UNITED STATES SECURITIES AND
EXCHANGE COMMISSION
Washington, D.C. 20549
Schedule 13G
(RULE 13d-102)
Under the Securities Exchange Act of 1934
(Amendment No. 0 )*
Information to be included in statements filed
pursuant to Rule 13d-1 (b) (c) and (d) and Amendments thereto
filed pursuant to Rule 13d-2 (b).
Nuvelo, Inc.
(Name of Issuer)
Common shares
(Title of Class of Securities)
67072M301
(CUSIP Number)
December 2, 2008
(Date of Event which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant
to which this Schedule is filed:
[X] Rule 13d-1 (b)
[X] Rule 13d-1 (c)
[ ] Rule 13d-1 (d)
*The remainder of this cover page shall be filled out for a
reporting person's initial filing on this form with respect to the
subject class of securities, and for any subsequent amendment
containing information which would alter the disclosures provided
in a prior cover page.
The information required in the remainder of this cover page shall
not be deemed to be "filed" for the purpose of Section 18 of the Securities
Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of
that section of the Act but shall be subject to all other provisions of
the Act (however, see the Notes).
SCHEDULE 13G
Issuer: Nuvelo, Inc. CUSIP No.: 67072M301
1 NAMES OF REPORTING PERSONS I.R.S.
IDENTIFICATION NOS. OF ABOVE PERSONS
Arnhold and S. Bleichroeder Advisers, LLC
Tax ID # 57-1156902
2 CHECK THE APPROPRIATE BOX IF A MEMBER
OF A GROUP
(a)
(b)
3 SEC USE ONLY
4 CITIZENSHIP OR PLACE OF ORGANIZATION
State of Delaware
NUMBER OF SHARES 5 SOLE VOTING POWER - 4,229,526
BENEFICIALLY 6 SHARED VOTING POWER - 0
OWNED BY EACH 7 SOLE DISPOSITIVE POWER - 4,229,526
REPORTING PERSON 8 SHARED DISPOSITIVE POWER - 0
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WITH:
9 AGGREGATE AMOUNT BENEFICIALLY OWNED
BY EACH REPORTING PERSON
4,229,526
10 CHECK IF THE AGGREGATE AMOUNT IN
ROW (11) EXCLUDES CERTAIN SHARES
N/A
11 PERCENT OF CLASS REPRESENTED BY AMOUNT
IN ROW 9:
7.88%
12 TYPE OF REPORTING PERSON
IA
SCHEDULE 13G
Issuer: Nuvelo, Inc. CUSIP No.: 67072M301
ITEM 1
(a) Name of Issuer:
Nuvelo, Inc.
(b) Address of Issuer's Principal Executive Offices:
201 Industrial Road, Suite 310
San Carlos, CA 94070
ITEM 2
(a) Name of Person Filing: Arnhold and S. Bleichroeder Advisers, LLC
(b) Address of Principal Business Office:
1345 Avenue of the Americas
New York, NY 10105
(c) Citizenship: Delaware, USA (Place of Incorporation)
(d) Title of Class of Securities: Common Shares
(e) CUSIP Number: 67072M301
SCHEDULE 13G
Issuer: Nuvelo, Inc. CUSIP No.: 67072M301
ITEM 3
If this statement is filed pursuant to Sections 240.
13d-1(b), or 240.13d-2(b) or (c), check whether
the person filing is a:
(a) [ ] Broker or dealer registered under
Section 15 of the Act (15 U.S.C. 78o);
(b) [ ] Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c) [ ] Insurance Company as defined in section
3(a)(19) of the Act (15 U.S.C. 78C);
(d) [ ] Investment company registered under Section
8 of the Investment Company Act if 1940
(15 U.S.C. 80a-8);
(e) [X] An investment adviser in accordance with Section
240.13d-1(b)(1)(ii)(E);
(f) [ ] An employee benefit plan or endowment fund in accordance with
Section 240.13d-1(b)(1)(ii)(F);
(g) [ ] A parent holding company or control person in accordance with
Section 240.13d-1(b)(1)(ii)(G);
(h) [ ] A savings associations as defined in Section 3(b) of the
Federal Deposit Insurance Act (12 U.S.C. 1813);
(i) [ ] A church plan that is excluded from the
definition of an insurance company under Section 3 (c)(14) of
the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j) [ ] Group, in accordance with section 240.13d-1 (b)(1)(ii)(J).
SCHEDULE 13G
Issuer: Nuvelo, Inc. CUSIP No.: 67072M301
ITEM 4. Ownership.
(a) Amount beneficially owned: 4,229,526
(b) Percent of class: 7.88%
(c) Number of shares as to which the person has:
(i) Sole power to vote or to direct the vote 4,229,526
(ii) Shared power to vote or to direct the vote 0
(iii) Sole power to dispose or to direct the disposition of 4,229,526
(iv) Shared power to dispose or to direct the disposition of 0
ITEM 5. Ownership of Five Percent or Less of a Class.
N/A
ITEM 6. OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON
Arnhold and S. Bleichroeder, LLC (ASB), an investment adviser registered
under Section 203 of the Investment Advisers Act of 1940, may be deemed
currently to be the beneficial owner of 4,229,526 shares, or 7.88% of the
shares believed to be outstanding, as a result of acting as investment
adviser to various clients. Clients of ASB have the right to receive and
the ultimate power to direct the receipt of dividends from, or the proceeds
of the sale of, such securities. First Eagle Value in Biotechnology Master
Fund, Ltd. ("FEVBM"), a Cayman Islands company for which ASB acts as
investment adviser, may be deemed to beneficially own 2,700,581 of these
4,229,526 shares, which equates to 5.03% of the Common Stock. This Schedule
13G/A is being filed to reflect that FEVBM's ownership of the common stock
exceeded 5% as of December 2, 2008.
ITEM 7. IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED
THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY OR CONTROL
PERSON.
N/A
ITEM 8. Identification and Classification of Members of the Group.
N/A
ITEM 9. Notice of Dissolution of Group
N/A
SCHEDULE 13G
Issuer: Nuvelo, Inc. CUSIP No.: 67072M301
ITEM 10. Certification
By signing below I certify that, to the best of my knowledge and
belief, the securities referred to above were acquired and held in the
ordinary course of business and were not acquired and are not held for the
purpose of or with the effect of changing or influencing the control of the
issuer of such securities and were not acquired and are not held in
connection with or as a participant in any transaction having that purpose
of effect.
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief,
I certify that the information set forth in this statement is true,
complete and correct.
Date: December 8, 2008
Signature: /s/ Mark Goldstein
Name/Title: Mark Goldstein, Senior Vice President
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