Scilex Holding Company (Nasdaq: SCLX) announced that its majority stockholder, Sorrento Therapeutics, Inc. (Nasdaq: SRNE, “Sorrento”) today posted a supplement to its previously issued “Frequently Asked Questions” document under the “Investors” section of its website at www.sorrentotherapeutics.com regarding its recent dividend to Sorrento stockholders of shares of common stock of Scilex Holding Company held by Sorrento.

The supplement to the FAQs provides notice regarding the Depository Trust and Clearing Corporation’s removal of the contra-CUSIP on Scilex common stock that was distributed as a dividend to Sorrento’s stockholders and provides notice to brokerage firms, banks, dealers and similar organizations listed therein that a dividend confirmation had previously been distributed to such firms by Scilex’s transfer agent and requests that such firms contact Scilex’s transfer agent if they have not received such confirmation. The supplement also reiterates a question related to issues that may arise with respect to the dividend in connection with short positions in Sorrento common stock.

The supplement to the FAQs and related annex are included in this press release and can also be found Scilex’s website https://www.scilexholding.com/investors/faqs/

SUPPLEMENT TO FREQUENTLY ASKED QUESTIONS REGARDING THE DIVIDEND OF SCILEX HOLDING COMPANY COMMON STOCK BY SORRENTO THERAPEUTICS, INC.

This supplement is a supplement to the Frequently Asked Questions Regarding the Dividend of Scilex Holding Company Common Stock by Sorrento Therapeutics, Inc. (Sorrento) that was issued by Sorrento on January 29, 2023 (the FAQ), a copy of which can be found under the “Investors” section of its website at www.sorrentotherapeutics.com.

This supplement is being issued to update and supplement the information in the FAQ to notify investors regarding certain matters relating to the dividend and reiterate certain questions and answers from the FAQ. Capitalized terms used in this supplement shall have their respective meetings set forth in the FAQ.

NOTICE OF REMOVAL OF CONTRA-CUSIP BY DTCC

Effective as of February 2, 2023, the Depository Trust and Clearing Corporation has removed the “contra-CUSIP” that it had previously imposed on the Dividend Stock. Any shares of Dividend Stock held by your brokerage firm, bank, dealer or other similar organization for your benefit now bear only Scilex’s CUSIP number, which is 80880W106. If you are entitled to receive Dividend Stock, please contact your brokerage firm, bank, or other similar organization immediately to confirm that the CUSIP number appears on your brokerage statement with respect to your Dividend Stock.

NOTICE TO BROKERAGE FIRMS, BANKS, DEALERS AND OTHER SIMILAR ORGANIZATIONS

If the name of your firm, bank or other similar organization is set forth on Annex B of the FAQ, which Annex B is repeated below for convenience, and your firm, bank or similar organization has not received the Dividend Confirmation that was mailed to your firm, bank or similar organization, please contact Scilex’s transfer agent immediately to obtain a copy of the Dividend Confirmation. Scilex’s transfer agent’s contact information is as follows:

Continental Stock Transfer & Trust Company

Telephone Number: 800-509-5586

Email Address: cstmail@continentalstock.com

Several major brokers have confirmed to Sorrento and Scilex that they are adding the Scilex share positions to the individual brokerage accounts of Sorrento shareholders receiving the Dividend Stock

SUPPLEMENTAL QUESTION AND ANSWER

Q: If I loaned my shares of Sorrento common stock to short sellers or any other party as of the Record Date, am I still entitled to receive Dividend Stock as of the Payment Date? 

A: Only Record Holders as of the Record Date are entitled to receive the Dividend Stock. If you were the Record Holder as of the Record Date and are entitled to receive the Dividend Stock, but have not received the Dividend Stock, you may be entitled to receive Dividend Stock from the short seller or other party who borrowed your shares of Sorrento common stock, whether through the lending programs implemented by your brokerage firm, bank, dealer and other similar organization or otherwise. If you were a Record Holder as of the Record Date and have not received your Dividend Stock, please consult with your financial advisor, broker or other agent immediately to determine how to receive your Dividend Stock.

Annex B

Broker List

Broker Name Broker Address   Broker Name Broker Address
ABN AMRO CLEARING CHICAGO LLC 175 WEST JACKSON BLVD.CHICAGOIL ILLINOIS60604 US   Albert Fried & Company LLC 45 BROADWAY, 24TH FLOOR24TH FLOORNEW YORKNY NEW YORK10006 US
AMALGAMATED BANK 275 7TH AVENUENEW YORKNY NEW YORK10003 US   AMERICAN ENTERPRISE INVESTMENT SERVICES INC. 682 AMERIPRISE FINANCIAL CENTERMINNEAPOLISMN MINNESOTA55474 US
APEX CLEARING CORPORATION 2 GATEWAY CENTER 283-299 MARKET ST16TH FLOORNEWARKNJ NEW JERSEY07102-5005 US   BANK OF AMERICA, NA/GWIM TRUST OPERATIONS 901 MAIN STREET12TH FLOORDALLASTX TEXAS23113 US
BANK OF NEW YORK MELLON 111 SANDERS CREEK PARKWAY 2ND FLOOR2ND FLOOREAST SYRACUSENY NEW YORK13057 US.   BARCLAYS CAPITAL INC. DTC CUSTODY PARTICIPANT- NY WINDOW -570 WASHINGTON BLVD (ATTN: ROSA HICKS-MILLER OR ROBERT MENDEZJERSEY CITYNJ NEW JERSEY07310 US
BARCLAYS CAPITAL INC. DTC CUSTODY PARTICIPANT- NY WINDOW -570 WASHINGTON BLVD (ATTN: ROSA HICKS-MILLER OR ROBERT MENDEZJERSEY CITYNJ NEW JERSEY07310 US   BMO CAPITAL MARKETS CORP. 3 2ND STREET12TH FLOORJERSEY CITYNJ NEW JERSEY07302 US
BMO HARRIS BANK NA/TRUST 11270 W PARK PLMILWAUKEEWI WISCONSIN53224 US   BMO Nesbitt Burns Inc., Toronto 250 YONGE STREET, 7TH FLOOR7TH FLOORTORONTOON ONTARIOM5B 2M8 CA CANADA
BNP PARIBAS, NEW YORK BRANCH/BNP PARIBAS PRIME BROKERAGE CUSTODIAN 100 WEST 33RD STREET3RD FLOORNEW YORKNY NEW YORK10001   BNP PARIBAS, NEW YORK BRANCH/BNP PARIBAS PRIME BROKERAGE CUSTODIAN 100 WEST 33RD STREET3RD FLOORNEW YORKNY NEW YORK10001
BNY MELLON PO BOX 392002500 ROSS STREETPITTSBURGHPA PENNSYLVANIA15262 US   BNY MELLON/WEALTH MANAGEMENT 1 FREEDOM VALLEY DRIVEOAKSPA PENNSYLVANIA19456 US
BNYMELLON 111 SANDERS CREEK PARKWAY 2ND FLOOR2ND FLOOREAST SYRACUSENY NEW YORK13057 US   BNYMELLON/RE BARCLAYS CAPITAL SECURITIES LTD. ONE WALL STREETNEW YORKNY NEW YORK10286
BNYMELLON/RE CACEIS BANK LUXEMBOURG 500 Grant St.BNY Mellon CenterPITTSBURGHPA PENNSYLVANIA15258   BNYMELLON/RE CACEIS BANK, NETHERLANDS 111 SANDERS CREEK PARKWAYEAST SYRACUSENY NEW YORK13057
BNYMELLON/RE CHARLES STANLEY AND COMPANY, LIMITED 111 SANDERS CREEK PARKWAY 2ND FLOOR2ND FLOOREAST SYRACUSENY NEW YORK13057 US   BNYMELLON/RE ETF - ISHARES DTC/NSCC 111 SANDERS CREEK PARKWAYEAST SYRACUSENY NEW YORK13057
BNYMELLON/RE WINTERFLOOD SECURITIES LTD 500 Grant St.BNY Mellon CenterPITTSBURGHPA PENNSYLVANIA15258   BOFA 4804 Deer Lake Drive EastFL9-803-04-04- 4th floorJACKSONVILLEFL FLORIDA32246 US
BOFA 4804 Deer Lake Drive EastFL9-803-04-04- 4th floorJACKSONVILLEFL FLORIDA32246 US   BOFA SECURITIES INC 4804 Deer Lake Drive EastFL9-803-04-04- 4th floorJACKSONVILLEFL FLORIDA32246 US
BROWN BROTHERS HARRIMAN & CO. 140 BROADWAYATTN: CORPORATE ACTIONS VAULTNEW YORKNY NEW YORK10005 US   BROWN BROTHERS HARRIMAN & CO./ETF 140 BROADWAYNEW YORKNY NEW YORK10005
CALDWELL SECURITIES LTD./CDS** 55 UNIVERSITY AVENUESUITE 340TORONTOON ONTARIOM5J 2H7 CANADA   CANACCORD GENUITY CORP. 609 GRANVILLE STVANCOUVERBC BRITISH COLUMBIAV7Y 1H2 CA CANADA
CANTOR, FITZGERALD & CO. 135 E 57TH ST 5TH FLNEW YORKNY NEW YORK10041 US   CDS CLEARING AND DEPOSITORY SERVICES INC. 100 ADELAIDE STREET WESTTORONTOON ONTARIOM5H 1S3 CA CANADA
CETERA INVESTMENT SERVICES LLC 400 FIRST STREET SOUTH, SUITE 300SUITE 300ST. CLOUDMN MINNESOTA56302-0283 US   CHARLES SCHWAB & CO., INC. 211 MAIN STREETSAN FRANCISCOCA CALIFORNIA94105 US
CI INVESTMENT SERVICES INC. 199 BAY STREETSUITE 2600TORONTOON ONTARIOM5L 1E2 CA CANADA   CIBC WORLD MARKETS INC./CDS** 161 BAY STREET 10 FLTORONTOON ONTARIOM5J 2S8 CA CANADA
CITIBANK, N.A./ETF 3800 CITIGROUP CENTERB2/2TAMPAFL FLORIDA33610   CITIBANK, NATIONAL ASSOCIATION 3800 CITIBANK CENTER TAMPABLDG.B FIRST FLOOR ZONE 8TAMPAFL FLORIDA33610-9122 US
CITIGROUP GLOBAL MARKETS, INC. 580 CROSSPOINT PARKWAYGETZVILLENY NEW YORK14068 US   CLEAR STREET LLC 4 World Trade Center, 45th Floor150 Greenwich StreetNEW YORKNY NEW YORK10007
CLEARSTREET IO 55 BROADWAY (SUITE 2102)CORPORATE ACTIONSNEW YORKNEW YORK10006 US   COMMERCE BANK 922 WALNUT STREETMAIL STOP TBTS-2KANSAS CITYMO MISSOURI64106 US
COR CLEARING LLC 9300 UNDERWOOD AVESUITE 400OMAHANE NEBRASKA68114 US   Credential Securities Inc. 800-1111 WEST GEORGIA STREETVANCOUVERBC BRITISH COLUMBIAV6E 4T6 CA CANADA
CREST INTERNATIONAL NOMINEES LIMITED 33 CANNON STREETLONDONEC4M 5SB GB UNITED KINGDO   CURVATURE SECURITIES, LLC 39 MAIN STREETCHATHAMNJ NEW JERSEY07928 US
D.A. DAVIDSON & CO. 8 3RD STREET NORTHGREAT FALLSMT MONTANA59401 US   DEPOSITO CENTRAL DE VALORES S.A., DEPOSITO DE VALORES AVENIDA APOQUINDO # 4001FLOOR 12, C.P.7550162, SANTIAGOCL CHILE
DESJARDINS SECURITIES INC. 1253 McGill College10TH FLOORMONTREALQUEBECH3B 2Y5 CA CANADA   DEUTSCHE BANK AG NY/US CUSTODY 1251 Avenue Of The AmericasNEW YORKNY NEW YORK10020
DEUTSCHE BANK SECURITIES INC. 60 WALL STREET9TH FLOORNEW YORKNY NEW YORK10005 US   DRIVEWEALTH, LLC 15 EXCHANGE PLACE10TH FLOORJERSEY CITYNEW JERSEY07302
E*TRADE CLEARING LLC HARBORSIDE FINANCIAL CENTER501 PLAZA 11JERSEY CITYNJ NEW JERSEY07311 US   EDWARD D. JONES & CO., L.P. 12555 MANCHESTER ROADST. LOUISMO MISSOURI63131-3729 US
EDWARD D. JONES & CO., L.P. 201 PROGRESS PARKWAYMARYLAND HEIGHTSMO MISSOURI63043 US   FIDELITY CLEARING CANADA ULC/CDS** 483 BAY ST.SOUTH TOWERTORONTOON ONTARIOM5G2N7 CA CANADA
FIFTH THIRD BANK 5001 KINGSLEY DRIVEMAIL DROP 1MOB28CINCINNATIOH OHIO45227 US   FOLIO INVESTMENTS, INC. 8180 GREENSBORO DRIVE8TH FLOORMCLEANVA VIRGINIA22102 US
FUTU CLEARING INC. 12750 Merit DriveSUITE 475DALLASTX TEXAS75251   GMP SECURITIES L.P. 145 KING STREET WEST, SUITE 30011TH FLOORTORONTOON ONTARIOMJ5 1J8 CA CANADA
GOLDMAN, SACHS & CO. LLC 222 SOUTH MAIN STREETAttn: Mandatory Corporate ActionsSALT LAKE CITYUT UTAH84101 US   HAYWOOD SECURITIES INC./CDS** 200 BURRARD STWATERFRONT CENTRE SUITE 700VANCOUVERBC BRITISH COLUMBIAV6C 3L6 CANADA
HILLTOP SECURITIES INC. 1201 ELM ST.35TH FLOORDALLASTX TEXAS75270 US   HRT FINANCIAL LLC 150 GREENWICH STREET (ATTN: SETTLEMENT) FOUR WORLD TRADE CENTER57TH FLOORNEW YORKNY NEW YORK10007 US
HSBC BANK USA, NA/HSBC CUSTODY & CLEARING SERVICES FOR STOCK LOAN 452 FIFTH AVENUEATTN: HBUS CCS SETTSNEW YORKNY NEW YORK10018 US   HSBC BANK USA, NATIONAL ASSOCIATION 452 FIFTH AVENUEATTN: HBUS CCS SETTSNEW YORKNEW YORK10018 US
INTERACTIVE BROKERS LLC 2 PICKWICK PLAZA2ND FLOORGREENWICHCT CONNECTICUT06830 US   J.P. MORGAN CHASE BANK NA/FBO BLACKROCK CTF 1111 POLARIS PARKWAYCOLUMBUSOH OHIO43240
J.P. MORGAN CLEARING CORP. FOUR CHASE METROTECH CENTER3RD FLOORBROOKLYNNY NEW YORK11201 US   JANNEY MONTGOMERY SCOTT LLC 1717 ARCH STREET17TH FLOORPHILADELPHIAPA PENNSYLVANIA19103 US
JEFFERIES LLC 101 HUDSON STREET, 11th FloorNEW JERSEYNJ NEW JERSEY07302 US   JPMORGAN CHASE BANK, NATIONAL ASSOCIATION FOUR CHASE METROTECH CENTER3RD FLOORBROOKLYNNY NEW YORK11201 US
JPMORGAN CHASE BANK/EUROCLEAR BANK FOUR CHASE METROTECH CENTER3RD FLOORBROOKLYNNY NEW YORK11245 US   JPMORGAN CHASE BANK/IA FOUR CHASE METROTECH CENTER3RD FLOORBROOKLYNNY NEW YORK11201 US
KEYBANK NATIONAL ASSOCIATION 4900 TIEDEMAN RDBROOKLYNOH OHIO44144 US   LAURENTIAN BANK SECURITIES INC. 1981 MCGILL COLLEGE AVE.SUITE 100MONTREALQUEBECH3A 3K3 CA CANADA
LPL FINANCIAL LLC 4707 EXECUTIVE DRIVESAN DIEGOCA CALIFORNIA92121 US   MANUFACTURERS AND TRADERS TRUST COMPANY ONE M&T PLAZATRUST OPS 8TH FLOORBUFFALONY NEW YORK14203 US
MANULIFE SECURITIES INCORPORATED 1235 NORTH SERVICE ROAD WESTOAKVILLEON ONTARIOL6M 2W2 CA CANADA   MARSCO INVESTMENT CORPORATION 101 EISENHOWER PARKWAYROSELANDNJ NEW JERSEY07068 US
MERRILL LYNCH, PIERCE, FENNER & SMITH INCORPORATED 4804 Deer Lake Drive EastFL9-803-04-04- 4th floorJACKSONVILLEFL FLORIDA32246 US   MIRAE ASSET SECURITIES (USA) INC./STOCK LOAN CONDUIT ACCOUNT 810 SEVENTH AVE37TH FLOORNEW YORKNY NEW YORK10019
MIRAE ASSET SECURITIES (USA), INC. 810 SEVENTH AVE37TH FLOORNEW YORKNY NEW YORK10019   MITSUBISHI UFJ TRUST & BANKING CORPORATION, NEW YORK BRANCH 280 PARK AVE39TH FL-WEST BLDGNEW YORKNY NEW YORK10017
Morgan Stanley 1300 THAMES STREETTHAMES STREET WHARFBALTIMOREMD MARYLAND21231 US   MORGAN STANLEY & CO. LLC 1300 THAMES ST.BALTIMOREMD MARYLAND
MORGAN STANLEY SMITH BARNEY LLC 1 NEW YORK PLAZA39TH FLOORNEW YORKNY NEW YORK10004 US   MURIEL SIEBERT & CO., INC. 77 SUMMER STREET3RD FLOORBOSTONMA MASSACHUSETTS02210 US
NATIONAL FINANCIAL SERVICES LLC 499 WASHINGTON BOULEVARD5TH FLOORJERSEY CITYNJ NEW JERSEY07310 US   NBCN INC. 1010 rue De La GauchetièreMezzanine 100MONTREALQUEBECH3B 5J2 CA CANADA
NOMURA INTERNATIONAL TRUST COMPANY 309 WEST 49TH STREET10TH FLOORNEW YORKNY NEW YORK10019 US   ODLUM BROWN LIMITED 250 HOWE STREETSUITE 1100VANCOUVERBC BRITISH COLUMBIAV6C 3R8 CA CANADA
OPPENHEIMER & CO. INC. 85 BROAD STREETNEW YORKNY NEW YORK10004 US   PERSHING LLC 1 PERSHING PLAZAJERSEY CITYNJ NEW JERSEY07399 US
PHILLIP CAPITAL INC. 141 W. JACKSON BLVD. SUITE 3050CHICAGOIL ILLINOIS60604 US   PI FINANCIAL CORP. 666 BURRARD STSUITE 1900VANCOUVERBC BRITISH COLUMBIAV6C 3N1 CA CANADA
PNC BANK, NATIONAL ASSOCIATION 4100 W 150TH STREETASSET MOVEMENT TEAM 3RD FL, LOCATOR B7-YB17-03-03CLEVELANDOH OHIO44135 US   PRINCIPAL BANK 711 HIGH STREETDES MOINESIA IOWA50392
QUESTRADE INC./CDS** 5650 YONGE ST.,Suite 1700TORONTOON ONTARIOM2M 4G3 CA CANADA   Raymond James & Associates, Inc. 880 CARILLON PKWYST. PETERSBURGFL FLORIDA33733-2749 US
RAYMOND JAMES LTD. 925 WEST GEORGIA STREETSUITE 2200VANCOUVERBC BRITISH COLUMBIAV6C 3L2 CA CANADA   RBC CAPITAL MARKETS, LLC 60 SOUTH 6TH ST.MINNEAPOLISMN MINNESOTA55402 US
RBC DOMINION SECURITIES INC 21 COMMERCE COURT SOUTH2ND FLOORTORONTOON ONTARIOM5L 1A7 CANADA   RELIANCE TRUST COMPANY 1100 ABERNATHY RD.500 NORTHPARK SUITE 400ATLANTAGA GEORGIA30113 US
RELIANCE TRUST COMPANY 4900 W. BROWN DEER RDMILWAUKEEWI WISCONSIN53223 US   ROBERT W. BAIRD & CO. INCORPORATED 777 E WISCONSIN AVE9TH FLOORMILWAUKEEWI WISCONSIN53202 US
ROBINHOOD SECURITIES, LLC 500 COLONIAL CENTER PARKWAYSUITE 100LAKE MARYFL FLORIDA32746 US   SAFRA SECURITIES LLC 546 5TH AVENUENEW YORKNY NEW YORK10036 US
SCOTIA CAPITAL (USA) INC. 150 KING STREET W5TH FLOORTORONTOON ONTARIOM5H 1J9 CA CANADA   SEI PRIVATE TRUST COMPANY 1 FREEDOM VALLEY DRIVEOAKSPA PENNSYLVANIA19456 US
SEI PRIVATE TRUST COMPANY 1 FREEDOM VALLEY DRIVEOAKSPA PENNSYLVANIA19456 US   SG AMERICAS SECURITIES, LLC 480 WASHINGTON BLVD.20TH FLOORJERSEY CITYNJ NEW JERSEY07310 US
SSB - BLACKROCK INSTITUTIONAL TRUST 50 California StreetSan FranciscoCA CALIFORNIA94163   SSB - TRUST CUSTODY 30 ADELAIDE ST EASTSUITE 800TORONTOON ONTARIOM5C 3G6 CA CANADA
SSB&T CO/CLIENT CUSTODY SERVICES 1776 HERITAGE DRIVENORTH QUINCYMA MASSACHUSETTS02171   STATE STREET BANK & TRUST CO 16 WALL STREET5TH FLOORNEW YORKNY NEW YORK10005 US
STATE STREET BANK & TRUST COMPANY / ISHARES EUROPE 1776 HERITAGE DRIVENORTH QUINCYMA MASSACHUSETTS02171   STATE STREET BANK & TRUST/STATE STREET TOTALETF 1776 Heritage DriveNORTH QUINCYMA MASSACHUSETTS02717
STATE STREET BANK AND TRUST COMPANY 30 ADELAIDE ST EASTSUITE 800TORONTOON ONTARIOM5C 3G6 CA CANADA   STIFEL, NICOLAUS & COMPANY, INCORPORATED 501 N BROADWAYST. LOUISMO MISSOURI63102 US
STONEX FINANCIAL INC. 2 PERIMETER PARK SOUTHSUITE 100 WBIRMINGHAMAL ALABAMA35243 US   TD AMERITRADE CLEARING, INC. 200 S 108TH AVEOMAHANE NEBRASKA68154 US
TD WATERHOUSE CANADA INCATTN: MANDATORY CORPORATE ACTIONS 77 BLOOR STREET WEST3RD FLOORTORONTOON ONTARIOM5S 1M2 CA CANADA   TEXAS TREASURY SAFEKEEPING TRUST COMPANY 208 E 10TH STAUSTINTX TEXAS78701 US
THE BANK OF NEW YORK MELLON 500 GRANT STREET27TH FLOORPITTSBURGHPA PENNSYLVANIA15258 US   THE HUNTINGTON NATIONAL BANK 7 EASTON OVAL EA4E62COLUMBUSOH OHIO43209 US
THE NORTHERN TRUST COMPANY 333 South Wabash Ave, 32nd FloorAttn: Trade Securities ProcessingCHICAGOIL ILLINOIS60603 US   TRADESTATION SECURITIES, INC. 120 RIVERSIDE PLAZASUITE 1650CHICAGOIL ILLINOIS60606 US
U.S. BANCORP INVESTMENTS, INC. 60 LIVINGSTON AVEEP-MN-WN1BST. PAULMN MINNESOTA55107-1419 US   U.S. BANK N.A./ETF 1555 N RIVER CENTER DRIVEMILWAUKEEWI WISCONSIN53212
U.S. BANK NATIONAL ASSOCIATION 1555 NORTH RIVERCENTER DRIVE, SUITE 302SUITE 302MILWAUKEEWI WISCONSIN53212 US   UBS AG 480 WASHINGTON BLVD.12TH FLOORJERSEY CITYNJ NEW JERSEY07310 US
UBS FINANCIAL SERVICES INC. 1000 HARBOR BOULEVARDWEEHAWKENNJ NEW JERSEY07086 US   UBS SECURITIES LLC 677 WASHINGTON BLVDSTAMFORDCT CONNECTICUT06901 US
UMB BANK, NATIONAL ASSOCIATION 928 GRAND BLVDKANSAS CITYMO MISSOURI64106 US   VANGUARD MARKETING CORPORATION 100 VANGUARD BLVDMALVERNPA PENNSYLVANIA19355 US
VELOCITY CLEARING, LLC 1301 Route 36Suite 109 (Attn: Chris Felicetti)HAZLETNEW JERSEY7730 US   VELOX CLEARING LLC 2400 E. KATELLA AVENUESUITE 725AANAHEIMCA CALIFORNIA92806 US
VIRTU AMERICAS LLC ONE LIBERTY PLAZA, 165 BROADWAY5TH FLOORNEW YORKNY NEW YORK10006 US   VISION FINANCIAL MARKETS LLC 4 HIGH RIDGE PARKSUITE 100STAMFORDCT CONNECTICUT06905 US
WEDBUSH SECURITIES INC 1000 WILSHIRE BLVD8TH FLOORLOS ANGELESCA CALIFORNIA90017 US   WEDBUSH SECURITIES INC. 1000 WILSHIRE BLVD.LOS ANGELESCA CALIFORNIA90017 US
WELLS FARGO BANK, N.A./SIG 733 MARQUETTE AVE 4TH FLOORMAC N9306-04DMINNEAPOLISMN MINNESOTA55402 US   WELLS FARGO CLEARING SERVICES LLC 1 NORTH JEFFERSONMAIL CODE: H0006-094ST. LOUISMO MISSOURI63103 US
WELLS FARGO SECURITIES, LLC 1525 WEST W T HARRIS BLVDCHARLOTTENC NORTH CAROLINA28262 US   WILSON-DAVIS & CO., INC. 236 SOUTH MAIN STREETSALT LAKE CITYUT UTAH84101 US

About Scilex Holding Company 

Scilex Holding Company, a majority-owned by Sorrento Therapeutics, Inc., is an innovative revenue-generating company focused on acquiring, developing, and commercializing non-opioid pain management products for the treatment of acute and chronic pain. Scilex is uncompromising in its focus to become the global pain management leader committed to social, environmental, economic, and ethical principles to responsibly develop pharmaceutical products to maximize quality of life. Results from the Phase III Pivotal Trial C.L.E.A.R Program for SEMDEXA™, its novel, non-opioid product for the treatment of lumbosacral radicular pain (sciatica), were announced in March 2022.  Scilex has applied for breakthrough therapy designation and expects to seek priority review for SEMDEXA™ for the treatment of sciatica.  Scilex targets indications with high unmet needs and large market opportunities with non-opioid therapies for the treatment of patients with moderate to severe pain.  Scilex launched its first commercial product in October 2018, in-licensed a commercial product in June 2022, and is developing its late-stage pipeline, which includes a pivotal Phase 3 candidate and one Phase 2 and one Phase 1 candidate.  Its commercial product, ZTlido® (lidocaine topical system) 1.8%, or ZTlido®, is a prescription lidocaine topical product approved by the U.S. Food and Drug Administration for the relief of pain associated with postherpetic neuralgia, which is a form of post-shingles nerve pain.  Scilex in-licensed the exclusive right to commercialize Gloperba® (colchicine USP) oral solution, an FDA-approved prophylactic treatment for painful gout flares in adults, in the U.S. Scilex is planning to commercialize Gloperba® in 2023 and is well-positioned to market and distribute the product. Scilex’s three product candidates are SP-102 (injectable dexamethasone sodium phosphate viscous gel product containing 10 mg dexamethasone), or SEMDEXA™, a Phase 3, novel, viscous gel formulation of a widely used corticosteroid for epidural injections to treat lumbosacral radicular pain, or sciatica, with FDA Fast Track status; SP-103 (lidocaine topical system) 5.4%, a Phase 2, triple-strength formulation of ZTlido®, for the treatment of low back pain, with FDA Fast Track status; and SP-104, 4.5 mg Delayed Burst Release Low Dose Naltrexone Hydrochloride (DBR-LDN) Capsule, for the treatment of chronic pain, fibromyalgia that has completed multiple Phase 1 trial programs and expected to initiate Phase 2 trials this year. For further information regarding the SP-102 Phase 3 efficacy trial, see NCT identifier NCT03372161 – Corticosteroid Lumbar Epidural Analgesia for Radiculopathy – Full Text View – ClinicalTrials.gov.

Scilex Holding Company is headquartered in Palo Alto, California, with operations in both Palo Alto and San Diego, California. For further information please visit www.scilexholding.com.

About Sorrento Therapeutics, Inc.

Sorrento is a clinical and commercial stage biopharmaceutical company developing new therapies to treat cancer, pain (non-opioid treatments), autoimmune disease and COVID-19. Sorrento's multimodal, multipronged approach to fighting cancer is made possible by its extensive immuno-oncology platforms, including key assets such as Abivertinib, next-generation tyrosine kinase inhibitors (“TKIs”), fully human antibodies (“G-MAB™ library”), immuno-cellular therapies (“DAR-T™”), antibody-drug conjugates (“ADCs”), and oncolytic virus (“Seprehvec™”). Sorrento is also developing potential antiviral therapies and vaccines against coronaviruses, including STI-1558, COVI-MSC™; and diagnostic test solutions, including COVIMARK™.

Sorrento's commitment to life-enhancing therapies for patients is also demonstrated by our effort to advance a TRPV1 agonist, non-opioid pain management small molecule, resiniferatoxin (“RTX”), and SP-102 (10 mg, dexamethasone sodium phosphate viscous gel) (SEMDEXA™), a novel, viscous gel formulation of a widely used corticosteroid for epidural injections to treat lumbosacral radicular pain, or sciatica, and to commercialize ZTlido® (lidocaine topical system) 1.8% for the treatment of postherpetic neuralgia (PHN). RTX has been cleared for a Phase II trial for intractable pain associated with cancer and a Phase II trial in osteoarthritis patients. Positive final results from the Phase III Pivotal Trial C.L.E.A.R. Program for SEMDEXA™, its novel, non-opioid product for the treatment of lumbosacral radicular pain (sciatica), were announced in March 2022. ZTlido® was approved by the FDA on February 28, 2018.

For more information visit www.sorrentotherapeutics.com.

Contacts:

For Scilex Holding Company

Jaisim ShahChief Executive OfficerScilex Holding Company960 San Antonio RoadPalo Alto, CA 94303Office: (650) 516-4310

Email: jshah@scilexpharma.com

Website:  www.sorrentotherapeutics.com and www.scilexholding.com

Investors and Media Contact:Elizabeth CzerepakEmail: mediarelations@sorrentotherapeutics.comWebsite: www.sorrentotherapeutics.com

Sorrento® and the Sorrento logo are registered trademarks of Sorrento Therapeutics, Inc.

G-MAB™, DAR-T™, Seprehvec™, SOFUSA™, COVI-MSC™, COVIMARK™, Ovydso™ and Fujovee™ are trademarks of Sorrento Therapeutics, Inc.

SEMDEXA™ (SP-102) is a trademark owned by Semnur Pharmaceuticals, Inc., a wholly-owned subsidiary of Scilex Holding Company.  A proprietary name review by the FDA is planned.

ZTlido® is a registered trademark owned by Scilex Pharmaceuticals Inc., a wholly-owned subsidiary of Scilex Holding Company.

Gloperba® is an exclusive, transferable license to use the trademark by Scilex Holding Company.

All other trademarks are the property of their respective owners. 

© 2023 Sorrento Therapeutics, Inc. All Rights Reserved.

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