Anavex Life Sciences Corporation (AVXL) Options

Article doubting current treatment of ALZ from a poster on I-V.

https://news.uchicago.edu/where-has-alzheimers-research-gone-wrong

I don't know how much the authors know about what we're doing. I believe that if they looked at slowing brain shrinking they'd agree it's a step in the right direction, even if it's not curative.

Gary

If Anavex were bought out @$120 per share after EMA approval, that would represent less value than what Karuna received for its schizophrenia drug while awaiting FDA approval.

When it comes to a pre-revenue company, I spent decades in IMGN and watched the price rise and fall based on a variety of news events. Even an approval ment little when monetized, instead of waiting for growing revenue from the partnered who licensed the approved drug, Kadcyla.

Everything changed with approval of a wholly owned drug, but sadly in IMGN's case they took a buyout, that was quite profitable to all, but many believe they'd have gone much further had they remained independent.

I believe that the Analyst's $40+ targets anticipate European approval, but they're only a starting point. At that point I believe we'll not only add several more analysts, but I suspect their targets will be into triple digits. Of course if like IMGN management choose a buyout, then we may be looking at somewhere in the $80 to $120 range. If they wait, it could go far higher. Sadly, too many companies don't wait, often Institutional ownership is happy with the big payoff, rather than taking the longer, but larger gain.

Gary

Well dang, thanks for the pointing that out. I still think we’re #1!

Looks like a Low Volume Day 714,000 shares traded. Of that total 64,000 were MOC order. The only other notable bit of volume was when we hit low for the day. $8.63 Then someone bought 34,000 shares.
John k9uwa

Great find!

Except for an oddity near the bottom of the list, it is in alphabetical order.  That is why Anavex is at the top. 

I just emailed her the link to the “10 biotech companies to watch in 2025” that has Anavex at the top of the list!

https://www.labiotech.eu/best-biotech/biotech-companies-2025/

The only thing that will convince "the public" about how good Blarcamesine is, is approval and the resulting availability.
What you are talking about is PR campaign which will have a short term impact on the SP at best.

Wonder how much USAID money has been diverted to the New Republic over the last 4 years?

Evidently not enough to hire real investigative journalists.

"shouldn’t Anavex & Missling be doing this" perhaps it is better coming from one our knowledgeable posters and stock owners than it would be from Missling.

BIG THANKS POWER. Yes I read the article and yes I read all the comments below the article.
John k9uwa

"Awaiting blarcamesine as an approved drug. Everyone will benefit." I can see it now. Eventually all us Old Coots will take a blarcamesine daily the same as we now do with a baby aspirin. Preventative Medicine. And yes I do think we will see some increase in AVXL price once we pass Clock Stop One.

And to "DoTheRightThing" re: your comments about 10 years of pricing of Anavex. I am thinking that ALL of us who have played the game with AVXL are Way ahead due to trading in one fashion or another... A few days ago one of our posters said once he took out enough to buy a new car. I will say back in 2021 I took out enough to buy another Residential Rental property. That was #14 for us.
John k9uwa

Ever hear of hockey stick?

By the way, nobody is putting a gun to a patient’s head to try either Leqembi or Kisunla
You realize losing your mind is a death sentence. People will try anything.
Ease of use Blarcamesine will be a Godsend.

re: but let’s be thankful that there are patients who are seeing even modest benefits with the currently approved treatments.

Some EMA researchers have refuted the mabs' claim of any significant, noticeable, clinical efficacy....implying that claims were made by others too closely tied to the pharmas to be reliable sources.

Maybe Blarcamesine will prove to be superior and maybe not ...

Bio*4, just to set your mind at ease, Blarcamesine has proven to be superior and will be approved by EMA in a matter of months.

fda will follow once DJT and RFK, Jr. hear about it.

Where have you been? People have been saying the same thing over and over again since the beginning.

The article on Fox “News” was reporting on a study by the Washington University School of Medicine in St. Louis that was recently published in the Alzheimer’s Association journal. I’m not sure why you have a problem with that.

By the way, nobody is putting a gun to a patient’s head to try either Leqembi or Kisunla.

Maybe Blarcamesine will prove to be superior and maybe not, but let’s be thankful that there are patients who are seeing even modest benefits with the currently approved treatments.

Maybe we should put fliers on telephone poles announcing the benefits of blarcamesine.

"melissa.rudy@fox.com"--also sent this Fox news reporter and informed her about Blarcamesine---perhaps more here should do the same-----The squeaky wheel gets the oil" !!!!

While you are thinking about "all the people on statins now," Bourbon, you might also want to take a quick look at the February edition of PTAD, which includes a paper showing a greater propensity of statin users to develop AD, particularly those with the wild type gene. To the extent that 2-73 and/or 3-71 are shown to act (to some significant degree) as preventative, that could add a very large target market.

It's been well over a decade only three things will help approvals partnership or a buyout everything else is useless word salad

As Mayomobile has pointed out, the EMA is a better fit for an AD drug approval for blarcamesine

you should have stopped at the first sentence, which was spot on. the rest was politics, but I will let it slide.

We'll NEVER hear about that again.

As Mayomobile has pointed out, the EMA is a better fit for an AD drug approval for blarcamesine. I don't at all buy that the FDA is corrupt. However, it is also lucky that we're dealing with the EMA now rather than the FDA which is, like most of the civil government, engulfed in a paralytic chaos.

Anavex planned to begin its Parkinson's Phase 3 trial by late January, which has clearly slipped. I think the issue is at the FDA end. I think they are presently a mess.

Where's that PDD trial news?

Didn't you hear, it starts right after the rare disease trial gets going.

A money heavy partner could change that pretty fast.

An EMA approval is what will change things. It will be big news.

I hope you’re correct.

See how Anavex Life Sciences Corp (and its shareholders) will benefit when this or some other prodromal test for Alzheimer's becomes a standard medical practice, used on all people starting in their middle ages.

yes easy effective testing will sell 273, think of all the people on statins now. this will become a standard test for middle age. all funnelling people into the one safe easy and effective treatment for early alzheimers

My Mother dreamed in five different languages...
AND was a District Teacher's Teacher for 30+ years.
I have trouble at times with one, English.
Language is not an issue and your bigotry is poorly founded..
Presentation perhaps is.
Misslling is NOT a Top Gear presenter.

You have ZERO evidence of this assertion but it was wise of Missling to avoid any conflicts of interest with the Big Pharma influenced FDA, and instead work with the European Medicines Agency (EMA) to submit Blarcamesine trial data for Anavex's initial commercial approval.

It would be better if he invested his time in an English-speaking and effective presentation class for (arrogant) Germans.

Who will fire him? BODs are in his pocket, most of them are his college buddies. He, CMO and accountant should have been fired after rett failure.

That’s wonderful, but shouldn’t Anavex & Missling be doing this?

Sent an email to Melissa and informed her about Blarcamesine.

Her email address is:

melissa.rudy@fox.com

New Dr Missling post - https://www.linkedin.com/posts/christopher-missling-phd-18924a_brainhealth-mentalhealth-anavex-activity-7298359518164336640-CK68/?utm_source=share&utm_medium=member_desktop&rcm=ACoAAAk2y8EBSCkG-CZG-fmrfHJbdOROejFU-zA

Why am I here? I’ve asked myself that same question many times over the past 10 years.

While I have no association with kund, I am pleased to see how much his written english has improved over these past several years. Unfortunately, the same cannot be said about our bumbling CEO’s spoken english. He still is hard to listen to 10 years later—embarrassing.

Why are you here Guzzi?

Crazy that folks can’t understand how great A2-73 is and that Anavex EMA approval at >83% chance is an almost certainty!!!

Why are you here?

Are you an associate of kund?

Some suggest there is a 4% chance of ALZ approval by the EMA. Apparently there is a 3% chance an asteroid hits somewhere in the Southern hemisphere in 7 years.

Knowing Anavex’s luck, they’ll get full approval from both the EMA & the FDA on the same day this asteroid hits Earth.

With the FDA, it’s also about WHERE the trials are being run. Since ours were run outside the USA, the FDA’s enthusiasm for the results has been muted.

It’s time for a better spokes person to take this company to a higher respectable level.
Dr Missling is brilliant and I give him lots of credit to get this far, but AVXL needs a better public figure to relay how good Blarcasemine is.

Just another day of nothing. Another month of nothing. Probably another year of nothing. Where's that PDD trial news? We'll never hear about it again.

It's all about who sponsor the Alzheimer's Association and pays a lot of money for commercials to Fox.

Not applying with the FDA (yet) don't help either.

A money heavy partner could change that pretty fast.

I'm not surprised.

It’s not hard to believe. Our CEO can barely utter a sentence coherently in English without using UHH several times.

It’s sad that after TEN years, we’re still wondering why nothing seems to change.

https://www.foxnews.com/health/two-alzheimers-drugs-help-patients-live-independently-home-longer-periods

Hard to believe that we are still seeing this kind of reporting! sad

Even without the fractional pennies THAT is not asking a lot
and frankly would barely get me minimal return on the latest
trading attempt.

Yet Another Prodromal Test for Eventual Alzheimer's

I and others frequently post the discovery of new medical tests that predict a patient's probability (or inevitability) of developing Alzheimer's disease. There are now a number of these tests.

But, presently, they serve no useful purpose; merely to inform a person that he or she is likely to get Alzheimer's.

This new test appears to be very reliable. But it requires the extraction of cerebrospinal fluid. Not an easy or convenient procedure. Right now, because there is no useful prophylactic treatment for Alzheimer's, this new test will be but a medical curiosity, used only very infrequently in certain medical studies.

But, if you are good at 8th-grade arithmetic, run the numbers and see how Anavex Life Sciences Corp (and its shareholders) will benefit when this or some other prodromal test for Alzheimer's becomes a standard medical practice, used on all people starting in their middle ages.

Obviously, if this or other tests yield positive results, showing that the tested person is going to get Alzheimer's, blarcamesine therapy will be fully indicated and used. Millions will have either lengthy, additional years of normal cognition; or, very likely, will never get Alzheimer's at all; the blarcamesine Alzheimer's prophylaxis effect. It very likely will occur when therapy starts long before any Alzheimer's symptoms have ever appeared.

Awaiting blarcamesine as an approved drug. Everyone will benefit.