Yourgene Health Launches LightBench Detect for Fetal Fraction Enrichment
June 20 2022 - 5:41AM
Business Wire
- Offers flexibility in blood collection tube choice enabling
cost-effective workflows in non-invasive prenatal testing
- Scalable and precise DNA size selection reduces no-call rates
for improved patient outcomes
Yourgene Health plc (“Yourgene”, AIM: YGEN), a leading
international molecular diagnostics group, announces today the
launch of the LightBench® Detect, the latest addition to its
Ranger® Technology instrumentation portfolio at the 26th
International Conference on Prenatal Diagnosis and Therapy (ISPD).
The Company has worked closely with its clinical laboratory
partners to develop size selection methodologies optimised for
improving the performance of liquid biopsy workflows, most notably
non-invasive prenatal testing (NIPT). The LightBench Detect helps
NIPT providers to reduce no-call rates by optimising average fetal
fraction. Leveraging the unique size selection capabilities of
Ranger Technology, the LightBench Detect also enables laboratories
to consider the use of EDTA blood collection tubes (BCTs) instead
of expensive specialised preservation blood collection tubes (BCT)
in their workflows to help reduce overall costs.
The LightBench Detect is a clinical-grade 3-in-1 electrophoretic
instrument offering liquid biopsy and NIPT laboratories the ability
to automate the process of DNA size selection and enrichment from
samples stored for prolonged periods in EDTA BCTs. This core
capability is complemented by the ability to perform fragment
length analysis and fluorescence assays for quality control
purposes. Cell free DNA (cfDNA) fragments of fetal origin are
typically <150bp in length, meaning size selection using the
instrument can enrich for fetal fraction to reduce the number of
no-call results or screening failures, helping improve overall
patient outcomes. Use of the technology in NIPT offers scalable and
precise DNA size selection and achieves >97% reproducibility,
ensuring consistent enrichment of the fetal fraction.
The use of this patent-pending, EDTA-enabling, technology will
be presented by the Centre de recherche du CHU de Québec-Université
Laval*. The group worked with Yourgene to compare fetal fraction in
61 samples collected from singleton pregnancies in Vancouver over a
two-month period. Samples stored in the expensive BCTs had fetal
fractions below 4% (a common pass/fail threshold) 12% of the time,
while samples stored in inexpensive EDTA tubes had zero cases of
fetal fraction below 4% when paired with size selection. A low
fetal fraction in NIPT will result in a no result and potentially a
re-draw blood sample from the pregnant mother. They demonstrated
that Ranger Technology offers an alternative solution to the use of
expensive BCTs for stabilising NIPT samples. Yourgene has now made
this capability accessible to the market via the LightBench
Detect.
Lyn Rees, CEO of Yourgene Health, said: “Every once in a
while, a technology comes along that has the potential to disrupt
standard clinical testing workflows and make real improvements,
both to the test performance and the economics and efficiencies of
a test. Working with Université Laval has enabled us to deliver the
LightBench Detect, which radically improves efficiencies by giving
labs flexibility of choice around the blood collection tube they
use without impacting performance. We are so excited to roll out
this capability to other NIPT providers.”
For further information about the LightBench Detect, visit:
https://www.yourgene-health.com/lightbench-detect
Yourgene will be attending the ISPD in Montreal, Canada from
19–23 June 2022. Visit booth #205 to learn more.
*Daryabari et al., Improving fetal fraction in NIPT by
size-selection of samples collected in EDTA gel tubes [Poster
presented at ISPD 2022 P-88]
ENDS
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Zyme Communications Dr Michelle Ricketts Tel: +44 (0)7789 053
885 Email: michelle.ricketts@zymecommunications.com
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