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| Holder | Type | Held (Actual) | % of Outstanding | Market Value | Date Reported |
|---|---|---|---|---|---|
| GSK Equity Investments, Limited | Institution | 9,190,606 | 15.87% | US$ 23.34M | 2026-03-31 |
| Pfizer Venture Investments LLC | Institution | 2,362,348 | 4.08% | US$ 6.00M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 1,799,880 | 3.11% | US$ 4.57M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 1,189,235 | 2.05% | US$ 3.02M | 2026-03-31 |
| Ms. Esther Rajavelu | Insider | 986,851 | 1.70% | US$ 2.51M | 2026-05-04 |
| GV Management Company, LLC | Institution | 889,979 | 1.54% | US$ 2.26M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 885,631 | 1.53% | US$ 2.25M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 519,922 | 0.90% | US$ 1.32M | 2026-03-31 |
| BlackRock, Inc. | Institution | 433,202 | 0.75% | US$ 1.10M | 2026-03-31 |
| Anson Group | Institution | 421,956 | 0.73% | US$ 1.07M | 2026-03-31 |
| Dr. Ankit Mahadevia | Insider | 383,795 | 0.66% | US$ 974.84k | 2025-08-28 |
| Citadel Advisors LLC | Institution | 376,458 | 0.65% | US$ 956.20k | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 333,115 | 0.58% | US$ 846.11k | 2026-03-31 |
| Mr. Timothy Keutzer | Insider | 288,547 | 0.50% | US$ 732.91k | 2026-02-06 |
| GSA Capital Partners LLP | Institution | 278,304 | 0.48% | US$ 706.89k | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 264,115 | 0.46% | US$ 670.85k | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 214,751 | 0.37% | US$ 545.47k | 2026-03-31 |
| Ionic Capital Management LLC | Institution | 195,939 | 0.34% | US$ 497.69k | 2026-03-31 |
| Squarepoint OPS LLC | Institution | 194,301 | 0.34% | US$ 493.52k | 2026-03-31 |
| Marshall Wace LLP | Institution | 157,072 | 0.27% | US$ 398.96k | 2026-03-31 |
| Mr. Satyavrat Shukla | Insider | 127,856 | 0.22% | US$ 324.75k | 2025-04-01 |
| Coutts Diversifying Alternatives Multi-Manager Fund | Institution | 125,762 | 0.22% | US$ 319.44k | 2025-12-31 |
| Northern Trust Global Investments | Institution | 120,984 | 0.21% | US$ 307.30k | 2026-03-31 |
| Bridgeway Capital Management, LLC | Institution | 114,800 | 0.20% | US$ 291.59k | 2026-03-31 |
| Jane Street Group, LLC | Institution | 106,345 | 0.18% | US$ 270.12k | 2026-03-31 |
| Dr. Milind Deshpande | Insider | 71,454 | 0.12% | US$ 181.49k | 2025-06-12 |
| Shay Capital LLC | Institution | 70,354 | 0.12% | US$ 178.70k | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 59,668 | 0.10% | US$ 151.56k | 2026-03-31 |
| Mr. Scott Jackson | Insider | 55,000 | 0.09% | US$ 139.70k | 2025-06-12 |
| Dr. John Pottage | Insider | 55,000 | 0.09% | US$ 139.70k | 2025-06-12 |
| Dr. Patrick Vink | Insider | 55,000 | 0.09% | US$ 139.70k | 2025-06-12 |
| Ms. Kathleen Tregoning | Insider | 55,000 | 0.09% | US$ 139.70k | 2025-06-12 |
| Ms. Cynthia Smith | Insider | 55,000 | 0.09% | US$ 139.70k | 2025-06-12 |
| Mr. Frank Thomas | Insider | 55,000 | 0.09% | US$ 139.70k | 2025-06-12 |
| Invesco Capital Management LLC | Institution | 45,374 | 0.08% | US$ 115.25k | 2026-03-31 |
| Quadrature Capital Limited | Institution | 40,128 | 0.07% | US$ 101.93k | 2026-03-31 |
| OMERS Administration Corporation | Institution | 39,400 | 0.07% | US$ 100.08k | 2026-03-31 |
| Verdad Advisers, L.P. | Institution | 33,455 | 0.06% | US$ 84.98k | 2026-03-31 |
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