Explanation of Responses:
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1)
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The number of shares disposed of represents 5,963 shares acquired under the Issuer's 2008 Employee Stock Purchase Plan.
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2)
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Pursuant to the Agreement and Plan of Merger, dated September 5, 2013, between the Issuer, Otsuka Pharmaceutical Co. Ltd., and Autumn Aquisition Corporation (the "Merger Agreement"), each share of Common Stock was exchanged for $8.50 in cash.
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3)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $408,595.20, which represents the difference between $8.50 and the exercise price of the option per share.
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4)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $200,630,72, which represents the difference between $8.50 and the exercise price of the option per share.
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5)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $149,833.72, which represents the difference between $8.50 and the exercise price of the option per share.
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6)
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The option originally provided for vesting as to 1/4th of the shares on June 24, 2009 and as to 1/48th of the shares on each one month anniversary thereafter.
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7)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $203,511.84, which represents the difference between $8.50 and the exercise price of the option per share.
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8)
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The option originally provided for vesting as to 1/4th of the shares on June 22, 2010 and as to 1/48th of the shares on each one month anniversary thereafter.
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9)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $247,375.35, which represents the difference between $8.50 and the exercise price of the option per share.
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10)
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The option originally provided for vesting as to 1/4th of the shares on May 28, 2011 and as to 1/48th of the shares on each one month anniversary thereafter. Pursuant to the Merger Agreement, the option vested in full immediately prior to the closing of the merger.
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11)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $744,507.60, which represents the difference between $8.50 and the exercise price of the option per share.
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12)
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The option originally provided for vesting as to 1/4th of the shares on September 16, 2012 and as to 1/48th of the shares on each one month anniversary thereafter. Pursuant to the Merger Agreement, the option vested in full immediately prior to the closing of the merger.
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13)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $943,500.00, which represents the difference between $8.50 and the exercise price of the option per share.
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14)
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The option originally provided for vesting as to 1/48th of the shares on April 7, 2012 and each one month anniversary thereafter. Pursuant to the Merger Agreement, the option vested in full immediately prior to the closing of the merger.
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15)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $1,189,800.00, which represents the difference between $8.50 and the exercise price of the option per share.
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16)
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The option originally provided for vesting as to 1/48th of the shares on January 6, 2013 and each one month anniversary thereafter. Pursuant to the Merger Agreement, the option vested in full immediately prior to the closing of the merger.
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17)
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Pursuant to the Merger Agreement, the option was cancelled in exchange for a cash payment of $1,042,200.00, which represents the difference between $8.50 and the exercise price of the option per share.
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