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| Holder | Type | Held (Actual) | % of Outstanding | Market Value | Date Reported |
|---|---|---|---|---|---|
| RA Capital Management, L.P. | Institution | 12,198,625 | 20.51% | US$ 358.76M | 2026-03-31 |
| RA Capital Healthcare Fund, L.P. | Institution | 10,259,291 | 17.25% | US$ 301.73M | 2026-03-04 |
| FMR LLC | Institution | 7,747,629 | 13.03% | US$ 227.86M | 2026-03-31 |
| Nextech Invest Ltd. | Institution | 4,055,861 | 6.82% | US$ 119.28M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 3,890,589 | 6.54% | US$ 114.42M | 2026-03-31 |
| Alta Partners Nextgen Fund II, L.P. | Institution | 3,823,425 | 6.43% | US$ 112.45M | 2025-12-19 |
| Alta Partners LP | Institution | 3,823,425 | 6.43% | US$ 112.45M | 2026-03-31 |
| Farallon Capital Management, L.L.C. | Institution | 3,580,818 | 6.02% | US$ 105.31M | 2026-03-31 |
| TCG Crossover Management, LLC | Institution | 3,248,980 | 5.46% | US$ 95.55M | 2026-03-31 |
| The Column Group, LLC | Institution | 2,898,103 | 4.87% | US$ 85.23M | 2025-02-27 |
| TCG Crossover Fund I, L.P. | Institution | 2,898,103 | 4.87% | US$ 85.23M | 2025-02-27 |
| Commodore Capital Master LP | Institution | 2,750,000 | 4.62% | US$ 80.88M | 2025-05-07 |
| Commodore Capital LP | Institution | 2,475,000 | 4.16% | US$ 72.79M | 2026-03-31 |
| BlackRock, Inc. | Institution | 2,217,929 | 3.73% | US$ 65.23M | 2026-03-31 |
| Paradigm Biocapital Advisors LP | Institution | 2,054,991 | 3.46% | US$ 60.44M | 2026-03-31 |
| BVF Partners L.P. | Institution | 1,976,196 | 3.32% | US$ 58.12M | 2026-03-31 |
| RA Capital Nexus Fund, L.P. | Institution | 1,496,613 | 2.52% | US$ 44.02M | 2026-03-04 |
| Farallon Capital Offshore Investors II, L.P | Institution | 1,452,596 | 2.44% | US$ 42.72M | 2026-03-31 |
| Dr. Todd Harris | Insider | 1,358,631 | 2.28% | US$ 39.96M | 2026-05-05 |
| Caligan Partners, LP | Institution | 1,276,968 | 2.15% | US$ 37.56M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 1,216,078 | 2.04% | US$ 35.76M | 2026-03-31 |
| Biotechnology Value Fund L.P. | Institution | 1,135,053 | 1.91% | US$ 33.38M | 2025-12-31 |
| Vanguard Capital Management, LLC | Institution | 1,125,970 | 1.89% | US$ 33.11M | 2026-03-31 |
| 5AM Venture Management, LLC | Institution | 1,029,298 | 1.73% | US$ 30.27M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 986,061 | 1.66% | US$ 29.00M | 2026-03-31 |
| Logos Global Management, L.P. | Institution | 850,000 | 1.43% | US$ 25.00M | 2026-03-31 |
| Biotechnology Value Fund II, L.P. | Institution | 829,908 | 1.40% | US$ 24.41M | 2025-12-31 |
| Barclays PLC | Institution | 808,077 | 1.36% | US$ 23.77M | 2026-03-31 |
| Canaan Management, Inc. | Institution | 750,000 | 1.26% | US$ 22.06M | 2026-03-31 |
| Canaan XI | Institution | 750,000 | 1.26% | US$ 22.06M | 2026-03-31 |
| Farallon Capital Institutional Partners, L.P. | Institution | 739,107 | 1.24% | US$ 21.74M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 658,482 | 1.11% | US$ 19.37M | 2026-03-31 |
| Jennison Associates LLC | Institution | 632,432 | 1.06% | US$ 18.60M | 2026-03-31 |
| Sio Capital Management, LLC | Institution | 605,439 | 1.02% | US$ 17.81M | 2026-03-31 |
| Farallon Capital Partners, L.P. | Institution | 579,376 | 0.97% | US$ 17.04M | 2026-03-31 |
| Deerfield Management Company, L.P. | Institution | 549,000 | 0.92% | US$ 16.15M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 526,604 | 0.89% | US$ 15.49M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 351,479 | 0.59% | US$ 10.34M | 2026-03-31 |
| Elmind Capital, L.P. | Institution | 350,000 | 0.59% | US$ 10.29M | 2026-03-31 |
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