RNS Number:9370S
Skyepharma PLC
05 December 2003

For Immediate Release                                            5 December 2003

                         SkyePharma PLC ("the Company")

                    Notification of Major Interest in Shares

In accordance with the Companies Act 1985 (as amended) the Company was informed
by Fidelity Investments on 4 December 2003 that FMR Corp and its direct and
indirect subsidiaries and Fidelity International Limited and its direct and
indirect subsidiaries, both being non-beneficial holders ("Fidelity"), had
increased their total holding to 73,754,491 ordinary shares of 10p each,
representing 11.93% of the issued share capital of the Company.  In addition
Fidelity have informed the Company that they also hold 5,000,000 SkyePharma PLC
6% Convertible Bonds due 2005.

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