper 3 weeks ago
HALO is down ~30% also. But that's just the market being stupid, right?
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biotechinvestor1 biotechinvestor1 3 weeks ago
.... and the market participants handicapped the odds with a 33% drop in Ateogen's stock price
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biotechinvestor1 biotechinvestor1 3 weeks ago
Wrong again. I'm not a Helen cheerleader. Eveyone here knows that. I have been critical of her when evidence warrants it (eg Evotec, Antares, etc).

It is actually you who is drinking the coolaid of Alteogen's and Merck's management. I trust the market percipitants over alteogen's delusional claims. 

Markets are the best handicappers of future events. 
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PaladinConqueror59 PaladinConqueror59 3 weeks ago
lol

If there is a suspension of sales in time for the release date of the product, it will be hurt, so it is to prevent it in advance.
.
PLZ
SEARCH PATENT DOCUMENT
AND SESRCH ENABLEMENT REQUIREMENTS.
AND AMGEN V SANOFI CASE.
.
You're smarter than the legal team of big pharmaceutical companies, aren't you?
.
This is my last post at this time.
Bye BI1, No conversation with you seems to be beneficial.
.
Trust Helen.
I will Trust Merck, Daiichi, Sandoz.
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stockrafter stockrafter 3 weeks ago
Yes, more info to the ongoing competition saga....

Been watching the Daiichi part of the saga, and would suggest a minor correction to your conclusion.........."

β€œThe conclusion is that, Alteogen and Daiichi, concluded that it did not infringe on the Halozyme patent." The courts will eventually make the final call on infringement, IMO

Looks like investors will need to keep a watch on any new petition filings related to Daiichi, as well as Sandoz, and the ongoing MSD petitions, which seems MSD has filed a second petition to a second MDASE patent β€œ12018298.”

https://pharmaphorum.com/news/daiichi-sankyo-partners-alteogen-subcutaneous-enhertu

https://www.businesswire.com/news/home/20230102005028/en/Alteogen-Enters-Into-an-Exclusive-License-Agreement-to-Develop-and-Commercialize-Biosimilar-Products-Enabled-by-Alteogen%E2%80%99s-Hybrozyme%E2%84%A2-Technology
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biotechinvestor1 biotechinvestor1 3 weeks ago
Good, at least you gave up on the silly martial law excuse.

Stocks in any country go up and down. Nobody denies that. However, you are making a claim that a 33% drop in Alteogen (coinciding with patent vilation news) is not because of the news but because of characteristics of derivatives in a particular foreign market and that things are volatile over there. However, the chart of the very company you're making this claim about rejects your argument. Alt's chart does not show frequent 30% drops as you claim.

On one hand, ALT CEO claims that they're not infringing on any of Halozyme's patents and on the other hand Merck is trying to invalidate one of Halozyme's patents. Ask yourselves this question, if they didn't think they're infringing why would they move to invalidate a patent?

Also remember, as Helen said in her Q&A this week, it is not just the one patent (the one Merck is trying to invalidate) that Alteogen is infringing, rather it's a whole portfolio of other patents thag Alt is violation of.



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PaladinConqueror59 PaladinConqueror59 3 weeks ago
Hedge funds short stock futures position, sell spot stock to maximize profits and buy back down below. and publishing bearish news.
That's KOSPI & KOSDAQ 's characteristic.

and you can see Alteogen's longterm chart for yourself. There have not been many (or hardly any) sudden 30% drops in the price over the past 5 or 10 years. -->
lots of drops 5 years.
Every time that fell, there was always malicious news, like termination of his contract with Merck.
But what is the price of Alteogen now?


As you know, biosimilar companies are quite specialized in patents that are released in time for the patent expiration of the original drug.
It must have been reviewed by MERCK, DAIICHI, and SANDOZ.
If they can't use ENHAZE, they can use MDASE, but why did they do that?

AND plz Search AMGEN V SANOFI.

MDASE US9,447,401's claim seq id no:3 / 204 F replace to P
---> Alteogen's not use seq id no;3 and do not replace them

US 11,952,600 claim 1, at least 95% of the residues of the amino acid sequence of the modified PH20 polypeptide are identical to the residues in an amino acid sequence selected from the group consisting of SEQ ID NOs: 3
and 32-66 the modification at position 320 is a replacement selected from among H, K, R and S.

It is almost impossible for competitors to choose the best sequence, truncate position, and replacement targets while experimenting with such a large number of cases.

MDASE have violated enablement requirements.

We can just wait USTPO'S judgment.
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biotechinvestor1 biotechinvestor1 3 weeks ago
Nice try! But you are incorrect. The price drop in Alteogen occured well before the Martial Law. The price dropped 33% from 450k to 290k on the news of patent infringment between November 15 and 25. The Martial law was Dec 3 to Dec 4. There was no material change in price of Alteogen stock on Dec 3 or 4. Everyone can see that and here is the chart:


Alteogen Inc
https://g.co/kgs/prrHssx
Regarding the "deravatives" nonesense, you can see Alteogen's longterm chart for yourself. There have not been many (or hardly any) sudden 30% drops in the price over the past 5 or 10 years. So, to say that this new sudden and significant drop is due to "deravatives" makes little sense.

You know it's related to the patnet infringement, when their CEO is constantly issuing memos and talking to media pleading that they are not in trouble with patent infringement. 

Regarding Sandoz, they are doing a biosimilar product with Alteogen. Halzoyme doesn't work with biosimilar makers (at least not so far). Halo prefers to have the royalty percentage from higher base price of brands vs. genereics.

Other Alteogen partners are forced to go with alteogen, because halozyme has an exclusive contract in that class of medication with another pharma.


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PaladinConqueror59 PaladinConqueror59 3 weeks ago
Nope, Kosdaq is not same Nasdaq.
The Korean stock market fluctuates depending on derivatives positions.
And there's also the influence of martial law.

Search Amgen v Sanofi PCSK9 case.
it's same as this case.

MDASE's scope of a patent claim(distinct polypeptide is 1.50 x 10^63 and 1.35 x 10^66) is so large.
That scope of the claim is the scope that another inventor cannot complete even if he studies for life.

Sandoz and other global pharma choose Alteogen. Why did they do that?
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