TIDMAGL
Angle PLC
01 April 2022
For immediate release 01 April 2022
ANGLE plc ("the Company")
PARSORTIX SYSTEM DEMONSTRATES ABILITY TO ISOLATE CTCs FOR
DOWNSTREAM MOLECULAR ANALYSIS, IDENTIFYING KEY DRUG TARGETS
INVOLVED IN CANCER METASTASIS
World-class research identifies specific genetic steps in the
metastatic process, paving the way to test targeted treatment
approaches
Metastatic process driven by invasion of CTCs and CTC clusters
found to be dependent on druggable gene targets
ANGLE plc (AIM:AGL OTCQX:ANPCY), a world-leading liquid biopsy
company, is pleased to announce that the Molecular Oncology
Laboratory at the Swiss Federal Institute of Technology (ETH)
Zurich, Switzerland, has published results of work undertaken in
preclinical models of metastatic breast cancer (MBC), where they
have identified specific genes involved in various steps of the
metastatic process. This included actionable targets found to be
required for the formation of circulating tumour cells (CTCs) and
their seeding at secondary metastatic tumour site. In a preclinical
model, targeted therapy was found to reduce metastasis and has the
potential to improve patient outcomes.
Researchers used ANGLE's Parsortix(R) system to isolate single
CTCs and CTC clusters from preclinical MBC models engineered with
CRISPR technology, and the CTCs were analysed using DNA sequencing.
The team identified metastasis-relevant genes, where
loss-of-function of the genes resulted in decreased CTC cluster
generation and reduced metastatic burden. This has clinical
relevance as it has been estimated that CTC clusters have
23-50-fold increased metastatic potential compared to single CTCs
and confer a higher risk of death in MBC patients. The authors also
identified actionable gene targets, such as PLK1, that are required
for the formation of both single CTCs and CTC clusters. Treatment
with approved targeted therapy reduced CTC shedding and metastasis
formation in the preclinical model. This is particularly relevant
to patient outcomes given that 90% of cancer deaths are a result of
metastasis.
This study adds to the growing body of evidence demonstrating
the ability of the Parsortix system to isolate single CTCs and CTC
clusters, enabling the identification of actionable targets
involved in the metastatic spread of cancer. This research has
potential clinical applicability in discovering and testing, new
and existing, targeted therapies.
In the United States, breast cancer is the most frequently
diagnosed cancer in women with 287,000 new cases expected in 2022,
accounting for 31% of all new cancer cases. It is estimated that 6%
of patients have metastatic disease at diagnosis and approximately
20-30% of all breast cancer patients will eventually develop
metastatic disease. Identification of appropriate targets will be
essential to enable the development of targeted therapies for
MBC.
Prof Nicola Aceto, ETH Zurich, commented:
"Our study provides a novel CTC-based tool to study spontaneous
breast cancer metastasis in a highly clinically relevant fashion.
Using this model in combination with a CRISPR-based approach, we
demonstrate the involvement of targetable players in the metastatic
spread of cancer, with potential clinical applicability."
ANGLE Founder and Chief Executive, Andrew Newland, added:
"We are pleased to report on the use of the Parsortix system for
the isolation of single CTCs and CTC clusters in preclinical MBC
models, allowing the identification of actionable targets involved
in cancer metastasis. ANGLE's ability to provide such actionable
insight shows potential to guide targeted drug development, which
can be achieved through our growing pharma services business."
The research has been published as a peer-reviewed publication
in the Journal Cancer Research and is available online at
https://angleplc.com/library/publications/ .
For further information:
ANGLE plc +44 (0) 1483 343434
Andrew Newland, Chief Executive
Ian Griffiths, Finance Director
Andrew Holder, Head of Investor Relations
Berenberg (NOMAD and Joint Broker)
Toby Flaux, Ciaran Walsh, Milo Bonser +44 (0) 20 3207 7800
Jefferies (Joint Broker)
Max Jones, Thomas Bective +44 (0) 20 7029 8000
FTI Consulting
Simon Conway, Ciara Martin +44 (0) 203 727 1000
Matthew Ventimiglia (US) +1 (212) 850 5624
For Frequently Used Terms, please see the Company's website on
https://angleplc.com/investor-relations/glossary/
Notes for editors
About ANGLE plc www.angleplc.com
ANGLE is a world leading liquid biopsy company with
sample-to-answer solutions. ANGLE's proven patent protected
platforms include a circulating tumor cell (CTC) harvesting
technology and a downstream analysis system for cost effective,
highly multiplexed analysis of nucleic acids and proteins.
ANGLE's cell separation technology is called the Parsortix(R)
system, and it enables a liquid biopsy (a simple blood test) to be
used to provide the cells of interest to the user in a format
suitable for multiple types of downstream analyses. The system is
based on a microfluidic device that captures cells based on a
combination of their size and compressibility. The system is
epitope independent and can capture all types of CTCs as well as
CTC clusters in a viable form (alive). CTCs enable the complete
picture of a cancer to be seen; as being an intact cell they allow
DNA, RNA and protein analysis and may provide comparable analysis
to a tissue biopsy. Because CTC analysis is a non-invasive process,
unlike tissue biopsy, it can be repeated as often as needed. This
is important because cancer develops and changes over time and
there is a clear medical need for up-to-date information on the
status of a patient's tumor. In addition, the live CTCs harvested
by the Parsortix system can be cultured, which offers the potential
for testing tumor response to drugs outside the patient.
The Parsortix technology is the subject of 26 granted patents in
Europe, the United States, China, Australia, Canada, India, Japan
and Mexico with three extensive families of patents are being
progressed worldwide.
The Parsortix system has a CE Mark in Europe for the indicated
use and, in the United States, a De Novo Submission has been made
to FDA for the Parsortix(R) PC1 system seeking FDA clearance with
Class II Classification for use with metastatic breast cancer
patients. FDA clearance is seen as the global standard. ANGLE is
seeking to be the first ever FDA cleared system for harvesting CTCs
for subsequent analysis.
ANGLE has also completed two separate 200 subject clinical
studies under a program designed to develop an ovarian cancer
pelvic mass triage test, with the results showing best in class
accuracy (AUC-ROC) of 95.1%. The pelvic mass triage assay has
undergone further refinement and optimisation and a 200 patient
clinical verification study has now completed enrolment.
ANGLE's technology for the multiplex evaluation of proteins and
nucleic acids of all types is called the HyCEAD(TM) platform and is
based on a patented flow through array technology. It provides for
low cost, highly multiplexed, rapid and sensitive capture of
targets from a wide variety of sample types. A proprietary
chemistry approach (the HyCEAD method) allows for the capture and
amplification of over 100 biomarkers simultaneously in a single
reaction. The HyCEAD system is extremely sensitive and is ideal for
measuring gene expression and other markers directly from Parsortix
harvests and was used in the ovarian cancer pelvic mass triage test
to achieve best in class accuracy (AUC-ROC) of 95.1%.
ANGLE's proprietary technologies can be combined to provide
automated, sample-to-answer results in both centralised laboratory
and point-of-use cartridge formats.
ANGLE has established formal collaborations with world-class
cancer centres and major corporates such as Abbott, Philips and
QIAGEN, and works closely with leading CTC translational research
customers. These Key Opinion Leaders (KOLs) are working to identify
applications with medical utility (clear benefit to patients), and
to secure clinical data that demonstrates that utility in patient
studies. The body of evidence as to the benefits of the Parsortix
system is growing rapidly from our own clinical studies in
metastatic breast cancer and ovarian cancer and also from KOLs with
59 peer-reviewed publications and numerous publicly available
posters, available on our website.
ANGLE has established clinical services laboratories in the UK
and USA to accelerate commercialisation of the Parsortix system and
act as demonstrators to support product development. The
laboratories offer services to pharmaceutical and biotech customers
for use of Parsortix in cancer drug trials and, once the
laboratories are accredited and tests validated, will provide
Laboratory Developed Tests (LDTs) for patient management.
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