RNS Number:2740L
New Opportunities Inv. Trust PLC
19 May 2003

                                  SCHEDULE 10

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES

1)      Name of company

NEW OPPORTUNITIES INVESTMENT TRUST PLC


2)      Name of shareholder having a major interest

REGEN THERAPEUTICS PLC


3)      Please state whether notification indicates that it is in respect of
holding of the shareholder named in 2 above or in respect of a non-beneficial 
interest or in the case of an individual holder if it is a holding of that 
person's spouse or children under the age of 18

SHAREHOLDER IN 2, ABOVE

4)      Name of the registered holder(s) and, if more than one holder, the
number of shares held by each of them

SHAREHOLDER IN 2, ABOVE

5)      Number of shares/amount of stock acquired

NIL

6)     Percentage of issued class

N/A

7)     Number of shares/amount of stock disposed

500,000

8)     Percentage of issued class

2.12%

9)     Class of security

REDEEMABLE ORDINARY SHARES OF 5 PENCE EACH

10)     Date of transaction

NOT ADVISED

11)     Date company informed

19 MAY 2003

12)     Total holding following this notification

560,606 SHARES

13)     Total percentage holding of issued class following this notification

2.38%

14)     Any additional information



15)     Name of contact and telephone number for queries

IAN LANCASTER, DIRECTOR, NEW OPPORTUNITIES INVESTMENT TRUST PLC, 020 7332 2070

16)     Name and signature of authorised company official responsible for making
this notification

     IAN LANCASTER, DIRECTOR


     Date of notification 19 MAY 2003


                      This information is provided by RNS
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END

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