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| Holder | Type | Held (Actual) | % of Outstanding | Market Value | Date Reported |
|---|---|---|---|---|---|
| Nextech Invest Ltd. | Institution | 7,162,637 | 6.92% | US$ 57.44M | 2026-03-31 |
| Nextech Crossover I SCSP | Institution | 7,162,637 | 6.92% | US$ 57.44M | 2025-06-30 |
| EcoR1 Capital, LLC | Institution | 6,728,116 | 6.50% | US$ 53.96M | 2026-03-31 |
| Ecor1 Capital Fund Qualified, L.P. | Institution | 6,283,426 | 6.07% | US$ 50.39M | 2025-07-29 |
| BlackRock, Inc. | Institution | 5,984,552 | 5.78% | US$ 48.00M | 2026-03-31 |
| Viking Global Investors LP | Institution | 5,824,533 | 5.63% | US$ 46.71M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 5,387,783 | 5.20% | US$ 43.21M | 2026-03-31 |
| SR One Capital Management, LP | Institution | 4,514,929 | 4.36% | US$ 36.21M | 2026-03-31 |
| VR Management, LLC | Institution | 4,319,765 | 4.17% | US$ 34.64M | 2026-03-31 |
| New Enterprise Associates, Inc. | Institution | 4,118,621 | 3.98% | US$ 33.03M | 2026-03-31 |
| Alkeon Capital Management, LLC | Institution | 3,751,818 | 3.62% | US$ 30.09M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 3,702,196 | 3.58% | US$ 29.69M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 3,687,007 | 3.56% | US$ 29.57M | 2026-03-31 |
| Column Group Venture Partners II, L.P. | Institution | 3,540,777 | 3.42% | US$ 28.40M | 2024-09-30 |
| The Column Group, LLC | Institution | 3,540,777 | 3.42% | US$ 28.40M | 2026-03-31 |
| Pfizer Venture Investments LLC | Institution | 3,442,940 | 3.33% | US$ 27.61M | 2026-03-31 |
| Venrock Healthcare Capital Partners EG, L.P. | Institution | 3,415,564 | 3.30% | US$ 27.39M | 2026-03-31 |
| OrbiMed Advisors LLC | Institution | 2,693,929 | 2.60% | US$ 21.61M | 2026-03-31 |
| AIHC Capital Management Limited | Institution | 2,459,551 | 2.38% | US$ 19.73M | 2026-03-31 |
| FMR LLC | Institution | 2,434,080 | 2.35% | US$ 19.52M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 2,422,741 | 2.34% | US$ 19.43M | 2026-03-31 |
| SR One Capital Opportunities Fund I, LP | Institution | 2,330,218 | 2.25% | US$ 18.69M | 2025-08-12 |
| First Turn Management, LLC | Institution | 2,017,284 | 1.95% | US$ 16.18M | 2026-03-31 |
| Artal Group S.A. | Institution | 1,990,617 | 1.92% | US$ 15.96M | 2026-03-31 |
| Vivo Capital, LLC | Institution | 1,848,786 | 1.79% | US$ 14.83M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1,838,801 | 1.78% | US$ 14.75M | 2026-03-31 |
| MPM BioImpact LLC | Institution | 1,803,945 | 1.74% | US$ 14.47M | 2026-03-31 |
| Paradigm Biocapital Advisors LP | Institution | 1,701,217 | 1.64% | US$ 13.64M | 2026-03-31 |
| Morgan Stanley | Institution | 1,665,288 | 1.61% | US$ 13.36M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 1,471,290 | 1.42% | US$ 11.80M | 2026-03-31 |
| Franklin Resources, Inc. | Institution | 1,452,705 | 1.40% | US$ 11.65M | 2026-03-31 |
| Integral Health Asset Management, LLC | Institution | 1,400,000 | 1.35% | US$ 11.23M | 2026-03-31 |
| Woodline Partners LP | Institution | 1,247,515 | 1.21% | US$ 10.01M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 1,215,827 | 1.17% | US$ 9.75M | 2026-03-31 |
| Royce & Associates, LP | Institution | 1,207,223 | 1.17% | US$ 9.68M | 2026-03-31 |
| Braidwell LP | Institution | 1,128,040 | 1.09% | US$ 9.05M | 2026-03-31 |
| Silverarc Capital Management, LLC | Institution | 1,100,010 | 1.06% | US$ 8.82M | 2026-03-31 |
| Bank of America Corporation | Institution | 1,043,159 | 1.01% | US$ 8.37M | 2026-03-31 |
| Invus Financial Advisors, LLC | Institution | 1,007,575 | 0.97% | US$ 8.08M | 2026-03-31 |
| Euclidean Capital LLC | Institution | 989,410 | 0.96% | US$ 7.94M | 2026-03-31 |
| ArrowMark Colorado Holdings, LLC | Institution | 960,517 | 0.93% | US$ 7.70M | 2026-03-31 |
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