Entest BioMedical and RenovoCyte Begin Pilot Study of "Universal Donor" Stem Cell Treatment of Canine Osteoarthritis
November 18 2011 - 8:06AM
Marketwired
Entest BioMedical Inc. (OTCQB: ENTB) (PINKSHEETS: ENTB) and
RenovoCyte LLC today announced the treatment of the first canine
patient of a 10 dog pilot study utilizing Canine Endometrial
Regenerative Cells (CERC) licensed from Medistem Inc. (PINKSHEETS:
MEDS) in the treatment of canine osteoarthritis. The procedure was
performed at Entest's McDonald Animal Hospital in Santa Barbara
(http://www.mcdonaldvet.info/), which is currently accepting dogs
with osteoarthritis who meet inclusion criteria. Osteoarthritis is
considered one of the most common causes of lameness in dogs and
decreased quality of life. It is caused by a deterioration of joint
cartilage, followed by pain and loss of range of motion of the
joint.
The CERC is a "universal donor" stem cell product that does not
require matching with the recipient allowing for the generation of
standardized products that can be delivered to the office of the
veterinarian ready for injection. This is in stark contrast to
current stem cell therapies utilized in veterinary applications
which require the extraction, manipulation, and subsequent
replantation of tissue from the animal being treated. CERC is the
canine equivalent of Medistem's Endometrial Regenerative Cell
(ERC). Medistem was recently granted approval from the FDA to
initiate a clinical trial in human patients using its ERCs.
"Endometrial Regenerative Cells produce substantially higher
amounts of growth factors as compared to other adult stem cells,
are potent at inhibiting inflammation, and can home to the site of
tissue injury and exert a healing effect," said Dr. Greg McDonald,
Chief Veterinarian of the McDonald Animal Hospital.
David Koos, Chairman and CEO of Entest, commented, "This marks
the beginning of a new era in veterinary regenerative medicine. For
the first time a stem cell product exists which can be generated
inexpensively in the laboratory, shipped and stored frozen at the
office of the veterinarian, and injected intravenously without need
for specialized equipment. We believe that positioning ourselves in
the veterinary market will allow rapid proof of concept, both
clinically and financially."
"As a practicing veterinarian I witness first-hand the
devastating effects of osteoarthritis in pet dogs, for which no
curative treatment exists to date," said Dr. Shelley Zacharias, of
RenovoCyte (www.renovocyte.com). "Promising data from this pilot
study will be a fundamental step in creating a
clinically-applicable stem cell therapy that is inexpensive, easy
to use, and can be implemented on a wide-scale."
A spokesperson for Entest noted the Company is also currently
conducting a 10 dog safety study on its immune-therapeutic cancer
vaccine for dogs, having treated 3 dogs so far.
About Entest BioMedical Inc.:
Entest BioMedical Inc. (OTCQB: ENTB) is a developer of
veterinary medicines that harness the animal's own reparative /
immunological mechanisms. The company's products include an
immuno-therapeutic cancer vaccine for canines (ImenVax™). The
company's immuno-therapeutic cancer vaccine utilizes an
encapsulation device as the vaccine delivery system and requires a
simple implant procedure.
Disclaimer
This news release may contain forward-looking statements.
Forward-looking statements are inherently subject to risks and
uncertainties, some of which cannot be predicted or quantified.
Future events and actual results could differ materially from those
set forth in, contemplated by, or underlying the forward-looking
statements. The risks and uncertainties to which forward-looking
statements are subject include, but are not limited to, the effect
of government regulation, competition and other material risks.
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Contact: Entest BioMedical Inc. David R. Koos Chairman & CEO
619.702.1404 Direct 619.330.2328 Fax Email Contact
www.EntestBio.com
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