SCHEDULE 10                                  
                                                                               
                   NOTIFICATION OF MAJOR INTERESTS IN SHARES                   

1. Name of company

Acambis plc                                                                    

2. Name of shareholder having a major interest

Fidelity International Limited (FIL) (and its direct and indirect subsidiaries 
incorporating Fidelity Investment Services Limited (FISL)) and Mr Edward C     
Johnson 3d                                                                     

3. Please state whether notification indicates that it is in respect of holding
of the shareholder named in 2 above or in respect of a non-beneficial interest
or in the case of an individual holder if it is a holding of that person's
spouse or children under the age of 18

As above                                                                       

4. Name of the registered holder(s) and, if more than one holder, the number of
shares held by each of them

Chase Manhattan Bank London 2,845,508 shares*                                  
                                                                               
Chase Manhattan Bank London 173,268 shares**                                   
                                                                               
* For this holding, FISL acts as the management company                        
                                                                               
** For this holding, FIL acts as the management company.                       

5. Number of shares / amount of stock acquired

N/a                                                                            

6. Percentage of issued class

N/a                                                                            

7. Number of shares / amount of stock disposed

1,060,665                                                                      

8. Percentage of issued class

1.01%                                                                          

9. Class of security

Ordinary shares of 10p each                                                    

10. Date of transaction

N/a                                                                            

11. Date company informed

7 November 2003                                                                

12. Total holding following this notification

3,018,776 ordinary shares                                                      

13. Total percentage holding of issued class following this notification

2.87%                                                                          

14. Any additional information

N/a                                                                            

15. Name of contact and telephone number for queries

Elizabeth Brown, Company Secretary                                             
                                                                               
+44 (0) 1223 275 300                                                           

16. Name and signature of authorised company official responsible for making
this notification

Elizabeth Brown                                                                

Date of notification

10 November 2003                                                               

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END