FORM 3
        
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

BAYER HEALTHCARE LLC		 2. Date of Event Requiring Statement (MM/DD/YYYY)
6/8/2022 

 3. Issuer Name and Ticker or Trading Symbol

Senti Biosciences, Inc. [SNTI]
(Last)        (First)        (Middle)

100 BAYER BOULEVARD, 		 4. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director                          ___X___ 10% Owner
_____ Officer (give title below)        _____ Other (specify below)
(Street)

WHIPPANY, NJ 07981      

(City)              (State)              (Zip)
5. If Amendment, Date Original Filed(MM/DD/YYYY)
 

6. Individual or Joint/Group Filing(Check Applicable Line)

___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		2. Amount of Securities Beneficially Owned
(Instr. 4)		3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 5878488 D (1) 

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 4)		2. Date Exercisable and Expiration Date
(MM/DD/YYYY)		3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		4. Conversion or Exercise Price of Derivative Security5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date ExercisableExpiration DateTitleAmount or Number of Shares
Explanation of Responses:
(1) The securities reported are held directly by Bayer HealthCare LLC, a Delaware limited liability company, which is controlled by Bayer US Holding LP ("BUSH LP"), a Delaware limited partnership. Bayer World Investments B.V. ("BWI"), a Dutch private limited company, is the general partner of BUSH LP. BWI is an indirect, wholly owned subsidiary of Bayer Aktiengesellschaft, a publicly-held German stock corporation. Accordingly, Bayer Aktiengesellschaft may be deemed to be an indirect beneficial owner of the shares beneficially owned directly by Bayer HealthCare LLC.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
BAYER HEALTHCARE LLC
100 BAYER BOULEVARD
WHIPPANY, NJ 07981
X

Bayer US Holding LP
100 BAYER BOULEVARD
WHIPPANY, NJ 07981
X

Bayer World Investments B.V.
SIRIUSDREEF 36
HOOFDDORP, P7 2132WT
X

BAYER AKTIENGESELLSCHAFT
BAYERWERK, GEBAEUDE W11
KAISER-WILHELM-ALLEE 1
LEVERKUSEN, 2M 51373
X
Signatures
Bayer HealthCare LLC, By: /s/ Keith R. Abrams, Name: Keith R. Abrams, Title: Assistant Secretary2/13/2023
**Signature of Reporting PersonDate

Bayer US Holding LP, By: /s/ Keith R. Abrams, Name: Keith R. Abrams, Title: Assistant Secretary2/13/2023
**Signature of Reporting PersonDate

Bayer World Investments B.V., By: /s/ Patrick Lennaerts, Name: Patrick Lennaerts, Title: Managing Director2/13/2023
**Signature of Reporting PersonDate

Bayer Aktiengesellschaft, By: /s/ Deny-Jean Silny, Name: Deny-Jean Silny, Title: Legal Head Mergers & Acquisitions2/13/2023
**Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
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