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Northwest Biotherapeutics Inc (QB)

Northwest Biotherapeutics Inc (QB) (NWBO)

0.265355
0.00
(0.00%)
Closed February 19 3:00PM

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NWBO Discussion

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Locknload56 Locknload56 10 minutes ago
We are ALL Roswell !
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FeMike FeMike 47 minutes ago
Fair enough, thanks Doc.
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DocLee DocLee 1 hour ago
FeMike, there was no argument. You made a statement which I found to be very pessimistic and did not trust. As this discussion board is infested with peddlers of pessimistic statements which are factually unfounded, I asked you for the facts on which your pessimism was based. You provided those facts, I sought NWBO's comments on those facts and NWBO did not dismiss them as incorrect. Accordingly, I accepted that what you said is factually correct. How your scenario plays out in the coming weeks/months is open to debate.
However, I did not "claim that reimbursement will be fully negotiated upon approval". I said that whilst the MHRA were deliberating part of my expectations were that Management would be working with NICE to agree an acceptable price for DCVax-L. That was not a prediction but was an expectation and when the MAA was granted : "if it transpires that in the 26 months between November 2022 when the phase 3 trial results were first published and now management has not been seriously addressing the price of DCVax-L with NICE, my faith in them will be destroyed. Clearly, I must await the MHRA's decision before I can learn just what Management has been doing (or not doing) in that 26 month period and I presume that is why I was advised by NWBO to "keep the faith".
As to NWBO cutting corners on the NICE approval, that has never been suggested. What has been alluded to is that NWBO has been in discussion with NICE for years. I'm sure that this has been useful for both sides so that when negotiations are fully under way (if the first steps have not already been taken unofficially) all the groundwork will have been done. As to NICE, I am sure that without prompting they can see the importance of DCVax-L so will (I hope) pull out all the stops to get a quick and mutually fair agreement so that 25-30 patients with GBM per week in the UK can receive potentially life-saving treatment where none currently exists.
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OracleConqueror191 OracleConqueror191 2 hours ago






















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DocLee DocLee 2 hours ago
Thanks, FeMike, for your DD and I just hope (but not holding my breath) that the NICE bureaucrats and their advisors don't dawdle in their internal discussions once they receive NWBO's evidence package - if they've not already received it.
If the latter is the case, I would like to know why NWBO has not sent it already, especially when they decided on the timing about a year ago. After all, after a 10-year phase 3 trial and over a year of analysis of the results just what new evidence might NWBO think could appear in the time between the ASM and the granting of the MAA that might materially affect their calculations on the projected unit price?
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DocLee DocLee 3 hours ago
Biosect, I understand what you are saying "We know they [NWBO] requested to be in the expedited process, but it does not seem as though they are.." but it would be somewhat peculiar for NICE not to be in talks with NWBO over the likely price of DCVax-L especially when (as most unprejudiced commentators all agree) ) the MHRA are imminently likely to be giving its blessing to DCVax-L. After all, NICE and NWBO have been in talks for years so why stop now, just when when an agreed price is the last piece of the jigsaw for a treatment which is clearly needed and is the first advance in 30 years of the treatment of a near universal killer.

I doubt that NICE protocols are so inflexible that the process can only run like a commuter train stopping at every intermediate station. Instead, when the need is there the protocols must/should/could/ought to be be adjustable so that the process becomes an express train with no stopping from beginning to end.... and the need for a speedy resolution of the negotiations is definitely there.
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pgsd pgsd 5 hours ago
Definitely interesting as the trial was recently updated, showing 'not recruiting' but it appears to still be active.

Updated:2024-11-27 01:06:13
Trial ID:2024-516613-21-00
Trial Phase:Phase I and Phase II (Integrated)

'On the EU Clinical Trials Register, a "not recruiting" status means that a clinical trial is currently not actively seeking new participants, although it may still be ongoing with enrolled participants receiving treatment or undergoing assessments; essentially, the trial is not actively enrolling new individuals at this time'

https://clinicaltrials.eu/trial/study-on-murcidencel-for-children-adolescents-and-young-adults-with-high-risk-progressive-or-recurrent-metastatic-tumors/

•Timeline Consistency:

The "new" Murcidencel trial has a start date of 2015 , which coincides with the completion of the DCVax-L Phase III trial . This suggests that the trial might have been conducted using DCVax-L, but the official INN "Murcidencel" was assigned later.
https://x.com/peter_brit/status/1892053443973612020

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manibiotech manibiotech 6 hours ago
They built their own academic facility per article
Feel free to email them and let us know if you find out anything different 
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Bright Boy Bright Boy 7 hours ago
Great post !! The Roswrell Parks deal is worth multiple millions in clinical trial expense and time, not to mention the multiple billions, when the trials are successful. All of the medical community knows this as well as most institutional players, but Griffin et al managed to mask the value and destroy momentum by painting the screen red.Law enforcement probably knows this as well.

Cheers,

BB
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XMaster2023 XMaster2023 7 hours ago
Greater than yours….
By far.
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XMaster2023 XMaster2023 7 hours ago
And you don’t see any association with NWBO?
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AAPL31415926 AAPL31415926 7 hours ago
Northwest Biotherapeutics (NWBO) acquired an exclusive license for a portfolio of dendritic cell technologies and intellectual property (IP) from Roswell Park Comprehensive Cancer Center. This deal, finalized on June 12, 2024, includes:

Five new patent families filed in 2023, which have their full potential patent life ahead of them.
Enhanced versions of dendritic cells (DCs) and DC-based therapies.
Conditioning regimens designed to enhance patient responses.
Approaches to reprogram the tumor microenvironment to boost immune therapies and help overcome resistance to checkpoint inhibitors.

These technologies are already in Phase 2 clinical trials for two different cancers, with a third trial pending. The license complements NWBO's existing portfolio, which was also developed by Dr. Pawel Kalinski at Roswell Park. The acquisition was aimed at enhancing NWBO's capabilities in developing personalized immune therapies for solid tumor cancers.
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NotSure2 NotSure2 8 hours ago
Mani, wait for Dstock to find the correlation, I believe he used his post for today. Pretty sure he'll find something.

(maybe a new McDonnald has open its door 2-3 minute walk from the Roswell academic center, which would clearly corrolate with NWBO future employees being able to take a quick lunch. Or maybe there is a new bus stop near by, which clearly indicate the city anticipation to future NWBO workers).

Whatever it is, Dstock will be able to find the correlation, just a little more patience is needed.
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norisknorewards norisknorewards 8 hours ago
In your doomsday nafariously depressing scenerio, at least I can see the silver lining...

The end of seeing your daily bitsching as I will keep on trucking on.

But if I felt there was an inkling of reason to be concerned here, I'd have sold a long while ago. The news to me seems to keep getting better and better.
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hankmanhub hankmanhub 9 hours ago
So what exactly did NWBO acquire from Roswell, and what did they not get?
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manibiotech manibiotech 9 hours ago
This article clearly says it's Roswell academic center .
So at least I  don't see any correlation with NWBO
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hankmanhub hankmanhub 9 hours ago
based on the deal between NWBO and Roswell park
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starric starric 9 hours ago
Oh ok I see. Thnx!

https://clinicaltrials.eu/inn/murcidencel/




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flipper44 flipper44 9 hours ago
That is correct.
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SkyLimit2022 SkyLimit2022 10 hours ago
suit,



I’m not an expert on this topic, but I believe that a company applying to commercialize a novel cell-based technology in the U.S. market needs to include a robust section in its BLA application about…

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manibiotech manibiotech 10 hours ago
I will be happy if it stays above .30 for time being 
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Lykiri Lykiri 11 hours ago
I think this is the study: COMBINED ANTITUMOR THERAPY WITH EX VIVO MANIPULATED DENDRITIC CELLS PRODUCING INTERLEUKIN-12 IN CHILDREN, ADOLESCENTS, AND YOUNG ADULTS WITH PROGRESSIVE, RECURRENT, OR PRIMARILY METASTATIC HIGH-RISK TUMORS.

https://www.clinicaltrialsregister.eu/ctr-search/trial/2014-003388-39/CZ

It appears that the name murcidencel was initially used but later removed to avoid confusion with DCVax-L.
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DavidW2 DavidW2 11 hours ago
$1T MC? LOL. I am very happy if it can reach 50 B MC, by that time, I hope I am still alive to enjoy the profit.
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jtaylor042 jtaylor042 11 hours ago
$1T MC, in what would be the shortest time for any company to do it. My reaction was rude, and it should not have been.

I would happily accept my skepticism turning into a plate of crow in this instance.
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froggmister froggmister 11 hours ago
Because there is a possibility.
Of course there's a possibility. It's possible that meteor heading our way will not only hit us but will hit a nuclear power plant. But what are THE ODDS that the MRHA will reject a treatment that:
1. Was featured in JAMA with the top neurologists in the world signing off on survival efficacy
2. Approved the Pediatric trial with contemporaneous controls
3. With a benign safety profile
4. For a cancer indications (both nGBM and rGBM) which have no current good options
5. It went before the CHM in July
6. With the only reasonable argument for rejection being the trial design "confounding" the results, months after the CHM (where that issue might come up) the MHRA still saw fit to use considerable resources to send inspectors around the world to $NWBO trial sites.

While it's frustrating, it's not crazy that a treatment with a complex trial and a complex manufacturing profile would take longer than, say, an already-approved-elsewhere skin eczema treatment. To think it will be rejected outright takes some logic ninja.
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manibiotech manibiotech 12 hours ago
https://oncdata.com/roswell-park-gmp-engineering-and-cell-manufacturing-facility/


Here is the full article referenced in that video 
Video mentions CAR-t, TCR and dendritic cell vaccines . Not sure how you conclude they are NWBO clean rooms ?
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manibiotech manibiotech 12 hours ago
On you tube says it was uploaded 4 days ago
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hankmanhub hankmanhub 12 hours ago
Does NWBO now own the 20 clean rooms at Roswell that are spoke of in this video clip? Can you date when this video clip was made?
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NotSure2 NotSure2 12 hours ago
Havent seen the trial (no idea of which trial you are talking about and/or why you are asking me).

Its Not sure2 btw, Not sure was alrdy taken, I do not believe that username follow NWBO.
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theorysuit theorysuit 12 hours ago
Not sure but have you seen the trial? It is a monstrousity...wonder why they didn't apply to the FDA first?
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martyDg martyDg 12 hours ago
Duh! What do you think? Because there is a possibility. There’s no such thing as “de-risk,” according to cult long. You’re gullible if you believe that. There’s no such thing as 100% approval. Even in a soap advertisement, you can only kill 99.9% of germs, and that remaining 0.1% can still harm you.
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martyDg martyDg 13 hours ago
If the MHRA rejects it, that will be the final nail in the coffin. LP will finally be unable to dangle any more carrots in front of us. Only the gullible will still believe after this. 
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DavidW2 DavidW2 13 hours ago
What is Xmaster MC prediction?
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Jackxkr Jackxkr 13 hours ago
Y is it getting rejected, on what premise?
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theorysuit theorysuit 13 hours ago
if this gets rejected, it is toast with zero cash and big time debt.

but yeah the pumpers will say de-risked and breakthrough cancer therapy.....cough cough yeah right.
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KRISGO KRISGO 14 hours ago
If this belongs to NWBO, why wouldn't they notify investors before it begins? Or are they waiting for approval to use PR to target the shorts? Or is the news source unreliable and untrustworthy?

In this study, a new treatment is being tested for children, adolescents, and young adults with high-risk tumors that are either getting worse, have come back, or have spread to other parts of the body. These types of tumors are serious and can be difficult to treat with standard methods. The treatment being studied is a special type of vaccine called the autologous dendritic cell vaccine. This vaccine is made from the patient’s own cells and is designed to help the immune system fight the cancer. The vaccine works by using dendritic cells, which are a type of immune cell, to produce a substance called interleukin-12 that can boost the body’s natural defenses against cancer.
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RobotDroid RobotDroid 14 hours ago
Accelerated is a word Linda has zero knowledge of. Inept mute worlds worst ceo ever.
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RobotDroid RobotDroid 14 hours ago
Forever.
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RobotDroid RobotDroid 14 hours ago
As you are on most intelligent longs list.
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jtaylor042 jtaylor042 14 hours ago
Fair enough. I hope I am right in this regard and that I am wrong on your market cap predictions.

Best.
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exwannabe exwannabe 14 hours ago
So a P1/P2 trial of Murcidencel being run in Czechia by some 3rd party is listed iin.climnicatrials.eu (not Eudora,).

Weird.

Maybe Advent is expanding? First Brazil, now Czechia/.
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biosectinvestor biosectinvestor 14 hours ago
Look, the application was submitted and you have no basis, whatsoever to say one way or the other, how they have responded to regulators, whether it was sufficient or not is speedy or not. Everything you post on the topic is garbage speculation and given your predisposition, not particularly relevant or appropriate to rely upon. 
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JTORENCE JTORENCE 15 hours ago
psych7 Buyers Galore?? Buy: 1,790,145 ----Sell: 902,548
Go back to sleep jerk.
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martyDg martyDg 15 hours ago
That's not true? Lol. Where have you been this whole time? In a cave? Management is on the next level of slow. That's how they earned the title "Slowpokes". Anyway, you believe what you want to believe. I'm not going to argue with you.
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manibiotech manibiotech 15 hours ago
Common Doc this has happened innumerable times . 2 cent gain on average to below average volume ... really!!. Unless rise continues every day for several days , it's not convincing . Didn't we enter home stretch in Aug , which was SOS prediction also I guess , amongst many other times . 
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XMaster2023 XMaster2023 15 hours ago
This is my Opinion. It’s cynical and as I get older I get more cynical. Sorry in advance. I see a grocery bag filled with unmarked bills.
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dstock07734 dstock07734 15 hours ago
You increased your position? After all you are not so dumb.
Congrats!
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jtaylor042 jtaylor042 15 hours ago
I certainly won't dispute undue influence of the ultra wealthy on governance. But it seems to me that we should presume judges neutral unless there is evidence of wrongdoing. I don't see a benefit in presuming them biased, even if as you assert, they have erred in a decision.

Best.
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underpar71 underpar71 15 hours ago
Yeah, buyers galore, 2.8 million shares, lol
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DJPele DJPele 15 hours ago
These spikes in share price have randomly occurred within the last 3 months.

I wouldn't think anything of it unless it's followed by news of some sort, or a 15%+ jump.
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